Predictions for the Leptonic Dirac CP-Violating Phase

We explore the effects of correlations among observable parameters of neutrino mixing on predictions for the leptonic Dirac CP-violating phase. We focus on a standard class of theoretical models that include a single source of CP-violation due to charged lepton corrections. We take two complementary approaches -- one in which the model parameters are uncorrelated and one in which correlations are introduced as a way to optimally reproduce the experimentally measured mixing angles. We find that in both cases we can guarantee a physically meaningful prediction for the most likely value of the leptonic Dirac CP-violating phase.Comment: 27 pages, 9 figure

Intracranial Hypertension Secondary to Eosinophilic Meningitis Caused by Angiostrongylus Cantonensis

Angiostrongylus Cantonensis, a nematode, is a well-known cause of eosinophilic meningitis in endemic areas such as Southeast Asia, the Pacific Islands, and Hawaii. Nevertheless, an increasing number of cases in the southeast of the U.S. have been documented recently, specifically in Louisiana, Texas, and Florida. Infection is acquired after ingesting undercooked fresh water snails, mollusks, or undercooked vegetables contaminated by the slime from infected snails or slugs. Typical signs and symptoms include fever, general malaise, meningeal signs, headaches, photophobia, nausea and vomiting. Here we present a 23 year-old woman who presented to our emergency department with signs and symptoms consistent with intracranial hypertension, malaise, mild photophobia, and without fever, or meningeal signs. We also provide a review of the most recent literature regarding eosinophilic meningitis secondary to A. cantonensis

Full Recovery From Cocaine-Induced Toxic Leukoencephalopathy: Emphasizing the Role of Neuroinflammation and Brain Edema

Toxic leukoencephalopathy (TL) is characterized by white matter disease on magnetic resonance imaging (MRI) and evidence of exposure to a neurotoxic agent. We describe a case of cocaine-induced TL in which extensive white matter disease did not preclude full recovery. A 57-year-old man with substance abuse disorder presented with a 5-day history of strange behavior. On admission, he was alert but had difficulty concentrating, psychomotor retardation, and diffuse hyperreflexia. Brain MRI revealed confluent subcortical white matter hyperintensities with restricted diffusion in some but not in other areas. Electroencephalography (EEG) showed mild diffuse slowing. Blood tests were normal except for mild hyperammonemia. Urine screen was positive for cocaine and benzodiazepine but quantitative analysis was significant only for cocaine. Prednisone 60-mg qd was initiated on day 4, tapered over a 5-day period, and discontinued on day 9. He was discharged after 3 weeks. Cognitive function returned to normal 2 weeks after discharge. Five months later, neurologic exam and EEG were normal and MRI showed near-100% resolution of white matter lesions. TL has been attributed to white matter ischemia/hypoxia resulting in demyelination/axonal injury. The clinical, EEG, and MRI findings and time course of recovery of our patient suggest that cocaine-induced inflammation/edema resulted in TL but not in ischemic/hypoxic injury. While inflammation/edema may have regressed when cocaine was discontinued, we cannot exclude a role for prednisone in protecting the patient from the ischemic/hypoxic sequelae of inflammation/edema. MRI is indispensable for diagnosing TL but EEG may provide additional useful diagnostic and prognostic information

Facile, Green Synthesis of Large Single Crystal Copper Micro and Nanoparticles with Ascorbic Acid and Gum Arabic

Large single crystal colloidal copper particles with diameters between 0.5 - 2 μm were created using a green synthesis process. The process used ascorbic acid to reduce Schweizer’s reagent created in situ using copper salts in the presence of various concentrations of gum arabic. The Schweizer’s reagents were created by varying the concentrations of ammonium hydroxide and copper nitrate solutions, copper hydroxide, or copper sulfate. The pH of the solution was controlled by the addition of ascorbic acid. Particle formation was favored at high temperature using copper sulfate at pH values ranging from 7.5 to 9, while the optimal formation occurred at a pH value of 8.5. At high concentrations, copper particle formation was found to occur from the aggregation of smaller particles which continued to nucleate once aggregated, and this resulted in the creation of globular particles and large aggregates of micron-sized particles. The addition of gum arabic resulted in the creation of large single crystal particles that did not aggregate. SEM was used to observe the effect of increasing gum arabic concentrations and EDX was used to confirm the elemental purity of the particles

Dexamethasone as Abortive Treatment for Refractory Seizures or Status Epilepticus in the Inpatient Setting

