Can Levothyroxine Be Taken as Evening Dose? Comparative Evaluation of Morning versus Evening Dose of Levothyroxine in Treatment of Hypothyroidism

152 drug naïve primary hypothyroid patients were divided into morning (Group 1) and evening (Group 2) dosing group and evaluated for change in biochemical profile, physical functioning and Quality of Life during the course of 12 weeks of study. At the end of 12 weeks 70 (90.90%) subjects in Group 1 and 72 (96%) in Group 2 achieved euthyroidism. On evaluation clinical symptoms and total clinical scores improved in both the groups at the end of 6 and 12 weeks. Significant improvement in thyroid profile was seen in both the groups at the end of 6 and 12 weeks (P value <.0001). On intergroup comparison, no significant difference in thyroid profile was seen at 6 and 12 weeks between the morning and the evening dose group. Similar dose of levothyroxine was required to achieve euthyroidism in both the groups. Though an early restoration of euthyroidism was seen in evening group, the difference when compared to the morning group was not statistically significant. On assessment of QoL, statistically significant improvement in various parameters was seen in both the groups. Hence, from the study we inferred that evening dose is as efficacious as morning dose and provides an alternate dosing regimen

Response of bio-regulators to morphology and yield of clusterbean [Cyamopsis tetragonoloba (L.) Taub.] under different sowing environments

An experiment was conducted during kharif season of 2014, aims of the experiment were to investigate suitable sowing environment and bio-regulator and its effect on clusterbean (Cyamopsis tetragonoloba (L.) Taub.), experimental treatments were applied foliar spray of thiourea (500, 1000 ppm) and salicylic acid (50, 100 ppm) at 45 and 60 days after sowing under normal (15 July) and late (30 July) sowing environments. Normal sowing performed well as compared to late sowing, in respect to all morphology and yield parameters. Amongst foliar spray, significantly higher plant height (100.17 cm), number of branches per plant (7.99), leaf area index (4.85), seed yield (9.19 q/ha) and harvest index (29.39) were recorded in foliar spray of thiourea 500 ppm as compared to all other bio-regulators spray level. Similarly, salicylic acid 100 ppm found statistically at par with thiourea 500 ppm foliar spray at 45 and 60 DAS. Impacts of climate change have significant reflections on clusterbean productivity. Sowing dates plays a vital role to determining the productivity of clusterbean with bio-regulators spray by controlling the environmental factors

Anti-Obesity Vaccines Could Reverse the Epidemic

Obesity and excess weight are major risk factors for chronic diseases, including type II diabetes, cardiovascular diseases, gastrointestinal disorders and certain forms of cancer. Understanding the neuroendocrine mechanisms that govern body weight is an important research priority because such insight could guide the rational design of new agents to treat obesity. If this becomes a reality, it will be a dream come true for people who are suffering from obesity. In 2014, 39% of adults aged 18 years and older (38% of men and 40% of women) were overweight. In the modern world, we have a long list of measures that includes both medical and surgical, which can help us to reduce obesity out of which the therapeutic vaccines show promise. Recent studies have shown that therapeutic vaccines may be new targets for development of anti-obesity medications. These vaccines will aim at multiple targets, which include a spectrum of problems ranging from metabolic derangements to infectious agents including suppressing the appetite-stimulating hormone and blocking absorption of nutrients

SOME RESULTS ON SEMI-REFLEXIVITY AND REFLEXIVITY IN LOCALLY CONVEX SPACES

In this paper we discuss that if E[] is a barreled space such that every bounded subset of E is relatively compact, then E[] is reflexive, and that a barreled space E[τ] in which there is a denumerable system of convex compact subsets is reflexive. We also discuss Some hereditary-type properties of reflexive locally convex spaces. Keywords: Bornological space, barreled, hereditarily-reflexive, M-space, quasi-complete, reflexive, strong dual. AMS (2010) Mathematics Subject Classification: 46A25

