CD26/DPPIV and response to hepatitis B vaccination

The prevention of hepatitis B is important, since it is responsible for significant morbidity and mortality around the world. Unfortunately, hepatitis B vaccine does not always induce protective immunity. The lack of immune response to vaccine (non-responders) can depend on individual characteristics. The objective of this study was to correlate the CD26/DPPIV cellular expression and DPPIV serum activity with HBV vaccine response and its possible role as an indicator of immune competence acquisition. We also determined the cellular expression of CD3, CD19, CD56 and CD25 in peripheral blood T lymphocytes. Blood samples were obtained from 28 healthy human volunteers who were enrolled with a vaccination program. There were "responders" (RM = 13) and "non-responders" (NRM = 15), after vaccination. The lymphocyte populations were identified by flow cytometry. DPPIV serum activity was measured fluorimetrically. CD26 expression in responders (55.9 +/- 7.7%) versus in non-responders (51.9 +/- 7.0%) did not show a significant difference. The DPPIV serum activity in responders compared to in non-responder subgroup (59.9 +/- 8.4/50.3 +/- 10.6U/L) showed, however, a significant difference (P < 0.05). The expression of CD3, CD19 and CD56 on peripheral lymphocytes was similar between responders and non-responders. The expression of CD3CD26 (52.2 +/- 8.6%) and CD3CD25 (10.9 +/- 3.8%) in responders versus the expression of CD3CD26 (48.0 +/- 5.7%) and CD3CD25 (8 +/- 4.6%) in non-responders did not show statistically significant difference. CD25 referred as a marker of T lymphocyte activation was increased in responders (15.8 +/- 4.5%) versus in non-responders (10.1 +/- 4.8%), showing a significant difference (P = 0.003). It was, however, impossible to demonstrate an increase in CD3CD25 and CD3CD26 in the responder subgroup. This suggests that different lymphocyte subsets other than T cells are implicated in the response to hepatitis B vaccination

LAS REDES CIENTÍFICAS DE ENFERMERÍA: RED INTERNACIONAL DE ENFERMERÍA PARA LA SALUD DEL ADULTO MAYOR

Las Redes Internacionales de Enfermería de las Américas constituyen un conjunto de redes temáticas que tienen a la enfermería como un eje común. La Organización Panamericana de la Salud, la Oficina Regional de la Organización Mundial de la Salud (OPS/OMS), apoya y coordina el trabajo de las Redes Internacionales de Enfermería desde el año 2006.Se definen como una estrategia de comunicación, vinculación, cooperación y sinergia entre personas, instituciones, organizaciones interesadas en el desarrollo de los cuidados, la gestión, la investigación, la información y la educación en enfermería para contribuir con la cooperación técnica a nivel nacional e internacional en diferentes áreas temáticas prioritarias, así como para apoyar al desarrollo de los recursos humanos en enfermería y lograr la cobertura universal de salud, el acceso universal al cuidado de enfermería y a la atención de salud segura y de calidad. Las redes de enfermerías son una estrategia para potenciar la contribución de la enfermería a la salud y a las políticas mundiales de salud.

MITOS SOBRE LA SEXUALIDAD DE LOS ADULTOS MAYORES UN DESAFIO PARA EL CUIDADO DE ENFERMERIA

La sexualidad es una de las dimensiones de la salud de los individuos que puede influir en la calidad de vida de las personas y en su relación con el entorno; las experiencias constituyen la expresión de la misma y configuran una parte de la individualidad de las personas. Cuando se habla de vejez y sexualidad, surgen gran cantidad de mitos que limitan a los adultos mayores y a los profesionales de la salud en su interacción con los mismos, ya que se encuentran rodeados de prejuicios que desvían las formas naturales de expresión de la sexualidad.El presente artículo intenta hacer una aproximación a los mitos frente la sexualidad de los adultos mayores, los factores que influencian la misma, la percepción de los profesionales de enfermería y algunas propuestas para generar cambios significativos en la concepción que tiene la sociedad respeto a este tema