Refractory seizures or status epilepticus (RS/SE) continues to be a challenge in the inpatient setting. Failure to abort a seizure with antiepileptic drugs (AEDs) may lead to intubation and treatment with general anesthesia exposing patients to complications, extending hospitalization, and increasing the cost of care. Studies have shown a key role of inflammatory mediators in seizure generation and termination. We describe 4 patients with RS/SE that was aborted when dexamethasone was added to conventional AEDs: a 61-year-old female with temporal lobe epilepsy who presented with delirium, nonconvulsive status epilepticus, and oculomyoclonic status; a 56-year-old female with history of traumatic left frontal lobe hemorrhage who developed right face and hand epilepsia partialis continua followed by refractory focal clonic seizures; a 51-year-old male with history of traumatic intracranial hemorrhage who exhibited left-sided epilepsia partialis continua; and a 75-year-old female with history of breast cancer who manifested nonconvulsive status epilepticus and refractory focal clonic seizures. All patients continued experiencing RS/SE despite first- and second-line therapy, and one patient continued to experience RS/SE despite third-line therapy. Failure to abort RS/SE with conventional therapy motivated us to administer intravenous dexamethasone. A 10-mg load was given (except in one patient) followed by 4.0- 5.2 mg q6h. All clinical and electrographic seizures stopped 3-4 days after starting dexamethasone. When dexamethasone was discontinued 1-3 days after seizures stopped, all patients remained seizure-free on 2-3 AEDs. The cessation of RS/SE when dexamethasone was added to conventional antiseizure therapy suggests that inflammatory processes are involved in the pathogenesis of RS/SE

Warm molecular and ionized gas kinematics in the type-2 quasar J0945+1737

We analyse Near-Infrared Integral Field Spectrograph (NIFS) observations of the type-2 quasar (QSO2) SDSS J094521.33+173753.2 to investigate its warm molecular and ionized gas kinematics. This QSO2 has a bolometric luminosity of 1045.7 erg s−1 and a redshift of z = 0.128. The K-band spectra provided by NIFS cover a range of 1.99–2.40 μm where low ionization (Paα and Brδ), high ionization ([S XI]λ1.920 μm and [Si VI]λ1.963 μm), and warm molecular lines (from H21-0S(5) to 1-0S(1)) are detected, allowing us to study the multi-phase gas kinematics. Our analysis reveals gas in ordinary rotation in all the emission lines detected and also outflowing gas in the case of the low and high ionization emission lines. In the case of the nuclear spectrum, which corresponds to a circular aperture of 0.3″ (686 pc) in diameter, the warm molecular lines can be characterized using a single Gaussian component of full width at half maximum (FWHM) = 350 − 400 km s−1, while Paα, Brδ, and [Si VI] are best fitted with two blue-shifted Gaussian components of FWHM ∼ 800 and 1700 km s−1, in addition to a narrow component of ∼300 km s−1. We interpret the blue-shifted broad components as outflowing gas, which reaches the highest velocities, of up to −840 km s−1, in the south-east direction (PA ∼ 125°), extending up to a distance of ∼3.4 kpc from the nucleus. The ionized outflow has a maximum mass outflow rate of Ṁout,max = 42–51 M⊙ yr−1, and its kinetic power represents 0.1% of the quasar bolometric luminosity. Very Large Array (VLA) data of J0945 show extended radio emission (PA ∼ 100°) that is aligned with the clumpy emission traced by the narrow component of the ionized lines up to scales of several kiloparsecs, and with the innermost part of the outflow (central ∼0.4″ = 915 pc). Beyond that radius, at the edge of the radio jet, the high velocity gas shows a different PA of ∼125°. This might be an indication that the line-emitting gas is being compressed and accelerated by the shocks generated by the radio jet

Low-temperature gas opacity - AESOPUS: a versatile and quick computational tool

We introduce a new tool - AESOPUS: Accurate Equation of State and OPacity Utility Software - for computing the equation of state and the Rosseland mean (RM) opacities of matter in the ideal gas phase. Results are given as a function of one pair of state variables, (i.e. temperature T in the range 3.2 <= log(T) <= 4.5, and parameter R= rho/(T/10^6 K)^3 in the range -8 <= log(R) <= 1), and arbitrary chemical mixture. The chemistry is presently solved for about 800 species, consisting of almost 300 atomic and 500 molecular species. The gas opacities account for many continuum and discrete sources, including atomic opacities, molecular absorption bands, and collision-induced absorption. Several tests made on AESOPUS have proved that the new opacity tool is accurate in the results,flexible in the management of the input prescriptions, and agile in terms of computational time requirement. We set up a web-interface (http://stev.oapd.inaf.it/aesopus) which enables the user to compute and shortly retrieve RM opacity tables according to his/her specific needs, allowing a full degree of freedom in specifying the chemical composition of the gas. Useful applications may regard RM opacities of gas mixtures with i) scaled-solar abundances of metals, choosing among various solar mixture compilations available in the literature; ii) varying CNO abundances, suitable for evolutionary models of red and asymptotic giant branch stars and massive stars in the Wolf-Rayet stages; iii) various degrees of enhancement in alpha-elements, and C-N, Na-O and Mg-Al abundance anti-correlations, necessary to properly describe the properties of stars in early-type galaxies and Galactic globular clusters; iv) zero-metal abundances appropriate for studies of gas opacity in primordial conditions.Comment: 32 pages, 34 postscript figures, A&A in press; new section 4.1.2 showing first tests with stellar models, sections 2.2, 2.2.2 and 5 expanded; interactive web-page at http://stev.oapd.inaf.it/aesopu

