Response of Silicon photo-multipliers to a constant light flux

The response of a Silicon Photomultiplier to a constant illumination has been interpreted in term of Geiger- Mueller avalanche frequency, actually correlated to the photon flux via the photon detection efficiency. The hypothesis has been verified in laboratory tests and applied throughout the development of a device for real-time dosimetry in mammography

Development of an electrical impedance tomography set-up for the quantification of mineralization in biopolymer scaffolds

Objective. 3D cell cultures are becoming a fundamental resource for in-vitro studies, as they mimic more closely in-vivo behavior. The analysis of these constructs, however, generally rely on destructive techniques, that prevent the monitoring over time of the same construct, thus increasing the results variability and the resources needed for each experiment. Approach. In this work, we focus on mineralization, a crucial process during maturation of artificial bone models, and propose electrical impedance tomography (EIT) as an alternative non-destructive approach. In particular, we discuss the development of an integrated hardware/software system capable of acquiring experimental data from 3D scaffolds and reconstructing the corresponding conductivity maps. We also show how the same software can test how the measurement is affected by biological features such as scaffold shrinking during the culture. Main results. An initial validation, comprising the acquisition of both a non-conductive phantom and alginate/gelatin scaffolds with known calcium content will be presented, together with the in-silico study of a cell-induced mineralization process. This analysis will allow for an initial verification of the systems functionality while limiting the effects of biological variability due to cell number and activity. Significance. Our results show the potential of EIT for the non-destructive quantification of matrix mineralization in 3D scaffolds, and open to the possible long term monitoring of this fundamental hallmark of osteogenic differentiation in hybrid tissue engineered constructs

Binary Sequences for Online Electrochemical Impedance Spectroscopy of Battery Cells

Online diagnostic of lithium-ion battery (LIB) cells may have significant impact on chemical energy storage systems. Electrochemical impedance spectroscopy (EIS) is widely used for the characterization of LIBs and could be the most appropriate technique for online diagnostic, but its response time should be shortened. This work investigates the usage of multisine excitation to shorten the measurement time and simplify the hardware implementation for EIS of battery cells. Two types of multisine binary sequences are considered: sigma-delta modulated multisine sequences (SDMSs) and maximum length binary sequences (MLBSs). Their applicability to online and in situ EIS monitoring is evaluated by designing a measurement architecture also suitable to be implemented in a system-on-chip. The calibrated measurement system is compared with a benchtop reference instrument, reporting an RMSE deviation smaller than 5% in the frequency range of interest 1-200 Hz. The realized system is then used for online monitoring of the discharge process of a commercial 18650 LIB cell. The two proposed sequences are compared in terms of accuracy using a digital battery emulator circuit. Both the sequences demonstrated to be suitable for fast measurement and simple hardware integration, enabling online in situ EIS monitoring at cell level

A broadband current sensor based on the X-Hall architecture

A broadband current sensor, which is fully integrated and galvanically-isolated, is presented in this paper. The current sensor relies only on a Hall-effect probe to realize the magnetic sensing core so as to minimize the cost and the occupied space. Bandwidth limitations of state-of-the-art Hall-effect probes are overcame by combining the novel X-Hall architecture with a wide bandwidth differential-difference current-feedback amplifier. A prototype implemented in 0.16 \u3bcm BCD technology demonstrates a bandwidth wider than 20 MHz. Offset, sensitivity and power consumption are comparable to the state of the art. This is the first Hall-only current sensor achieving a bandwidth higher than 3 MHz

3D atomic structure from a single XFEL pulse

X-ray Free Electron Lasers (XFEL) are the most advanced pulsed x-ray sources. Their extraordinary pulse parameters promise unique applications. Indeed, several new methods have been developed at XFEL-s. However, no methods are known, which would allow ab initio atomic level structure determination using only a single XFEL pulse. Here, we present experimental results, demonstrating the determination of the 3D atomic structure from data obtained during a single 25 fs XFEL pulse. Parallel measurement of hundreds of Bragg reflections was done by collecting Kossel line patterns of GaAs and GaP. With these measurements, we reached the ultimate temporal limit of the x-ray structure solution possible today. These measurements open the way for studying non-repeatable fast processes and structural transformations in crystals for example measuring the atomic structure of matter at extremely non-ambient conditions or transient structures formed in irreversible physical, chemical, or biological processes. It would also facilitate time resolved pump-probe structural studies making them significantly shorter than traditional serial crystallography.Comment: 16 pages of manuscript followed by 15 pages of supplementary informatio

Shower development of particles with momenta from 15 GeV to 150 GeV in the CALICE scintillator-tungsten hadronic calorimeter

We present a study of showers initiated by electrons, pions, kaons, and protons with momenta from 15 GeV to 150 GeV in the highly granular CALICE scintillator-tungsten analogue hadronic calorimeter. The data were recorded at the CERN Super Proton Synchrotron in 2011. The analysis includes measurements of the calorimeter response to each particle type as well as measurements of the energy resolution and studies of the longitudinal and radial shower development for selected particles. The results are compared to Geant4 simulations (version 9.6.p02). In the study of the energy resolution we include previously published data with beam momenta from 1 GeV to 10 GeV recorded at the CERN Proton Synchrotron in 2010.Comment: 35 pages, 21 figures, 8 table

Pion and proton showers in the CALICE scintillator-steel analogue hadron calorimeter

Showers produced by positive hadrons in the highly granular CALICE scintillator-steel analogue hadron calorimeter were studied. The experimental data were collected at CERN and FNAL for single particles with initial momenta from 10 to 80 GeV/c. The calorimeter response and resolution and spatial characteristics of shower development for proton- and pion-induced showers for test beam data and simulations using Geant4 version 9.6 are compared.Comment: 26 pages, 16 figures, JINST style, changes in the author list, typos corrected, new section added, figures regrouped. Accepted for publication in JINS

Hadron shower decomposition in the highly granular CALICE analogue hadron calorimeter

The spatial development of hadronic showers in the CALICE scintillator-steel analogue hadron calorimeter is studied using test beam data collected at CERN and FNAL for single positive pions and protons with initial momenta in the range from 10 to 80 GeV/c. Both longitudinal and radial development of hadron showers are parametrised with two-component functions. The parametrisation is fit to test beam data and simulations using the QGSP_BERT and FTFP_BERT physics lists from Geant4 version 9.6. The parameters extracted from data and simulated samples are compared for the two types of hadrons. The response to pions and the ratio of the non-electromagnetic to the electromagnetic calorimeter response, h/e, are estimated using the extrapolation and decomposition of the longitudinal profiles.Comment: 38 pages, 19 figures, 5 tables; author list changed; submitted to JINS

Performance of the first prototype of the CALICE scintillator strip electromagnetic calorimeter

A first prototype of a scintillator strip-based electromagnetic calorimeter was built, consisting of 26 layers of tungsten absorber plates interleaved with planes of 45x10x3 mm3 plastic scintillator strips. Data were collected using a positron test beam at DESY with momenta between 1 and 6 GeV/c. The prototype's performance is presented in terms of the linearity and resolution of the energy measurement. These results represent an important milestone in the development of highly granular calorimeters using scintillator strip technology. This technology is being developed for a future linear collider experiment, aiming at the precise measurement of jet energies using particle flow techniques