Aanlandingsplicht

De EC heeft verschillende voorstellen gedaan met betrekking tot de vervorming van het Gemeenschappelijk Visserij Beleid. Een van de voorstellen is om vanaf 2014 voor verschillende vissoorten de verplichting tot het aanlanden van alle vangsten in te voeren, ook wel discard ban genoemd. Het ministerie maakt zich zorgen over de gevolgen die dit voorstel kan hebben voor de Nederlandse visserij en heeft IMARES en het LEI gevraagd om extra informatie over discardsvangsten. In dit werkdocument is ingegaan op de hoeveelheid gevangen discards (het deel van de vangst, dat, dood of levend, weer overboord wordt gegooid) per metier en de fluctuatie van de vangst van discards door het jaar heen. De studie is een feitelijke opsomming van de discardsgegevens die bij IMARES bekend zijn. Verder zal de overlevingskans van de gevangen discards centraal staan in dit document. Het ministerie wilde ook graag meer inzicht in de overleving van discards. Een aanlandingsplicht ligt minder voor de hand voor soorten met een hoge overlevingskans. Een literatuurstudie is uitgevoerd die geresulteerd heeft in een korte eerste inventarisatie van de Nederlandse en internationale literatuur over onderzoek naar de overleving van discards. Als laatste is er onderzoek gedaan naar de economische gevolgen in de platvissector voor een discard ban voor alle soorten vergeleken met een discard ban voor alleen de doelsoorten. Er is in deze studie onderscheid gemaakt tussen een discardban voor alle soorten en een discard ban voor de soorten genoemd in het voorstel van de EC

The STAP-study: The (cost) effectiveness of custom made orthotic insoles in the treatment for plantar fasciopathy in general practice and sports medicine: Design of a randomized controlled trial

Background: Plantar fasciopathy is a common cause of foot pain, accounting for 11 to 15 % of all foot symptoms requiring professional care in adults. Although many patients have complete resolution of symptoms within 12 months, many patients wish to reduce this period as much as possible. Orthotic devices are a frequently applied option of treatment in daily practice, despite a lack of evidence on the effectiveness. Therefore, the objective is to study the (cost)-effectiveness of custom made insoles by a podiatrist, compared to placebo insoles and usual care in patients with plantar fasciopathy in general practice and sports medicine clinics. Method/design: This study is a multi-center three-armed participant and assessor-blinded randomized controlled trial with 6-months follow-up. Patients with plantar fasciopathy, with a minimum duration of complaints of 2 weeks and aged between 18 and 65, who visit their general practitioner or sport physician are eligible for inclusion. A total of 185 patients will be randomized into three parallel groups. One group will receive usual care by the general practitioner or sports physician alone, one group will be referred to a podiatrist and will receive a custom made insole, and one group will be referred to a podiatrist and will receive a placebo insole. The primary outcome will be the change from baseline to 12 weeks follow-up in pain severity at rest and during activity on a 0-10 numerical rating scale (NRS). Secondary outcomes include foot function (according to the F

Monitoring catches in the pulse fishery

Dit rapport geeft informatie over de vangstsamenstelling van de Nederlandse pulsvisserij op platvis. Traditioneel wordt er in de Nederlandse platvisvisserij voornamelijk met de conventionele boomkor gevist. De afgelopen jaren heeft er een geleidelijke en gedeeltelijke overgang plaatsgevonden naar de pulsvisserij, waarbij de wekkerkettingen zijn vervangen door elektrodes. De Nederlandse demersale vissers zijn positief over het pulstuig, voornamelijk door lagere oliekosten en goede tong vangsten. In de zuidelijke Noordzee is sinds 2007 per lidstaat een ontheffing voor 5 procent van de boomkorvloot. Dat wil zeggen dat 5% van de boomkorvloot met het pulstuig mag vissen. In 2011 is bij de toekenning van de vergunningen door de EU de voorwaarde gesteld dat er meer informatie zou worden verzameld over de effecten van de pulsvisserij. Dit rapport beschrijft de onderzoeksactiviteiten die zijn uitgevoerd om aan deze voorwaarde van de EU te voldoen

Industrial survey for associated species: Results of a pilot-year

To increase scientific knowledge and stimulate discussion on management of data-limited species, Ekofish Group B.V., the North Sea Foundation (NSF) and IMARES started a research project. This project consisted of two phases. In the first phase, IMARES and NSF performed a literature study on the constrains in management and biological knowledge for species selected by Ekofish. After phase one, Ekofish Group B.V. requested IMARES to set up an industrial survey to gather more information on turbot, brill and lemon sole. A pilot-survey was designed and performed for these species to test whether an industrial survey is feasible and valuable for biological knowledge and if so, how this survey should be designed. To test the design of the survey, research will be done on the haul duration and mesh size. To examine the added value of the pilot survey, results are compared with the BTS. In this report, the results of this pilot survey are presented and answer will be given to the following research question: “Is an industrial survey for turbot, bill and lemon sole feasible and does it increase knowledge with respect to scientific surveys?

