Uji Iritasi Primer Lotion Ekstrak Etanolik Daun Kemangi (Ocimum Basilicum Linn) Pada Kelinci Jantan Berdasarkan Parameter Indeks Iritasi Primer

Kemangi (Ocimum basilicum L.) is Lamiaceae family, consists of volatile oil, saponin,flavonoid, tanin, and polifenole. One of its functions is as an antioxidant. The antioxidantmechanism is blocking free radical oxidative bound with LDL (Low Density Lipoprotein) (Udupa,2006). This study explores kemangi as a lotion formulation on its primary iritation effect using malerabbits. Kemangi leaves are extracted with soxhletation method and formulated on lotion. Primaryirritation test is conducted by using patch test on 12 male rabbits. Rabbits are divided into 2 groups,with incision and without incision. Each of it got same treatments normal control aquadest, lotionbase control, and 4 tapering dose of kemangi leaves extract. Each treatment is done 6 times ondifferent rabbits, with incision and without incision group. The treatment is applied on rabbits backafter 3 stage shaving. For incision group, after 3 stages shaving the skin is scratched with minorincision on cell surface. Toxic symptom is observed during 24 hours and 72 hours after lotionapplication. The study result is analyzed qualitatively and quantitatively. Qualitative analysisshowed that any erythema found as reddish spot on the rabbits back skin, but no edema found.Primary irritation index as quantitative analysis showed 0,083 for normal control aquadest; 0,207 forlotion base control; 0,292 for 0,25g/inci2kemangi leaves extract; 0,416 for 0,5g/inci2kemangileaves extract; 0,582 for 1 g/inci2kemangi leaves extract; 0,642 for 2 g/inci2kemangi leaves extract.It means kemangi leaves extract have no primary irritation effect

Toxoplasmosis in Kosovo pregnant women

This study presents the initial results of a collaborative project aimed at the evaluation of Toxoplasma seroprevalence in a population of Kosovar pregnant women. The serum samples of 334 pregnant women were tested to detect IgG, IgM, IgG avidity for toxoplasmosis. Data regarding age, occupation, area of origin and education were also obtained for the pregnant women examined; 97/334 (29.4%) resulted positive for IgG antibodies, four of whom (4.1%) were also positive for IgM, (1.2% of the total population examined). All four IgM-positive pregnant women also demonstrated low avidity tests. The rate of IgG seroprevalence found in our study was lower than that observed in various European countries, especially those of western Europe. Conversely, the percentage of recent infections was higher than expected. The higher rate of infections could be the result of a recent toxoplasmosis epidemic in Kosovo, most likely due to the altered hygienic conditions caused by the forced transfer of the ethnic-Albanian population from an area of low (Serbia) to high (Kosovo) toxoplasmosis prevalence

Encouraging female entrepreneurship in Jordan: environmental factors, obstacles and challenges

The number of female entrepreneurs and their contribution to the economy is steadily rising. Yet research suggests that female entrepreneurs face more challenges and barriers than their male counterparts. This is expected to be even more prevalent in Islamic contexts, which are characterised by conservative and patriarchal societies. In this research, 254 female business students from a private and a public university responded to a questionnaire that gauges their perceptions about potential barriers to entrepreneurship in Jordan and whether the business education they are receiving helps to prepare them for future entrepreneurial activity. Our results help to form a basis on which a deeper understanding of the phenomena can be achieved through more in depth future research. Among the main environmental factors that worry potential female entrepreneurs are the weakness of Jordanian economy, lack of finance, fear of risk, gender inequality and inability to maintain a work and private life balance. Our results also show that students are really not aware of the opportunities available to them and are unable to make a proper assessment. We call on both universities and the Jordanian government to put more emphasis on practical entrepreneurial education and encouraging women to play a much more active role within the workforce

Future therapeutic targets in rheumatoid arthritis?

Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by persistent joint inflammation. Without adequate treatment, patients with RA will develop joint deformity and progressive functional impairment. With the implementation of treat-to-target strategies and availability of biologic therapies, the outcomes for patients with RA have significantly improved. However, the unmet need in the treatment of RA remains high as some patients do not respond sufficiently to the currently available agents, remission is not always achieved and refractory disease is not uncommon. With better understanding of the pathophysiology of RA, new therapeutic approaches are emerging. Apart from more selective Janus kinase inhibition, there is a great interest in the granulocyte macrophage-colony stimulating factor pathway, Bruton's tyrosine kinase pathway, phosphoinositide-3-kinase pathway, neural stimulation and dendritic cell-based therapeutics. In this review, we will discuss the therapeutic potential of these novel approaches

Pengembangan Potensi TOGA di Desa Pucang Anom sebagai Wirausaha Minuman Herbal Celup dan Jelly Milkshake

Pucang Anom is one of the villages in Bondowoso which is known to have potential in agriculture. This can be proven by the breadth of land in Pucang Anom village, which almost 60% of the total is dominated by agricultural lands. This village has an abudant potential of famili medicinal plants (TOGA), but still underutilized and underestimated by the community. Even though TOGA can be processed into a product that has a high sale valus addition to the great benefits at the time of of the corona virus outbreak that is spreading through out the world. Therefore, KKN 04 Pucang Anom University of Jember on 6th of January until 19th of February 2020 had explored the potential in the village through the entepreneurship development of  TOGA as herbal beverage that rich in benefits. TOGA as a variety of its preparations that could be consumed by people invarious circles. The target of the program was to raise the enthusiasm of the community for enterpreneurship that was focused on processing technology and manufacturing products that did not yet exist in Pucang Anom village. Based on public response, it was known that 57% stated that they “really like” herbaldyed products and prossesed Herbal Jelly Milkshake, 100% said they werw “attracted” to the products, 95% said the were “innovative” products, and 100% stated thet the continuation of business potential was “needs to be continued”. Finally, the products won 1st place in the Product Expo of KKN Students of the University of Jember at 1st period in 2019/2020 academic year which was held on February 26, 2020

Bad news from Fallujah

This study uses the thematic analysis developed by the Glasgow University Media Group to explore how the US, UK and German national press covered the US/Coalition assault on the Iraqi city of Fallujah in November 2004. The study relies on quantitative and qualitative full text content analyses to assess 428 news, editorial and commentary items. The article suggests that, while government and military officials of the US/Coalition had argued the military ‘operation’ was necessary to secure Iraq and defeat an ‘insurgency’, organisations and actors from Iraqi society refer to the ‘operation’ as ‘collective punishment’ and a ‘massacre’ that targeted the Iraqi population. The article investigates how the press represented each of these perspectives. The findings suggest that the press overemphasised the US/Coalition perspective despite striking counter evidence. Critical aspects of coverage largely focused on tactical elements of the military dimension of the event. The article concludes that such findings are in accord with hegemonic models of media performance

Effect of exploitation and exploration on the innovative as outcomes in entrepreneurial firms

