Charm and Hidden Charm Scalar Resonances in Nuclear Matter

We study the properties of the scalar charm resonances $D_{s0}(2317)$ and $D_0(2400)$, and the theoretical hidden charm state X(3700) in nuclear matter. We find that for the $D_{s0}(2317)$ and X(3700) resonances, with negligible and small width at zero density, respectively, the width becomes about $100 {\rm MeV}$ and $200 {\rm MeV}$ at normal nuclear matter density, accordingly. For $D_0(2400)$ the change in width is relatively less important. We discuss the origin of this new width and trace it to reactions occurring in the nucleus. We also propose a possible experimental test for those modifications in nuclear matter, which will bring valuable information on the nature of those scalar resonances and the interaction of $D$ mesons with nucleons.Comment: 3 pages, 3 figures, to appear in the proceedings of the International Conference on Particles And Nuclei (PANIC08), Eilat, Israel, November 9-14, 200

Strange and charm mesons at fair

We study the properties of strange and charm mesons in hot and dense matter within a self-consistent coupled-channel approach for the experimental conditions of density and temperature expected for the CBM experiment at FAIR/GSI. The in-medium solution at finite temperature accounts for Pauli blocking effects, mean-field binding of all the baryons involved, and meson self-energies. We analyse the behaviour in this hot and dense environment of dynamically-generated baryonic resonances together with the evolution with density and temperature of the strange and open-charm meson spectral functions. We test the spectral functions for strange mesons using energy-weighted sum rules and finally discuss the implications of the properties of charm mesons on the Ds0(2317) and the predicted X(3700) scalar resonances.Molina Peralta, Raquel, [email protected] ; Nieves Pamplona, Juan Miguel, [email protected] ; Oset Báguena, Eulogio, [email protected]

Strange and charm mesons at fair

We study the properties of strange and charm mesons in hot and dense matter within a self-consistent coupled-channel approach for the experimental conditions of density and temperature expected for the CBM experiment at FAIR/GSI. The in-medium solution at finite temperature accounts for Pauli blocking effects, mean-field binding of all the baryons involved, and meson self-energies. We analyse the behaviour in this hot and dense environment of dynamically-generated baryonic resonances together with the evolution with density and temperature of the strange and open-charm meson spectral functions. We test the spectral functions for strange mesons using energy-weighted sum rules and finally discuss the implications of the properties of charm mesons on the Ds0(2317) and the predicted X(3700) scalar resonances.Molina Peralta, Raquel, [email protected] ; Nieves Pamplona, Juan Miguel, [email protected] ; Oset Báguena, Eulogio, [email protected]

Interaction of vector mesons with baryons and nuclei

After some short introductory remarks on particular issues on the vector mesons in nuclei, in this paper, we present a short review of recent developments concerning the interaction of vector mesons with baryons and with nuclei from a modern perspective using the local hidden gauge formalism for the interaction of vector mesons. We present results for the vector-baryon interaction and in particular for the resonances which appear as composite states, dynamically generated from the interaction of vector mesons with baryons, taking also the mixing of these states with pseudoscalars and baryons into account. We then venture into the charm sector, reporting on hidden charm baryon states around 4400 MeV, generated from the interaction of vector mesons and baryons with charm, which have a strong repercussion on the properties of the J/Psi N interaction. We also address the interaction of K* with nuclei and make suggestions to measure the predicted huge width in the medium by means of transparency ratio. The formalism is extended to study the phenomenon of J/psi suppression in nuclei via J/psi photo-production reactions

Protective intraoperative ventilation with higher versus lower levels of positive end-expiratory pressure in obese patients (PROBESE): study protocol for a randomized controlled trial

