12,597 research outputs found
Discrete Nonlinear Schrodinger Equations with arbitrarily high order nonlinearities
A class of discrete nonlinear Schrodinger equations with arbitrarily high
order nonlinearities is introduced. These equations are derived from the same
Hamiltonian using different Poisson brackets and include as particular cases
the saturable discrete nonlinear Schrodinger equation and the Ablowitz-Ladik
equation. As a common property, these equations possess three kinds of exact
analytical stationary solutions for which the Peierls-Nabarro barrier is zero.
Several properties of these solutions, including stability, discrete breathers
and moving solutions, are investigated
Prazosin + Naltrexone Decreases Alcohol Drinking More Effectively Than Does Either Drug Alone in P Rats with a Protracted History of Extensive Voluntary Alcohol Drinking, Dependence, and Multiple Withdrawals
Background
Prazosin (PRZ, an α1-adrenergic receptor antagonist) and naltrexone (NTX, a non-specific opioid receptor antagonist) each decrease alcohol drinking when administered to rats selectively-bred for high voluntary alcohol drinking (alcohol-preferring, or âPâ), and the combination of PRZ+NTX decreases alcohol drinking more effectively than does either drug alone. Since drug responsiveness can depend on history of alcohol drinking and dependence, we investigated whether various schedules of PRZ and NTX administration, alone or in combination, are effective in decreasing alcohol drinking in male P rats with a history of protracted voluntary alcohol drinking, dependence and repeated withdrawals closely resembling human alcoholism.
Methods
Male P rats became alcohol-dependent during 1 year of ad libitum 24 h/day access to food, water and 20% alcohol with repetitive temporary alcohol withdrawals. Four sequential studies then addressed effects of oral PRZ (2 mg/kg) and NTX (10 mg/kg), alone or together, on alcohol drinking during: 1) daily alcohol access with daily drug treatment, 2) intermittent alcohol access with daily drug treatment, 3) intermittent alcohol access with occasional drug treatment, and 4) post-deprivation reinstatement of alcohol access.
Results
The combination of PRZ+NTX consistently suppressed alcohol drinking during daily or intermittent alcohol access conditions and when drug treatment was either daily or occasional. PRZ+NTX was consistently more effective than either drug alone. The reduction in alcohol drinking was not due to sedation, motor effects or malaise.
Conclusions
Both daily and âas-neededâ treatment with PRZ+NTX are highly effective in suppressing daily, intermittent and post-deprivation alcohol drinking in male P rats with a protracted history of alcohol dependence and repeated withdrawals. This drug combination may be especially effective for treating individuals with long histories of heavy alcohol abuse, dependence and repeated relapse, as commonly encountered in clinical practice
Affine su(3) and su(4) fusion multiplicities as polytope volumes
Affine su(3) and su(4) fusion multiplicities are characterised as discretised
volumes of certain convex polytopes. The volumes are measured explicitly,
resulting in multiple sum formulas. These are the first polytope-volume
formulas for higher-rank fusion multiplicities. The associated threshold levels
are also discussed. For any simple Lie algebra we derive an upper bound on the
threshold levels using a refined version of the Gepner-Witten depth rule.Comment: 16 pages, LaTe
Re-evaluation of cosmic ray cutoff terminology
The study of cosmic ray access to locations inside the geomagnetic field has evolved in a manner that has led to some misunderstanding and misapplication of the terminology originally developed to describe particle access. This paper presents what is believed to be a useful set of definitions for cosmic ray cutoff terminology for use in theoretical and experimental cosmic ray studies
Use of soil moisture information in yield models
There are no author-identified significant results in this report
Deep far infrared ISOPHOT survey in "Selected Area 57", I. Observations and source counts
We present here the results of a deep survey in a 0.4 sq.deg. blank field in
Selected Area 57 conducted with the ISOPHOT instrument aboard ESAs Infrared
Space Observatory (ISO) at both 60 um and 90 um. The resulting sky maps have a
spatial resolution of 15 x 23 sq.arcsec. per pixel which is much higher than
the 90 x 90 sq.arcsec. pixels of the IRAS All Sky Survey. We describe the main
