159 research outputs found
Mete a colher: feminismo e violĂȘncia na obra de Berna Reale
âMete a colher: Feminismo e violĂȘncia na obra de Berna Realeâ Ă© um estudo sobre arte, feminismo e violĂȘncia contra a mulher que busca analisar a obra da artista paraense Berna Reale, cujo trabalho aborda as diversas formas de violĂȘncia que assolam a humanidade. A artista, objeto desta pesquisa, alĂ©m de exercer esse ofĂcio, tambĂ©m trabalha como perita criminal do Estado do ParĂĄ. As duas profissĂ”es de Reale estĂŁo bastante presentes em suas obras, nas quais ela utiliza seu prĂłprio corpo para realizar as performances com grande apelo estĂ©tico, trabalhando com o surpreendente e o perturbador. A partir de teorias multidisciplinares e trabalhos artĂsticos de mulheres, entende-se como a arte foi aliada do feminismo na reflexĂŁo dos estereĂłtipos de gĂȘnero e na denĂșncia das diversas formas de violĂȘncia sofrida pelas mulheres. Para explorar como as pautas do feminismo, incluindo a violĂȘncia contra a mulher, aparecem nas obras de Berna Reale, sĂŁo analisadas as performances âRosa PĂșrpuraâ (2014) e âFrioâ (2017). Berna utiliza seu prĂłprio corpo como instrumento para questionar e propor a reflexĂŁo acerca das variĂĄveis formas de violĂȘncia em uma poĂ©tica construĂda sob o olhar crĂtico da artista e da perita. Apesar de Berna nĂŁo se declarar abertamente feminista, ao questionar a condição violenta a qual as mulheres estĂŁo sujeitas tanto no espaço pĂșblico quanto no domĂ©stico, como apresentado nessa pesquisa, fica evidente que âRosa PĂșrpuraâ e âFrioâ corroboram com o discurso desse movimento
Economic impact analysis of the demonstrations in task-forces TF1 and TF3 - Deliverable D15.1:WP15. Economic impacts of the demonstrations, barriers towards scaling up and solutions
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Population stratification may bias analysis of PGC-1α as a modifier of age at Huntington disease motor onset
Huntingtonâs disease (HD) is an inherited neurodegenerative disorder characterized by motor, cognitive and behavioral disturbances, caused by the expansion of a CAG trinucleotide repeat in the HD gene. The CAG allele size is the major determinant of age at onset (AO) of motor symptoms, although the remaining variance in AO is highly heritable. The rs7665116 SNP in PPARGC1A, encoding the mitochondrial regulator PGC-1α, has been reported to be a significant modifier of AO in three European HD cohorts, perhaps due to affected cases from Italy. We attempted to replicate these findings in a large collection of (1,727) HD patient DNA samples of European origin. In the entire cohort, rs7665116 showed a significant effect in the dominant model (p value = 0.008) and the additive model (p value = 0.009). However, when examined by origin, cases of Southern European origin had an increased rs7665116 minor allele frequency (MAF), consistent with this being an ancestry-tagging SNP. The Southern European cases, despite similar mean CAG allele size, had a significantly older mean AO (p < 0.001), suggesting population-dependent phenotype stratification. When the generalized estimating equations models were adjusted for ancestry, the effect of the rs7665116 genotype on AO decreased dramatically. Our results do not support rs7665116 as a modifier of AO of motor symptoms, as we found evidence for a dramatic effect of phenotypic (AO) and genotypic (MAF) stratification among European cohorts that was not considered in previously reported association studies. A significantly older AO in Southern Europe may reflect population differences in genetic or environmental factors that warrant further investigation
Somatic âSolubleâ Adenylyl Cyclase Isoforms Are Unaffected in Sacytm1Lex/Sacytm1Lex âKnockoutâ Mice
BACKGROUND: Mammalian Soluble adenylyl cyclase (sAC, Adcy10, or Sacy) represents a source of the second messenger cAMP distinct from the widely studied, G protein-regulated transmembrane adenylyl cyclases. Genetic deletion of the second through fourth coding exons in Sacy(tm1Lex)/Sacy(tm1Lex) knockout mice results in a male sterile phenotype. The absence of any major somatic phenotype is inconsistent with the variety of somatic functions identified for sAC using pharmacological inhibitors and RNA interference. PRINCIPAL FINDINGS: We now use immunological and molecular biological methods to demonstrate that somatic tissues express a previously unknown isoform of sAC, which utilizes a unique start site, and which 'escapes' the design of the Sacy(tm1Lex) knockout allele. CONCLUSIONS/SIGNIFICANCE: These studies reveal increased complexity at the sAC locus, and they suggest that the known isoforms of sAC play a unique function in male germ cells