Recent Advances in Phytoremediation of Hazardous Substances using Plants: A Tool for Soil Reclamation and Sustainability

Phytoremediation techniques have emerged as a promising approach for soil reclamation and remediation of contaminated sites. This review article provides a comprehensive analysis of the different phytoremediation techniques used for soil reclamation and their effectiveness in removing contaminants from soil. The aim is to evaluate the current state of knowledge and to highlight potential avenues for future research in this field. The review begins with a discussion of the principles underlying phytoremediation, emphasizing the ability of plants to accumulate, tolerate, and detoxify contaminants through various mechanisms such as phytoaccumulation, rhizo-degradation, and rhizo-filtration. Different plant species and their suitability for phytoremediation are reviewed, considering factors such as metal tolerance, biomass production, and pollutant uptake efficiency. In addition, the role of soil amendments and their impact on improving phytoremediation efficiency is critically evaluated. Commonly used amendments, including chelating agents, organic matter, and pH adjusters, are reviewed with emphasis on their ability to increase metal bioavailability and plant uptake. The review also addresses challenges associated with phytoremediation, such as plant growth limitations, long-term sustainability, and potential risks associated with the release of pollutants into the atmosphere during biomass disposal. Strategies to mitigate these challenges, including plant breeding and genetic engineering, are discussed

Biomass Gasification and Applied Intelligent Retrieval in Modeling

Gasification technology often requires the use of modeling approaches to incorporate several intermediate reactions in a complex nature. These traditional models are occasionally impractical and often challenging to bring reliable relations between performing parameters. Hence, this study outlined the solutions to overcome the challenges in modeling approaches. The use of machine learning (ML) methods is essential and a promising integration to add intelligent retrieval to traditional modeling approaches of gasification technology. Regarding this, this study charted applied ML-based artificial intelligence in the field of gasification research. This study includes a summary of applied ML algorithms, including neural network, support vector, decision tree, random forest, and gradient boosting, and their performance evaluations for gasification technologies

Why Are Outcomes Different for Registry Patients Enrolled Prospectively and Retrospectively? Insights from the Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF).

Background: Retrospective and prospective observational studies are designed to reflect real-world evidence on clinical practice, but can yield conflicting results. The GARFIELD-AF Registry includes both methods of enrolment and allows analysis of differences in patient characteristics and outcomes that may result. Methods and Results: Patients with atrial fibrillation (AF) and ≥1 risk factor for stroke at diagnosis of AF were recruited either retrospectively (n = 5069) or prospectively (n = 5501) from 19 countries and then followed prospectively. The retrospectively enrolled cohort comprised patients with established AF (for a least 6, and up to 24 months before enrolment), who were identified retrospectively (and baseline and partial follow-up data were collected from the emedical records) and then followed prospectively between 0-18 months (such that the total time of follow-up was 24 months; data collection Dec-2009 and Oct-2010). In the prospectively enrolled cohort, patients with newly diagnosed AF (≤6 weeks after diagnosis) were recruited between Mar-2010 and Oct-2011 and were followed for 24 months after enrolment. Differences between the cohorts were observed in clinical characteristics, including type of AF, stroke prevention strategies, and event rates. More patients in the retrospectively identified cohort received vitamin K antagonists (62.1% vs. 53.2%) and fewer received non-vitamin K oral anticoagulants (1.8% vs . 4.2%). All-cause mortality rates per 100 person-years during the prospective follow-up (starting the first study visit up to 1 year) were significantly lower in the retrospective than prospectively identified cohort (3.04 [95% CI 2.51 to 3.67] vs . 4.05 [95% CI 3.53 to 4.63]; p = 0.016). Conclusions: Interpretations of data from registries that aim to evaluate the characteristics and outcomes of patients with AF must take account of differences in registry design and the impact of recall bias and survivorship bias that is incurred with retrospective enrolment. Clinical Trial Registration: - URL: http://www.clinicaltrials.gov . Unique identifier for GARFIELD-AF (NCT01090362)