instrumental effects encountered in our data, outline our data reduction and
analysis scheme and present astrometry and photometry of the detected point
sources. With a formal signal to noise ratio of 6.75 we have source detection
limits of 90 mJy at 60 um and 50 mJy at 90 um. To these limits we find
cumulated number densities of 5+-3.5 per sq.deg. at 60 um and 14.8+-5.0 per
sq.deg.at 90 um. These number densities of sources are found to be lower than
previously reported results from ISO but the data do not allow us to
discriminate between no-evolution scenarios and various evolutionary models.Comment: 15 pages, 11 figures, accepted by Astronomy & Astrophysic
Limitations of focussing on homophobic, biphobic and transphobic âbullyingâ to understand and address LGBT young peopleâs experiences within and beyond school
This paper presents new empirical data that highlight how a focus on âbullyingâ is too limited and narrow when thinking about homophobia, biphobia and transphobia that young people may experience. The paper draws on two recent studies with young lesbian, gay, bisexual and trans participants, which each identified issues and experiences not readily captured within dominant bullying discourses and understandings. Findings are examined within three sections: beyond âbullyingâ, questioning inevitability, and (in)appropriate responses. In conclusion, I set out some implications and suggestions for the development of practice and future research concerning homophobia, biphobia and transphobia in youth settings
Influence of pH, particle size and crystal form on dissolution behaviour of engineered nanomaterials
Virtuality in human supervisory control: Assessing the effects of psychological and social remoteness
Virtuality would seem to offer certain advantages for human supervisory control. First, it could provide a physical analogue of the 'real world' environment. Second, it does not require control room engineers to be in the same place as each other. In order to investigate these issues, a low-fidelity simulation of an energy distribution network was developed. The main aims of the research were to assess some of the psychological concerns associated with virtual environments. First, it may result in the social isolation of the people, and it may have dramatic effects upon the nature of the work. Second, a direct physical correspondence with the 'real world' may not best support human supervisory control activities. Experimental teams were asked to control an energy distribution network. Measures of team performance, group identity and core job characteristics were taken. In general terms, the results showed that teams working in the same location performed better than team who were remote from one another
Combining the α1-Adrenergic Receptor Antagonist, Prazosin, with the ÎČ-Adrenergic Receptor Antagonist, Propranolol, Reduces Alcohol Drinking More Effectively Than Either Drug Alone
Background
Evidence suggests that activation of the noradrenergic system may contribute to alcohol drinking in animals and humans. Our previous studies demonstrated that blocking α1-adrenergic receptors with the antagonist, prazosin, decreased alcohol drinking in rats under various conditions. Since noradrenergic activation is also regulated by ÎČ-adrenergic receptors, we now examine the effects of the ÎČ-adrenergic receptor antagonist, propranolol, alone or in combination with prazosin, on alcohol drinking in rats selectively bred for high voluntary alcohol intake and alcohol preference (P line).
Methods
Two studies were conducted with male P rats. In study one, rats were allowed to become alcohol-dependent during 14 weeks of ad libitum access to food, water and 20% alcohol and the effect of propranolol (5â15 mg/kg, IP) and prazosin (1â2 mg/kg, IP) on alcohol intake during withdrawal were assessed. In study two, the effect of propranolol (5 mg/kg, IP) and prazosin (2 mg/kg, IP) on alcohol intake following prolonged imposed abstinence was assessed.
Results
Alcohol drinking following propranolol treatment was variable, but the combination of propranolol + prazosin consistently suppressed alcohol drinking during both alcohol withdrawal and following prolonged imposed abstinence, and the combination of these two drugs was more effective than was treatment with either drug alone.
Conclusions
Treatment with prazosin + propranolol, or a combination of other centrally active α1- and ÎČ-adrenergic receptor antagonists, may assist in preventing alcohol relapse in some individuals
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