Preoperative assessment of meningioma aggressiveness by Thallium-201 brain SPECT

Introduction: Meningioma is usually a benign brain tumor, but sometimes with aggressive course. The aim of this study was to assess the ability of 201Tl Brain SPECT to differentiate the pathologic grade of meningioma preoperatively. Methods: Thirty lesions in 28 patients were evaluated in this study. Early (20 minutes) and late (3 hours) brain SPECT images were performed and early uptake ratio (EUR), late uptake ratio (LUR) and retention index (RI) were calculated. All patients were operated and pathologic grade of tumors were defined according to World Health Organization grading system. Results: SPECT results were compared in different pathologic groups. Data analysis clarified no significant difference of EUR in benign and aggressive meningioma (P=0.2). However LUR and RI were significantly higher in aggressive tumors (P=0.001 and P=0.02, respectively). Conclusion: According to our data Tl-201 Brain SPECT with early and late imaging has 80 sensitivity and specificity to differentiate malignant from benign meningioma

Impact of metoclopramide on image quality in myocardial perfusion imaging

Background: The effectiveness of metoclopramide in reducing gastrointestinal-induced artifacts in myocardial perfusion imaging (MPI) is a subject of debate. We examined the significance of this pharmacological intervention in the quality of images obtained from MPI studies. Patients and Methods: A total of 211 suspected or known cases with coronary artery disease routinely referred to our nuclear medicine department for MPI were randomly assigned to group A and group B. Group A (N=125) comprised patients who received 10 mg of metoclopramide orally after the injection of the radiotracer technetium-99m-labeled methoxyisobutyl isonitril (Tc-MIBI) 1 h before image acquisition, and group B (N=86) comprised patients who did not receive any pharmacological intervention and were considered the control group. All the scans in each group were assessed in the rest phase of a routine 2-day protocol. The single-photon emission computerized tomography (SPECT) images were visually evaluated in terms of extracardiac activities and their effects on image quality by three nuclear medicine physicians, who were blinded to the details of the protocol. Results: Of the 125 patients who had received metoclopramide, 16 (13%) had nonacceptable, 72 (57.6%) had acceptable (interpretable), and 37 (29.6%) had good image quality. The image quality in group B was nonacceptable in 10 (11.23%), acceptable in 48 (50.23%), and good in 28 (33.56%) patients. The overall interobserver agreement was good (κ: 0.6-0.9, P<0.05) among the three readers. Conclusion: There was no statistically significant difference in terms of MPI-SPECT image quality between patients who received metoclopramide and those in the control group. Metoclopramide, therefore, did not exert a remarkable effect on the quality of our MPI scans. © 2012 Wolters Kluwer Health | Lippincott Williams & Wilkins

Assessment of left ventricular mechanical dyssynchrony by phase analysis of gated-SPECT myocardial perfusion imaging and tissue Doppler imaging: Comparison between QGS and ECTb software packages

Background: Recently, the phase analysis of gated single-photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) has become feasible via several software packages for the evaluation of left ventricular mechanical dyssynchrony. We compared two quantitative software packages, quantitative gated SPECT (QGS) and Emory cardiac toolbox (ECTb), with tissue Doppler imaging (TDI) as the conventional method for the evaluation of left ventricular mechanical dyssynchrony. Methods and Results: Thirty-one patients with severe heart failure (ejection fraction ≤35%) and regular heart rhythm, who referred for gated-SPECT MPI, were enrolled. TDI was performed within 3 days after MPI. Dyssynchrony parameters derived from gated-SPECT MPI were analyzed by QGS and ECTb and were compared with the Yu index and septal-lateral wall delay measured by TDI. QGS and ECTb showed a good correlation for assessment of phase histogram bandwidth (PHB) and phase standard deviation (PSD) (r = 0.664 and r = 0.731, P < .001, respectively). However, the mean value of PHB and PSD by ECTb was significantly higher than that of QGS. No significant correlation was found between ECTb and QGS and the Yu index. Nevertheless, PHB, PSD, and entropy derived from QGS revealed a significant (r = 0.424, r = 0.478, r = 0.543, respectively; P < .02) correlation with septal-lateral wall delay. Conclusion: Despite a good correlation between QGS and ECTb software packages, different normal cut-off values of PSD and PHB should be defined for each software package. There was only a modest correlation between phase analysis of gated-SPECT MPI and TDI data, especially in the population of heart failure patients with both narrow and wide QRS complex. © 2014, American Society of Nuclear Cardiology

