Fluctuations in a superconducting quantum critical point of multi-band metals

In multi-band metals quasi-particles arising from different atomic orbitals coexist at a common Fermi surface. Superconductivity in these materials may appear due to interactions within a band (intra-band) or among the distinct metallic bands (inter-band). Here we consider the suppression of superconductivity in the intra-band case due to hybridization. The fluctuations at the superconducting quantum critical point (SQCP) are obtained calculating the response of the system to a fictitious space and time dependent field, which couples to the superconducting order parameter. The appearance of superconductivity is related to the divergence of a generalized susceptibility. For a single band superconductor this coincides with the \textit{Thouless criterion}. For fixed chemical potential and large hybridization, the superconducting state has many features in common with breached pair superconductivity with unpaired electrons at the Fermi surface. The T=0 phase transition from the superconductor to the normal state is in the universality class of the density-driven Bose-Einstein condensation. For fixed number of particles and in the strong coupling limit, the system still has an instability to the normal sate with increasing hybridization.Comment: 10 pages, 8 figure

Effects of Resistance Training on Muscle Quality Index, Muscle Strength, Functional Capacity, and Serum Immunoglobulin Levels between Obese and Non-obese Older Women

International Journal of Exercise Science 14(7): 707-726, 2021. Considering the negative impact of obesity on neuromuscular and immune systems, we sought to compare the effects of a 10-week resistance training (RT) program on muscle quality index (MQI), muscle strength, functional capacity, and immunoglobulins in older women with and without obesity. Thirty-nine older women participated in the present study (age: 69.02 ± 6.16, fat (%): 38.80% ± 6.28) and underwent a linear RT program performed on two non-consecutive days of the week. Body composition, functional tests, immunoglobulins, muscle quality of upper and lower limbs and absolute muscular strength of the upper and lower limbs were measured. Both groups displayed an increased statistically significant difference in MQI between pre-post training, however obese participants showed a lower field and laboratory MQI when compared to non-obese participants at the same time-points. Obese participants displayed an increased statistically significant 30-second chair stand test, with no differences for non-obese participants. Obese participants showed a higher statistically significant difference for immunoglobulin M when compared to the non-obese group at post-training. Finally, both groups displayed an increased statistically significant difference in muscle strength between pre-post-training. However, obese participants showed a statistically significant lower 10-RM low row score when compared to non-obese participants at post-training. Obese older women showed a lower field and laboratory MQI when compared to non-obese post-training, besides a lower 10-RM low row score which reinforces that obesity blunts the beneficial effects of RT on muscle quality and strength

Relative Handgrip Strength as a Simple Tool to Evaluate Impaired Heart Rate Recovery and a Low Chronotropic Index in Obese Older Women

International Journal of Exercise Science 11(2): 844-855, 2018. The aim of the present study was to compare differences in heart rate response following a treadmill exercise test in elderly obese women categorized into groups based on relative handgrip strength. Eighty-eight obese elderly women who were between the ages of 60 and 87 participated in the study and were categorized and enrolled to one of two groups based on lower (\u3c 1.51 m²) or higher (≥ 1.51 m²) relative handgrip strength, respectively. The heart rate recovery in the first and second minutes following the treadmill exercise test and the chronotropic index were compared between groups. The higher relative handgrip strength group presented a significantly higher peak heart rate during exercise and a quicker heart rate recovery following exercise versus the lower relative handgrip strength group (pp=0.059) toward a significantly greater chronotropic index in the higher versus the lower relative handgrip strength group. In conclusion, elderly women with greater relative handgrip strength also demonstrated a better heart rate response during and following exercise, possibly indicating better autonomic balance. The relative handgrip strength might be an important and inexpensive tool for the elderly obese women to indirect assess cardiovascular health

Low dynamic muscle strength and its associations with fatigue, functional performance, and quality of life in premenopausal patients with systemic lupus erythematosus and low disease activity : a case–control study

