Effect of zinc supplementation on serum mlondealdehyde and lipid profiles on beta thalassemia major patients

Objectives: Thalassemic patients are seriously at risk of serum dislipidemia, zinc deficiency and tissue damage due to oxidative stress induced by iron storage. In biologic systems, zinc may interact with iron and inhibit oxidative and reductive reactions resulted by iron and other chimiooxidative agents. The aim of this study was to evaluate the effect of zinc supplementation on serum Malondealdehyde (MDA) and lipid profiles in beta thalassemia major patients. Methods: In this clinical trial, 60 beta thalassemia major patients (male & female) older than 18 years old were assigned randomly in two groups as intervention and control groups(30 per group). The intervention group ingested zinc supplement as 220 mg zinc sulfate capsule contented 50 mg elemental zinc daily for 3 months. The control group did not receive any supplement in that time. Information about general characteristics, weight, height and dietary intake were gathered before and after the end of study. Blood samples were obtained from each subject prior and after the study and serum zinc, MDA, triglyceride, LDL-C and HDL-C levels were measured. Data analyzed with paired t-test, independent t-test and ANOVA. Results: Zinc supplementation caused significant increasing in daily caloric intake, body mass index, serum zinc and HDL-C levels and significant reduction in LDL-C levels in intervention group. No significant variations were observed for other variables in both of groups. Conclusion: Zinc supplementation had beneficial effects on serum lipid profiles in studied beta thalassemic patients and might have suitable role in delaying cardiovascular disease risks in these patients

Split torque transmission load sharing

Split torque transmissions are attractive alternatives to conventional planetary designs for helicopter transmissions. The split torque designs can offer lighter weight and fewer parts but have not been used extensively for lack of experience, especially with obtaining proper load sharing. Two split torque designs that use different load sharing methods have been studied. Precise indexing and alignment of the geartrain to produce acceptable load sharing has been demonstrated. An elastomeric torque splitter that has large torsional compliance and damping produces even better load sharing while reducing dynamic transmission error and noise. However, the elastomeric torque splitter as now configured is not capable over the full range of operating conditions of a fielded system. A thrust balancing load sharing device was evaluated. Friction forces that oppose the motion of the balance mechanism are significant. A static analysis suggests increasing the helix angle of the input pinion of the thrust balancing design. Also, dynamic analysis of this design predicts good load sharing and significant torsional response to accumulative pitch errors of the gears

Effects of vitamin e and zinc supplementation on antioxidants in beta thalassemia major patients

Objective: In beta thalassemic patients, tissue damage occurs due to oxidative stress and it happens because of the accumulation of iron in the body. This study was conducted to determine the effect of zinc and vitamin E supplementation on antioxidant status in beta-thalassemic major patients. Methods: This double blind randomized clinical trial was carried out on 120 beta thalassemic patients older than 18 years. Patients were randomly categorized in four groups. Zinc (50mg/day) and vitamin E (400mg/day) supplements were administered for former and latter group, respectively. In the third group both supplements were administered in similar doses. The fourth (control) group received no supplement. The effect of supplementations on serum zinc and vitamin E, superoxide dismutase (SOD), glutathione peroxidase (GPX), total antioxidant capacity (TAC) and body mass index (BMI) were measured at the beginning and the end of the study. Findings: Serum zinc levels in group 1 and 3 were significantly increased (P<0.007 and P<0.005, respectively). Serum vitamin E levels in group 2 and 3 were also increased significantly (P<0.001). Mean GPX activity in group1, 2 and 3 decreased significantly (P<0.015, P<0.032 and P<0.029, respectively). Mean SOD activity and TAC did not show significant change after supplementation. BMI had significant increase in all treated groups (P<0.001). Conclusion: Our results suggest that beta thalassemic patients have enhanced oxidative stress and administration of selective antioxidants may preclude oxidative damage. © 2011 by Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, All rights reserved

Analytic Approximate Solutions for MHD Boundary-Layer Viscoelastic Fluid Flow over Continuously Moving Stretching Surface by Homotopy Analysis Method with Two Auxiliary Parameters

In this study, a steady, incompressible, and laminar-free convective flow of a two-dimensional electrically conducting viscoelastic fluid over a moving stretching surface through a porous medium is considered. The boundary-layer equations are derived by considering Boussinesq and boundary-layer approximations. The nonlinear ordinary differential equations for the momentum and energy equations are obtained and solved analytically by using homotopy analysis method (HAM) with two auxiliary parameters for two classes of visco-elastic fluid (Walters’ liquid B and second-grade fluid). It is clear that by the use of second auxiliary parameter, the straight line region in ℏ-curve increases and the convergence accelerates. This research is performed by considering two different boundary conditions: (a) prescribed surface temperature (PST) and (b) prescribed heat flux (PHF). The effect of involved parameters on velocity and temperature is investigated

Thermodynamic analysis of turbulent combustion in a spark ignition engine. Experimental evidence

A method independent of physical modeling assumptions is presented to analyze high speed flame photography and cylinder pressure measurements from a transparent piston spark ignition research engine. The method involves defining characteristic quantities of the phenomena of flame propagation and combustion, and estimating their values from the experimental information. Using only the pressure information, the mass fraction curves are examined. An empirical burning law is presented which simulates such curves. Statistical data for the characteristics delay and burning angles which show that cycle to cycle fractional variations are of the same order of magnitude for both angles are discussed. The enflamed and burnt mass fractions are compared as are the rates of entrainment and burning

A Case for Redundant Arrays of Hybrid Disks (RAHD)

