Deep Multi-view Learning to Rank

We study the problem of learning to rank from multiple information sources. Though multi-view learning and learning to rank have been studied extensively leading to a wide range of applications, multi-view learning to rank as a synergy of both topics has received little attention. The aim of the paper is to propose a composite ranking method while keeping a close correlation with the individual rankings simultaneously. We present a generic framework for multi-view subspace learning to rank (MvSL2R), and two novel solutions are introduced under the framework. The first solution captures information of feature mappings from within each view as well as across views using autoencoder-like networks. Novel feature embedding methods are formulated in the optimization of multi-view unsupervised and discriminant autoencoders. Moreover, we introduce an end-to-end solution to learning towards both the joint ranking objective and the individual rankings. The proposed solution enhances the joint ranking with minimum view-specific ranking loss, so that it can achieve the maximum global view agreements in a single optimization process. The proposed method is evaluated on three different ranking problems, i.e. university ranking, multi-view lingual text ranking and image data ranking, providing superior results compared to related methods.Comment: Published at IEEE TKD

Comparison of two insertion techniques of classic laryngeal mask airway: standard versus 90-degree rotation

Background: Laryngeal mask airway (LMA) devices have been widely utilized as an alternative to tracheal intubation in various clinical situations. The rotation technique has been suggested to improve the insertion success rate of laryngeal masks. The objective of the present study was to compare the ease of insertion of laryngeal mask in terms of, success rate at the first attempt, number of LMA insertion attempts, time duration of LMA insertion and complications like blood stain on LMA and sore throat.Methods: This prospective cohort study was conducted to compare the success rate of insertion at the first attempts between standard technique and 90 degree rotational technique at Department of Anaesthesiology, Amala institute of medical sciences, Thrissur, India during the period from March 2014-september 2015. A total of 160 patients each group consisting of 80 was included in the study after meeting inclusion criteria. Success rate of insertion at first attempts, number of insertion attempts, and insertion time of successful attempt, overall success rate, blood staining of laryngeal mask airway (LMA) and postoperative sore throat were recorded.Results: Significant difference was existed between the two groups with regard to gender. Statistically insignificant differences were observed for demographics like age, weight, ASA grades between the two study groups. Significant differences were observed among the study groups on all findings of LMA insertion. Statistically insignificant difference was detected for the time of duration of LMA insertion and change in heart rate, but mean arterial pressure was found statistically significant between the two groups.Conclusions: This study found that 90 degree rotational technique has high success rate of insertion at first attempt & is less traumatic than standard technique

Influence of aging and hemorrhage injury on Sirt1 expression: Possible role of myc-Sirt1 regulation in mitochondrial function

AbstractTrauma–hemorrhage (T–H) causes hypoxia and organ dysfunction. Mitochondrial dysfunction is a major factor for cellular injury due to T–H. Aging also has been known to cause progressive mitochondrial dysfunction. In order to study the effect of aging on T–H-induced mitochondrial dysfunction, we recently developed a rodent mitochondrial genechip with probesets representing mitochondrial and nuclear genes contributing to mitochondrial structure and function. Using this chip we recently identified signature mitochondrial genes altered following T–H in 6 and 22month old rats; augmented expression of the transcription factor c-myc was the most pronounced. Based on reports of c-myc-IL6 collaboration and c-myc-Sirt1 negative regulation, we further investigated the expression of these regulatory factors with respect to aging and injury. Rats of ages 6 and 22months were subjected to T–H or sham operation and left ventricular tissues were tested for cytosolic cytochrome c, mtDNA content, Sirt1 and mitochondrial biogenesis factors Foxo1, Ppara and Nrf-1. We observed increased cardiac cytosolic cytochrome c (sham vs T–H, p<0.03), decreased mitochondrial DNA content (sham vs T–H, p<0.05), and decreased Sirt1 expression (sham vs TH, p<0.05) following T–H and with progressing age. Additionally, expression of mitochondrial biogenesis regulating transcription factors Foxo1 and Nrf-1 was also decreased with T–H and aging. Based upon these observations we conclude that Sirt1 expression is negatively modulated by T–H causing downregulation of mitochondrial biogenesis. Thus, induction of Sirt1 is likely to produce salutary effects following T–H induced injury and hence, Sirt1 may be a potential molecular target for translational research in injury resolution

Stereoselective synthesis towards (+)-trans-kumausyne employing vinylogous Mukaiyama type reaction on an α-chloro sulfide

1199-1205A stereoselective synthesis towards (+)-trans-kumausyne is disclosed. The key steps of the synthesis include stereoselective C-C formation employing vinylogous Mukaiyama type reaction of an &alpha;-chloro sulfide with 2-trimethylsiloxy furan and base-catalyzed isomerization followed by intramolecular oxa-Michael reaction

O odnosu seizmičnosti i tektonskih svojstava Idukki regije u jugoistočnoj Indiji

The detailed investigations of the lineament and seismicity data of Idukki area have been carried out in connection with the location of June 7, 1988 earthquake and its associated significant aftershocks. The analysis of lineament data has indicated three major lineaments namely Idamalayar, Periyar and Kambam which have influenced the entire lineament fabric of the Idukki area. The study has indicated that the June 7, 1988 earthquake was associated with Periyar lineament in Nedumkandam area which has been found to be located at a distance of 22 km off Idukki. It has been observed that the isoseismals pertaining to maximum intensity VI MM and above show unidirectional elongation in WNW-ESE while lower intensity isoseismals have bi-directional elongation in WNW-ESE and NE-SW. The Periyar lineament trending WNW-ESE and NE-SW trending Kambam lineament have served as conduits for the propagation of seismic energy over long distances since its transmission is more efficient along rupture zones than in the transverse direction

