الاحتياجات التدريبية لاعضاء الهيئة الادارية بجامعة الازهر لتطبيق الادارة الالكترونية

This study aims to identify the training needs of the administrative staff members of Al-Azhar university for the application of E-Management and to explore if these needs differ according to the participants\u27 gender, occupational level, educational level, experience and training in computer. The descriptive analytical approach was used and data were collected via the questionnaire.the questionnaire consisted of (49) items and the reliability coefficient was (0.97). the participants were 211 administrative staff members who were selected randomly from 12 faculties in Al-Azhar university .the data were statistically analyzed using means, standard deviations, one way analysis of variance, and T-Test. The results showed that there is a great need for training in the professional aspect while this need was less in the other aspects. Additionally, the results showed that there were statistically significant differences in the participants\u27 rating of the training needs according to their gender, occupational level, educational level, and training in computer. However, there were no statistical significant differences in the participants\u27 rating of the training needs according to experience. Furthermore, the study recommended providing some training courses for the administrative staff members of Al-Azhar university based on their needs in order to get them familiarized with the philosophy of E-Management and the requirements of its application

Clinico-pathological features of breast carcinoma in elderly Egyptian patients: A comparison with the non-elderly using population-based data

AbstractBackgroundBreast cancer (BC) is a major worldwide health care problem that mostly afflicts the elderly population in the more developed countries. It is not known how common is breast cancer among elderly Egyptian patients and whether this differs from the disease in younger patients.AimsTo study the clinico-pathological features of BC in elderly Egyptian patients (⩾65years of age) among the population of an Egyptian Governorate, Gharbiah, and to compare these features with those of younger patients (<65years).MethodsThis is a cross sectional study that compares elderly BC (EBC) and the non-elderly BC (NEBC) using the information from the Gharbiah Population-based Cancer registry (GPCR) during the years 1999–2007.ResultsOut of 6078 BCs, 12% were EBCs and 88% were NEBCs. Between 1999 and 2007, the crude incidence rate (CIR, per 100,000 populations) of EBC increased from 47 to 71 and that of NEBC increased from 16 to 17. Compared to NEBC patients, EBC patients were more likely to have a positive family history and present with a distant disease and less likely to present with a localized disease. EBCs were more likely to have lung metastases and less likely to have liver metastases. Histology, grade, hormone and HER-2 receptor statuses were comparable in both groups. Apart from hormonal therapies, the elderly were less likely to receive surgery, radiotherapy or chemotherapy.ConclusionEBC patients in Egypt present with advanced disease and are less likely to receive surgery, radiotherapy or chemotherapy compared to NEBC patients

Predictors of Long-term Disability in Multiple Sclerosis: Real World Data from a Cohort of Egyptian Patients

Background: Specification of prognostic factors in multiple sclerosis (MS) is crucial for clinicians to guide therapeutic protocols. This study aimed to identify demographic, clinical, and radiological factors associated with disability on a long-term basis in relapsing-remitting MS (RRMS) and secondary progressive MS (SPMS).Methods: This was a retrospective study conducted on patients with RRMS and SPMS with a disease duration of at least 10 years. Demographic, clinical, and radiological parameters were collected from the medical records.Results: During the study period, 217 patients were recruited with a mean disease duration of 14.9 ± 4.6 (range: 10-35) years. Regression analysis revealed that age (B = 0.071, CI: 0.00-0.132, P = 0.025), male sex (B = –0.825, CI: –1.444 to –0.206, P = 0.009), duration between first 2 attacks (B = -0.007, CI: -0.015-0.000, P = 0.037), and involvement of pyramidal (B = 0.754, CI: 0.051-1.457, P = 0.036) or cerebellar domains (B = 1.355, CI: 0.542-2.168, P = 0.001) at disease onset were the only parameters that had an independent effect on EDSS.Conclusion: Predictors of long-term disability in our cohort were closely similar, but not typically identical to predictors reported in the literature. Age, male sex, short duration between first 2 relapses pyramidal and cerebellar affection were the strongest predictors of disability in patients with RRMS and SPMS

