Estudio de factibilidad para la creación de una comercializadora internacional de Heliconias para la región Risaralda

En este proyecto se encuentra elaborado un Estudio De Factibilidad Para La Creación De Una Comercializadora Internacional De Heliconias Para La Región Risaralda, sustentado en un estudio de mercado hecho a profundidad sobre el estado del mercado de heliconias producidas en la región, aprovechando las bondades que la región ofrece en cuanto a clima, suelos entre otros recursos naturales que permiten obtener heliconias las cuales cumplan con los altos estándares de calidad y poder ser comercializadas en el mercado estadounidense, convirtiendo a Risaralda Heliconias en una empresa tanto financiera como económicamente sostenible que brinde garantías y mejores oportunidades a los productores de Heliconias.This project elaborates the development of a “Feasibility Study for Creating an International Trading Company of Heliconias for the Risaralda Region.” This was based on a in depth study centered on the market state of heliconas produced in the region, taking advantage of the region’s benefits in terms of; climate, soil, and other natural resources that enable the achievement of high quality heliconias, which fulfill the standards needed to be sold on the american market. As a result, making the Risalda’s Heliconia an economically sustainable financial company that guarantees stability and opportunities for the heliconia producers

Extended sensations on interactive telecommunication

Although computer science and telecommunications have evolved from the 90’s to nowadays, the way people communicate each other through electronic devices has stuck since the appearance of the videoconference. The audiovisual interaction seems enough, but we think the sensation of presence gets higher when we allow the person who we are talking to, taking part in our environment using and enriching it. In that way, the interaction is improved with new sensations which come from outside of our device. In this article, we propose a communication service which provides not only videoconference, but manages the smart environment where the interlocutor of the communication is, allowing him to access to any device connected through domotic and/or wireless network. The application is developed under the OSGi open specification and it almost doesn’t imply any cost increase over the bandwidth used during communication. Once explaining the technical foundations, its diverse applications in ubiquitous meetings and on-line games will be commented

Experiencias en entornos de Computación Ubicua mediante Arquitecturas Orientadas a Servicios

El desarrollo del proyecto Domoweb, cuyo objetivo principal, es la creación de un entorno domótico gestionado vía Web, nos ha permitido acumular experiencia sobre las arquitecturas orientadas a servicio, concretamente sobre la plataforma basada en la especificación de OSGi e implementada con software de fuentes abiertas. En este artículo, comentamos las decisiones tomadas durante el desarrollo del proyecto y ampliamos la visión inicial hacia ámbitos de computación ubicua más genéricos que el hogar digital. Además, señalamos la necesidad de integrar en la arquitectura propuesta, la gestión de los Servicios Web, ampliando de ese modo las capacidades del entorno y su funcionalidad

Smart Environment Vectorization : An Approach to Learning of User Lighting Preferences

The automation of smart environment systems is one of the main goals of smart home researching. This paper focus on learning user lighting preference, considering a working field like a standard office. A review of the smart environment and devices setup is done, showing a real configuration for test purposes. Suitable learning machine techniques are exposed in order to learn these preferences, and suggest the actions the smart environment should execute to satisfy the user preferences. Learning machine techniques proposed are fed with a database, so a proposal for the vectorization of data is described and analyzed.Ministerio de Educación y Ciencia TSI2006-13390-C02-02Junta de Andalucía TIC-214

Development Environment Using FPGA for Domotics Applications Based on X10 Technology

This communication proposes a basic software and hardware architecture of a controller for the X10 technology interface CM11A, oriented to the world of home automation. The implementation of the system is based in the use of programmable devices such as FPGA (Field Programmable Gate Array). With this controller an end user will be able to control and to manage a set of devices distributed in a domotics space.Ministerio de Educación y Ciencia TEC2005- 04359/MICMinisterio de Educación y Ciencia TSI2006-13390-C02-02Junta de Andalucía TIC2006-635Junta de Andalucía TIC214

Camelids in the south of the Iberian Peninsula in Roman and medieval times. Osteological evidence from the city of Cordoba (Spain)

This paper presents the results obtained concerning the possible presence of camelids in the city of Cordoba (Spain) in Roman and medieval times, after the review of all the faunal assemblages corresponding to these historical periods deposited in the Provincial Archaeological Museum of the city. This research has allowed the recovery and contextualization of nine dromedary bone remains corresponding to nine individuals, four of which have been dated by C. A stable isotope analysis has also been carried out which indicates the possible arrival of these animals from other provinces of the empire in Roman times and from North Africa in medieval times. Besides, we carried out a bibliographical update of all bone remains found in the Iberian Peninsula for the periods analyzed, concluding that the main use of them was for transporting and manufacturing different tools.This study have been funded through the Andalusian Regional Government’s I + D + i-FEDER Andalucía 2014-2020 program. C.A.M.E.L. Historical contextualization, Diet, Morphology, Genetic Study, and Lineage through the bone remains of camels recovered in archaeological sites in the southern Iberian Peninsula (Ref. 1380946-F) and Ministry of Science and Innovation of Spain through European Regional [SUMHAL, LIFEWATCH-2019-09-CSIC-13, POPE 2014-2020]. Both Dr. José A. Riquelme Cantal and Dr. Juan Manuel Garrido Anguita are the principal investigators leading the projects that have funded this research. Funding for open access charge: Universidad de Córdoba /CBUA