[EN] The main aim of this study is to establish the effect of the Exploitation and Exploration; and the influence of these learning flows on the Innovative Outcome (IO). The Innovative Outcome refers to new products, services, processes (or improvements) that the organization has obtained as a result of an innovative process. For this purpose, a relationship model is defined, which is empirically contrasted, and can explains and predicts the cyclical dynamization of learning flows on innovative outcome in knowledge intensive firms. The quantitative test for this model use the data from entrepreneurial firms biotechnology sector. The statistical analysis applies a method based on variance using Partial Least Squares (PLS). Research results confirm the hypotheses, that is, they show a positive dynamic effect between the Exploration and the Innovative as outcomes. In the same vein, they results confirm the presence of the cyclic movement of innovative outcome with the Exploitation.In addition, this research is part of the Project ECO2015-71380-R funded by the Spanish Ministry of Economy, Industry and Competitiveness and the State Research Agency. Co-financed by the European Regional Development Fund (ERDF).Vargas-Mendoza, NY.; Lloria, MB.; Salazar Afanador, A.; Vergara Domínguez, L. (2018). Effect of exploitation and exploration on the innovative as outcomes in entrepreneurial firms. International Entrepreneurship and Management Journal. 14(4):1053-1069. https://doi.org/10.1007/s11365-018-0496-5S10531069144Alegre, J., & Chiva, R. (2008). Assessing the impact of organizational learning capability on product innovation performance: an empirical test. Technovation, 28, 315–326.Amara, N., Landry, R., Becheikh, N., & Ouimet, M. (2008). Learning and novelty of innovation in established manufacturing SMEs. Technovation, 28, 450–463.Aragón-Mendoza, J., Pardo del Val, M., & Roig, S. (2016). The influence of institutions development in venture creation decision: a cognitive view. Journal of Business Research, 69(11), 4941–4946.Ardichvili, A. (2008). Learning and knowledge sharing in virtual communities of practice: motivators, barriers, and enablers. Advances in Developing Human Resources, 10(4), 541–554.Argyris, C., & Schön, D. (1978). Organizational learning: a theory of action perspective. Reading: Addison Wesley.Bagozzi, R. P., Yi, Y., & Singh, S. (1991). On the use of structural equation models in experimental designs: two extensions international. Journal of Research in Marketing, 8, 125–140.Belda, J., Vergara L., Salazar, A., & Safont G. (2018). Estimating the Laplacian matrix of Gaussian mixtures for signal processing on graphs, accepted for publication in Signal Processing.Boland, R. J. J., & Tenkasi, R. V. (1995). Perspective making and perspective taking in communities of knowing. Organization Science, 6(4), 350–372.Bontis, N., (1998). Intellectual capital: an exploratory study that develops measures models. Management Decision, 36, 63–76.Bontis, N. (1999). Managing an organizational learning system by aligning stocks and flows of knowledge: an empirical examination of intellectual capital, knowledge management, and business performance. 1999. Management of Innovation and New Technology Research Centre, McMaster University.Bontis, N., Keow, W., & Richardson, S. (2000). Intellectual capital and the nature of business in Malaysia. Journal of Intellectual Capital, 1(1), 85–100Bontis, N., Hullan, J., & Crossan, M. (2002). Managing an organizational learning system by aligning stocks and flows. Journal of Management Studies, 39, 438–469.Brachos, D., Kostopulos, K., Sodersquist, K. E., & Prastacos, G. (2007). Knowledge effectiveness, social context and innovation. Journal of Knowledge Management, 11(5), 31–44.Calantone, R. J., Cavusgil, S. T., & Zhao, Y. (2002). Learning orientation, firm innovation capability, and firm performance. Industrial Marketing Management, 31, 515–524.Chang, T. J., Yeh, S. P., & Yeh, I. J. (2007). The effects of joint rewards system in new product development. International Journal of Manpower, 28(3/4), 276–297.Chin, W. (1998). The partial least square approach to structural equation modeling. In G. A. Marcoulides (Ed.) (pp. 294–336). New Jersey: Lawrence Erlbaum Associates.Cho, N., Li, G., & Su, C. (2007). An empirical study on the effect of individual factors on knowledge sharing by knowledge type. Journal of Global Business and Technology, 3(2), 1–15.Cohen, W. M., & Levin, R. C. (1989). Empirical studies of innovation and market structure. In R. Schmalansee & R. D. Willing (Eds.), Handbook of industrial organization II. New York: Elsevier.Cohen, W. M., & Levinthal, D. A. (1990). Absorptive-capacity – a new perspective on learning and innovation. Administrative Science Quarterly, 35, 128–152.Cooper, R. G. (2000). New product performance: what distinguishes the star products. Austrian Journal of Management, 25, 17–45.Crossan, M., & Berdrow, I. (2003). Organizational learning and strategic renewal. Strategic Management Journal, 24, 1087–1105.Crossan, M., & Apaydin, M. (2010). A multi-dimensional framework