Metaheuristics for Transmission Network Expansion Planning

This chapter presents the characteristics of the metaheuristic algorithms used to solve the transmission network expansion planning (TNEP) problem. The algorithms used to handle single or multiple objectives are discussed on the basis of selected literature contributions. Besides the main objective given by the costs of the transmission system infrastructure, various other objectives are taken into account, representing generation, demand, reliability and environmental aspects. In the single-objective case, many metaheuristics have been proposed, in general without making strong comparisons with other solution methods and without providing superior results with respect to classical mathematical programming. In the multi-objective case, there is a better convenience of using metaheuristics able to handle conflicting objectives, in particular with a Pareto front-based approach. In all cases, improvements are still expected in the definition of benchmark functions, benchmark networks and robust comparison criteria

The Effect of Sustained Teacher Feedback on CAF, Content and Organization in EFL Writing

Despite teachers' mainstream practices in L2 writing classrooms addressing different dimensions of writing over time, much of the research on feedback in recent years has been of relative short duration and has mainly focused on accuracy. The current longitudinal study investigated the influence of sustained teacher written feedback on accuracy, syntactic complexity, fluency, content, and organization in an EFL context. Ninety-two learners were divided into four groups, receiving written corrective feedback, feedback on content and organization, multilateral feedback (i.e., on grammatical accuracy, content, and organization), and no feedback over a 3½-month period. They completed a pre-test, post-test, and delayed post-test and wrote and revised eight interim expository compositions on a weekly basis. Results showed that the three treatment groups significantly improved in the dimensions on which they received feedback. However, only the groups who received feedback on content and organization improved in fluency. Importantly, the multilateral group improved in accuracy as well as fluency, content and organization. Theoretically, the findings endorse the language learning potentials of sustained writing as long as it is guided by teacher feedback. The findings provide empirical support for the influence of sustained feedback on expanding and consolidating learners’ explicit knowledge of L2 writing

Parametric estimation of water retention using mGMDH method and principal component analysis

Performing a primary analysis, such as principal component analysis (PCA) may increase accuracy and reliability of developed pedotransfer functions (PTFs). This study focuses on the usefulness of the soil penetration resistance (PR) and principal components (PCs) as new inputs along with the others to develop the PTFs for estimating the soil water retention curve (SWRC) using a multi-objective group method of data handling (mGMDH). The Brooks and Corey (1964) SWRC model was used to give a description of the water retention curves and its parameters were determined from experimental SWRC data. To select eight PCs, PCA was applied to all measured or calculated variables. Penetration resistance, organic matter (OM), aggregates mean weight diameter (MWD), saturated hydraulic conductivity (Ks), macro porosity (Mp), micro porosity (Mip) and eight selected PCs were used as predictors to estimate the Brooks and Corey model parameters by mGMDH. Using PR or OM, Ks and MWD, improved the estimation of SWRC in some cases. Using the predicted PR can be useful in the estimation of SWRC. Using either the MP and Mip or the eight PCs significantly improved the PTFs accuracy and reliability. It would be very useful to apply PCA on the original variables as a primary analysis to develop parametric PTFs

Isolation of scFv antibody fragments against HER2 and CEA tumor antigens from combinatorial antibody libraries derived from cancer patients

Tumor cells expressing HER-2/neu and CEA antigens are potentially ideal targets for antibody-targeted therapy. In this study, two large human combinatorial libraries have been generated from the lymph nodes of breast cancer patients that express HER2 and CEA antigens in their tumors. These 'immune' libraries have been constructed in two different formats of scFv, differing in the length of the peptide linker connecting the two variable VH and VL domains. Libraries derived from these patients may contain a larger pool of anti-tumor antigen antibodies and are useful repertoire for isolating scFvs against any tumor markers. The results of this study showed that we were successful in obtaining human scFvs against HER-2/neu and CEA. For HER-2, cell-panning strategy was performed and resulted in two scFv binders that detected the complete HER-2 receptor on the cell membrane and internalized to the cells. Also, preliminary ELISA data showed that several anti-CEA scFv binders were isolated by panning. \ua9 2013 The International Alliance for Biological Standardization.Peer reviewed: YesNRC publication: Ye

