Behavior of Poly-A onto Kaolin

A combination of geochemical variables is necessary to explain the origin of life on Earth. Thus, in this work the sorption of Poly-A on a clay mineral (kaolinite) was studied to get an insight about the sorption capacity at different times and pH values, as well as to confirm the capabilities of the clay to protect the sorbate from an external source of ionizing radiation. Poly-A presented a high percentage of sorption in the clay, especially in acidic environments, and this percentage sharply decrease in alkaline media. On the other hand, Poly-A’s recovery was higher in the system with clay, confirming its protection role

La vanguardia en soluciones de redes para un mundo interconectado

Este artículo expone la implementación integral de NetServer en áreas fundamentales de infraestructura de red, como DHCP Server, DNS Server, Controlador de Dominio, servicios proxy, Cortafuegos, File Server, Print Server y servicios de VPN. Se detalla el proceso de configuración de cada componente, resaltando su integración para mejorar la conectividad y la seguridad de la red. Los resultados revelan una optimización notable en la eficiencia operativa, permitiendo una gestión centralizada y la entrega ágil de servicios de red. Esta implementación demuestra la versatilidad de NetServer para ofrecer soluciones completas que potencian la conectividad, la administración de recursos y la protección de datos en entornos diversos. Este estudio destaca la relevancia estratégica de NetServer en el fortalecimiento y la evolución de la infraestructura de red contemporánea.Este artículo expone la implementación integral de NetServer en áreas fundamentales de infraestructura de red, como DHCP Server, DNS Server, Controlador de Dominio, servicios proxy, Cortafuegos, File Server, Print Server y servicios de VPN. Se detalla el proceso de configuración de cada componente, resaltando su integración para mejorar la conectividad y la seguridad de la red. Los resultados revelan una optimización notable en la eficiencia operativa, permitiendo una gestión centralizada y la entrega ágil de servicios de red. Esta implementación demuestra la versatilidad de NetServer para ofrecer soluciones completas que potencian la conectividad, la administración de recursos y la protección de datos en entornos diversos. Este estudio destaca la relevancia estratégica de NetServer en el fortalecimiento y la evolución de la infraestructura de la red contemporánea

La tecnología lítica tallada del modo 3 del abrigo de Benzú (norte de Africa). Enmarque en su territorio inmediato

The rock-shelter of Benzú is located near the city of Ceuta in North Africa. The Benzú rock-shelter contains a sequence of 7 archaeological levels, which are associated with a clearly defined Mode 3 lithic technology. The similarities with other assemblages found in the south of the Iberian Peninsula are clear. We must also emphasise the exploitation of marine resources by these hunter-gatherer societies from the beginning of the Middle Pleistocene sequence. On the basis of this archaeological evidence and in the context of recent studies on North Africa, this work assesses the possible relationships and contacts between societies on both shores of the historical region of the Straits of Gibraltar.El Abrigo de Benzú está situado en la ciudad de Ceuta, en el norte de África. Cuenta con una secuencia de 7 estratos con tecnología muy definida de Modo 3-Paleolítico Medio. Las similitudes con los conjuntos del sur de la Península Ibérica son significativas. Destacamos también la explotación de recursos marinos por sociedades cazadoras-recolectoras desde el inicio de la secuencia en el Pleistoceno Medio. Con estas bases arqueológicas y el contexto de estudios recientes en la región norteafricana valoramos las posibles relaciones y contactos entre las sociedades de las dos orillas de la región geohistórica del Estrecho de Gibraltar

Middle Paleolithic Mode 3 lithic technology in the rock shelter Benzú (North Africa) and its inmediate enviromental relationships

Artículo sobre la tecnología de Modo 3 en Benzú y su relación con el ecosistema adyacente

La ocupación prehistórica e histórica del complejo "Cueva Enrique" (Ceuta). Síntesis de las actuaciones arqueológicas.

