A Quieter Cannon

Published Nov. 16, 2012.Reprinted with permission from the Columbia Missourian."Ammunition shortage leaves ‘Little Joe' transitioning to softer sound."Story by Brian Ransom

A Performance Project with an Historical and Analytical Perspective on the Concerto for Alto Saxophone and Orchestra, Op. 31 by Peter Jona Korn

Peter Jona Korn (1922-1998) is not a name immediately recognized in American music circles, yet during the 1940s and \u2750s he led a successful career as an American composer. His Saxophone Concerto - composed in 1956 for the virtuoso Sigurd Rascher, and revised by Korn in 1982 - is an important contribution to the saxophone repertoire. Many composers, including Glazounov, Ibert, and Larsson, wrote concertos for Sigurd Rascher. These works, once considered highly virtuosic, are now studied and performed by college level saxophonists. The original version of Korn\u27s Concerto, among the most technically demanding works, has remained in obscurity for over forty years. Nevertheless, the work is not only playable, but also compositionally sound and aesthetically pleasing. The Concerto received few performances and was never widely promoted, due to both the extremely demanding solo part as well as political factors pertaining to the composer. The intent of this dissertation is to reveal the work\u27s substantive value to the field of serious saxophone performance and pedagogy. Methodology includes the study of existing texts, personal interviews with Barbara Korn (widow of the composer), and computer music transcriptions. A wealth of information is available in a variety of documents in English and German by and about the composer. With the permission of Barbara Korn, I obtained the orchestra scores to the original Concerto and the 1982 revision, a score reduction of the original (rendered by Laurence Wyman), and the piano reduction of the 1982 version done by the composer. After analyzing and comparing these documents, this author transcribed the original Concerto into Finale computer program and made a piano reduction using Korn\u27s reduction of the 1982 revision as a template. Conclusions include the possibility of extra-musical content and its effect on the future of the Concerto. The oddly anticlimactic ending Korn wrote for the soloist raises questions about the Concerto\u27s acceptance by the saxophone community and the concertgoing public. It is this author\u27s hope that an analysis and discussion of the programmatic elements in the ending will encourage such acceptance

ARMD Workshop on Materials and Methods for Rapid Manufacturing for Commercial and Urban Aviation

This report documents the goals, organization and outcomes of the NASA Aeronautics Research Mission Directorates (ARMD) Materials and Methods for Rapid Manufacturing for Commercial and Urban Aviation Workshop. The workshop began with a series of plenary presentations by leaders in the field of structures and materials, followed by concurrent symposia focused on forecasting the future of various technologies related to rapid manufacturing of metallic materials and polymeric matrix composites, referred to herein as composites. Shortly after the workshop, questionnaires were sent to key workshop participants from the aerospace industry with requests to rank the importance of a series of potential investment areas identified during the workshop. Outcomes from the workshop and subsequent questionnaires are being used as guidance for NASA investments in this important technology area

Using long-term millisecond pulsar timing to obtain physical characteristics of the bulge globular cluster Terzan 5

Over the past decade the discovery of three unique stellar populations and a large number of confirmed pulsars within the globular cluster Terzan 5 has raised questions over its classification. Using the long-term radio pulsar timing of 36 millisecond pulsars in the cluster core, we provide new measurements of key physical properties of the system. As Terzan 5 is located within the galactic bulge, stellar crowding and reddening make optical and near infrared observations difficult. Pulsar accelerations, however, allow us to study the intrinsic characteristics of the cluster independent of reddening and stellar crowding and probe the mass density profile without needing to quantify the mass to light ratio. Relating the spin and orbital periods of each pulsar to the acceleration predicted by a King model, we find a core density of $1.58\times$10$^6$ M$_\odot$ pc$^{-3}$, a core radius of 0.16 pc, a pulsar density profile $n\propto r^{-3.14}$, and a total mass of M$_{\rm T}$($R_\perp<$1.0 pc)$\simeq3.0\times$10$^5$ M$_\odot$ assuming a cluster distance of 5.9 kpc. Using this information we argue against Terzan 5 being a disrupted dwarf galaxy and discuss the possibility of Terzan 5 being a fragment of the Milky Way's proto-bulge. We also discuss whether low-mass pulsars were formed via electron capture supernovae or exist in a core full of heavy white dwarfs and hard binaries. Finally we provide an upper limit for the mass of a possible black hole at the core of the cluster of 3.0$\times$10$^4$ M$_\odot$.Comment: 27 pages, 20 figures, 5 tables, thesis research, accepte