Background: Postoperative pulmonary complications (PPCs) increase the morbidity and mortality of surgery in obese patients. High levels of positive end-expiratory pressure (PEEP) with lung recruitment maneuvers may improve intraoperative respiratory function, but they can also compromise hemodynamics, and the effects on PPCs are uncertain. We hypothesized that intraoperative mechanical ventilation using high PEEP with periodic recruitment maneuvers, as compared with low PEEP without recruitment maneuvers, prevents PPCs in obese patients. Methods/design The PRotective Ventilation with Higher versus Lower PEEP during General Anesthesia for Surgery in OBESE Patients (PROBESE) study is a multicenter, two-arm, international randomized controlled trial. In total, 2013 obese patients with body mass index ≥35 kg/m2 scheduled for at least 2 h of surgery under general anesthesia and at intermediate to high risk for PPCs will be included. Patients are ventilated intraoperatively with a low tidal volume of 7 ml/kg (predicted body weight) and randomly assigned to PEEP of 12 cmH2O with lung recruitment maneuvers (high PEEP) or PEEP of 4 cmH2O without recruitment maneuvers (low PEEP). The occurrence of PPCs will be recorded as collapsed composite of single adverse pulmonary events and represents the primary endpoint. Discussion To our knowledge, the PROBESE trial is the first multicenter, international randomized controlled trial to compare the effects of two different levels of intraoperative PEEP during protective low tidal volume ventilation on PPCs in obese patients. The results of the PROBESE trial will support anesthesiologists in their decision to choose a certain PEEP level during general anesthesia for surgery in obese patients in an attempt to prevent PPCs. Trial registration ClinicalTrials.gov identifier: NCT02148692. Registered on 23 May 2014; last updated 7 June 2016. Electronic supplementary material The online version of this article (doi:10.1186/s13063-017-1929-0) contains supplementary material, which is available to authorized users

Strangeness and charm in nuclear matter

The properties of strange (K, (K) over bar and (K) over bar*) and open-charm (D, (D) over bar and D*) mesons in dense matter are studied using a unitary approach in coupled channels for meson-baryon scattering. In the strangeness sector, the interaction with nucleons always comes through vector-meson exchange, which is evaluated by chiral and hidden gauge Lagrangians. For the interaction of charmed mesons with nucleons we extend the SU(3) Weinberg-Tomozawa Lagrangian to incorporate spin-flavor symmetry and implement a suitable flavor symmetry breaking. The in-medium solution for the scattering amplitude accounts for Pauli blocking effects and meson self-energies. On one hand, we obtain the K, (K) over bar and (K) over bar* spectral functions in the nuclear medium and study their behaviour at finite density, temperature and momentum. We also make an estimate of the transparency ratio of the gamma A -> K+ K*(-) A' reaction, which we propose as a tool to detect in-medium modifications of the (K) over bar* meson. On the other hand, in the charm sector, several resonances with negative parity are generated dynamically by the s-wave interaction between pseudoscalar and vector meson multiplets with 1/2(+) and 3/2(+) baryons. The properties of these states in matter are analyzed and their influence on the open-charm meson spectral functions is studied. We finally discuss the possible formation of D-mesic nuclei at FAIR energies.This research was supported by DGI and FEDER funds, under Contract Nos. FIS2011-28853-C02-02, FIS2011-24149, FIS2011-24154, FPA2010-16963 and the Spanish Consolider-Ingenio 2010 Programme CPAN (CSD2007-00042), by Junta de Andalucia Grant No. FQM-225, by Generalitat Valenciana under Contract No. PROMETEO/2009/0090, by the Generalitat de Catalunya under contract 2009SGR-1289 and by the EU HadronPhysics3 project, Grant Agreement No. 283286. O.R. wishes to acknowledge support from the Rosalind Franklin Programme.Peer reviewe

Cardio4Health Study, a Cardiac Telerehabilitation Pilot Program Aimed at Patients After an Ischemic Event: Cross-sectional Study