Aging Influences Cardiac Mitochondrial Gene Expression and Cardiovascular Function following Hemorrhage Injury

Cardiac dysfunction and mortality associated with trauma and sepsis increase with age. Mitochondria play a critical role in the energy demand of cardiac muscles, and thereby on the function of the heart. Specific molecular pathways responsible for mitochondrial functional alterations after injury in relation to aging are largely unknown. To further investigate this, 6- and 22-month-old rats were subjected to trauma-hemorrhage (T-H) or sham operation and euthanized following resuscitation. Left ventricular tissue was profiled using our custom rodent mitochondrial gene chip (RoMitochip). Our experiments demonstrated a declined left ventricular performance and decreased alteration in mitochondrial gene expression with age following T-H and we have identified c-Myc, a pleotropic transcription factor, to be the most upregulated gene in 6- and 22-month-old rats after T-H. Following T-H, while 142 probe sets were altered significantly (39 up and 103 down) in 6-month-old rats, only 66 were altered (30 up and 36 down) in 22-month-old rats; 36 probe sets (11 up and 25 down) showed the same trend in both groups. The expression of c-Myc and cardiac death promoting gene Bnip3wereincreased, and Pgc1-α and Ppar-a a decreased following T-H. Eleven †RNA transcripts on mtDNA were upregulated following T-H in the aged animals, compared with the sham group. Our observations suggest a c-myc-regulated mitochondrial dysfunction following T-H injury and marked decrease in age-dependent changes in the transcrip-tional profile of mitochondrial genes following T-H, possibly indicating cellular senescence. To our knowledge, this is the first report on mitochondrial gene expression profile following T-H in relation to aging

Sex Hormones and Gender Effects following Trauma-Hemorrhage

Trauma is the leading cause of death in the industrialized world between the ages of one and 40. A number of risk factors including age and gender have been implicated in this regard. It is therefore not surprising that the majority of trauma victims are young males. Their mortality rate following trauma is not only higher compared to females, but they are also more prone to subsequent sepsis. Age and gender are therefore important factors in the prevalence of traumatic injury as well as in susceptibility to subsequent septic complications

Low Energy Solar Neutrinos and Spin Flavour Precession

The possibility that the Gallium data effectively indicates a time modulation of the solar active neutrino flux in possible connection to solar activity is examined on the light of spin flavour precession to sterile neutrinos as a subdominant process in addition to oscillations. We distinguish two sets of Gallium data, relating them to high and low solar activity. Such modulation affects principally the low energy neutrinos ($pp$ and $^7 Be$) so that the effect, if it exists, will become most clear in the forthcoming Borexino and LENS experiments and will provide evidence for a neutrino magnetic moment. Using a model previously developed, we perform two separate fits in relation to low and high activity periods to all solar neutrino data. These fits include the very recent charged current spectrum from the SNO experiment. We also derive the model predictions for Borexino and LENS experiments.Comment: 20 pages, 5 ps figures, 1 eps figure, final version to be published in JHE

Immune response modulation by curcumin in a latex allergy model

BACKGROUND: There has been a worldwide increase in allergy and asthma over the last few decades, particularly in industrially developed nations. This resulted in a renewed interest to understand the pathogenesis of allergy in recent years. The progress made in the pathogenesis of allergic disease has led to the exploration of novel alternative therapies, which include herbal medicines as well. Curcumin, present in turmeric, a frequently used spice in Asia has been shown to have anti-allergic and inflammatory potential. METHODS: We used a murine model of latex allergy to investigate the role of curcumin as an immunomodulator. BALB/c mice were exposed to latex allergens and developed latex allergy with a Th2 type of immune response. These animals were treated with curcumin and the immunological and inflammatory responses were evaluated. RESULTS: Animals exposed to latex showed enhanced serum IgE, latex specific IgG(1), IL-4, IL-5, IL-13, eosinophils and inflammation in the lungs. Intragastric treatment of latex-sensitized mice with curcumin demonstrated a diminished Th2 response with a concurrent reduction in lung inflammation. Eosinophilia in curcumin-treated mice was markedly reduced, co-stimulatory molecule expression (CD80, CD86, and OX40L) on antigen-presenting cells was decreased, and expression of MMP-9, OAT, and TSLP genes was also attenuated. CONCLUSION: These results suggest that curcumin has potential therapeutic value for controlling allergic responses resulting from exposure to allergens

'Preconditioning' with Low Dose Lipopolysaccharide Aggravates the Organ Injury/Dysfunction Caused by Hemorrhagic Shock in Rats

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are creditedRS is supported by the Program Science without Borders, CAPES Foundation, Ministry of Education of Brazil, Brasilia/DF, Brazil; NSAP is, in part, supported by the Bart’s and The London Charity (753/1722). The research leading to these results has received funding from the People Programme (Marie Curie Actions) of the European Union’s Seventh Framework Programme (FP7/2007-2013) under REA grant agreement no 608765, from the William Harvey Research Foundation and University of Turin (Ricerca Locale ex-60%). This work contributes to the Organ Protection research theme of the Barts Centre for Trauma Sciences, supported by the Barts and The London Charity (Award 753/1722