Belted sum decompositions of fully augmented links

Given two orientable, cusped hyperbolic 3-manifolds containing certain thrice-punctured spheres, Adams gave a diagrammatic definition for a third such manifold, their belted sum. Fully augmented links, or FALs, are hyperbolic links constructed by augmenting a link diagram. This work considers belted sum decompositions in which all manifolds involved are FAL complements. To do so, we provide explicit classifications of thrice punctured spheres in FAL complements, making them easily recognizable. These classifications are used to characterize belted sum prime FALs geometrically, combinatorially and diagrammatically. Finally we prove that, in the context of belted sums, every FAL complement canonically decomposes into FALs which are either prime or two-fold covers of the Whitehead link

Probabilistic Analysis and Design of a Raked Wing Tip for a Commercial Transport

An approach for conducting reliability-based design and optimization (RBDO) of a Boeing 767 raked wing tip (RWT) is presented. The goal is to evaluate the benefits of RBDO for design of an aircraft substructure. A finite-element (FE) model that includes eight critical static load cases is used to evaluate the response of the wing tip. Thirteen design variables that describe the thickness of the composite skins and stiffeners are selected to minimize the weight of the wing tip. A strain-based margin of safety is used to evaluate the performance of the structure. The randomness in the load scale factor and in the strain limits is considered. Of the 13 variables, the wing-tip design was controlled primarily by the thickness of the thickest plies in the upper skins. The report includes an analysis of the optimization results and recommendations for future reliability-based studies

Quantification of Transcriptome Responses of the Rumen Epithelium to Butyrate Infusion using RNA-seq Technology

Short-chain fatty acids (SCFAs), such as butyrate, produced by gut microorganisms, play a critical role in energy metabolism and physiology of ruminants as well as in human health. In this study, the temporal effect of elevated butyrate concentrations on the transcriptome of the rumen epithelium was quantified via serial biopsy sampling using RNA-seq technology. The mean number of genes transcribed in the rumen epithelial transcriptome was 17,323.63 ± 277.20 (±SD; N = 24) while the core transcriptome consisted of 15,025 genes. Collectively, 80 genes were identified as being significantly impacted by butyrate infusion across all time points sampled. Maximal transcriptional effect of butyrate on the rumen epithelium was observed at the 72-h infusion when the abundance of 58 genes was altered. The initial reaction of the rumen epithelium to elevated exogenous butyrate may represent a stress response as Gene Ontology (GO) terms identified were predominantly related to responses to bacteria and biotic stimuli. An algorithm for the reconstruction of accurate cellular networks (ARACNE) inferred regulatory gene networks with 113,738 direct interactions in the butyrate-epithelium interactome using a combined cutoff of an error tolerance (ɛ = 0.10) and a stringent P-value threshold of mutual information (5.0 × 10−11). Several regulatory networks were controlled by transcription factors, such as CREBBP and TTF2, which were regulated by butyrate. Our findings provide insight into the regulation of butyrate transport and metabolism in the rumen epithelium, which will guide our future efforts in exploiting potential beneficial effect of butyrate in animal well-being and human health

Upper Limits on Pulsed Radio Emission from the 6.85 s X-ray Pulsar XTE J0103-728 in the Small Magellanic Cloud

X-ray pulsations with a 6.85 s period were recently detected in the SMC and were subsequently identified as originating from the Be/X-ray binary system XTE J0103-728. The recent localization of the source of the X-ray emission has made a targeted search for radio pulsations from this source possible. The detection of pulsed radio emission from XTE J0103-728 would make it only the second system after PSR B1259-63 that is both a Be/X-ray binary and a radio pulsar. We observed XTE J0103-728 in Feb 2008 with the Parkes 64-m radio telescope soon after the identification of the source of X-ray pulsations was reported in order to search for corresponding radio pulsations. We used a continuous 6.4 hour observation with a 256 MHz bandwidth centered at 1390 MHz using the center beam of the Parkes multibeam receiver. In the subsequent data analysis, which included a folding search, a Fourier search, a fast-folding algorithm search, and a single-pulse search, no pulsed signals were found for trial dispersion measures (DMs) between 0 and 800 pc cm^-3. This DM range easily encompasses the expected values for sources in the SMC. We place an upper limit of ~45 mJy kpc^2 on the luminosity of periodic radio emission from XTE J0103-728 at the epoch of our observation, and we compare this limit to a range of luminosities measured for PSR B1259-63, the only Be/X-ray binary currently known to emit radio pulses. We also compare our limit to the radio luminosities of neutron stars having similarly long spin periods to XTE J0103-728. Since the radio pulses from PSR B1259-63 are eclipsed and undetectable during the portion of the orbit near periastron, repeated additional radio search observations of XTE J0103-728 may be valuable if it is undergoing similar eclipsing and if such observations are able to sample the orbital phase of this system well.Comment: 16 pages, including 1 table. Accepted for publication in Ap