BackgroundCenter-based cardiac rehabilitation programs (CRPs) reduce morbidity and mortality after an ischemic cardiac event; however, they are widely underused. Home-based CRP has emerged as an alternative to improve patient adherence; however, its safety and efficacy remain unclear, especially for older patients and female patients. ObjectiveThis study aimed to develop a holistic home-based CRP for patients with ischemic heart disease and evaluate its safety and impact on functional capacity, adherence to a healthy lifestyle, and quality of life. MethodsThe 8-week home-based CRP included patients of both sexes, with no age limit, who had overcome an acute myocardial infarction in the previous 3 months, had a left ventricular ejection fraction of ≥40%, and had access to a tablet or mobile device. The CRP was developed using a dedicated platform designed explicitly for this purpose and included 3 weekly exercise sessions combining tailored aerobic and strength training and 2 weekly educational session focused on lifestyle habits, therapeutic adherence, and patient empowerment. ResultsWe initially included 62 patients, of whom 1 was excluded for presenting with ventricular arrhythmias during the initial stress test, 5 were excluded because of incompatibility, and 6 dropped out because of a technological barrier. Ultimately, 50 patients completed the program: 85% (42/50) were male, with a mean age of 58.9 (SD 10.3) years, a mean left ventricular ejection fraction of 52.1% (SD 6.72%), and 25 (50%) New York Heart Association functional class I and 25 (50%) New York Heart Association II-III. The CRP significantly improved functional capacity (+1.6 metabolic equivalent tasks), muscle strength (arm curl test +15.5% and sit-to-stand test +19.7%), weekly training volume (+803 metabolic equivalent tasks), adherence to the Mediterranean diet, emotional state (anxiety), and quality of life. No major complications occurred, and adherence was excellent (>80%) in both the exercise and educational sessions. In the subgroup analysis, CRP showed equivalent beneficial effects irrespective of sex and age. In addition, patient preferences for CRP approaches were equally distributed, with one-third (14/50, 29%) of the patients preferring a face-to-face CRP, one-third (17/50, 34%) preferring a telematic CRP, and one-third (18/50, 37%) preferring a hybrid approach. Regarding CRP duration, 63% (31/50) of the patients considered it adequate, whereas the remaining 37% (19/50) preferred a longer program. ConclusionsA holistic telematic CRP dedicated to patients after an ischemic cardiac event, irrespective of sex and age, is safe and, in our population, has achieved positive results in improving maximal aerobic capacity, weekly training volume, muscle strength, quality of life, compliance with diet, and anxiety symptoms. The preference for a center- or home-based CRP approach is diverse among the study population, emphasizing the need for a tailored CRP to improve adherence and completion rates

Intraoperative transfusion practices in Europe

BACKGROUND: Transfusion of allogeneic blood influences outcome after surgery. Despite widespread availability of transfusion guidelines, transfusion practices might vary among physicians, departments, hospitals and countries. Our aim was to determine the amount of packed red blood cells (pRBC) and blood products transfused intraoperatively, and to describe factors determining transfusion throughout Europe. METHODS: We did a prospective observational cohort study enrolling 5803 patients in 126 European centres that received at least one pRBC unit intraoperatively, during a continuous three month period in 2013. RESULTS: The overall intraoperative transfusion rate was 1.8%; 59% of transfusions were at least partially initiated as a result of a physiological transfusion trigger- mostly because of hypotension (55.4%) and/or tachycardia (30.7%). Haemoglobin (Hb)- based transfusion trigger alone initiated only 8.5% of transfusions. The Hb concentration [mean (sd)] just before transfusion was 8.1 (1.7) g dl(-1) and increased to 9.8 (1.8) g dl(-1) after transfusion. The mean number of intraoperatively transfused pRBC units was 2.5 (2.7) units (median 2). CONCLUSION: Although European Society of Anaesthesiology transfusion guidelines are moderately implemented in Europe with respect to Hb threshold for transfusion (7-9 g dl(-1)), there is still an urgent need for further educational efforts that focus on the number of pRBC units to be transfused at this threshold. CLINICAL TRIAL REGISTRATION: NCT 01604083