Warm molecular and ionized gas kinematics in the type-2 quasar J0945+1737

We analyse Near-Infrared Integral Field Spectrograph (NIFS) observations of the type-2 quasar (QSO2) SDSS J094521.33+173753.2 to investigate its warm molecular and ionized gas kinematics. This QSO2 has a bolometric luminosity of 1045.7 erg s−1 and a redshift of z = 0.128. The K-band spectra provided by NIFS cover a range of 1.99–2.40 μm where low ionization (Paα and Brδ), high ionization ([S XI]λ1.920 μm and [Si VI]λ1.963 μm), and warm molecular lines (from H21-0S(5) to 1-0S(1)) are detected, allowing us to study the multi-phase gas kinematics. Our analysis reveals gas in ordinary rotation in all the emission lines detected and also outflowing gas in the case of the low and high ionization emission lines. In the case of the nuclear spectrum, which corresponds to a circular aperture of 0.3″ (686 pc) in diameter, the warm molecular lines can be characterized using a single Gaussian component of full width at half maximum (FWHM) = 350 − 400 km s−1, while Paα, Brδ, and [Si VI] are best fitted with two blue-shifted Gaussian components of FWHM ∼ 800 and 1700 km s−1, in addition to a narrow component of ∼300 km s−1. We interpret the blue-shifted broad components as outflowing gas, which reaches the highest velocities, of up to −840 km s−1, in the south-east direction (PA ∼ 125°), extending up to a distance of ∼3.4 kpc from the nucleus. The ionized outflow has a maximum mass outflow rate of Ṁout,max = 42–51 M⊙ yr−1, and its kinetic power represents 0.1% of the quasar bolometric luminosity. Very Large Array (VLA) data of J0945 show extended radio emission (PA ∼ 100°) that is aligned with the clumpy emission traced by the narrow component of the ionized lines up to scales of several kiloparsecs, and with the innermost part of the outflow (central ∼0.4″ = 915 pc). Beyond that radius, at the edge of the radio jet, the high velocity gas shows a different PA of ∼125°. This might be an indication that the line-emitting gas is being compressed and accelerated by the shocks generated by the radio jet

Identification and quantification of microplastics in wastewater using focal plane array-based reflectance micro-FT-IR imaging

Microplastics (<5 mm) have been documented in environmental samples on a global scale. While these pollutants may enter aquatic environments via wastewater treatment facilities, the abundance of microplastics in these matrices has not been investigated. Although efficient methods for the analysis of microplastics in sediment samples and marine organisms have been published, no methods have been developed for detecting these pollutants within organic-rich wastewater samples. In addition, there is no standardized method for analyzing microplastics isolated from environmental samples. In many cases, part of the identification protocol relies on visual selection before analysis, which is open to bias. In order to address this, a new method for the analysis of microplastics in wastewater was developed. A pretreatment step using 30% hydrogen peroxide (H2O2) was employed to remove biogenic material, and focal plane array (FPA)-based reflectance micro-Fourier-transform (FT-IR) imaging was shown to successfully image and identify different microplastic types (polyethylene, polypropylene, nylon-6, polyvinyl chloride, polystyrene). Microplastic-spiked wastewater samples were used to validate the methodology, resulting in a robust protocol which was nonselective and reproducible (the overall success identification rate was 98.33%). The use of FPA-based micro-FT-IR spectroscopy also provides a considerable reduction in analysis time compared with previous methods, since samples that could take several days to be mapped using a single-element detector can now be imaged in less than 9 h (circular filter with a diameter of 47 mm). This method for identifying and quantifying microplastics in wastewater is likely to provide an essential tool for further research into the pathways by which microplastics enter the environment.This work is funded by a NERC (Natural Environment Research Council) CASE studentship (NE/K007521/1) with contribution from industrial partner Fera Science Ltd., United Kingdom. The authors would like to thank Peter Vale, from Severn Trent Water Ltd, for providing access to and additionally Ashley Howkins (Brunel University London) for providing travel and assistance with the sampling of the Severn Trent wastewater treatment plant in Derbyshire, UK. We are grateful to Emma Bradley and Chris Sinclair for providing helpful suggestions for our research