93 research outputs found
Functional mapping of the auditory midbrain during mate call reception
- Publication venue
- Publication date
- 01/01/2004
- Field of study
We examined patterns of neural activity as assayed by changes in gene expression to localize representation of acoustic mating signals in the auditory midbrain of frogs. We exposed wild-caught male Physalaemus pustulosus to conspecific mating calls that vary in their behavioral salience, nonsalient mating calls, or no sound. We measured expression of the immediate early gene egr-1 (also called ZENK, zif268, NGFI-A, and krox-24) throughout the torus semicircularis, the auditory midbrain homolog of the inferior colliculus. Differential egr-1 induction in response to the acoustic stimuli occurred in the laminar, midline, and principal nuclei of the torus semicircularis, whereas the ventral region did not show significant effects of stimulus. The laminar nucleus differentially responded to conspecific mating calls compared with nonsalient mating calls, whereas the midline and principal nuclei responded preferentially to one of two conspecific calls. These responses were not explained by simple acoustic properties of the stimuli, and they demonstrate a functional heterogeneity of auditory processing of complex biological signals within the frog midbrain. Moreover, using analyses that assess the ability of the torus semicircularis as a whole to discriminate among acoustic stimuli, we found that activity patterns in the four regions together provide more information about biologically relevant acoustic stimuli than activity in any single region
The impact of working memory load on task execution and online plan adjustment during multitasking in a virtual environment
- Author
- Alderman N.
- Baddeley A.D.
- Baddeley A.D.
- Baddeley A.D.
- Baddeley A.D.
- Burgess P.W.
- Burgess P.W.
- Cowan N.
- Craik F.I.
- Crépeau F.
- Dawson D.R.
- Deyzac E.
- Emerson M.J.
- Evans F.J.
- Fortin S.
- Garden S.E.
- Garden S.E.
- Goldstein L.H.
- Hambrick D.Z.
- Knight C.
- Law A.S.
- Law A.S.
- Law A.S.
- Levine B.
- Levine B.
- Logie R.H.
- Logie R.H.
- Logie R.H.
- Logie R.H.
- McGeorge P.
- Meilinger T.
- Miyake A.
- Miyake A.
- Murray D.
- Phillips L.H.
- Phillips L.H.
- Rajendran G.
- Rand D.
- Saito S.
- Shallice T.
- Towse J.N.
- Trawley S.
- Unsworth N.
- Publication venue
- 'Informa UK Limited'
- Publication date
- 12/12/2012
- Field of study
Three experiments investigated the impact of working memory load on online plan adjustment during a test of multitasking in young, nonexpert, adult participants. Multitasking was assessed using the Edinburgh Virtual Errands Test (EVET). Participants were asked to memorize either good or poor plans for performing multiple errands and were assessed both on task completion and on the extent to which they modified their plans during EVET performance. EVET was performed twice, with and without a secondary task loading a component of working memory. In Experiment 1, articulatory suppression was used to load the phonological loop. In Experiment 2, oral random generation was used to load executive functions. In Experiment 3, spatial working memory was loaded with an auditory spatial localization task. EVET performance for both good- and poor-planning groups was disrupted by random generation and sound localization, but not by articulatory suppression. Additionally, people given a poor plan were able to overcome this initial disadvantage by modifying their plans online. It was concluded that, in addition to executive functions, multiple errands performance draws heavily on spatial, but not verbal, working memory resources but can be successfully completed on the basis of modifying plans online, despite a secondary task load
Freqüência de anticorpos anti-Erhlichia canis, Borrelia burgdorferi e antígenos de Dirofilaria immitis em cães na microrregião Ilhéus-Itabuna, Bahia, Brasil
- Author
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
Definition, aims, and implementation of GA2LEN/HAEi Angioedema Centers of Reference and Excellence
- Author
- Aberer W. (W.)
- Agondi R. (Rosana)
- Al-Ahmad M. (Mona)
- Al-Nesf M.A. (Maryam Ali)
- Ansotegui I.J. (I.)
- Arnaout R. (Rand)
- Arruda L.K. (Luisa Karla)
- Asero R. (Riccardo)
- Aygören-Pürsü E. (Emel)
- Banerji A. (Aleena)
- Bauer A. (Andrea)
- Ben-Shoshan M. (Moshe)
- Berardi A. (Alejandro)
- Bernstein J.A. (Jonathan A.)
- Betschel S. (Stephen)
- Bindslev-Jensen C. (Carsten)
- Bizjak M. (Mojca)
- Boccon-Gibod I. (Isabelle)
- Bork K. (Konrad)
- Bouillet L. (Laurence)
- Boysen H.B. (Henrik Balle)
- Brodszki N. (N.)
- Broesby-Olsen S. (Sigurd)
- Busse P. (Paula)
- Buttgereit T. (Thomas)
- Bygum A. (Anette)
- Caballero T. (Teresa)
- Campos R.A. (Régis A.)
- Cancian M. (Mauro)
- Castaldo A. (Anthony)
- Cherrez-Ojeda I. (Ivan)
- Cohn D.M. (Danny M.)
