Gastric-type adenocarcinoma of the cervix in a patient with Lynch syndrome: A case report

• Lynch syndrome (LS) is an uncommon, genetic disorder which predisposes affected individuals to colorectal, endometrial and ovarian malignancies. • We report a case of cervical gastric-type adenocarcinoma in a patient with LS. • Immunohistochemistry for mismatch repair proteins is a useful screening tool in tumours suspected to be associated with LS

Haemostasis in Open Carpal Tunnel Release: Tourniquet vs Local Anaesthetic and Adrenaline

Open carpal tunnel release is one of the commonest performed procedures in hand surgery. We performed a prospective randomised control trial to compare the efficacy and patient satisfaction of the traditional arm tourniquet versus infiltration of adrenaline and local anaesthetic solution to achieve haemostasis during the procedure. Using a combination of objective and subjective measures we concluded that infiltration of local anaesthetic and adrenaline not only provided adequate haemostasis but also provided a significantly more tolerable experience for the patient during the procedure

Haemostasis in Open Carpal Tunnel Release: Tourniquet vs Local Anaesthetic and Adrenaline

Open carpal tunnel release is one of the commonest performed procedures in hand surgery. We performed a prospective randomised control trial to compare the efficacy and patient satisfaction of the traditional arm tourniquet versus infiltration of adrenaline and local anaesthetic solution to achieve haemostasis during the procedure. Using a combination of objective and subjective measures we concluded that infiltration of local anaesthetic and adrenaline not only provided adequate haemostasis but also provided a significantly more tolerable experience for the patient during the procedure

Inhibition of Pediatric Glioblastoma Tumor Growth by the Anti-Cancer Agent OKN-007 in Orthotopic Mouse Xenografts

We thank the Peggy and Charles Stephenson Cancer Center at the University of Oklahoma, Oklahoma City, OK, for funding, who received an Institutional Development Award (IDeA) from the National Institute of General Medical Sciences of the National Institutes of Health under grant number P20 GM103639 for the use of the Histology and Immunohistochemistry Core for providing immunohistochemistry and photographic services. This work was also supported by Oklahoma State University, Center of Veterinary Health Science (Support Grant AE-1-50060 to P.C.S.), the Musella Foundation (R.A.T.), and the Childhood Brain Tumor Foundation (R.A.T.).Pediatric glioblastomas (pGBM), although rare, are one of the leading causes of cancer-related deaths in children, with tumors essentially refractory to existing treatments. Here, we describe the use of conventional and advanced in vivo magnetic resonance imaging (MRI) techniques to assess a novel orthotopic xenograft pGBM mouse (IC-3752GBM patient-derived culture) model, and to monitor the effects of the anti-cancer agent OKN-007 as an inhibitor of pGBM tumor growth. Immunohistochemistry support data is also presented for cell proliferation and tumor growth signaling. OKN-007 was found to significantly decrease tumor volumes (p<0.05) and increase animal survival (p<0.05) in all OKN-007-treated mice compared to untreated animals. In a responsive cohort of treated animals, OKN-007 was able to significantly decrease tumor volumes (p<0.0001), increase survival (p<0.001), and increase diffusion (p<0.01) and perfusion rates (p<0.05). OKN-007 also significantly reduced lipid tumor metabolism in responsive animals (Lip1.3 and Lip0.9)-to-creatine ratio (p<0.05), as well as significantly decrease tumor cell proliferation (p<0.05) and microvessel density (p<0.05). Furthermore, in relationship to the PDGFRα pathway, OKN-007 was able to significantly decrease SULF2 (p<0.05) and PDGFR-α (platelet-derived growth factor receptor-α) (p<0.05) immunoexpression, and significantly increase decorin expression (p<0.05) in responsive mice. This study indicates that OKN-007 may be an effective anti-cancer agent for some patients with pGBMs by inhibiting cell proliferation and angiogenesis, possibly via the PDGFRα pathway, and could be considered as an additional therapy for pediatric brain tumor patients.Yeshttp://www.plosone.org/static/editorial#pee