COVID-19 related acute genital ulcer: a case report

Acute vulvar ulcer (Lipschütz's ulcer) is a rare lesion with local hyperimmunoreactivity triggered by infection, which is characterized by acute, painful, and necrotic ulcerations. This condition is usually found in non-sexually active adolescents, and it resolves spontaneously. We report a case of a 35-year-old woman who was diagnosed with COVID-19 who did not have severe symptoms, but had high levels of D-dimer for 9 days. The COVID-19 diagnosis was followed by the appearance of an acute, necrotic, extremely painful vulvar ulcer, although symptoms caused by COVID-19 had improved. We emphasize the importance of the differential diagnosis to exclude diseases such as Behçet's syndrome, Sexually Transmitted Infections, as well as the presence of viruses that generally trigger Lipschütz's ulcer, such as Epstein-Barr virus and cytomegalovirus. No treatment is usually necessary, however, in the present report due to the pain experienced by the patient, we successfully used oral prednisone.info:eu-repo/semantics/publishedVersio

LA CALIDAD DE LA EDUCACION, UNA PROBLEMATICA COLOMBIANA - THE QUALITY OF EDUCATION, A PROBLEM COLOMBIAN

Hablar de  calidad de la educación implica, abordar múltiples factores que inciden en ella, como por ejemplo las inequidades socioeconómicas de las familias y por ende de  los estudiantes Colombianos, que influyen de manera determinante en esta. Colombia, como país en vías de desarrollo; posee características especiales y una de ellas está relacionada específicamente con la calidad de la educación. A través del tiempo la educación colombiana ha venido siendo sometida a los vaivenes de las modificaciones de los gobiernos de turno que ven la educación  como un proceso sin importancia, en razón a que no les genera muchos dividendos. Es por ello que la educación y por ende su calidad, se ve reflejada en resultados académicos que no solo son el fruto de la labor docente sino fundamentalmente de las políticas del gobierno de Turno. La calidad de la educación es una de las expresiones más utilizadas en el ámbito educativo, sobre todo cuando de desea justificar cualquier proceso de evaluación o de cambio (Calidad de la Educación, s.f., p. 1), tema que nos ocupa en esta reflexión. Es necesario señalar que nuestra colectividad vive en la actualidad cambios sociales que riñen con los objetivos y  condiciones con que fue creada la escuela. Es posible afirmar que la escuela y la educación en general se encuentran  hoy sumidas en  dificultades profundas, ya que no se perciben por ningún lado las respuestas a las solicitudes que a menudo se hacen por parte de la comunidad; y aquí radica precisamente el incidente que establece desde donde se puede avizorar la calidad de la educación

Tracking of MVPA across childhood and adolescence

\ua9 2024 The AuthorsObjectives: Tracking of physical activity from childhood onwards is an important public health issue, but evidence on tracking is limited. This study quantified the tracking of Moderate-Vigorous Physical Activity (MVPA) across childhood and adolescence in a recent cohort from England. Design: Longitudinal, with a socio-economically representative sample from North-East England, over an 8-year period. Methods: Measures of time spent in MVPA, with an Actigraph GT1M accelerometer, were made at age 7–8y (n = 622, T1), age 9–10y (n = 585, T2), age 12–13y (n = 525, T3) and age 14–16y (n = 361, T4). Tracking of MVPA was assessed using rank order correlations between time spent in MVPA T1–T2, T1–T3, and T1–T4, and by using Cohen\u27s kappa to examine tracking of meeting the MVPA guideline (mean of 60 min/d). We examined whether tracking varied by sex, socio-economic status (SES), initial MVPA, or initial body fatness. Results: Rank order correlations were all statistically significant at p &lt; 0.01 and moderate: 0.58 between T1 and T2; 0.42 between T1 and T3; 0.41 between T1 and T4. Cohen\u27s kappas for meeting the global MVPA guideline were all significant, weakening from moderate to low over the 8 years. Tracking was stronger in higher SES compared to lower SES groups, and there was some evidence that it was stronger in girls than boys, but the other explanatory variables had little influence on tracking. Conclusions: Tracking of MVPA from mid-childhood to mid-adolescence in this cohort was moderate. This study suggests there is a need to establish high MVPA by mid-childhood, and to mitigate the age-related reduction in MVPA which occurs from mid-childhood

