Lifestyle and health factors associated with progressing and remitting trajectories of untreated lower urinary tract symptoms among elderly men.

BackgroundKnowledge of factors associated with the course of lower urinary tract symptoms (LUTS) before treatment is needed to inform preventive interventions. In a prospective study of elderly men untreated for LUTS, we identified factors associated with symptom progression and remission.MethodsIn community-dwelling US men aged ≥65 years, the American Urological Association Symptom Index (AUA-SI) was repeated four times, once at baseline (2000-2002) and then every 2 years thereafter. Analyses included 1740 men with all four AUA-SI assessments, who remained free from diagnosed prostate cancer, and who reported no treatment for LUTS or BPH during follow-up that averaged 6.9 (±0.4) years. LUTS change was determined with group-based trajectory modelingof the repeated AUA-SI measures. Multivariable logistic regression was then used to determine the baseline factors associated with progressing compared with stable trajectories, and with remitting compared with progressing trajectories. Lifestyle, body mass index (BMI) (kg/m(2)), mobility, mental health (Short-Form 12), medical history and prescription medications were considered for selection. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated for variables in each model.ResultsWe identified 10 AUA-SI trajectories: 4 stable (1277 men, 73%), three progressing (345 men, 20%), two remitting (98 men, 6%) and one mixed (20 men, 1%). Men in progressing compared with stable trajectories were more likely to have mobility limitations (OR=2.0, 95% CI: 1.0-3.8), poor mental health (OR=1.9, 95% CI: 1.1-3.4), BMI≥25.0 kg m(-2) (OR=1.7, 95% CI: 1.0-2.8), hypertension (OR=1.5, 95% CI: 1.0-2.4) and back pain (OR=1.5, 95% CI: 1.0-2.4). Men in remitting compared with progressing trajectories more often used central nervous system medications (OR=2.3, 95% CI: 1.1-4.9) and less often had a history of problem drinking (OR=0.4, 95% CI: 0.2-0.9).ConclusionsSeveral non-urological lifestyle and health factors were independently associated with risk of LUTS progression in older men

A smart itsy bitsy spider for the Web

Artificial Intelligence Lab, Department of MIS, University of ArizonaAs part of the ongoing Illinois Digital Library Initiative project, this research proposes an intelligent agent approach to Web searching. In this experiment, we developed two Web personal spiders based on best first search and genetic algorithm techniques, respectively. These personal spiders can dynamically take a userâ s selected starting homepages and search for the most closely related homepages in the Web, based on the links and keyword indexing. A graphical, dynamic, Java-based interface was developed and is available for Web access. A system architecture for implementing such an agent-based spider is presented, followed by detailed discussions of benchmark testing and user evaluation results. In benchmark testing, although the genetic algorithm spider did not outperform the best first search spider, we found both results to be comparable and complementary. In user evaluation, the genetic algorithm spider obtained significantly higher recall value than that of the best first search spider. However, their precision values were not statistically different. The mutation process introduced in genetic algorithm allows users to find other potential relevant homepages that cannot be explored via a conventional local search process. In addition, we found the Java-based interface to be a necessary component for design of a truly interactive and dynamic Web agent

An extended and revised Lake Suigetsu varve chronology from ∼50 to ∼10 ka BP based on detailed sediment micro-facies analyses

Lake Suigetsu (Japan) is a key site for radiocarbon (14C) calibration and palaeo-environmental reconstruction in East Asia. Here we present a description of the sediment (micro)facies, which in combination with a new approach to varve interpolation allows construction of a revised varve based chronology that extends the previous 2012 varve based chronology by ∼10 ka, back to ∼50 ka BP. Challenges in varve counting and interpolation, which were previously discussed in detail only for the Last Glacial-Interglacial Transition, are described here back to ∼50 ka BP. Furthermore, the relative merits of varve counting by μXRF scanning and by thin-section microscopy are discussed. Facies analysis reveals four facies zones, their transitions driven by both local and climatic controls. The lamination quality of the sediment is highly variable and varve interpolation reveals that in the analysed time interval, on average, only 50% of the annual cycles are represented by seasonal layers. In the remaining years seasonal layers are indistinguishable, i.e. either did not form or were not preserved. For varve interpolation an advanced version of the Varve Interpolation Program was used, which enabled the construction of the longest, purely varve dated chronology published, despite long intervals of poor lamination quality. The calculated interpolation uncertainty is +8.9% and −4.6%, which is well within expectations considering the high degree of interpolation and the length of the record

Evidence for a bi-partition of the Younger Dryas Stadial in East Asia associated with inversed climate characteristics compared to Europe

The Younger Dryas Stadial (YDS) was an episode of northern hemispheric cooling which occurred within the Last Glacial Interglacial Transition (LGIT). A major driver for the YDS climate was a weakening of the Atlantic Meridional Overturning Circulation (AMOC). It has been inferred that the AMOC began to strengthen mid-YDS, producing a bipartite structure of the YDS in records from continental Europe. These records imply that the polar front and westerlies shifted northward, producing a warmer second phase of the YDS in Europe. Here we present multi-proxy data from the sediments of Lake Suigetsu (Japan), as evidence that a related bi-partition of the YDS also occurred in East Asia. Besides showing for the first time that the bi-partition was not limited to the North Atlantic/European region, the data also imply a climatic dipole between Europe and East Asia since the cold-warm characteristics are reversed at Lake Suigetsu. We suggest that changes in eastward moisture transport from the North Atlantic are the primary mechanism by which the teleconnection can be explained

WIGGLE-MATCHING USING KNOWN-AGE PINE FROM JERMYN STREET, LONDON

A slice of pine from the period covered by single-year calibration data (Stuiver 1993) was selected to serve as part of the quality assurance procedures of the English Heritage radiocarbon dating program. following successful wiggle-matching, of (14)C measurements from structural 15th century English oak timbers (Hamilton et al. 2007). The timber selected was a roofing element front it house on Jermyn Street, central London, demonstrated by dendrochronology to have been felled in AD 1670. Eighteen single-ring samples were dated by the (14)C laboratories at Groningen, Oxford, and SUERC: each laboratory was sent a random selection of 6 samples. This approach was intended to mimic the mix of samples and relative ages incorporated into Bayesian chronological models during the project research. This paper presents the results of this study.</p

When and Why? The Chronology and Context of Flint Mining at Grime’s Graves, Norfolk, England

New radiocarbon dating and chronological modelling have refined understanding of the character and circumstances of flint mining at Grime’s Graves through time. The deepest, most complex galleried shafts were worked probably from the third quarter of the 27th century cal BC and are amongst the earliest on the site. Their use ended in the decades around 2400 cal BC, although the use of simple, shallow pits in the west of the site continued for perhaps another three centuries. The final use of galleried shafts coincides with the first evidence of Beaker pottery and copper metallurgy in Britain. After a gap of around half a millennium, flint mining at Grime’s Graves briefly resumed, probably from the middle of the 16th century cal BC to the middle of the 15th. These ‘primitive’ pits, as they were termed in the inter-war period, were worked using bone tools that can be paralleled in Early Bronze Age copper mines. Finally, the scale and intensity of Middle Bronze Age middening on the site is revealed, as it occurred over a period of probably no more than a few decades in the 14th century cal BC. The possibility of connections between metalworking at Grime’s Graves at this time and contemporary deposition of bronzes in the nearby Fens is discussed