Software reusability development through NFL approach for identifying security based inner relationships of affecting factors

In component based software reusability development process, the software developers have to choose the best components which are self adaptive future to overcome the functional errors, framework mismatches, violation of user level privacy issues and data leakage feasibilities. The software developers can build high quality software applications by taking the consideration of the reusable components which are more suitable to provide high level data security and privacy. This paper has proposing the neural based fuzzy framework based approach to estimate the reusable components which are directly and indirectly involve the security and privacy to improve the quality of the software system. This approach has considered the twenty effecting factors and fifty three attribute matrices. It has formed with three stages of execution scenarios. The first stage has executed with eleven effecting factors and eighteen attribute matrices for identification of supporting software reusability components, the second stage has executed with four effecting factors and thirty five attribute matrices for identification of sub-internal relationships in terms of security-privacy, and the third stage has executed with eight effecting factors and six attribute matrices for identification of sub of sub-internal relationships in terms of security risk estimation. This analytical finding proposes a fuzzy logic model to evaluate the most feasible effecting factors that influence the enterprise level data security-privacy practices at real time environment

Hand Factors in Cardiac Development

Congenital heart defects account for 1% of infant mortality and 10% of in utero deaths. As the vertebrate embryo develops, multiple tissue types develop in tandem to morphologically pattern the functional heart. Underlying cardiac development is a network of transcription factors known to tightly control these morphological events. Members of the Twist family of basic helix–loop–helix transcription factors, Hand1 and Hand2, are essential to this process. The expression patterns and functional role of Hand factors in neural crest cells, endocardium, myocardium, and epicardium is indicative of their importance during cardiogenesis; however, to date, an extensive understanding of the transcriptional targets of Hand proteins and their overall mechanism of action remain unclear. In this review, we summarize the recent findings that further outline the crucial functions of Hand factors during heart development and in post‐natal heart function

A Protective Mechanism to Avoid Eavesdropping Attack in MANET

Wireless ad hoc network is self-directed and infrastructure less network. Wireless ad hoc network is particularly inclined due to its basic characteristics, such as open medium, dynamic topology, distributed cooperation, and capability constraint. Routing plays an imperative part in the security of the whole system. Secure transmission of data in wireless ad hoc environment is an imperative concern. Any aggressor get remote flag by using transceiver and without being caught. The objective of this paper is to propose new secure unobservable routing protocol where attacker gets blocked while making spoofing or DOS attacks. Only oblivious message could be gathered by attacker. Proposed protocol will also protect privacy information among network and will detect and block attacking nodes through trust mechanism. DOI: 10.17762/ijritcc2321-8169.160412

A Clinical Study on the efficacy of Ashvagandha Ksheerapaka in Stree Vandhyatva w.s.r. to Anovulation

Fertility is an existential necessity and as such has assumed over whelming importance from time immemorial. However, not all couples who desire a pregnancy will achieve one spontaneously and a proportion of couples will need medical help to resolve underlying fertility problems. Infertility has been recognized as a public health issue world wide by the World Health Organization. Infertility severely affects the couples psychologically, sexually and socially. Anovulation accounts for 25 - 40% of the female infertility. Ayurveda offers several potent combinations in such a condition. The aim of the present paper is to address this problem by studying the efficacy of Ashvagandha Ksheerapaka in the induction of ovulation

Food spectrum and dietary preferences of the Indian anchovy Stolephorus indicus (van Hasselt, 1823) from Thiruvananthapuram coast, Kerala

The food preferences of the Indian anchovy Stolephorus indicus (van Hasselt, 1823) along the Thiruvananthapuram coast of Kerala was studied for a period of one year from June 2013 to May 2014, dividing the entire period into three seasons as pre-monsoon, monsoon and post-monsoon. A total of 141 samples were collected and the gut contents were analysed. The principal food item was the crustaceans which included copepods, lucifers, mysids, Acetes and amphipods. The other preferred prey items were molluscs (bivalves and gastropods), small fishes, tintinnids and dinoflagellates. The gastrosomatic and stomach fullness indices revealed almost uniform feeding preferences with copepods being the preferred food item throughout the three seasons. Analysis of variance showed significant (p0.05) seasonal variation was observed in the gut contents of S. indicus. Analyses of the different prey indices [prey diversity index (H), niche width indices (B) and prey evenness indices (e)] of S. indicus for the three seasons indicated an almost uniform distribution of prey species throughout the study period which directly indicate the abundance of the prey items and indirectly indicate a stable potential fishery and ecosystem

Empowering Visually Impaired through the Assistance of SAHAYAK – A Walking Aid for the Blind

To help blind people overcoming difficulty in their movement in the physical environment and even in their home, a study on an engineering concept is very much necessary. So, our research comes out with an aid that will help blind people in their surroundings. It can detect any obstacle that will block the path of the blind. And The motion of the user can be sensed by the bot. Thus, Blind people can comfortably receive the help of our bot in assisting their movement from one place to another. This paper describes about an automated vehicle which can be controlled by an ultrasonic sensor to avoid obstacles when they move in their environment. Our automated robotic system is made up of an ultrasonic sensor and Arduino micro controller controls our automated bot. It is located in the front part of the bot. The ultrasonic sensor retrieves the data from the environment through the sensors attached to the bot. When any obstacle is detected then immediately that path is changed and an obstacle free path is chosen. The bot wheel is moved based on the data received by the controller from the sensor. The direction and wheel movement of the bot and will be decided from the ultrasonic sensor sensing and also using wheel encoder. It is used for detection and avoidance of interference. The controller is also programmed to be used with an android application