The DUNE far detector vertical drift technology. Technical design report

DUNE is an international experiment dedicated to addressing some of the questions at the forefront of particle physics and astrophysics, including the mystifying preponderance of matter over antimatter in the early universe. The dual-site experiment will employ an intense neutrino beam focused on a near and a far detector as it aims to determine the neutrino mass hierarchy and to make high-precision measurements of the PMNS matrix parameters, including the CP-violating phase. It will also stand ready to observe supernova neutrino bursts, and seeks to observe nucleon decay as a signature of a grand unified theory underlying the standard model. The DUNE far detector implements liquid argon time-projection chamber (LArTPC) technology, and combines the many tens-of-kiloton fiducial mass necessary for rare event searches with the sub-centimeter spatial resolution required to image those events with high precision. The addition of a photon detection system enhances physics capabilities for all DUNE physics drivers and opens prospects for further physics explorations. Given its size, the far detector will be implemented as a set of modules, with LArTPC designs that differ from one another as newer technologies arise. In the vertical drift LArTPC design, a horizontal cathode bisects the detector, creating two stacked drift volumes in which ionization charges drift towards anodes at either the top or bottom. The anodes are composed of perforated PCB layers with conductive strips, enabling reconstruction in 3D. Light-trap-style photon detection modules are placed both on the cryostat's side walls and on the central cathode where they are optically powered. This Technical Design Report describes in detail the technical implementations of each subsystem of this LArTPC that, together with the other far detector modules and the near detector, will enable DUNE to achieve its physics goals

Iridium-catalyzed hydrogen production from hydrosilanes and water

The iridium(III) complex [Ir(H)(CF3SO3)(NSiN)(coe)] (NSiN=fac-coordinated bis(pyridine-2-yloxy)methylsilyl, coe=cyclooctene) has been proven to be an effective catalyst precursor for hydrogen production from the hydrolysis of hydrosilanes at room temperature. The reaction performance depends both on the nature of the silane and the solvent. Interestingly, high turnover frequencies of around 105 h-1 were obtained by using Et2SiH2 or (Me2HSi)2O as hydrogen sources and THF as the solvent. Moreover a mechanistic insight into this Ir-catalyzed hydrogen generation process, based on both theoretical calculations and NMR spectroscopy, is reported. The overall catalytic cycle can be viewed as a two-stage process that involves water-promoted Si-H bond activation followed by water splitting by a proton transfer.The authors express their appreciation to the support from the MINECO/FEDER projects CONSOLIDER INGENIO-2010 MULTICAT CSD2009-00050, CTQ2011-27593 and CTQ2012-35665 and DGA/FSE (group E07) is also acknowledged.Peer Reviewe

Monoanionic NSiN-type ligands in transition metal coordination chemistry and catalysis

Dedicated to Prof. Pierre Braunstein on the occasion of his 70th birthday with our most sincere congratulations for his leadership and outstanding contributions to the field of Coordination Chemistry and Catalysis, and best wishes.The number of late transition metal complexes bearing tridentate monoanionic silyl-based NSiN-type ligands has grown in the last few years. This review describes the synthetic methodologies that allow preparation of NSiN ligands precursors as well as the chemical and structural behavior of the transition metal complexes resulting from the reaction of these ligand precursors with different metallic starting materials. In addition, a description of the catalytic processes based on Rh- and Ir-NSiN catalysts so far reported is included. Moreover, an analysis of the chemistry of iridium complexes with different fac-κ3-(Si,N,N)-NSiN ligands allows to conclude that the nature of the silyl group along with the donor ability of the nitrogen atoms at the NSiN ligands influence on the reactivity and potential catalytic activity of the respective complexes.Financial support from MINECO/FEDER project CTQ2015-67366-P and DGA/FSE group E07 is gratefully acknowledged. Dr. R. Lalrempuia acknowledged ARAID-Foundation for funding parts of this work.Peer reviewe

Osmium−allenylidene complexes containing an N-Heterocyclic carbene ligand

4 pages, 3 figures.Complex [(η6-p-cymene)OsCl(IPr)]OTf (1) reacts with 1,1-diphenyl-2-propyn-1-ol to afford the hydroxyvinylidene derivative [(η6-p-cymene)OsCl{CCHC(OH)Ph2}(IPr)]OTf (2), which dehydrates to form [(η6-p-cymene)OsCl(CCCPh2)(IPr)]OTf (3). Treatment in acetonitrile under reflux of the BF4-salt of 3 with AgBF4 leads to the tetrakis(solvento) derivative [Os(CCCPh2)(CH3CN)4(IPr)][BF4]2 (4). At 95 °C, the addition of PiPr3 to an acetonitrile solution of 4 yields the dicationic mixed PiPr3-IPr osmium−allenylidene complex [Os(CCCPh2)(CH3CN)3(IPr)(PiPr3)][BF4]2 (5), which in 2-propanol and in the presence of NaCl evolves into the five-coordinate hydride−alkenylcarbyne [OsHCl(CCHCPh2)(IPr)(PiPr3)][BF4] (6). The X-ray structures of 2, 5, and 6 are also reported.Financial support from the MCYT of Spain (Projects CTQ2005-00656 and Consolider Ingenio 2010 CSD2007-00006) and Diputación General de Aragón (E35) is acknowledged. R.L. thanks the Spanish Ministerio de Educación y Ciencia for his postdoctoral fellowship, and R.C. thanks CSIC and MEC for funding through the “Ramon y Cajal” Program.Peer reviewe