- Costa C. (Célia)
- Craig T.
- Criado P.R. (Paulo Ricardo)
- Criado R.F. (Roberta F.)
- Csuka D. (Dorottya)
- Dissemond J. (Joachim)
- Doorn M.B.A. (Martijn) van
- Du-Thanh A. (Aurélie)
- Ensina L.F. (Luis Felipe)
- Ertaş R. (Ragıp)
- Fabiani J.E. (José E.)
- Fantini C. (Claudio)
- Farkas H. (Henriette)
- Ferrucci S.M. (Silvia Mariel)
- Figueras-Nart I. (Ignasi)
- Fili N.L. (Natalia L.)
- Fomina D. (Daria)
- Fukunaga A. (Atsushi)
- Gelincik A. (Asli)
- Giménez-Arnau A.
- Godse K.
- Gompels M. (Mark)
- Gonçalo M. (Margarida)
- Gotua M. (M.)
- Gower R. (Richard)
- Grumach A.S. (Anete S.)
- Guidos-Fogelbach G. (Guillermo)
- Hide M. (Michihiro)
- Ilina N. (Natalia)
- Inomata N. (Naoko)
- Jakob T. (Thilo)
- Josviack D.O. (Dario O.)
- Kang H.-R. (Hye-Ryun)
- Kaplan A. (Allen)
- Kasperska-Zając A. (Alicja)
- Katelaris C. (Constance)
- Kessel A. (Aharon)
- Kleinheinz A. (Andreas)
- Kocatürk E.
- Košnik M. (Mitja)
- Krasowska D. (Dorota)
- Kulthanan K. (Kanokvalai)
- Kumaran M.S. (M. Sendhil)
- Larco Sousa J.I. (José Ignacio)
- Longhurst H.J. (Hilary J.)
- Lumry W. (William)
- MacGinnitie A. (Andrew)
- Magerl M. (Markus)
- Makris M.P. (Michael P.)
- Malbrán A. (Alejandro)
- Marsland A. (Alexander)
- Martinez-Saguer I. (Inmaculada)
- Maurer M. (Marcus)
- Medina I.V. (Iris V.)
- Meshkova R. (Raisa)
- Metz M. (Martin)
- Nasr I. (Iman)
- Nicolay J. (Jan)
- Nishigori C. (Chikako)
- Ohsawa I. (Isao)
- Papadopoulos N.
- Parisi C.A.S. (Claudio A. S.)
- Peter J.G. (Jonathan Grant)
- Pfützner W. (W.)
- Popov T.A.
- Prior N. (Nieves)
- Ramon G.D. (German D.)
- Reich A. (Adam)
- Reshef A. (Avner)
- Riedl M.A. (Marc A.)
- Ritchie B. (Bruce)
- Rudenko M. (Michael)
- Röckmann-Helmbach H. (Heike)
- Salman A. (Andaç)
- Sanchez-Borges M. (Mario)
- Schmid-Grendelmeier P. (Peter)
- Serpa F.S. (Faradiba S.)
- Serra-Baldrich E. (Esther)
- Sheikh F.R. (Farrukh R.)
- Smith W. (William)
- Soria A. (Angèle)
- Staubach P. (Petra)
- Steiner U.C. (Urs C.)
- Stobiecki M. (Marcin)
- Sussman G. (Gordon)
- Tagka A. (Anna)
- Thomsen S.F. (Simon Francis)
- Treudler R. (Regina)
- Valle S. (Solange)
- Varga L. (Lilian)
- Vázquez D.O. (Daniel O.)
- Wagner N. (Nicola)
- Wang L. (Liangchun)
- Weber-Chrysochoou C. (Christina)
- Ye Y.-M. (Young-Min)
- Zalewska-Janowska A. (Anna)
- Zanichelli A. (Andrea)
- Zhao Z. (Zuotao)
- Zhi Y. (Yuxiang)
- Zuberbier T. (Torsten)
- Zwiener R.D. (Ricardo D.)
- Özyurt K. (Kemal)
- Publication venue
- 'Wiley'
- Publication date
- 05/04/2020
- Field of study
Observation of a new boson at a mass of 125 GeV with the CMS experiment at the LHC
- Author
- Abbaneo D.
- Abbiendi G.
- Abbrescia M.
- Abdullin S.
- Abdulsalam A.
- Acharya B.S.
- Acosta D.
- Acosta J.G.
- Adair A.
- Adam N.
- Adam W.
- Adamczyk D.
- Adams M.R.
- Adams T.
- Adiguzel A.
- Adler V.
- Adolphi R.
- Adzic P.
- Afanasiev S.
- Agostino L.
- Agram J.-L.
- Aguilar-Benitez M.
- Aguilo E.
- Ahmad M.
- Ahmad M.K.H.
- Ahuja S.
- Akchurin N.
- Akgun B.
- Akgun U.
- Akin I.V.
- Alagoz E.
- Albajar C.
- Albayrak E.A.
- Albergo S.
- Albert M.
- Albrow M.
- Alcaraz Maestre J.
- Aldaya Martin M.
- Aldá Júnior W.L.