of organizational innovation: a systematic review of the literature. Journal of Management Studies, 47(6), 1154–1191.Crossan, M., Lane, H. W., & White, R. E. (1999). An organizational learning framework: from intuition to institution. Academy of Management Review, 24, 522–537.Damanpour, F., & Aravind, D. (2012). Managerial innovation: conceptions, processes, and antecedents. Management and Organization Review, 8(2), 423–454.Damanpour, F., & Shanthi, G. (2001). The dynamics of the adoption of products and process innovations in organizations. Journal of Management Studies, 38(1), 21–65.Decarolis, D. M., & Deeds, D. L. (1999). The impact of stock and flows of organizational knowledge on firm performance: An empirical investigation of the biotechnology industry. Strategic Management Journal, 20, 953–968.Demartini, C. (2015). Relationships between social and intellectual capital: empirical Evidence from IC statements. Knowledge and Process Management, 22(2), 99–111.Dupuy, F. (2004). Sharing knowledge: they why and how of organizational change. Hampshire: Palgrave Macmillan.Fornell, C., & Bookstein, F. I. (1982). Two structural equation models: LISREL and PLS applied to consumer exit-voice theory. Journal of Marketing Research, 19, 440–452.Ganter, A., & Hecker, A. (2013). Deciphering antecedents of organizational innovation. Journal of Business Research, 66(5), 575–584.Ganter, A., & Hecker, A. (2014). Configurational paths to organizational innovation: qualitative comparative analyses of antecedents and contingencies. Journal of Business Research, 67, 1285–1292.Gopalakrishnan, S., & Damanpour, F. (1997). A review of innovation research in economics, sociology and technology management. International Journal of Management Science, 25, 15–28.Hedberg, B. (1981). How organizations learn and unlearn. In P. Nystrom & W. Starbuck (Eds.), Handbook of organizational design. New York: Oxford University.Hedlund, G., & Nonaka, I. (1993). Models of knowledge management in the west and Japan. In: P. Lorange, B. Chacravrarthy, J. Ross, and J. Van de ven (Eds.) Cambridge: Basil Blackwell.Henseler, J., Ringle, C.M., & Sinkovics, R.R. (2009). The use the partial least squares path modeling. In: R. Sinkovics and N. Pervez (Eds.) 277–319.Hsu, I. (2006). Enhancing employee tendencies to share knowledge-case studies on nine companies in Taiwan. International Journal of Information Management, 26(4), 326–338.Hsu, I. (2008). Knowledge sharing practices as a facilitating factor for improving organizational performance though human capital: a preliminary test. Expert Systems with Application, 35, 316–1326.Huang, Q., Davison, R., & Gu, J. (2008). Impact of personal and cultural factors on knowledge sharing in China. Asia Pacific Journal Management, 25(3), 451–471.Ibarra, H. (1993). Network centrality, power, and innovation involvement – determinants of technical and administrative roles. Academy of Management Journal, 36(3), 471–501.Iebra, I. L., Zegarra, P. S., & Zegarra, A. S. (2011). Learning for sharing: an empirical analysis of organizational learning and knowledge sharin. International Entrepreneurship Management Journal, 7, 509–518.Ipe, M. (2003). Knowledge sharing in organizations: a conceptual framework. Human Resource Development Review, 2(4), 337–359.Jenkin, T. (2013). Extending the 4I organizational learning model: information sources, foraging processes and tools. Administrative Sciences, 3, 96–109.Jiménez-Jiménez, D., & Sanz-Valle, R. (2011). Innovation, organizational learning, and performance. Journal of Business Research, 64, 408–417.Kane, G. C., & Alavi, M. (2007). Information technology and organizational learning: an investigation of exploration and exploitation processes. Organization Science, 18(5), 796–812.Kleinbaum, D. G., Kupper, N. N., Muller, K. E. (1988). Applied regression analysis and other Multivariable’s methods, PWS KENT.Klomp, L., & Van Leeuwen, G. (2001). Linking innovation and firm performance: a new approach. International Journal of the Economics of Business, 8(3), 343–364.Lansisalmi, H., Kivimaki, M., Aalto, P., & Ruoranen, R. (2006). Innovation in healthcare: a systematic review of recent research. Nursing Science Quarterly, 19(1), 66–72.Laperrière, A., & Spence, M. (2015). Enacting international opportunities: the role of organizational learning in knowledge-intensive business services. Journal of International Entrepreneurship, 13(3), 212–241.Levitt, B., & March, J. G. (1988). Organizational learning. Annual Review of Sociology, 14, 319–340.Lin, H. (2007). Knowledge sharing and firm innovation capability: an empirical study. International Journal of Manpower, 28(3/4), 315–332.Lloria, M. B., & Moreno-Luzón, M. D. (2014). Organizational learning: proposal of an integrative scale and research instrument. Journal of Business Research, 67, 692–697.March, J. G. (1991). Exploration and exploitation in organizational learning. Organizational Science, 2, 71–87.Matikainen, M., Terho, H., Parvinen, P., & Juppo, A. (2016). The role and impact of firm’s strategic orientations on launch performance: significance of relationship