Parametric estimation of water retention using Mgmdh method and principal component analysis

Performing a primary analysis, such as principal component analysis (PCA) may increase accuracy and reliability of developed pedotransfer functions (PTFs). This study focuses on the usefulness of the soil penetration resistance (PR) and principal components (PCs) as new inputs along with the others to develop the PTFs for estimating the soil water retention curve (SWRC) using a multi-objective group method of data handling (mGMDH). The Brooks and Corey (1964) SWRC model was used to give a description of the water retention curves and its parameters were determined from experimental SWRC data. To select eight PCs, PCA was applied to all measured or calculated variables. Penetration resistance, organic matter (OM), aggregates mean weight diameter (MWD), saturated hydraulic conductivity (Ks), macro porosity (Mp), micro porosity (Mip) and eight selected PCs were used as predictors to estimate the Brooks and Corey model parameters by mGMDH. Using PR or OM, Ks and MWD, improved the estimation of SWRC in some cases. Using the predicted PR can be useful in the estimation of SWRC. Using either the MP and Mip or the eight PCs significantly improved the PTFs accuracy and reliability. It would be very useful to apply PCA on the original variables as a primary analysis to develop parametric PTFs

Gated spect phase analysis of abnormal left ventricular wall motion polar maps in patients with normal perfusion, normal global function, and low pretest probability of ischemic heart disease

Background: One of the probable reasons for wall motion polar map abnormalities is left ventricular (LV) dyssynchrony. The objective of this study was to evaluate LV dyssynchrony via the phase analysis on myocardial perfusion imaging (MPI) in patients with a low pretest probability of ischemic heart disease (IHD) and normal electrocardiography (ECG)-gated MPI as the possible contributor to LV regional wall motion polar map abnormalities. Methods: A total of 181 patients with a low likelihood of IHD, normal MPI, a normal global function, and a normal global ejection fraction were divided into 2 groups: Group A: 81 patients with abnormal regional wall motion and Group B: 100 patients with normal wall motion polar maps. Dyssynchrony in the LV wall was assessed in terms of the phase analysis indices of entropy, the phase histogram bandwidth, and the phase standard deviation quantified by quantitative gated SPECT software, and the results for both groups were compared. Results: The mean entropy values in the LV anterior, lateral, inferior, and particularly septal walls (P < 0.0001), as well as the mean entropy value in the LV apical wall (P = 0.030), in Group A were significantly higher than those in Group B. Moreover, the phase histogram bandwidth and the phase standard deviation were considerably higher in Group A than in Group B in all LV walls (P < 0.0001), except the LV apical wall (P = 0.063 and P = 0.036) respectively. Conclusions: Assessment of the phase analysis indices for LV dyssynchrony could be used in patients with a low probability of IHD, a normal LV perfusion, and abnormal wall motion polar maps as a complementary tool for the interpreting physician. © 2020, Iranian Heart Association. All rights reserved

Influence of respiratory motion correction on quantification of myocardial perfusion SPECT

Background: Respiratory-related cardiac motion could have considerable effects on myocardial perfusion imaging, leading to misinterpretation of the images. In this study, we examined the influence of respiratory correction on ECG-gated myocardial perfusion SPECT (RC-GSPECT) concerning regional myocardial perfusion and function. Materials and Methods: Using the NCAT phantom, a typical torso phantom was generated. SimSET, a Monte Carlo simulator, was used to image the photon emerging from the phantom. Twenty-six patients underwent a 2-day stress-rest ECG-gated myocardial perfusion SPECT (GSPECT) imaging. A separate study was also performed by simultaneous respiratory and cardiac triggering with the real-time position management (RPM) for respiratory correction (RC). Results: In simulation study, count density in the inferior and inferoseptal walls increased in the lower bin of the respiratory cycle. On the other hand, there was a higher correlation between RC-GSPECT and echocardiography for left ventricular ejection fraction (LVEF) (r = 0.95, P < .01 vs r = 0.88, P < .01 for GSPECT). Conclusion: We proposed a new approach for respiratory and cardiac-gated SPECT to eliminate respiratory motion artifacts. RC-GSPECT is a feasible method in MPI studies and may play an important role to improve the quality of MPI images, particularly in the inferior wall. © 2014, American Society of Nuclear Cardiology