- Alemany-Fernandez R.
- Alexander J.
- Aliev T.
- Alimena J.
- Allfrey P.
- Almeida N.
- Alverson G.
- Alves G.A.
- Aly A.
- Amaglobeli N.
- Amapane N.
- Ambroglini F.
- Amsler C.
- Anagnostou G.
- Anastassov A.
- Andelin D.
- Anderson J.
- Anderson M.
- Andrea J.
- Andreev V.
- Andreev V.
- Andreev Y.
- Andrews W.
- Anfreville M.
- Angelini F.
- Anghel I.M.
- Anisimov A.
- Anjos T.S.
- Ansari M.H.
- Antonelli L.
- Anttila E.
- Antunovic Z.
- Apanasevich L.
- Apollinari G.
- Appelt E.
- Apresyan A.
- Apyan A.
- Arce P.
- Arcidiacono R.
- Ardalan F.
- Arenton M.W.
- Arezzini S.
- Arfaei H.
- Argiro S.
- Arisaka K.
- Arndt K.
- Arneodo M.
- Arora S.
- Asavapibhop B.
- Asawatangtrakuldee C.
- Asghar M.I.
- Askew A.
- Aspell P.
- Assran Y.
- Ata M.
- Atac M.
- Attebury G.
- Attikis A.
- Auffray E.
- Autermann C.
- Auzinger G.
- Avdeeva E.
- Avery P.
- Avetisyan A.
- Avila C.
- Awad A.
- Ayan A.S.
- Azarkin M.
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- Aziz T.
- Azzi P.
- Azzolini V.
- Azzurri P.
- Baarmand M.M.
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- Barashko V.
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- Publication venue
- North-Holland Publishing
- Publication date
- 27/08/2014
- Field of study
Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK.
- Author
- Aban Marites
- Abayomi Fatola
- Abeyskera Kushala
- Aboagye Jeremy
- Adam Matthew
- Adams Kirsty
- Adamson James
- Adelaja Yemi A.
- Adlou Syed
- Ahmed Khatija
- Akhalwaya Saajida
- Akhalwaya Yasmeen
- Alcock Andrew
- Aley Parvinder K.
- Ali Aabidah
- Allen Elizabeth R.
- Allen Lauren
- Almeida Thamires C. D. S. C
- Alves Mariana P.S.
- Amorim Fabio
- Andritsou Foteini
- Angus Brian
- Anslow Rachel
- Appleby Matthew
- Arbe-Barnes Edward H.
- Ariaans Mark P.
- Arns Beatriz
- Arruda Laiana
- Awedetan Gbadebo
- Azi Lorena
- Azi Paula
- Babbage Gavin
- Bailey Catherine
- Baillie Vicky L.
- Baker Kenneth F.
- Baker Megan
- Baker Natalie
- Baker Philip
- Baldwin Lisa
- Baleanu Ioana
- Bandeira Danieli
- Bara Anna
- Barbosa Marcella A.S.
- Barker Debbie
- Barlow Gavin D.
- Barnabas Shaun L.
- Barnes Eleanor
- Barr Andrew S.
- Barrett Jessica
- Barrett Jordan R.
- Bates Louise
- Batten Alexander
- Beadon Kirsten
- Beales Emily
- Beckley Rebecca
- Belij-Rammerstorfer Sandra
- Bell Jonathan
- Bellamy Duncan
- Bellei Nancy
- Belton Sue
- Berg Adam
- Bermejo Laura
- Berrie Eleanor
- Berry Lisa
- Berzenyi Daniella
- Beveridge Amy
- Bewley Kevin R.
- Bexhell Helen
- Bhikha Sutika
- Bhorat Asad E.
- Bhorat Qasim E.
- Bhorat Zaheda E.
- Bibi Sagida
- Bijker Else
- Birch Geeta
- Birch Sarah
- Bird Adam
- Bird Olivia
- Bisnauthsing Karen
- Bittaye Mustapha
- Blackstone Katherine
- Blackwell Luke
- Bletchly Heather
- Blundell Caitlin L.
- Blundell Susannah R.
- Bodalia Pritesh
- Boettger Bruno C.
- Bolam Emma
- Boland Elena
- Bormans Daan
- Borthwick Nicola
- Bowring Francesca
- Boyd Amy
- Bradley Penny
- Brenner Tanja
- Briner Carmen
- Brown Claire
- Brown Phillip
- Brown-O'Sullivan Charlie
- Bruce Scott
- Brunt Emily
- Buchan Ruaridh
- Budd William
- Bulbulia Yusuf A.
- Bull Melanie
- Burbage Jamie
- Burhan Hassan
- Burn Aileen
- Buttigieg Karen R.
- Byard Nicholas
- Cabera Puig Ingrid
- Calderon Gloria
- Calvert Anna
- Camara Susana
- Cao Michelangelo
- Cappuccini Federica
- Cardoso João R.
- Carr Melanie
- Carroll Miles W.
- Carson-Stevens Andrew
- Carvalho José A.M.
- Carvalho Yasmin de M.
- Casey Helen R.