The role of frailty in geriatric cranial neurosurgery for primary central nervous system neoplasms

OBJECTIVE. Frailty is a clinical state of increased vulnerability due to age-associated decline and has been well established as a perioperative risk factor. Geriatric patients have a higher risk of frailty, higher incidence of brain cancer, and increased postoperative complication rates compared to nongeriatric patients. Yet, literature describing the effects of frailty on short- and long-term complications in geriatric patients is limited. In this study, the authors evaluate the effects of frailty in geriatric patients receiving cranial neurosurgery for a primary CNS neoplasm. METHODS. The authors conducted a retrospective cohort study of geriatric patients receiving cranial neurosurgery for a primary CNS neoplasm between 2010 and 2017 by using the Nationwide Readmission Database. Demographics and frailty were queried at primary admission, and readmissions were analyzed at 30-, 90-, and 180-day intervals. Complications of interest included infection, anemia, infarction, kidney injury, CSF leak, urinary tract infection, and mortality. Nearest-neighbor propensity score matching for demographics was implemented to identify nonfrail control patients with similar diagnoses and procedures. The analysis used Welch two-sample t-tests for continuous variables and chi-square test with odds ratios. RESULTS. A total of 6713 frail patients and 6629 nonfrail patients were identified at primary admission. At primary admission, frail geriatric patients undergoing cranial neurosurgery had increased odds of developing acute posthemorrhagic anemia (OR 1.56, 95% CI 1.23–1.98; p = 0.00020); acute infection (OR 3.16, 95% CI 1.70–6.36; p = 0.00022); acute kidney injury (OR 1.32, 95% CI 1.07–1.62; p = 0.0088); urinary tract infection prior to discharge (OR 1.97, 95% CI 1.71–2.29; p < 0.0001); acute postoperative cerebral infarction (OR 1.57, 95% CI 1.17–2.11; p = 0.0026); and mortality (OR 1.64, 95% CI 1.22–2.24; p = 0.0012) compared to nonfrail geriatric patients receiving the same procedure. In addition, frail patients had a significantly increased inpatient length of stay (p < 0.0001) and all-payer hospital cost (p < 0.0001) compared to nonfrail patients at the time of primary admission. However, no significant difference was found between frail and nonfrail patients with regard to rates of infection, thromboembolism, CSF leak, dural tear, cerebral infarction, acute kidney injury, and mortality at all readmission time points. CONCLUSIONS. Frailty may significantly increase the risks of short-term acute complications in geriatric patients receiving cranial neurosurgery for a primary CNS neoplasm. Long-term analysis revealed no significant difference in complications between frail and nonfrail patients. Further research is warranted to understand the effects and timeline of frailty in geriatric patients

Severe brain injury ICU outcomes are associated with Cranial-Arterial Pressure Index and noninvasive Bispectral Index and transcranial oxygen saturation: a prospective, preliminary study

INTRODUCTION: The purpose of this study was to determine if noninvasive transcranial oxygen saturation (StcO(2)) and Bispectral Index (BIS) correlate with severe traumatic brain injury intensive care unit (ICU) outcomes. METHODS: This is a prospective observational study. Values of intracranial pressure (ICP), mean arterial pressure (MAP), BIS, and StcO(2 )were recorded hourly for the first six, post-injury days in 18 patients with severe brain injury. Included in the analyses was the Cranial-Arterial Pressure (CAP) Index, which is ICP/(MAP - ICP). RESULTS: After 1,883 hours of data were analyzed, we found that StcO(2 )and BIS are associated with survival, good neurological outcome, ICP ≤20, cerebral perfusion pressure (CPP) ≥60, and CAP index ≤0.30 (p ≤ 0.001). Survival and good outcome are independently associated with BIS ≥60, StcO(2 )≥70, and ICP ≤20 (p < 0.0001). BIS ≥60 or StcO(2 )≥70 is associated with survival, good outcome, CPP ≥60, ICP ≤20, CAP index ≤0.30, and fewer ICP interventions (p < 0.0001). With BIS ≥60 or StcO(2 )≥70, the rate of CPP ≥60 is 97.2% and the rate of ICP≤ 25 is 97.1%. An increased CAP index is associated with death, poor neurological outcome, and increased ICP interventions (p < 0.0001). With CAP index >0.25, MAP is not related to ICP (p = 0.16). CONCLUSION: Numerous significant associations with ICU outcomes indicate that BIS and StcO(2 )are clinically relevant. The independent associations of BIS, StcO(2), and ICP with outcomes suggest that noninvasive multi-modal monitoring may be beneficial. Future studies of patients with BIS ≥60 or StcO(2 )≥70 will determine if select patients can be managed without ICP monitoring and whether marginal ICP can be observed. An increased CAP index is associated with poor outcome