Rhus coriaria induces senescence and autophagic cell death in breast cancer cells through a mechanism involving p38 and ERK1/2 activation

Here, we investigated the anticancer effect of Rhus coriaria on three breast cancer cell lines. We demonstrated that Rhus coriaria ethanolic extract (RCE) inhibits the proliferation of these cell lines in a time- and concentration-dependent manner. RCE induced senescence and cell cycle arrest at G1 phase. These changes were concomitant with upregulation of p21, downregulation of cyclin D1, p27, PCNA, c-myc, phospho-RB and expression of senescence-associated β-galactosidase activity. No proliferative recovery was detected after RCE removal. Annexin V staining and PARP cleavage analysis revealed a minimal induction of apoptosis in MDA-MB-231 cells. Electron microscopy revealed the presence of autophagic vacuoles in RCE-treated cells. Interestingly, blocking autophagy by 3-methyladenine (3-MA) or chloroquine (CQ) reduced RCE-induced cell death and senescence. RCE was also found to activate p38 and ERK1/2 signaling pathways which coincided with induction of autophagy. Furthermore, we found that while both autophagy inhibitors abolished p38 phosphorylation, only CQ led to significant decrease in pERK1/2. Finally, RCE induced DNA damage and reduced mutant p53, two events that preceded autophagy. Our findings provide strong evidence that R. coriaria possesses strong anti-breast cancer activity through induction of senescence and autophagic cell death, making it a promising alternative or adjunct therapeutic candidate against breast cancer.UAEU Program for Advanced Research (Grant 31S111-UPAR) and by the Zayed Center for Health Sciences (ZCHS) research grant (grant 31R021) and College of Science Individual Research Grant (grant 31S123) to Rabah Iratni

Synthesis of New Chromene Derivatives Targeting Triple-Negative Breast Cancer Cells

Breast cancer continues to be the leading cause of cancer-related deaths among women worldwide. The most aggressive type of breast cancer is triple-negative breast cancer (TNBC). Indeed, not only does TNBC not respond well to several chemotherapeutic agents, but it also frequently develops resistance to various anti-cancer drugs, including taxane mitotic inhibitors. This necessitates the search for newer, more efficacious drugs. In this study, we synthesized two novel chromene derivatives (C1 and C2) and tested their efficacy against a battery of luminal type A and TNBC cell lines. Our results show that C1 and C2 significantly and specifically inhibited TNBC cell viability but had no effect on the luminal A cell type. In addition, these novel compounds induced mitotic arrest, cell multinucleation leading to senescence, and apoptotic cell death through the activation of the extrinsic pathway. We also showed that the underlying mechanisms for these actions of C1 and C2 involved inhibition of microtubule polymerization and disruption of the F-actin cytoskeleton. Furthermore, both compounds significantly attenuated migration of TNBC cells and inhibited angiogenesis in vitro. Finally, we performed an in silico analysis, which revealed that these novel variants bind to the colchicine binding site in β-tubulin. Taken together, our data highlight the potential chemotherapeutic properties of two novel chromene compounds against TNBC.Scopu

Effects of hospital facilities on patient outcomes after cancer surgery: an international, prospective, observational study