- Cashen Paul
- Castro Lucia Carratala
- Castro Thais
- Cathie Katrina
- Cavey Ana
- Cerbino-Neto José
- Chadwick Jim
- Chapman David
- Charlton Sue
- Chelysheva Irina
- Chester Oliver
- Chita Sunder
- Cho Jee-Sun
- Cicconi Paola
- Cifuentes Liliana
- Clark Elizabeth
- Clark Matthew
- Clarke Andrea
- Clemens Sue Ann Costa
- Clutterbuck Elizabeth A.
- Colin-Jones Rachel
- Collins Andrea M.
- Collins Sarah L.K.
- Conlon Christopher P.
- Connarty Sean
- Coombes Naomi
- Cooper Cushla
- Cooper Rachel
- Cornelissen Lynne
- Corrah Tumena
- Cosgrove Catherine
- Cox Tony
- Crocker Wendy E.M.
- Crosbie Sarah
- Cullen Dan
- Cullen Lorraine
- Cunha Debora R.M.F.
- Cunningham Christina
- Cuthbertson Fiona C.
- Cutland Clare L.
- Da Guarda Suzete N. Farias
- da Silva Moraes Antonio Carlos
- da Silva Larissa P.
- Damratoski Brad E.
- Danos Zsofia
- Dantas Maria T.D.C.
- Darroch Paula
- Darton Thomas C.
- Datoo Mehreen S.
- Datta Chandrabali
- Davids Malika
- Davies Hannah
- Davies Sarah L.
- Davis Elizabeth
- Davis John
- Davis Judith
- De Jager Jeanne
- De Nobrega Maristela M.D.
- De Oliveira Kalid Lis Moreno
- Dearlove David
- Demissie Tesfaye
- Desai Amisha
- Dheda Keertan
- Di Marco Stefania
- Di Maso Claudio
- Dinelli Maria I.S.
- Dinesh Tanya
- Docksey Claire
- Dold Christina
- Dong Tao
- Donnellan Francesca R.
- Dos Santos Erika Pachecho
- Dos Santos Tannyth
- dos Santos Thainá G.
- Douglas Alexander D.
- Douglas Naomi
- Downing Charlotte
- Drake Jonathan
- Drake-Brockman Rachael
- Driver Kimberley
- Drury Ruth
- Du Plessis Joan
- Dunachie Susanna J.
- Duncan Christopher J. A.
- Durham Benjamin S.
- Dutra Lidiana
- Easom Nicholas J.W.
- Edwards Mandy
- Edwards Nick J.
- El Muhanna Omar M.
- Elias Sean C.
- Elmore Mike
- Emary Katherine R. W.
- English Marcus
- Esmail Alisgair
- Essack Yakub Moosa
- Ewer Katie J.
- Fairlie Lee
- Farmer Eoghan
- Farooq Mutjaba
- Farrar Madi
- Farrugia Leonard
- Faulkner Beverley
- Faust Saul N.
- Fedosyuk Sofiya
- Felle Sally
- Feng Shuo
- Feng Shuo
- Ferreira Da Silva Carla
- Ferreira Daniela M.
- Field Samantha
- Finn Adam
- Fisher Richard
- Flaxman Amy
- Fletcher James
- Fofie Hazel
- Fok Henry
- Folegatti Pedro M.
- Ford Karen J.
- Fowler Jamie
- Fraiman Pedro H.A.
- Francis Emma
- Franco Marilia M.
- Frater John
- Freire Marilúcia S.M.
- Fry Samantha H.
- Fudge Sabrina
- Furze Julie
- Fuskova Michelle
- Galian-Rubio Pablo
- Galiza Eva
- Garlant Harriet
- Gavrila Madita
- Geddes Ailsa
- Gibbons Karyna A.
- Gilbert Sarah C
- Gilbride Ciaran
- Gill Hardeep
- Glynn Sharon
- Godwin Kerry
- Gokani Karishma
- Goldoni Ursula Carvalho
- Goncalves Maria
- Gonzalez Isabela G.S.
- Goodman Anna L.
- Goodwin Jayne
- Goondiwala Amina
- Gordon-Quayle Katherine
- Gorini Giacomo
- Grab Janet
- Gracie Lara
- Green Catherine M.
- Green Christopher A.
- Greenland Melanie
- Greenwood Nicola
- Greffrath Johann
- Groenewald Marisa M.
- Grossi Leonardo
- Gupta Gaurav
- Hackett Mark
- Hallis Bassam
- Hamaluba Mainga
- Hamilton Elizabeth
- Hammersley Daniel
- Hanrath Aidan T.
- Hanumunthadu Brama
- Harris Clair
- Harris Stephanie A.
- Harris Tara
- Harrison Daisy
- Harrison Thomas D.
- Hart Thomas C.
- Hartnell Birgit
- Hassan Shadin
- Haughney John
- Hawkins Sophia
- Hay Jodie
- Head Ian
- Heath Paul T.
- Henry John
- Hermosin Herrera Macarena
- Hettle David B.
- Hill Adrian V. S.
