Single cell analysis reveals immune cell-adipocyte crosstalk regulating the transcription of thermogenic adipocytes.

Immune cells are vital constituents of the adipose microenvironment that influence both local and systemic lipid metabolism. Mice lacking IL10 have enhanced thermogenesis, but the roles of specific cell types in the metabolic response to IL10 remain to be defined. We demonstrate here that selective loss of IL10 receptor α in adipocytes recapitulates the beneficial effects of global IL10 deletion, and that local crosstalk between IL10-producing immune cells and adipocytes is a determinant of thermogenesis and systemic energy balance. Single Nuclei Adipocyte RNA-sequencing (SNAP-seq) of subcutaneous adipose tissue defined a metabolically-active mature adipocyte subtype characterized by robust expression of genes involved in thermogenesis whose transcriptome was selectively responsive to IL10Rα deletion. Furthermore, single-cell transcriptomic analysis of adipose stromal populations identified lymphocytes as a key source of IL10 production in response to thermogenic stimuli. These findings implicate adaptive immune cell-adipocyte communication in the maintenance of adipose subtype identity and function

Prevalence of Postpartum Family Planning Service Coverage in Selected Referral Facilities of Nepal

Introduction: Nepal Society of Obstetricians and Gynecologists jointly with the Nepalese government and with the support from the International Federation of Obstetrics and Gynecology has implemented an initiative to institutionalize postpartum family planning services in selected major referral facilities of Nepal to address the gap of low uptake of postpartum family planning in Nepal. The aim of the study is to find the prevalence of the service coverage of postpartum contraception in the selected facilities. Methods: A descriptive cross-sectional study was conducted in seven major referral facilities across Nepal. Data were collected from the hospital records of all women who delivered in these facilities between October 2018 and March 2019. Ethical approval for this study was obtained from Nepal Health Research Council. Data analysis was done with SPSS version 23. Results: Among the 29,072 deliveries from all the facilities, postpartum family planning counseling coverage was 27,301 (93.9%). The prevalence of uptake of Postpartum Intrauterine Device is 1581 (5.4%) and female sterilization is 1830 (6.3%). In total 11387 mothers (52.2%) had the intention to choose a postpartum family planning method. However, 36% of mothers neither used nor had the intention to choose a postpartum family planning method. Conclusions: The coverage of Postpartum Intrauterine Device counseling service coverage in Nepal is higher in 2018 as compared to 2016-2017 and in other countries implementing Postpartum Intrauterine Device initiatives. However, the prevalence of service coverage of immediate Postpartum Family Planning methods, mainly Postpartum Intrauterine Device in 2018 is lower in Nepal as compared to 2016-2017, and other countries implementing Postpartum Intrauterine Device initiative. More efforts are needed to encourage mothers delivering in the facilities to use the postpartum family planning method

A review of gallium nitride LEDs for multi-gigabit-per-second visible light data communications

The field of visible light communications (VLC) has gained significant interest over the last decade, in both fibre and free-space embodiments. In fibre systems, the availability of low cost plastic optical fibre (POF) that is compatible with visible data communications has been a key enabler. In free-space applications, the availability of hundreds of THz of the unregulated spectrum makes VLC attractive for wireless communications. This paper provides an overview of the recent developments in VLC systems based on gallium nitride (GaN) light-emitting diodes (LEDs), covering aspects from sources to systems. The state-of-the-art technology enabling bandwidth of GaN LEDs in the range of >400 MHz is explored. Furthermore, advances in key technologies, including advanced modulation, equalisation, and multiplexing that have enabled free-space VLC data rates beyond 10 Gb/s are also outlined

Handover - Enabling Learning in Communication for Safety (HELiCS): a report on achievements at two hospital sites

The provision of health care is becoming increasingly complex and fragmented.1,2 As a result, to ensure continuity of care, the handover of clinical tasks is becoming more frequent and important. However, the general lack of clinical handover planning and training in handover communication creates unacceptable risks for patients.1 Not surprisingly, clinical handover has been identified as a major international policy and research priority

Embedding Fiber Bragg Grating Sensors in Carbon Composite Structures for Accurate Strain Measurement