Background: The purpose of the present study was to compare dynamic muscle strength, functional performance, fatigue, and quality of life in premenopausal systemic lupus erythematosus (SLE) patients with low disease activity versus matched-healthy controls and to determine the association of dynamic muscle strength with fatigue, functional performance, and quality of life in SLE patients. Methods: We evaluated premenopausal (18–45 years) SLE patients with low disease activity (Systemic lupus erythematosus disease activity index [SLEDAI]: mean 1.5 ± 1.2). The control (n = 25) and patient (n = 25) groups were matched by age, physical characteristics, and the level of physical activities in daily life (International Physical Activity Questionnaire IPAQ). Both groups had not participated in regular exercise programs for at least six months prior to the study. Dynamic muscle strength was assessed by one-repetition maximum (1-RM) tests. Functional performance was assessed by the Timed Up and Go (TUG), in 30-s test a chair stand and arm curl using a 2-kg dumbbell and balance test, handgrip strength and a sit-and-reach flexibility test. Quality of life (SF-36) and fatigue were also measured. Results: The SLE patients showed significantly lower dynamic muscle strength in all exercises (leg press 25.63%, leg extension 11.19%, leg curl 15.71%, chest press 18.33%, lat pulldown 13.56%, 1-RM total load 18.12%, P < 0.001-0.02) compared to the controls. The SLE patients also had lower functional performance, greater fatigue and poorer quality of life. In addition, fatigue, SF-36 and functional performance accounted for 52% of the variance in dynamic muscle strength in the SLE patients. Conclusions: Premenopausal SLE patients with low disease activity showed lower dynamic muscle strength, along with increased fatigue, reduced functional performance, and poorer quality of life when compared to matched controls

Monocitose é um marcador de risco independente para a doença arterial coronariana

Reseña de la obra de George L. MOSSE: Soldados caídos. La transformación de la memoria de las guerras mundiales, traducción de Ángel Alcalde, Zaragoza, Prensas Universitarias de Zaragoza, 2016 [ed. original en inglés de 1990], 310 pp. ISBN: 978-84-16515-39-4. A cargo de Claudio Hernández Burgos

Perfil epidemiológico e sociodemográfico de pacientes diabéticos de 3 unidades básicas de saúde do município de Coari-AM / Epidemiological and socio-demographic profile of diabetic patients of 3 basic health units of city Coari-AM

Introdução: O Diabetes Mellitus é um distúrbio metabólico de caráter crônico e não transmissível, caracterizado pela hiperglicemia plasmática, decorrente da secreção deficiente ou resistência à ação da insulina sobre os tecidos. De acordo com a Organização Mundial de Saúde (OMS), nas últimas décadas, houve um aumento significativo da prevalência do Diabetes em todo o mundo. Objetivo: Analisar o perfil epidemiológico e sociodemográfico de pacientes diagnosticados com diabetes (tipo 1 e 2) em Unidades Básicas de Saúde (UBS) do município de Coari-AM. Métodos: Estudo epidemiológico transversal de amostragem não-probabilística, realizado em três Unidades Básicas de Saúde do município de Coari-Amazonas. Todos os casos de Diabetes Mellitus (tipo 1 e 2) apresentaram em seu prontuário, o diagnóstico da doença registrados e atendidos nas Unidades Básicas de Saúde selecionadas. Foi aplicado questionário para obtenção de dados (idade, sexo, renda, escolaridade, tempo de diagnóstico, medicamentos para tratamento e prática de exercício físico). Resultados: O estudo revelou que dentre os indivíduos avaliados (92 pacientes), 85,0% foram diagnosticados com  DM-tipo 2 , com predominância do sexo feminino (58,7%), apresentando faixa etária entre 51 a 60 anos (32,6%), com baixos níveis de escolaridade (84,7%) e renda (75%). Conclusão: A população de diabéticos analisada é composta majoritariamente por adultos de meia-idade, portadores de Diabetes mellitus-tipo 2, apresentando baixa renda e baixa escolaridade. Cabe ressaltar, que os dados apresentados nesse estudo poderão subsidiar o planejamento estratégico de ações direcionadas para a promoção de cuidados terapêuticos para os diabéticos e preventivas para a população geral de Coari

