Polymer induced condensation of dna supercoils

Macromolecular crowding is thought to be a significant factor driving DNA condensation in prokaryotic cells. Whereas DNA in prokaryotes is supercoiled, studies on crowding-induced DNA condensation have so far focused on linear DNA. Here we compare DNA condensation by poly(ethylene oxide) for supercoiled and linearized pUC18 plasmid DNA. It is found that supercoiling has only a limited influence on the critical amount of PEO needed to condense plasmid DNA. In order to pack DNA supercoils in condensates, it seems inevitable that they must be deformed in one way or another, to facilitate dense packing of DNA. Analytical estimates and Monte Carlo simulations indicate that packing of DNA supercoils in condensates is most likely facilitated by a decrease of the superhelical diameter rather than by unwinding of the supercoil

So You've Busted Your Knee: An Introduction to Physical Therapy for the New ACL Patient

B.A. (Bachelor of Arts

Learning to Race through Coordinate Descent Bayesian Optimisation

In the automation of many kinds of processes, the observable outcome can often be described as the combined effect of an entire sequence of actions, or controls, applied throughout its execution. In these cases, strategies to optimise control policies for individual stages of the process might not be applicable, and instead the whole policy might have to be optimised at once. On the other hand, the cost to evaluate the policy's performance might also be high, being desirable that a solution can be found with as few interactions as possible with the real system. We consider the problem of optimising control policies to allow a robot to complete a given race track within a minimum amount of time. We assume that the robot has no prior information about the track or its own dynamical model, just an initial valid driving example. Localisation is only applied to monitor the robot and to provide an indication of its position along the track's centre axis. We propose a method for finding a policy that minimises the time per lap while keeping the vehicle on the track using a Bayesian optimisation (BO) approach over a reproducing kernel Hilbert space. We apply an algorithm to search more efficiently over high-dimensional policy-parameter spaces with BO, by iterating over each dimension individually, in a sequential coordinate descent-like scheme. Experiments demonstrate the performance of the algorithm against other methods in a simulated car racing environment.Comment: Accepted as conference paper for the 2018 IEEE International Conference on Robotics and Automation (ICRA

First reports of computed tomographic colonography for the screening of colorectal polyps in acromegalic patients

*Aim:* To analyze the CTC performance for the screening of colorectal polyps in acromegalic patients. 

*Materials and Methods:* A prospective study of 21 acromegalic patients, 12 male and 9 female, average age 49, who underwent CTC and CC. CTC was performed with a GE Helical Multislice Computed Tomography Apparatus. The colonoscopy was performed, in the same day, without previous knowledge of the CTC diagnostics. The study evaluated the capacity of CTC to detect patients with colorectal polyps and identify each colorectal lesion described by CC. 

*Results:* In two patients (2/21), CC was incomplete. However, in all patients CTC was complete. In Phase I (“Per Patient”), CTC diagnosed 8 of the 9 patients with colorectal polyps and showed 88% sensitivity, 75% specificity and 81% accuracy. In Phase II (“Per Polyp”), out of the 21 acromegalic patients included in this study, 12 presented normal findings at CC. A total of 19 polyps were identified in 9 patients. 10 of the 19 polyps were smaller than 10 mm, and 9 were equal to or larger than 10. CTC identified 7 of the 9 polyps ≥ 10 mm described by CC and only 6 of the 10 small polyps identified at CC were detected by CTC. The histological analysis of resected lesions revealed 12 tubular adenomas, 6 hyperplastic polyps and 1 colonic tubulo-villous adenoma with an adenocarcinoma focus. 

*Conclusion:* In this study, CTC was performed without complications and a complete and safe colorectal evaluation was possible in all acromegalic patients. Moreover, CTC showed good sensitivity to identify acromegalic patients with colorectal polyps

Testing Photovoltaic Pavers for Roadway Applications

Concrete and asphalt are the primary materials used to construct roadways for motor vehicles, bike paths for pedestrians and bicyclists, and runways for aircraft. Solar Roadways®, Inc. (SR) in Sandpoint, ID, proposed using robust, Solar Road Panels (SRPs) as an alternative roadway material due to the potential for creating a modular, multi-functional infrastructure product with cost-savings, user-safety, power-generation, and a better alternative in terms of environmental sustainability when compared to contemporary pavement materials. Typical roadway construction materials, on average, need to be replaced every 10-15 years while also requiring regular annual maintenance to maintain proper safety standards. SR’s novel roadway material is intended to extend roadway replacement timelines, lower annual maintenance costs, and provide energy to the power grid. In this study, we tested the mechanical properties of the “SR3” model prototype SRP and evaluated its suitability as a replacement roadway material with the added benefit of generating electric power. Specifically, we tested this unique pavement material in submerged water environments, under extreme temperature conditions, and under dynamic loading conditions

A theoretical approach for green supply chain

This paper aims to discuss theoretically the Green Supply Chain (GSC) concept, its implementation and prospective benefits by reviewing the current and past literature on the subject. The main issues found in this research are about: basic steps to create the GSC, methods to manage it and the result of its implementation. GSC is usually started by an end producer, which has an environmental management system, and desires to pass good environmental practices to its suppliers. The implementation of GSC can be also done by market requirements. The results include cost reduction, resource conservation, public image improvement, and market competitiveness among others benefits that are describe in this work. Problems for greening the supply chain are the reduction of flexibility of suppliers and the culture of organizations. This paper can help companies meet global market requirements and public administrators to understand the environmental performance through industrial cluster

Device and method to enhance availability of cluster-based processing systems

An electronic computing device including at least one processing unit that implements a specific fault signal upon experiencing an associated fault, a control unit that generates a specific recovery signal upon receiving the fault signal from the at least one processing unit, and at least one input memory unit. The recovery signal initiates specific recovery processes in the at least one processing unit. The input memory buffers input data signals input to the at least one processing unit that experienced the fault during the recovery period

El Sol (1977-08-24)

Vol.2, no.4https://scholarworks.utrgv.edu/el_sol/1007/thumbnail.jp