orientation. Journal of Business & Industrial Marketing, 31(5), 625–639.Mone, M. A., McKinley, W., & Barker, V. L. (1998). Organizational decline and innovation: a contingency framework. Academy of Management Review, 23, 115–132.Moreno-Luzón, M. D., & Lloria, B. (2008). The role of non-structural and informal mechanisms of integration and integration as forces in knowledge creation. British Journal of Management, 19, 250–276.Moskaliuk, J., Bokhorst, F., & Cress, U. (2016). Learning from others' experiences: how patterns foster interpersonal transfer of knowledge-in-use. Computers in Human Behavior, 55, 69–75.Nonaka, I., & Takeuchi, H. (1995). The knowledge-creating company. How Japanese companies create the dynamics of innovation. New York: Oxford University Press.Nonaka, I., & von Krogh, G. (2009). Perspective tacit knowledge and knowledge conversion: controversy and advancement in organizational knowledge creation theory. Organization Science, 20(3), 635–652.Parida, V., Lahti, T., & Wincent, J. (2016). Exploration and exploitation and firm performance variability: a study of ambidexterity in entrepreneurial firms. International Entrepreneurship Management Journal, 12, 1147–1164.Pew, H., Plowman, D., & Hancock, P. (2008). The involving research on intellectual capital. Journal of Intellectual Capital, 9, 585–608.Potter, R. E., & Balthazard, P. A. (2004). The role of individual memory and attention processes during electronic brainstorming. MIS Quarterly, 28(4), 621–643.Ramadani, V., Hyrije, A. A., Léo-Paul, D., Gadaf, R., & Sadudin, I. (2017). The impact of knowledge spillovers and innovation on firm-performance: findings from the Balkans countries. International Entrepreneurship Management Journal, 13, 299–325.Ren, S., Shu, R., Bao, Y., & Chen, X. (2016). Linking network ties to entrepreneurial opportunity discovery and exploitation: the role of affective and cognitive trust. International Entrepreneurship and Management Journal, 12(2), 465–485.Ringle, C. M., Wende, S., & Will, A. (2005). Smart PLS 2.0 (M3) beta, Hamburg: http://www.smartpls.de .Ringle, C. M., Sarstedt, M., & Straub, D. (2012). A critical look at the use of PLS-SEM. MIS Quarterly, 36(1), iii–xiv.Sanchez, R., & Heene, A. (1997). A competence perspective on strategic learning and knowledge management. En Sanchez, R. and Heene, A. (eds.) Strategic learning and knowledge management. John Wiley and Sons.Seidler-de Alwis, R., & Hartmann, E. (2008). The use of tacit knowledge within innovative companies: knowledge management in innovative enterprises. Journal of Knowledge Management, 12(1), 133–147.Shrivastava, P. (1983). A typology of organizational learning systems. Journal of Management Studies, 20, 7–28.Tansky, J., Ribeiro, D., & Roig, S. (2010). Linking entrepreneurship and human resources in globalization. Human Resource Management, 49(2), 217–223.Teece, D. (2012). Dynamic capabilities: routines versus entrepreneurial action. Journal of Management Studies, 49(8), 1395–1401.Tenenhaus, M., Vinzi, V., Chatelin, Y., & Lauro, C. (2005). PLS path modeling. Computational Statistics and Data Analysis, 49, 159–205.vande Vrande, V., de Jong, J., Vanhaverbeke, W., & Rochemont, M. (2009). Open innovation in SMEs: trends, motives and management challenges. Technovation, 29, 423–437.Vargas, N., & Lloria, M. B. (2014). Dynamizing intellectual capital through enablers and learning flows. Industrial Management and Data Systems, 114(1), 2–20.Vargas, N., & Lloria, M. B. (2017). Performance and intellectual capital: how enablers drive value creation in organisations. Knowledge and Process Management, 24(2), 114–124.Vargas, N., Lloria, M. B., & Roig-Dobón, S. (2016). Main drivers of human capital, learning and performance. The Journal of Technology Transfer, 41(5), 961–978.Vergara, L., Salazar, A., Belda, J., Safont, G., Moral, S., & Iglesias, S. (2017). Signal processing on graphs for improving automatic credit card fraud detection. Proceeding of 2017 I.E. 51st international Carnahan Conference on Security Technology (ICCST 2017), https://doi.org/10.1109/CCST.2017.8167820 , 23–26 Oct, 2017, Madrid, Spain.Wallin, M. W., & Von Krogh, G. (2010). Organizing for open innovation: focus o the integration of knowledge. Organizational Dynamics, 39(2), 145–154.Wang, C. L., & Ahmed, P. K. (2004). Linking innovation and firm performance: a new approach. European International Journal of Technology Management, 27, 674–688.Wold, H. (1980). Model construction and evaluation when theoretical knowledge is scarce. In J. Kmenta & J. B. Ramsey (Eds.), Evaluation of econometric models (pp. 47–74). Cambridge: Academic Press.Wold, H. (1985). Factors influencing the outcome of economic sanctions. In Sixto Ríos Honorary. Trabajos de Estadística and de Investigación Operativa, 36(3), 325–337

La thrombose de varicocèle : une étiologie rare de douleur testiculaire [Varicocele thrombosis: a rare etiology of testicular pain]

Acute testicular pain is frequent in urology. If torsion of the spermatic cord and orchiepididymitis are usual, varicocele thrombosis is an unusual clinical entity we reported