Fiber Bragg grating (FBG) sensors written by femtosecond laser pulses in polyamide-coated low bending loss optical fibers are successfully embedded in carbon composite structures, following laminating and light resin molding processes which optimize the size of each ply to address esthetic, drapability, and structural requirements of the final components. The sensors are interrogated by a tunable laser operating at around 1.55 μm, and their response to temperature and strain variations is characterized in a thermally controlled chamber and by bending tests using suspended calibrated loads and a laser scanning system. Experimental results are in good agreement with simulations, confirming that the embedding process effectively overcomes potential issues related to FBG spectral distortion, birefringence, and losses. In particular, the effects of the composite material nonhomogeneity and FBG birefringence are investigated to evaluate their impact on the monitoring capabilities. A bimaterial mechanical beam model is proposed to characterize the orthotropic laminates, pointing out better accuracy in estimating the applied load with respect to the classical homogeneous beam model. A comparative analysis, performed on different instrumented carbon composite samples and supported by theory, points out the repeatability of the FBG sensors' embedding process and the effectiveness of the technology for real-time accurate strain measurement. Based on such measurements, damages and/or changes in local stiffness can be effectively detected, allowing for structural health monitoring (SHM) of composite structures for applications in specific industrial fields such as automotive and aerospace

Neural Network-Based Joint Spatial and Temporal Equalization for MIMO-VLC System

The limited bandwidth of white light-emitting diode (LED) limits the achievable data rate in a visible light communication (VLC) system. A number of techniques, including multiple-input-multiple-output (MIMO) system, are investigated to increase the data rate. The high-speed optical MIMO system suffers from both spatial and temporal cross talks. The spatial cross-talk is often compensated by the MIMO decoding algorithm, while the temporal cross talk is mitigated using an equalizer. However, the LEDs have a non-linear transfer function and the performance of linear equalizers are limited. In this letter, we propose a joint spatial and temporal equalization using an artificial neural network (ANN) for an MIMO-VLC system. We demonstrate using a practical imaging/non-imaging optical MIMO link that the ANN-based joint equalization outperforms the joint equalization using a traditional decision feedback as ANN is able to compensate the non-linear transfer function as well as cross talk

MIMO Visible Light Communications Using a Wide Field-of-View Fluorescent Concentrator

This letter reports a demonstration of a 2 x 2 multiple-input multiple-output (MIMO) indoor visible-light communication (VLC) system using a novel fluorescent optical concentrator-based receiver. This potentially allows a high degree of spatial multiplexing to be achieved using a simple receiver structure that can have a wide field-of-view. Details of a two-channel MIMO VLC system that operates at 32 Mb/s with a receiver acceptance angle of ±22.5° are given, and future directions are discussed.PostprintPeer reviewe

Novel fast color-converter for visible light communication using a blend of conjugated polymers

The authors thank EPSRC for financial support from UP-VLC Project Grant (EP/K00042X/1).Visible Light Communications (VLC) is a promising new technology which could offer higher data transmission rates than existing broadband RF/microwave wireless technologies. In this paper, we show that a blend of semiconducting polymers can be used to make a broadband, balanced color converter with a very high modulation bandwidth to replace commercial phosphors in hybrid LEDs for visible light communications. The resulting color converter exploits partial Förster energy transfer in a blend of the highly fluorescent green emitter BBEHP-PPV and orange-red emitting MEH-PPV. We quantify the efficiency of the photoinduced energy transfer from BBEHP-PPV to MEH-PPV, and demonstrate modulation bandwidths (electrical-electrical) of ∼200 MHz, which are 40 times higher than commercially available phosphor LEDs. Furthermore, the VLC data rate achieved with this blend using On-Off Keying (OOK) is many times (∼35) higher than that measured with a commercially available phosphor color converter.PostprintPeer reviewe

Visible Light Communication Using a Blue GaN μLED and Fluorescent Polymer Color Converter

This letter presents a novel technique to achieve high-speed visible light communication (VLC) using white light generated by a blue GaN mu LED and a yellow fluorescent copolymer. We generated white light suitable for room illumination by optimizing the ratio between the blue electroluminescence of the mu LED and yellow photoluminescence of the copolymer color converter. Taking advantage of the components' high bandwidth, we demonstrated 1.68 Gb/s at a distance of 3 cm (at 240 lx illumination). To the best of our knowledge, this is the fastest white light VLC results using a single blue LED/color converter combination.PostprintPeer reviewe

Colloidal Quantum Dot Color Converters for Visible Light Communications

The properties and performance of CdSSe/ZnS colloidal quantum dot composite materials for use as InGaN LED color converters in visible light communications applications is reported. 500Mb/s optical wireless transmission is demonstrated