- Hill Catherine
- Hill Helen
- Hill Jennifer
- Hirsch Ian
- Hodges Gina
- Hodgson Susanne H. C.
- Horne Elizea
- Hou Mimi M.
- Houlihan Catherine
- Howe Elizabeth
- Howell Nicola
- Humphreys Jonathan
- Humphries Holly E.
- Hurley Katrina
- Huson Claire
- Hyamns Catherine
- Hyder-Wright Angela
- Ikram Sabina
- Ishwarbhai Alka
- Ivan Monica
- Iveson Poppy
- Iyer Vidyashankara
- Izu Alane
- Jackson Frederic
- Jackson Susan
- Jaumdally Shameem
- Jeffers Helen
- Jenkin Daniel
- Jesudason Natasha
- Joe Carina C. D.
- Jones Bryony
- Jones Christopher
- Jones Elizabeth
- Jones Kathryn
- Jorge Marianna Rocha
- Jose Aylin
- Joshi Amar
- Júnior Eduardo A.M.S.
- Kadziola Joanne
- Kailath Reshma
- Kana Faeeza
- Karampatsas Konstantinos
- Kasanyinga Mwila
- Keen Jade
- Kelly Dearbhla M.
- Kelly Debbie
- Kelly Elizabeth J.
- Kelly Sarah
- Kerr David
- Kerridge Simon
- Kfouri Renato de Ávila
- Khan Liaquat
- Khozoee Baktash
- Kidd Sarah
- Killen Annabel
- Kinch Jasmin
- Kinch Patrick
- King Lloyd D.W.
- King Thomas B.
- Kingham Lucy
- Klenerman Paul
- Knapper Francesca
- Knight Julian C.
- Knott Daniel
- Koen Anthonet
- Koleva Stanislava
- Kwatra Gaurav
- Lambe Teresa
- Lang Gail
- Lang Matilda
- Larkworthy Colin W.
- Larwood Jessica P.J.
- Law Rebecca
- Lawrie Alison M.
- Lazarus Erica M.
- Lazarus Rajeka
- Leach Amanda
- Lees Emily A.
- Lelliott Alice
- Lemm Nana-Marie
- Lessa Alvaro
- Leung Stephanie
- Li Yuanyuan
- Lias Amelia M.
- Liatsikos Kostas
- Libri Vincenzo
- Lillie Patrick J.
- Linder Aline
- Lipworth Samuel
- Liu Shuchang
- Liu Xinxue
- Lloyd Adam
- Lloyd Stephanie
- Loew Lisa
- Lopez Ramon Raquel
- Lora Leandro
- Lowthorpe Vicki
- Luz Kleber
- MacDonald Jonathan C.
- MacGregor Gordon
- Madhavan Meera
- Madhi Shabir A.
- Mainwaring David O.
- Makambwa Edson
- Makinson Rebecca
- Malahleha Mookho
- Malamatsho Ross
- Mallett Garry
- Mallory Raburn
- Mansatta Kushal
- Maoko Takalani
- Mapetla Katlego
- Marchevsky Natalie G.
- Marinou Spyridoula
- Marlow Emma
- Marques Gabriela N.
- Marriott Paula
- Marshall Julia L.
- Marshall Richard P.
- Martins Flávia J.
- Masenya Masebole
- Masilela Mduduzi
- Masters Shauna K.
- Mathew Moncy
- Matlebjane Hosea
- Matshidiso Kedidimetse
- Mazur Olga
- Mazzella Andrea
- McCaughan Hugh
- McEwan Joanne
- McGlashan Joanna
- McGregor Alastair
- McInroy Lorna
- McIntyre Zoe
- McLenaghan Daniela
- McRobert Nicky
- McSwiggan Steve
- Megson Clare
- Mehdipour Savviz
- Meijs Wilma
- Mendes Ana V .A.
- Mendonça Renata N.Á.
- Mentzer Alexander J.
- Milan Eveline P.
- Minassian Angela M.
- Mirtorabi Neginsadat
- Mitton Celia
- Mnyakeni Sibusiso
- Moghaddas Fiona
- Molapo Kgaogelo
- Moloi Mapule
- Moore Maria
- Moraes-Pinto M. Isabel
- Moran Marni
- Morey Ella
- Morgans Róisín
- Morris Helen C.
- Morris Sheila
- Morris Susan
- Morrison Hazel
- Morselli Franca
- Morshead Gertraud
- Morter Richard
- Mottal Lynelle
- Moultrie Andrew
- Moya Nathifa
- Mpelembue Mushiya
- Msomi Sibekezelo
- Mugodi Yvonne
- Mujadidi Yama F.
- Mukhopadhyay Ekta
- Muller Jilly
- Munro Alasdair
- Munro Claire
- Murphy Sarah
- Mweu Philomena
- Myasaki Celia Hatsuko
- Naik Gurudutt
- Naker Kush
- Nana Anusha
- Nastouli Eleni
- Nazir Abida
- Ndlovu Bongani
- Neffa Fabio
- Njenga Cecilia
- Noal Helena
- Novaes Gabrielle
- Noé Andrés
- Nugent Fay L.