Artículo de síntesis sobre las actuaciones en Cueva Enrique

Isolation and characterization of mercury resistant trichoderma strains from soil with high levels of mercury and its effects on Arabidopsis thaliana mercury uptake

"Traditional mining activities are usually correlated with high levels of soil pollution, which is a major environmental concern. Extensive mining activities have taken place in the San Joaquin region in the State of Querétaro, México resulting in high levels of mercury soil pollution (up to 1532 ± 300 mg/kg). We isolated mercury-resistant fungal strains from the San Joaquin region soils and identified them through morphologic characteristics and ITS rDNA region sequence analysis. We determined that fungi isolated belong to the genus Trichoderma. All the isolates selected showed the ability to catalyze the volatilization of Hg. For air sampling, an active sampling device was constructed and using acid KMnO4 as an absorbent, the concentration of mercury in solution was determined through the cold vapor atomic absorption method. The results show mercury volatilization from the fungal species assay, with a maximum of 213.04 ± 32.6 µg/m3 while mycelium accumulation ranged from less than 17.5 ± 2.9 to 20.0 ± 3.4 µg/g. The fungal isolates were also evaluated for their ability to reduce mercury uptake in Arabidopsis thaliana. These observations suggest the utility of Trichoderma for the mobilization of mercury in those contaminated soils.

Cueva de Enrique (Ceuta). Un nuevo yacimiento con tecnología de Modo 3 en el entorno de Benzú.

Artículo sobre Cueva Enrique, en el entorno Benzú

Implication of type 4 NADPH oxidase (NOX4) in tauopathy.

Aggregates of the microtubule-associated protein tau are a common marker of neurodegenerative diseases collectively termed as tauopathies, such as Alzheimer’s disease (AD) and frontotemporal dementia. Therapeutic strategies based on tau have failed in late stage clinical trials, suggesting that tauopathy may be the consequence of upstream causal mechanisms. As increasing levels of reactive oxygen species (ROS) may trigger protein aggregation or modulate protein degradation and, we had previously shown that the ROS producing enzyme NADPH oxidase 4 (NOX4) is a major contributor to cellular autotoxicity, this study was designed to evaluate if NOX4 is implicated in tauopathy. Our results show that NOX4 is upregulated in patients with frontotemporal lobar degeneration and AD patients and, in a humanized mouse model of tauopathy induced by AVV-TauP301L brain delivery. Both, global knockout and neuronal knockdown of the Nox4 gene in mice, diminished the accumulation of pathological tau and positively modified established tauopathy by a mechanism that implicates modulation of the autophagy-lysosomal pathway (ALP) and, consequently, improving the macroautophagy flux. Moreover, neuronal-targeted NOX4 knockdown was sufficient to reduce neurotoxicity and prevent cognitive decline, even after induction of tauopathy, suggesting a direct and causal role for neuronal NOX4 in tauopathy. Thus, NOX4 is a previously unrecognized causative, mechanism-based target in tauopathies and blood-brain barrier permeable specific NOX4 inhibitors could have therapeutic potential even in established disease.post-print5895 K

The occupation of Benzu Cave (Ceuta) by Neolithic and Bronze Age Societies

Abstract This study presents the results of the archaeological investigation in Benzú Cave, located on the North African shore of the Strait of Gibraltar. The archaeological deposits, approximately 1 m deep, belong to two occupational levels dated to theNeolithic and the Bronze Age. Awide range of artifacts was found, and this led to an interdisciplinary study that led us to reach new conclusions concerning the material life, subsistence economy, and environment of the Neolithic and Bronze Age societies in northern Africa and the southern Iberian Peninsula.Résumé Cette étude présente les résultats des recherches archéologiques menées dans la grotte de Benzú, située sur la rive nord-africaine du détroit de Gibraltar. Les gisements archéologiques, d'environ un mètre de profondeur, appartiennent à deux niveaux d'occupation datant du néolithique et de l'âge du bronze. Une large gamme d'artefacts ont été trouvés, ce qui a conduit à une étude interdisciplinaire qui nous a amenés à tirer de nouvelles conclusions concernant la vie matérielle, l'économie de subsistance et l'environnement des sociétés du Néolithique et de l'Age du Bronze en Afrique du Nord et au sud de la Péninsule Ibérique