9 research outputs found
Sensory Evaluation of Antioxidant Enriched and Iron Based Prebiotic Milk Cake
The main objective of this research study was to develop antioxidant enriched and iron based prebiotic milk cake and to evaluate sensory analysis of newly prepared milk cake. In this research study, control milk cake was developed without prebiotics and experimental milk cake was prepared by different percentage of prebiotics. As a prebiotics kiwi fruits powder was used. The nutritional value of bakery goods and their potential for use in feeding programmes and emergencies captured the attention of customers. After sensory analysis, it was found that T3 treatment combination was showed higher overall acceptability
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Fast response and low temperature sensing of acetone and ethanol using Al-doped ZnO microrods
We report low temperature acetone and ethanol sensing properties of Al-doped ZnO microrods synthesized using hydrothermal technique. We observe the acetone detection at room temperature as well as ethanol and acetone detection at low temperature of 150 °C using Al-doped ZnO microrods. 3 wt% Al-doped ZnO microrods sensor exhibits the highest response of 231 toward 8100 parts per million (ppm) of ethanol at 150 °C. The response & recovery time are found to be ultrafast of 60 ms & 870 ms for ethanol and 110 ms & 330 ms for acetone of the Al-doped ZnO microrods at an operating temperature of 150 °C, respectively. In addition, sensing mechanism has explained to illuminate the improved sensing performances of Al-doped ZnO microrods. Thus it is revealed that Al-doped ZnO microrods are promising as an ultrafast gas sensor
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Alterations of ATM and CADM1 in Chromosomal 11q22.3–23.2 Region are Associated with the Development of Invasive Cervical Carcinoma.
To understand the importance of chr11q22.3–
23.2 region in the development of cervical cancer, we have
studied the genetic and epigenetic alterations of the candidate
genes ATM, PPP2R1B, SDHD and CADM1 in cervical
intraepithelial neoplasia (CIN) and cervical carcinoma
(CACX) samples. Our study revealed low expression and
high alterations (methylation/deletion) (55–59%) of ATM
and CADM1 genes along with poor patient outcome. The
alterations of ATM and CADM1 are associated with the
progression of tumor from CIN to Stage I/II, thus implying
their role in early invasiveness. The two genes, PPP2R1B
and SDHD, lying in between ATM and CADM1, have low
frequency of alterations, and majority of the alterations
are in CACX samples, indicating that their alterations might be associated with disease progression. Expressions (mRNA/
protein) of the genes showed concordance with their
molecular alterations. Significant co-alteration of ATM and
CADM1 points to their synergic action for the development
of CACX. Mutation is, however, a rare phenomenon for
inactivation of ATM. Association between the alteration of
ATM and CHEK1 and poor survival of the patients having
co-alterations of ATM and CHEK1 points to the DNA
damage response pathway disruption in development
of CACX. Thus, our data suggest that inactivation of
ATM–CHEK1-associated DNA damage response pathway
and CADM1-associated signaling network might have an
important role in the development of CACX
Human papillomavirus prevalence in postradiotherapy uterine cervical carcinoma patients: correlation with recurrence of the disease
Singh RK, Maulik S, Mitra S, Mondal RK, Basu PS, Roychowdhury S, Panda CK. Human papillomavirus
prevalence in postradiotherapy uterine cervical carcinoma patients: correlation with recurrence of
the disease. Int J Gynecol Cancer 2006;16:1048–1054.
To understand the role of human papillomavirus (HPV) in recurrence of uterine cervical cancer (CA-CX)
after radiotherapy, we have analyzed the HPV prevalence in the exfoliated cells of 56 patients and their
corresponding plasma. HPV DNA was detected in exfoliated cells of 78% (44/56) patients (HPV-16, 68%;
HPV-18, 14%; HPV-X [other than 16, 18], 11%; and mixed infection of HPV-16 and HPV-18 in three cases).
HPV DNA in plasma was present in only 25% (11/44) of the HPV-positive exfoliated cells (positive predictive
value, 100%; negative predictive value, 27%) with concordance in HPV types. The recurrence of the
disease was significantly associated with the presence of HPV in the exfoliated cell (P ¼ 0.01) and plasma
(P ¼ 0.007) as well as high viral load in the exfoliated cell (P ¼ 0.0002). Kaplan–Meier disease-free estimates
have also shown the significant association between HPV prevalence in plasma and recurrence of the
disease (P ¼ 0.045). Thus, it indicates that in postradiotherapy CA-CX patients, the high viral load in the
exfoliated cell as well as HPV presence in the plasma samples could be used in early detection of the patients
at increased risk for disease recurrence and progressio
Inactivation of PTCH1 is associated with the development of cervical carcinoma: clinical and prognostic implication
“Nation” Within the Nation: Revisiting the Failed Revolution of Morichjhãpi in Amitav Ghosh's The Hungry Tide
Deletions in Chromosome 4 Differentially Associated With the Development of Cervical Cancer: Evidence of Slit2 as a Candidate Tumor Suppressor Gene
The aim of this study was to locate the candidate
tumor suppressor genes (TSGs) loci in the chromosomal
4p15-16, 4q22-23 and 4q34-35 regions associated
with the development of uterine cervical carcinoma
(CA-CX). Deletion mapping of the regions by microsatellite
markers identified six discrete areas with high frequency
of deletions, viz. 4p16.2 (D1: 40%), 4p15.31 (D2:
35–38%), 4p15.2 (D3: 37–40%), 4q22.2 (D4: 34%),
4q34.2-34.3 (D5: 37–59%) and 4q35.1 (D6: 40–50%).
Significant correlation was noted among the deleted
regions D1, D2 and D3. The deletions in D1, D2, D5 and
D6 regions are suggested to be associated with the cervical
intraepithelial neoplasia (CIN), and deletions in the D2,
D3, D5 and D6 regions seems to be associated with progression
of CA-CX. The deletions in the D2 and D6
regions showed significant prognostic implications
(P = 0.001; 0.02). The expression of the candidate TSG
SLIT2 mapped to D2 region gradually reduced from normal cervix uteri fi CIN fi CA-CX. SLIT2 promoter
hypermethylation was seen in 28% CIN samples and significantly
increased with tumor progression (P = 0.04).
Significant correlation was seen between SLIT2 deletion
and its promoter methylation (P = 0.001), indicating that
both these phenomena could occur simultaneously to
inactivate this gene. Immunohistochemical analysis
showed reduced expression of SLIT2 in cervical lesions
and CA-CX cell lines. Although no mutation was detected
in the SLIT2 promoter region (–432 to + 55 bp), CC and
AA haplotypes were seen in –227 and –195 positions,
respectively. Thus, it indicates that inactivation of SLIT2-
ROBO1 signaling pathway may have an important role in
CA-CX development