- Nunes Géssika
- O'Brien Katie
- O'Connor Daniel
- O'Reilly Paula
- O'Reilly Peter J.
- Odam Miranda
- Oelofse Suzette
- Oguti Blanche
- Olchawski Victoria
- Oldfield Neil J.
- Oliveira Catarina
- Oliveira Marianne G.
- Oosthuizen Angela
- Osborne Piper
- Owen David R.J.
- Owen Lydia
- Owens Daniel
- Owino Nelly
- Pacurar Mihaela
- Padayachee Sherman D.
- Paiva Brenda V.B.
- Palhares Edna M.F.
- Palmer Susan
- Parkinson Sivapriyai
- Parracho Helena M.R.T.
- Parsons Karen
- Patel Bhumika
- Patel Dipak
- Patel Faeezah
- Patel Kelly
- Patrick-Smith Maia
- Payne Ruth O.
- Peng Yanchun
- Penn Elizabeth J.
- Pennington Anna
- Peralta Alvarez Marco Polo
- Perring James
- Perry Nicola
- Perumal Rubeshan
- Petkar Sahir
- Philip Tricia
- Phillips Daniel J.
- Phillips Jennifer
- Phohu Mary Kgomotso
- Pickup Lorinda
- Pieterse Sonja
- Piper Jo
- Pipini Dimitra
- Pittella Ana
- Plank Mary
- Plested Emma
- Pollard Andrew J
- Pollard Samuel
- Pollock Katrina M.
- Pooley Jennifer
- Pooran Anil
- Poulton Ian
- Powers Claire
- Presa Fernando B.
- Price David A.
- Price Vivien
- Primeira Marcelo
- Proud Pamela C.
- Provstgaard-Morys Samuel
- Pueschel Sophie
- Pulido David
- Quaid Sheena
- Rabara Ria
- Radford Alexandra
- Radia Kajal
- Rajapaska Durga
- Rajeswaran Thurkka
- Ramasamy Maheshi N.
- Ramos Lopez Fernando
- Ramos Alberto San Francisco
- Rampling Tommy
- Rand Jade
- Ratcliffe Helen
- Rawlinson Tom
- Rea David
- Rees Byron
- Reiné Jesús
- Resuello-Dauti Mila
- Reyes Pabon Emilia
- Rhead Sarah
- Ribiero Carla M.
- Ricamara Marivic
- Richter Alex
- Ritchie Adam J.
- Ritchie Neil
- Robbins Alexander J.
- Roberts Hannah
- Robinson Hannah
- Robinson Ryan E.
- Rocchetti Talita T.
- Rocha Beatriz Pinho
- Roche Sophie
- Rollier Christine
- Rose Louisa
- Ross Russell Amy L.
- Rossouw Lindie
- Royal Simon
- Rudiansyah Indra
- Ruiz Sarah
- Saich Stephen
- Sala Claudia
- Sale Jessica
- Salman Ahmed M.
- Salvador Natalia
- Salvador Stephannie
- Sampaio Milla
- Samson Annette D.
- Sanchez-Gonzalez Amada
- Sanders Helen
- Sanders Katherine
- Santos Guerra Mayara F.S.
- Santos Erika
- Satti Iman
- Saunders Caroline
- Saunders Jack E.
- Sayed Aakifah
- Schim van der Loeff Ina
- Schmid Annina B.
- Schofield Ella
- Schwarzbold Alexandre V.
- Screaton Gavin
- Seddiqi Samiullah
- Segireddy Rameswara R.
- Senger Roberta
- Serrano Sonia
- Shah Rajiv
- Shaik Imam
- Sharpe Hannah E.
- Sharrocks Katherine
- Shaw Robert
- Shea Adam
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- Shepherd James G.
- Shiham Farah
- Sidhom Emad
- Silk Sarah E.
- Silva-Junior Gilberto
- Silva-Reyes Laura
- Silveira Anderson D.
- Silveira Mariana B.V.
- Singh Nisha
- Sinha Jaisi
- Skelly Donal T.
- Smith Andrew
- Smith Catherine C.
- Smith Daniel C.
- Smith David J.
- Smith Holly E.
- Smith Nick
- Snape Matthew D.
- Soares Airanuédida
- Soares Tiago
- Solórzano Carla
- Song Rinn
- Sorio Guilherme L.
- Sorley Kim
- Sosa-Rodriguez Tiffany
- Souza Alessandra R.
- Souza Bruno S.D.F.
- Souza Cinthia M.C.D.L.
- Spencer Alexandra J.
- Spina Fernanda
- Spoors Louise
- Sprinz Eduardo
- Stafford Lizzie
- Stamford Imogen
- Starinskij Igor
- Stein Ricardo
- Steven Jill
- Stockdale Lisa
- Stockwell Lisa V.
- Strickland Louise H.
- Stuart Arabella C.
- Sturdy Ann
- Sutherland Rebecca K.
- Sutton Natalina
- Szigeti Anna
- Tahiri-Alaoui Abdessamad
- Tanner Rachel
- Taoushanis Carol
- Tarr Alexander W.