Background Early death after cancer surgery is higher in low-income and middle-income countries (LMICs) compared with in high-income countries, yet the impact of facility characteristics on early postoperative outcomes is unknown. The aim of this study was to examine the association between hospital infrastructure, resource availability, and processes on early outcomes after cancer surgery worldwide.Methods A multimethods analysis was performed as part of the GlobalSurg 3 study-a multicentre, international, prospective cohort study of patients who had surgery for breast, colorectal, or gastric cancer. The primary outcomes were 30-day mortality and 30-day major complication rates. Potentially beneficial hospital facilities were identified by variable selection to select those associated with 30-day mortality. Adjusted outcomes were determined using generalised estimating equations to account for patient characteristics and country-income group, with population stratification by hospital.Findings Between April 1, 2018, and April 23, 2019, facility-level data were collected for 9685 patients across 238 hospitals in 66 countries (91 hospitals in 20 high-income countries; 57 hospitals in 19 upper-middle-income countries; and 90 hospitals in 27 low-income to lower-middle-income countries). The availability of five hospital facilities was inversely associated with mortality: ultrasound, CT scanner, critical care unit, opioid analgesia, and oncologist. After adjustment for case-mix and country income group, hospitals with three or fewer of these facilities (62 hospitals, 1294 patients) had higher mortality compared with those with four or five (adjusted odds ratio [OR] 3.85 [95% CI 2.58-5.75]; p&lt;0.0001), with excess mortality predominantly explained by a limited capacity to rescue following the development of major complications (63.0% vs 82.7%; OR 0.35 [0.23-0.53]; p&lt;0.0001). Across LMICs, improvements in hospital facilities would prevent one to three deaths for every 100 patients undergoing surgery for cancer.Interpretation Hospitals with higher levels of infrastructure and resources have better outcomes after cancer surgery, independent of country income. Without urgent strengthening of hospital infrastructure and resources, the reductions in cancer-associated mortality associated with improved access will not be realised

تصورات طلاب الدبلوم العام نحو الممارسات الديمقراطية لأعضاء هيئة التدريس بجامعة الأزهر

The purpose of this study was to investigate perceptions of the General Diploma students at Al-Azhar University towards the democratic practices of faculty members. Moreover it aimed to show whether their perceptions vary according to gender, age, major, experience and the type of education. The study used a descriptive survey method based on a questionnaire consisting of (39) items, and making sure of the Psychometric characteristics of the tool, the study sample consisted of (710) of diploma students at Al Azhar university for the academic year 2012/2013. Study findings showed that perceptions of General Diploma students at Al Azhar University towards the democratic practices of faculty members were generally medium in all fields except the field of study course which was little. Also there were some significant differences at the level of (0, 05) in perceptions of general diploma students at Al Azhar University towards the democratic practices of faculty members. This was due to the variables of gender, age, major, experience, and the type of education

Dimensions of Agile Maturity in CS Education

Agile software development is becoming a matured, effective approach and has wide acceptance according to the recently published trends. Due to its success, agile practices have moved into other disciplines including Computing Education. Most of the computer science academic programs are currently rigid and use waterfall process model in delivery. Lightweight process framework like Agile is recommended to computer science education in order to improve quality and reacting to changes and industry requirements. This paper discusses and presents a framework to adopting and evaluating agile practices in computer science education

Middle Cerebellar Peduncle Lesions and Their Relation to Affective and Cognitive Impairment in Multiple Sclerosis: Middle Cerebellar Peduncle and Psychocognition in Multiple Sclerosis

Background: Cerebellum has long been known to modulate not only motor coordination but also affective and cognitive functions. This study aimed to assess the impact of middle cerebellar peduncle (MCP) lesions on affective and cognitive function in patients with multiple sclerosis (MS). Methods: This was a cross-sectional study conducted on patients with relapsing-remitting MS (RRMS). All patients were subjected to 3-Tesla magnetic resonance imaging (3T MRI), brief international cognitive assessment for MS (BICAMS), and Depression, Anxiety, and Stress Score-21 (DASS-21) upon recruitment. Results: Of the 30 patients recruited, 33.3% and 36.7% had right and left MCP lesions, respectively. Patients with right MCP lesions had significantly worse symbol digit modality test (SDMT) scores (P = 0.036), worse California verbal learning test (CVLT) immediate recall scores (P = 0.011), and worse CVLT delayed free recall scores (P = 0.049), whereas patients with left MCP lesions had lower DASS-21 scores (P &lt; 0.005). On multivariate regression analysis, the presence of left MCP lesion was associated with an 8.9-point reduction in DASS-21 scores (CI: -16.985- -0.805, P = 0.033), whereas right MCP lesions did not have an independent effect on BICAMS scores after adjustment for age and educational level. Conclusion: Left MCP lesions were associated with significantly lower DASS-21 scores, whereas none of the MCP lesions had an independent impact on cognition