Obesity and excess weight are major risk factors for chronic diseases, including type II diabetes, cardiovascular diseases, gastrointestinal disorders and certain forms of cancer. Understanding the neuroendocrine mechanisms that govern body weight is an important research priority because such insight could guide the rational design of new agents to treat obesity. If this becomes a reality, it will be a dream come true for people who are suffering from obesity. In 2014, 39% of adults aged 18 years and older (38% of men and 40% of women) were overweight. In the modern world, we have a long list of measures that includes both medical and surgical, which can help us to reduce obesity out of which the therapeutic vaccines show promise. Recent studies have shown that therapeutic vaccines may be new targets for development of anti-obesity medications. These vaccines will aim at multiple targets, which include a spectrum of problems ranging from metabolic derangements to infectious agents including suppressing the appetite-stimulating hormone and blocking absorption of nutrients