Unenhanced CT imaging is highly sensitive to exclude pheochromocytoma: A multicenter study

Background: A substantial proportion of all pheochromocytomas is currently detected during the evaluation of an adrenal incidentaloma. Recently, it has been suggested that biochemical testing to rule out pheochromocytoma is unnecessary in case of an adrenal incidentaloma with an unenhanced attenuation value ≤10Hounsfield Units (HU) at computed tomography (CT). Objectives: We aimed to determine the sensitivity of the 10HU threshold value to exclude a pheochromocytoma. Methods: Retrospective multicenter study with systematic reassessment of preoperative unenhanced CT scans performed in patients in whom a histopathologically proven pheochromocytoma had been diagnosed. Unenhanced attenuation values were determined independently by two experienced radiologists. Sensitivity of the 10HU threshold was calculated, and interobserver consistency was assessed using the intraclass correlation coefficient (ICC). Results: 214 patients were identified harboring a total number of 222 pheochromocytomas. Maximum tumor diameter was 51 (39–74)mm. The mean attenuation value within the region of interest was 36±10HU. Only one pheochromocytoma demonstrated an attenuation value ≤10HU, resulting in a sensitivity of 99.6% (95% CI: 97.5–99.9). ICC was 0.81 (95% CI: 0.75–0.86) with a standard error of measurement of 7.3HU between observers. Conclusion: The likelihood of a pheochromocytoma with an unenhanced attenuation value ≤10HU on CT is very low. The interobserver consistency in attenuation measurement is excellent. Our study supports the recommendation that in patients with an adrenal incidentaloma biochemical testing for ruling out pheochromocytoma is only indicated in adrenal tumors with an unenhanced attenuation value >10HU

Hereditary diffuse gastric cancer: updated clinical guidelines with an emphasis on germline CDH1 mutation carriers.

Germline CDH1 mutations confer a high lifetime risk of developing diffuse gastric (DGC) and lobular breast cancer (LBC). A multidisciplinary workshop was organised to discuss genetic testing, surgery, surveillance strategies, pathology reporting and the patient's perspective on multiple aspects, including diet post gastrectomy. The updated guidelines include revised CDH1 testing criteria (taking into account first-degree and second-degree relatives): (1) families with two or more patients with gastric cancer at any age, one confirmed DGC; (2) individuals with DGC before the age of 40 and (3) families with diagnoses of both DGC and LBC (one diagnosis before the age of 50). Additionally, CDH1 testing could be considered in patients with bilateral or familial LBC before the age of 50, patients with DGC and cleft lip/palate, and those with precursor lesions for signet ring cell carcinoma. Given the high mortality associated with invasive disease, prophylactic total gastrectomy at a centre of expertise is advised for individuals with pathogenic CDH1 mutations. Breast cancer surveillance with annual breast MRI starting at age 30 for women with a CDH1 mutation is recommended. Standardised endoscopic surveillance in experienced centres is recommended for those opting not to have gastrectomy at the current time, those with CDH1 variants of uncertain significance and those that fulfil hereditary DGC criteria without germline CDH1 mutations. Expert histopathological confirmation of (early) signet ring cell carcinoma is recommended. The impact of gastrectomy and mastectomy should not be underestimated; these can have severe consequences on a psychological, physiological and metabolic level. Nutritional problems should be carefully monitored

Finding synergies for the 3Rs – Repeated dose toxicity testing: Report from an EPAA partners' forum

The European Partnership for Alternative Approaches to Animal Testing (EPAA) convened a Partners' Forum on repeated dose toxicity (RDT) testing to identify synergies between industrial sectors and stakeholders along with opportunities to progress these in existing research frameworks. Although RTD testing is not performed across all industrial sectors, the OECD accepted tests can provide a rich source of information and play a pivotal role for safety decisions relating to the use of chemicals. Currently there are no validated alternatives to repeated dose testing and a direct one-to-one replacement is not appropriate. However, there are many projects and initiatives at the international level which aim to implement various aspects of replacement, reduction and refinement (the 3Rs) in RDT testing. Improved definition of use, through better problem formulation, aligned to harmonisation of regulations is a key area, as is the more rapid implementation of alternatives into the legislative framework. Existing test designs can be optimised to reduce animal use and increase information content. Greater use of exposure-led decisions and improvements in dose selection will be beneficial. In addition, EPAA facilitates sharing of case studies demonstrating the use of Next Generation Risk Assessment applying various New Approach Methodologies to assess RDT

Monitoring catches in the pulse fishery

Dit rapport geeft informatie over de vangstsamenstelling van de Nederlandse pulsvisserij op platvis. Traditioneel wordt er in de Nederlandse platvisvisserij voornamelijk met de conventionele boomkor gevist. De afgelopen jaren heeft er een geleidelijke en gedeeltelijke overgang plaatsgevonden naar de pulsvisserij, waarbij de wekkerkettingen zijn vervangen door elektrodes. De Nederlandse demersale vissers zijn positief over het pulstuig, voornamelijk door lagere oliekosten en goede tong vangsten. In de zuidelijke Noordzee is sinds 2007 per lidstaat een ontheffing voor 5 procent van de boomkorvloot. Dat wil zeggen dat 5% van de boomkorvloot met het pulstuig mag vissen. In 2011 is bij de toekenning van de vergunningen door de EU de voorwaarde gesteld dat er meer informatie zou worden verzameld over de effecten van de pulsvisserij. Dit rapport beschrijft de onderzoeksactiviteiten die zijn uitgevoerd om aan deze voorwaarde van de EU te voldoen

Industrial survey for associated species: Results of a pilot-year

To increase scientific knowledge and stimulate discussion on management of data-limited species, Ekofish Group B.V., the North Sea Foundation (NSF) and IMARES started a research project. This project consisted of two phases. In the first phase, IMARES and NSF performed a literature study on the constrains in management and biological knowledge for species selected by Ekofish. After phase one, Ekofish Group B.V. requested IMARES to set up an industrial survey to gather more information on turbot, brill and lemon sole. A pilot-survey was designed and performed for these species to test whether an industrial survey is feasible and valuable for biological knowledge and if so, how this survey should be designed. To test the design of the survey, research will be done on the haul duration and mesh size. To examine the added value of the pilot survey, results are compared with the BTS. In this report, the results of this pilot survey are presented and answer will be given to the following research question: “Is an industrial survey for turbot, bill and lemon sole feasible and does it increase knowledge with respect to scientific surveys?