Successful treatment of metastatic melanoma by adoptive transfer of blood-derived polyclonal tumor-specific CD4+ and CD8+ T cells in combination with low-dose interferon-alpha
A phase I/II study was conducted to test the feasibility and safety of the adoptive transfer of tumor-reactive T cells and daily injections of interferon-alpha (IFNα) in metastatic melanoma patients with progressive disease. Autologous melanoma cell lines were established to generate tumor-specific T cells by autologous mixed lymphocyte tumor cell cultures using peripheral blood lymphocytes. Ten patients were treated with on average 259 (range 38â474) million T cells per infusion to a maximum of six infusions, and clinical response was evaluated according to the response evaluation criteria in solid tumors (RECIST). Five patients showed clinical benefit from this treatment, including one complete regression, one partial response, and three patients with stable disease. No treatment-related serious adverse events were observed, except for the appearance of necrotic-like fingertips in one patient. An IFNα-related transient leucopenia was detected in 6 patients, including all responders. One responding patient displayed vitiligo. The infused T-cell batches consisted of tumor-reactive polyclonal CD8+ and/or CD4+ T cells. Clinical reactivity correlated with the functional properties of the infused tumor-specific T cells, including their in vitro expansion rate and the secretion of mainly Th1 cytokines as opposed to Th2 cytokines. Our study shows that relatively low doses of T cells and low-dose IFNα can lead to successful treatment of metastatic melanoma and reveals a number of parameters potentially associated with this success
Height and timing of growth spurt during puberty in young people living with vertically acquired HIV in Europe and Thailand
Objective: The aim of this study was to describe growth during puberty in young people with vertically acquired HIV. Design: Pooled data from 12 paediatric HIV cohorts in Europe and Thailand. Methods: One thousand and ninety-four children initiating a nonnucleoside reverse transcriptase inhibitor or boosted protease inhibitor based regimen aged 1-10 years were included. Super Imposition by Translation And Rotation (SITAR) models described growth from age 8 years using three parameters (average height, timing and shape of the growth spurt), dependent on age and height-for-age z-score (HAZ) (WHO references) at antiretroviral therapy (ART) initiation. Multivariate regression explored characteristics associated with these three parameters. Results: At ART initiation, median age and HAZ was 6.4 [interquartile range (IQR): 2.8, 9.0] years and -1.2 (IQR: -2.3 to -0.2), respectively. Median follow-up was 9.1 (IQR: 6.9, 11.4) years. In girls, older age and lower HAZ at ART initiation were independently associated with a growth spurt which occurred 0.41 (95% confidence interval 0.20-0.62) years later in children starting ART age 6 to 10 years compared with 1 to 2 years and 1.50 (1.21-1.78) years later in those starting with HAZ less than -3 compared with HAZ at least -1. Later growth spurts in girls resulted in continued height growth into later adolescence. In boys starting ART with HAZ less than -1, growth spurts were later in children starting ART in the oldest age group, but for HAZ at least -1, there was no association with age. Girls and boys who initiated ART with HAZ at least -1 maintained a similar height to the WHO reference mean. Conclusion: Stunting at ART initiation was associated with later growth spurts in girls. Children with HAZ at least -1 at ART initiation grew in height at the level expected in HIV negative children of a comparable age
Professoras e crianças pequenas no contexto da Educação Infantil pelotense em meados do século XX
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