The Effects of Resistance Training Volume on Skeletal Muscle Proteome

International Journal of Exercise Science 10(7): 1051-1066, 2017. Studies are conflicting to whether low volume resistance training (RT) is as effective as high-volume RT protocols with respect to promoting morphological and molecular adaptations. Thus, the aim of the present study was to compare, using a climbing a vertical ladder, the effects of 8 weeks, 3 times per week, resistance training with 4 sets (RT4), resistance training with 8 sets (RT8) and without resistance training control (CON) on gastrocnemius muscle proteome using liquid chromatography mass spectrometry (LC-MS/MS) and cross sectional area (CSA) of rats. Fifty-two proteins were identified by LC-MS/MS, with 39 in common between the three groups, two in common between RT8 and CON, one in common between RT8 and RT4, four exclusive in the CON, one in the RT8, and four in the RT4. The RT8 group had a reduced abundance of 12 proteins, mostly involved in muscle protein synthesis, carbohydrate metabolism, tricarboxylic acid cycle, anti-oxidant defense, and oxygen transport. Otherwise one protein involved with energy transduction as compared with CON group showed high abundance. There was no qualitative protein abundance difference between RT4 and CON groups. These results revealed that high volume RT induced undesirable disturbances on skeletal muscle proteins, while lower volume RT resulted in similar gains in skeletal muscle hypertrophy without impairment of proteome. The CSA was significantly higher in RT8 group when compared to RT4 group, which was significantly higher than CON group. However, no differences were found between trained groups when the gastrocnemius CSA were normalized by the total body weight

Individually tailored dosage regimen of full-spectrum Cannabis extracts for autistic core and comorbid symptoms: a real-life report of multi-symptomatic benefits

Autism Spectrum Disorders (ASD) may significantly impact the well-being of patients and their families. The therapeutic use of cannabis for ASD has gained interest due to its promising results and low side effects, but a consensus on treatment guidelines is lacking. In this study, we conducted a retrospective analysis of 20 patients with autistic symptoms who were treated with full-spectrum cannabis extracts (FCEs) in a response-based, individually-tailored dosage regimen. The daily dosage and relative proportions of cannabidiol (CBD) and tetrahydrocannabinol (THC) were adjusted based on treatment results following periodic clinical evaluation. Most patients (80%) were treated for a minimum of 6 months. We have used a novel, detailed online patient- or caregiver-reported outcome survey that inquired about core and comorbid symptoms, and quality of life. We also reviewed patients’ clinical files, and no individual condition within the autistic spectrum was excluded. This real-life approach enabled us to gain a clearer appraisal of the ample scope of benefits that FCEs can provide for ASD patients and their families. Eighteen patients started with a CBD-rich FCE titrating protocol, and in three of them, the CBD-rich (CBD-dominant) FCE was gradually complemented with low doses of a THC-rich (THC-dominant) FCE based on observed effects. Two other patients have used throughout treatment a blend of two FCEs, one CBD-rich and the other THC-rich. The outcomes were mainly positive for most symptoms, and only one patient from each of the two above-mentioned situations displayed important side effects one who has used only CBD-rich FCE throughout the treatment, and another who has used a blend of CBD-Rich and THC-rich FCEs. Therefore, after FCE treatment, 18 out of 20 patients showed improvement in most core and comorbid symptoms of autism, and in quality of life for patients and their families. For them, side effects were mild and infrequent. Additionally, we show, for the first time, that allotriophagy (Pica) can be treated by FCEs. Other medications were reduced or completely discontinued in most cases. Based on our findings, we propose guidelines for individually tailored dosage regimens that may be adapted to locally available qualified FCEs and guide further clinical trials