Hybrid Hard Disk Drive was originally concepted by Samsung, which incorporates a Flash memory in a magnetic disk. The combined ultra-high-density benefits of magnetic storage and the low-power and fast read access of NAND technology inspires us to construct Redundant Arrays of Hybrid Disks (RAHD) to offer a possible alternative to today’s Redundant Arrays of Independent Disks (RAIDs) and/or Massive Arrays of Idle Disks (MAIDs). We first design an internal management system (including Energy-Efficient Control) for hybrid disks. Three traces collected from real systems as well as a synthetic trace are then used to evaluate the RAHD arrays. The trace-driven experimental results show: in the high speed mode, a RAHD outplays the purely-magnetic-disk-based RAIDs by a factor of 2.4–4; in the energy-efficient mode, a RAHD4/5 can save up to 89% of energy at little performance degradationPeer reviewe

Turbulent flame propagation and combustion in spark ignition engines

Pressure measurements synchronized with high-speed motion picture records of flame propagation have been made in a transparent piston engine. The data show that the initial expansion speed of the flame front is close to that of a laminar flame. As the flame expands, its speed rapidly accelerates to a quasi-steady value comparable with that of the turbulent velocity fluctuations in the unburned gas. During the quasi-steady propagation phase, a significant fraction of the gas behind the visible front is unburned. Final burnout of the charge may be approximated by an exponential decay in time. The data have been analyzed in a model independent way to obtain a set of empirical equations for calculating mass burning rates in spark ignition engines. The burning equations contain three parameters: the laminar burning speed s l, a characteristic speed u T, and a characteristic length l T. The laminar burning speed is known from laboratory measurements. Tentative correlations relating u T and l T to engine geometry and operating variables have been derived from the engine data. © 1983

SAT based Enforcement of Domotic Effects in Smart Environments

The emergence of economically viable and efficient sensor technology provided impetus to the development of smart devices (or appliances). Modern smart environments are equipped with a multitude of smart devices and sensors, aimed at delivering intelligent services to the users of smart environments. The presence of these diverse smart devices has raised a major problem of managing environments. A rising solution to the problem is the modeling of user goals and intentions, and then interacting with the environments using user defined goals. `Domotic Effects' is a user goal modeling framework, which provides Ambient Intelligence (AmI) designers and integrators with an abstract layer that enables the definition of generic goals in a smart environment, in a declarative way, which can be used to design and develop intelligent applications. The high-level nature of domotic effects also allows the residents to program their personal space as they see fit: they can define different achievement criteria for a particular generic goal, e.g., by defining a combination of devices having some particular states, by using domain-specific custom operators. This paper describes an approach for the automatic enforcement of domotic effects in case of the Boolean application domain, suitable for intelligent monitoring and control in domotic environments. Effect enforcement is the ability to determine device configurations that can achieve a set of generic goals (domotic effects). The paper also presents an architecture to implement the enforcement of Boolean domotic effects, and results obtained from carried out experiments prove the feasibility of the proposed approach and highlight the responsiveness of the implemented effect enforcement architectur

Non-Fourier heat transport in metal-dielectric core-shell nanoparticles under ultrafast laser pulse excitation

Relaxation dynamics of embedded metal nanoparticles after ultrafast laser pulse excitation is driven by thermal phenomena of different origins the accurate description of which is crucial for interpreting experimental results: hot electron gas generation, electron-phonon coupling, heat transfer to the particle environment and heat propagation in the latter. Regardingthis last mechanism, it is well known that heat transport in nanoscale structures and/or at ultrashort timescales may deviate from the predictions of the Fourier law. In these cases heat transport may rather be described by the Boltzmann transport equation. We present a numerical model allowing us to determine the electron and lattice temperature dynamics in a spherical gold nanoparticle core under subpicosecond pulsed excitation, as well as that of the surrounding shell dielectric medium. For this, we have used the electron-phonon coupling equation in the particle with a source term linked with the laser pulse absorption, and the ballistic-diffusive equations for heat conduction in the host medium. Either thermalizing or adiabatic boundary conditions have been considered at the shell external surface. Our results show that the heat transfer rate from the particle to the matrix can be significantly smaller than the prediction of Fourier's law. Consequently, the particle temperature rise is larger and its cooling dynamics might be slower than that obtained by using Fourier's law. This difference is attributed to the nonlocal and nonequilibrium heat conduction in the vicinity of the core nanoparticle. These results are expected to be of great importance for analyzing pump-probe experiments performed on single nanoparticles or nanocomposite media

The Role of Pore Structure of SMFs-based Pd Nanocatalysts in Deactivation Behavioral Pattern Upon Acetylene Hydrogenation Reaction

In this research, SMFs panels were applied for further deposition of CNFs, ZnO and Al2O3 to hydro-genate selectively acetylene to ethylene. To understand the role of different structures of the examined supports, the characterization methods of SEM, ASAP, NH3-TPD and N2 adsorption-desorption isotherms were used. Following the characterization of green oil by FTIR, the presence of more unsaturated constitu-ents and then, more branched hydrocarbons formed upon the reaction over alumina-supported catalyst in comparison with the ones supported on CNFs and ZnO was confirmed, which in turn, could block the pores mouths. Besides the limited hydrogen transfer, the lowest pore diameters of Al2O3 / SMFs close to the sur-face, supported by N2 adsorption-desorption isotherms could explain the fast deactivation of this catalyst, compared to the other ones. When you are citing the document, use the following link http://essuir.sumdu.edu.ua/handle/123456789/3521