- Tarrant Richard
- Taylor Iona Jennifer
- Taylor Justin
- Taylor Keja
- Taylor Ursula
- te Water Naude Rebecca
- Themistocleous Andreas
- Themistocleous Yrene
- Thomas Kelly
- Thomas Merin
- Thomas Tonia M.
- Thombrayil Asha
- Thompson Amber
- Thompson Ameeka
- Thompson Fawziyah
- Thompson Kevin
- Thomson Emma C.
- Thomson Julia
- Thornton-Jones Viv
- Tighe Patrick J.
- Tinoco Lygia Accioly
- Tiongson Gerlynn
- Tladinyane Bonolo
- Tomasicchio Michele
- Tomic Adriana
- Tonks Susan
- Toshner Mark
- Tran Nguyen
- Tree Julia
- Trillana Gerry
- Trinham Charlotte
- Trivett Rose
- Truby Adam
- Tsheko Betty Lebogang
- Turabi Aadil
- Turner Cheryl
- Turner David P. J.
- Turner Richard
- Török M Estée
- Ulaszewska Marta
- Underwood Benjamin R.
- van Eck Samual
- Varughese Rachel
- Vekemans Johan
- Verbart Dennis
- Verheul Marije
- Vichos Iason
- Vieira Taiane
- Villafana Tonya L.
- Voysey Merryn
- Waddington Claire S.
- Walker Laura
- Wallis Erica
- Wand Matthew
- Warbick Deborah
- Wardell Theresa
- Warimwe George
- Warren Sarah C.
- Watkins Bridget
- Watson Ekaterina
- Watson Marion E. E.
- Webb Stewart
- Webb-Bridges Alice
- Webster Angela
- Weckx Lily Y.
- Welch Jessica
- Wells Jeanette
- West Alison
- White Caroline
- White Rachel
- Williams Christopher J.
- Williams Paul
- Williams Rachel L.
- Winslow Rebecca
- Woodyer Mark
- Worth Andrew T.
- Wright Danny
- Wroblewska Marzena
- Yao Andy
- Zimmer Rafael
- Zizi Dalila
- Zuidewind Peter
- Publication venue
- 'Elsevier BV'
- Publication date
- 03/12/2020
- Field of study
BACKGROUND: A safe and efficacious vaccine against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), if deployed with high coverage, could contribute to the control of the COVID-19 pandemic. We evaluated the safety and efficacy of the ChAdOx1 nCoV-19 vaccine in a pooled interim analysis of four trials. METHODS: This analysis includes data from four ongoing blinded, randomised, controlled trials done across the UK, Brazil, and South Africa. Participants aged 18 years and older were randomly assigned (1:1) to ChAdOx1 nCoV-19 vaccine or control (meningococcal group A, C, W, and Y conjugate vaccine or saline). Participants in the ChAdOx1 nCoV-19 group received two doses containing 5 × 1010 viral particles (standard dose; SD/SD cohort); a subset in the UK trial received a half dose as their first dose (low dose) and a standard dose as their second dose (LD/SD cohort). The primary efficacy analysis included symptomatic COVID-19 in seronegative participants with a nucleic acid amplification test-positive swab more than 14 days after a second dose of vaccine. Participants were analysed according to treatment received, with data cutoff on Nov 4, 2020. Vaccine efficacy was calculated as 1 - relative risk derived from a robust Poisson regression model adjusted for age. Studies are registered at ISRCTN89951424 and ClinicalTrials.gov, NCT04324606, NCT04400838, and NCT04444674. FINDINGS: Between April 23 and Nov 4, 2020, 23 848 participants were enrolled and 11 636 participants (7548 in the UK, 4088 in Brazil) were included in the interim primary efficacy analysis. In participants who received two standard doses, vaccine efficacy was 62·1% (95% CI 41·0-75·7; 27 [0·6%] of 4440 in the ChAdOx1 nCoV-19 group vs71 [1·6%] of 4455 in the control group) and in participants who received a low dose followed by a standard dose, efficacy was 90·0% (67·4-97·0; three [0·2%] of 1367 vs 30 [2·2%] of 1374; pinteraction=0·010). Overall vaccine efficacy across both groups was 70·4% (95·8% CI 54·8-80·6; 30 [0·5%] of 5807 vs 101 [1·7%] of 5829). From 21 days after the first dose, there were ten cases hospitalised for COVID-19, all in the control arm; two were classified as severe COVID-19, including one death. There were 74 341 person-months of safety follow-up (median 3·4 months, IQR 1·3-4·8): 175 severe adverse events occurred in 168 participants, 84 events in the ChAdOx1 nCoV-19 group and 91 in the control group. Three events were classified as possibly related to a vaccine: one in the ChAdOx1 nCoV-19 group, one in the control group, and one in a participant who remains masked to group allocation. INTERPRETATION: ChAdOx1 nCoV-19 has an acceptable safety profile and has been found to be efficacious against symptomatic COVID-19 in this interim analysis of ongoing clinical trials. FUNDING: UK Research and Innovation, National Institutes for Health Research (NIHR), Coalition for Epidemic Preparedness Innovations, Bill & Melinda Gates Foundation, Lemann Foundation, Rede D'Or, Brava and Telles Foundation, NIHR Oxford Biomedical Research Centre, Thames Valley and South Midland's NIHR Clinical Research Network, and AstraZeneca
Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK
- Author
- Aban Marites
- Abayomi Fatola
- Abeyskera Kushala
- Aboagye Jeremy
- Adam Matthew
- Adams Kirsty
- Adamson James
- Adelaja Yemi A.