Evaluation of Oryza sativa x O. glaberrima derived progenies for resistance to rootknot nematode and identification of introgressed alien chromosome segments using SSR markers

The genus Oryza has two cultivated species, Asian rice (Oryza sativa L.) and African rice (Oryza glaberrima Steud.) and 22 wild species. O. glaberrima is low yielding but has useful genes for resistance to biotic and abiotic stresses. Introgression lines derived from backcrossing of O. sativa x O. glaberrima, using O. sativa as recurrent parent, were evaluated for tolerance to root-knot nematode (Meloidogyne graminicola). Testing in sick plots infested with nematodes showed reduction in plant height, shoot and root biomass and leaf area index compared to the control. Based on gall rating and the ratio of the final population to the initial population of nematodes (Pf/Pi ratio), three introgression lines were found to be resistant to nematodes (IR80311-9-B-B-1-2 and IR80311-2-B-B-1-2 under screenhouse and IR80311-48-BB- 1 under phytotron conditions). Gall rating and the Pf/Pi ratio showed positive correlation (r = 0.61). Analysis of 122 introgression lines using simple sequence repeat (SSR) markers detected introgression of O. glaberrima segments into O. sativa

The impact of long dry periods on the aboveground biomass in a tropical forest: 20 years of monitoring

Background Long-term studies of community and population dynamics indicate that abrupt disturbances often catalyse changes in vegetation and carbon stocks. These disturbances include the opening of clearings, rainfall seasonality, and drought, as well as fire and direct human disturbance. Such events may be super-imposed on longer-term trends in disturbance, such as those associated with climate change (heating, drying), as well as resources. Intact neotropical forests have recently experienced increased drought frequency and fire occurrence, on top of pervasive increases in atmospheric CO2 concentrations, but we lack long-term records of responses to such changes especially in the critical transitional areas at the interface of forest and savanna biomes. Here, we present results from 20 years monitoring a valley forest (moist tropical forest outlier) in central Brazil. The forest has experienced multiple drought events and includes plots which have and which have not experienced fire. We focus on how forest structure (stem density and aboveground biomass carbon) and dynamics (stem and biomass mortality and recruitment) have responded to these disturbance regimes. Results Overall, the biomass carbon stock increased due to the growth of the trees already present in the forest, without any increase in the overall number of tree stems. Over time, both recruitment and especially mortality of trees tended to increase, and periods of prolonged drought in particular resulted in increased mortality rates of larger trees. This increased mortality was in turn responsible for a decline in aboveground carbon toward the end of the monitoring period. Conclusion Prolonged droughts influence the mortality of large trees, leading to a decline in aboveground carbon stocks. Here, and in other neotropical forests, recent droughts are capable of shutting down and reversing biomass carbon sinks. These new results add to evidence that anthropogenic climate changes are already adversely impacting tropical forests

Gauge symmetry and W-algebra in higher derivative systems

The problem of gauge symmetry in higher derivative Lagrangian systems is discussed from a Hamiltonian point of view. The number of independent gauge parameters is shown to be in general {\it{less}} than the number of independent primary first class constraints, thereby distinguishing it from conventional first order systems. Different models have been considered as illustrative examples. In particular we show a direct connection between the gauge symmetry and the W-algebra for the rigid relativistic particle.Comment: 1+22 pages, 1 figure, LaTeX, v2; title changed, considerably expanded version with new results, to appear in JHE

DevOps for network function virtualisation: an architectural approach

The Service Programming and Orchestration for Virtualised Software Networks (SONATA) project targets both the flexible programmability of software networks and the optimisation of their deployments by means of integrating Development and Operations in order to accelerate industry adoption of software networks and reduce time-to-market for networked services. SONATA supports network function chaining and orchestration, making service platforms modular and easier to customise to the needs of different service providers, and introduces a specialised Development and Operations model for supporting developers