Tau Protein Phosphorylated at Threonine-231 Is Expressed Abundantly in the Cerebellum in Prion Encephalopathies

ACKNOWLEDGMENTS: The authors want to express their gratitude to the following: Dr. P. Davies † (Albert Einstein College of Medicine, Bronx, NY, USA) and Lester I. Binder † (North Western, Chicago, IL, USA) for the generous gift of mAbs TG-3 and Alz-50, and Tau-1, Tau-5 and Tau-7, respectively; Tec. Amparo Viramontes Pintos for the handling of the brain tissue; support in the confocal microscopy unit of CIIDIR Durango, Instituto Politécnico Nacional; Union Medica University Clinic, Dominican Republic, for their support and collaboration in the development of this research project. We also want to express our gratitude to the Mexican families who have donated the brain of their loved ones affected with Alzheimer's disease and made our research possible. This work is dedicated to the memory of Professor Dr. José Raúl Mena López †. †Deceased. This work was supported by Fondo Nacional de Ciencia y Tecnologia, FONDOCyT, from the Ministry of Higher Education, Science and Technology, Dominican Republic (2015-3A2-127 to MP-H) and (2018-2019-2A3-208 to JL-M and MP-H).Peer reviewedPublisher PD

Long-Term Real-World Effectiveness and Safety of Ustekinumab in Crohn’s Disease Patients: The SUSTAIN Study

Background Large real-world-evidence studies are required to confirm the durability of response, effectiveness, and safety of ustekinumab in Crohn’s disease (CD) patients in real-world clinical practice. Methods A retrospective, multicentre study was conducted in Spain in patients with active CD who had received ≥1 intravenous dose of ustekinumab for ≥6 months. Primary outcome was ustekinumab retention rate; secondary outcomes were to identify predictive factors for drug retention, short-term remission (week 16), loss of response and predictive factors for short-term efficacy and loss of response, and ustekinumab safety. Results A total of 463 patients were included. Mean baseline Harvey-Bradshaw Index was 8.4. A total of 447 (96.5%) patients had received prior biologic therapy, 141 (30.5%) of whom had received ≥3 agents. In addition, 35.2% received concomitant immunosuppressants, and 47.1% had ≥1 abdominal surgery. At week 16, 56% had remission, 70% had response, and 26.1% required dose escalation or intensification; of these, 24.8% did not subsequently reduce dose. After a median follow-up of 15 months, 356 (77%) patients continued treatment. The incidence rate of ustekinumab discontinuation was 18% per patient-year of follow-up. Previous intestinal surgery and concomitant steroid treatment were associated with higher risk of ustekinumab discontinuation, while a maintenance schedule every 12 weeks had a lower risk; neither concomitant immunosuppressants nor the number of previous biologics were associated with ustekinumab discontinuation risk. Fifty adverse events were reported in 39 (8.4%) patients; 4 of them were severe (2 infections, 1 malignancy, and 1 fever). Conclusions Ustekinumab is effective and safe as short- and long-term treatment in a refractory cohort of CD patients in real-world clinical practice

Using Interpretable Machine Learning to Identify Baseline Predictive Factors of Remission and Drug Durability in Crohn’s Disease Patients on Ustekinumab

Ustekinumab has shown efficacy in Crohn's Disease (CD) patients. To identify patient profiles of those who benefit the most from this treatment would help to position this drug in the therapeutic paradigm of CD and generate hypotheses for future trials. The objective of this analysis was to determine whether baseline patient characteristics are predictive of remission and the drug durability of ustekinumab, and whether its positioning with respect to prior use of biologics has a significant effect after correcting for disease severity and phenotype at baseline using interpretable machine learning. Patients' data from SUSTAIN, a retrospective multicenter single-arm cohort study, were used. Disease phenotype, baseline laboratory data, and prior treatment characteristics were documented. Clinical remission was defined as the Harvey Bradshaw Index <= 4 and was tracked longitudinally. Drug durability was defined as the time until a patient discontinued treatment. A total of 439 participants from 60 centers were included and a total of 20 baseline covariates considered. Less exposure to previous biologics had a positive effect on remission, even after controlling for baseline disease severity using a non-linear, additive, multivariable model. Additionally, age, body mass index, and fecal calprotectin at baseline were found to be statistically significant as independent negative risk factors for both remission and drug survival, with further risk factors identified for remission