- Adlou Syed
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- Wroblewska Marzena
- Yao Andy
- Zimmer Rafael
- Zizi Dalila
- Zuidewind Peter
- Publication venue
- 'Elsevier BV'
- Publication date
- 09/01/2021
- Field of study
Background
A safe and efficacious vaccine against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), if deployed with high coverage, could contribute to the control of the COVID-19 pandemic. We evaluated the safety and efficacy of the ChAdOx1 nCoV-19 vaccine in a pooled interim analysis of four trials.
Methods
This analysis includes data from four ongoing blinded, randomised, controlled trials done across the UK, Brazil, and South Africa. Participants aged 18 years and older were randomly assigned (1:1) to ChAdOx1 nCoV-19 vaccine or control (meningococcal group A, C, W, and Y conjugate vaccine or saline). Participants in the ChAdOx1 nCoV-19 group received two doses containing 5 × 1010 viral particles (standard dose; SD/SD cohort); a subset in the UK trial received a half dose as their first dose (low dose) and a standard dose as their second dose (LD/SD cohort). The primary efficacy analysis included symptomatic COVID-19 in seronegative participants with a nucleic acid amplification test-positive swab more than 14 days after a second dose of vaccine. Participants were analysed according to treatment received, with data cutoff on Nov 4, 2020. Vaccine efficacy was calculated as 1 - relative risk derived from a robust Poisson regression model adjusted for age. Studies are registered at ISRCTN89951424 and ClinicalTrials.gov, NCT04324606, NCT04400838, and NCT04444674.
Findings
Between April 23 and Nov 4, 2020, 23 848 participants were enrolled and 11 636 participants (7548 in the UK, 4088 in Brazil) were included in the interim primary efficacy analysis. In participants who received two standard doses, vaccine efficacy was 62·1% (95% CI 41·0–75·7; 27 [0·6%] of 4440 in the ChAdOx1 nCoV-19 group vs71 [1·6%] of 4455 in the control group) and in participants who received a low dose followed by a standard dose, efficacy was 90·0% (67·4–97·0; three [0·2%] of 1367 vs 30 [2·2%] of 1374; pinteraction=0·010). Overall vaccine efficacy across both groups was 70·4% (95·8% CI 54·8–80·6; 30 [0·5%] of 5807 vs 101 [1·7%] of 5829). From 21 days after the first dose, there were ten cases hospitalised for COVID-19, all in the control arm; two were classified as severe COVID-19, including one death. There were 74 341 person-months of safety follow-up (median 3·4 months, IQR 1·3–4·8): 175 severe adverse events occurred in 168 participants, 84 events in the ChAdOx1 nCoV-19 group and 91 in the control group. Three events were classified as possibly related to a vaccine: one in the ChAdOx1 nCoV-19 group, one in the control group, and one in a participant who remains masked to group allocation.
Interpretation
ChAdOx1 nCoV-19 has an acceptable safety profile and has been found to be efficacious against symptomatic COVID-19 in this interim analysis of ongoing clinical trials
Whole-genome sequencing reveals host factors underlying critical COVID-19
- Author
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- Publication venue
- Springer Science and Business Media LLC
- Publication date
- 07/07/2022
- Field of study
Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care1 or hospitalization2,3,4 after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically ill individuals compared with 48,400 controls to discover and replicate 23 independent variants that significantly predispose to critical COVID-19. We identify 16 new independent associations, including variants within genes that are involved in interferon signalling (IL10RB and PLSCR1), leucocyte differentiation (BCL11A) and blood-type antigen secretor status (FUT2). Using transcriptome-wide association and colocalization to infer the effect of gene expression on disease severity, we find evidence that implicates multiple genes—including reduced expression of a membrane flippase (ATP11A), and increased expression of a mucin (MUC1)—in critical disease. Mendelian randomization provides evidence in support of causal roles for myeloid cell adhesion molecules (SELE, ICAM5 and CD209) and the coagulation factor F8, all of which are potentially druggable targets. Our results are broadly consistent with a multi-component model of COVID-19 pathophysiology, in which at least two distinct mechanisms can predispose to life-threatening disease: failure to control viral replication; or an enhanced tendency towards pulmonary inflammation and intravascular coagulation. We show that comparison between cases of critical illness and population controls is highly efficient for the detection of therapeutically relevant mechanisms of disease
Bat predation and sexual advertisement in a neotropical anuran
- Publication venue
- Universidad Nacional Autónoma de México (UNAM)
- Publication date
- 01/01/1982
- Field of study
Clustering Evolving Data Stream with Affinity Propagation Algorithm
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2014
- Field of study
- …