Guggulsterone-Mediated Enhancement of Radiosensitivity in Human Tumor Cell Lines

Purpose: To observe the effect of guggulsterone (GS) on the radiation response in human cancer cell lines. Materials and methods: The radiation response of cancer cells treated with GS was observed by cell survival studies, cell growth assay, NF-κB activity assay, western blotting of some key growth promoting receptors, the DNA repair protein γH2AX, and flow cytometry for DNA analyses. Results: GS inhibited radiation induced NF-κB activation and enhanced radiosensitivity in the pancreatic cell line, PC-Sw. It reduced both cell cycle movement and cell growth. GS reduced ERα protein in MCF7 cells and IGF1-Rβ protein in colon cancer cells and pancreatic cancer cells and inhibited DNA double strand break (DSB) repair following radiation. Conclusion: GS induced radiation sensitization may be due to several different mechanisms including the inhibition of NF-κB activation and reductions in IGF1-Rβ. In addition, GS induced γH2AX formation, primarily in the S-phase, indicates that DNA DSB's in the S-phase may be another reason for GS induced radiosensitivity. ERα down-regulation in response to GS suggests that it can be of potential use in the treatment of estrogen positive tumors that are resistant to tamoxifen

Cervical lymph node metastasis in squamous cell carcinoma of the buccal mucosa:a retrospective study on pattern of involvement and clinical analysis

The study was performed with an aim to map the pattern of metastasis of squamous cell carcinomas of buccal mucosa to various cervical lymph node levels and analyze its correlation with primary tumor size and histo-pathological grading. 254 patients with squamous cell carcinoma of the buccal mucosa treated with surgery first approach were analyzed retrospectively. The tumor size was noted from pre-operative CT Scans and were divided into early and advanced tumors. The resected specimen was studied to note the histo-pathological grading of the squamous cell carcinoma and the metastatic deposits at various lymph node levels. Out of 254 patients (149 females, 105 males), 145 patients showed histo-pathologically proven metastatic deposits in one or more lymph nodes out of which there were 56 patients showing occult metastasis. 78/145 patients showed metastatic involvement of level IB and/or IA lymph nodes, 31 showed involvement of level II and/or I lymph nodes, 27 showed involvement of level III with or without involvement of level I and II and 9 showed metastasis to level IV and V lymph nodes with or without level I, II or III lymph nodes. Cervical lymph node metastasis had statistically significant association with tumor size with advanced tumors showing worse pattern of metastatic spread beyond level I and II lymph nodes. As the degree of differentiation of squamous cell carcinoma reduced, they were more prone for cervical metastasis with moderately and poorly differentiated squamous cell carcinoma showing higher involvement of level III, IV and V lymph nodes. The majority of buccal mucosa cases showed metastasis to level I, II and III lymph nodes out of which level IB and/or IA was most frequently involved. Metastasis to level IV and V lymph nodes was rare and was seen especially in patients with advanced primary tumor and poor histo-pathologic differentiation

The subcoronary Toronto stentless versus supra-annular Perimount stented replacement aortic valve: Early clinical and hemodynamic results of a randomized comparison in 160 patients

BackgroundA stentless valve is expected to be hemodynamically superior to a stented valve. The aim of this study was to compare early postoperative hemodynamic function and clinical events in a randomized, prospective series of 160 stentless and stented biological replacement aortic valves.MethodsWe randomized 160 consecutive patients on 1 surgeon’s list to receive either a Toronto stentless porcine valve (St Jude Medical, Inc, St Paul, Minn) or a Perimount stented bovine pericardial valve (Edwards Lifesciences, Irvine, Calif). Echocardiography was performed at discharge, between 3 and 6 months, and at 1 year after surgery. Statistical analysis was performed by both intention to treat and actual valves implanted.ResultsThe mean labeled size of both designs of valve was 24.7. There were no statistically significant differences in results at any time interval or whether analysis was performed by actual valves implanted or intention to treat. At 3 to 6 months for the Toronto versus the Perimount valve, the effective orifice area was 1.58 versus 1.66 cm2, the mean pressure difference was 7.54 versus 7.42 mm Hg, and the peak velocity was 2.07 versus 2.0.1 m/s. There was no difference in mortality, regression of left ventricular hypertrophy, or complications other than paraprosthetic regurgitation at 12 months or on follow-up for a proportion of the sample to 8 years. The incidence of regurgitation through the valves was similar for Toronto (10%) and Perimount (13.8%) at 1 year, but mild paraprosthetic regurgitation was found in 5 patients with the Perimount valve and none with Toronto valves.ConclusionsThere were no significant differences in hemodynamic function or clinical events between the stented and stentless biological valves chosen for comparison in the early postoperative period or in preliminary follow-up to 5 years

Deletion of a Hand1 lncRNA-Containing Septum Transversum Enhancer Alters lncRNA Expression but Is Not Required for Hand1 Expression

We have previously identified a Hand1 transcriptional enhancer that drives expression within the septum transversum, the origin of the cells that contribute to the epicardium. This enhancer directly overlaps a common exon of a predicted family of long non-coding RNAs (lncRNA) that are specific to mice. To interrogate the necessity of this Hand1 enhancer, as well as the importance of these novel lncRNAs, we deleted the enhancer sequences, including the common exon shared by these lncRNAs, using genome editing. Resultant homozygous Hand1 enhancer mutants (Hand1ΔST/ΔST) present with no observable phenotype. Assessment of lncRNA expression reveals that Hand1ΔST/ΔST mutants effectively eliminate detectable lncRNA expression. Expression analysis within Hand1ΔST/ΔST mutant hearts indicates higher levels of Hand1 than in controls. The generation of Hand1 compound heterozygous mutants with the Hand1LacZ null allele (Hand1ΔST/LacZ) also did not reveal any observable phenotypes. Together these data indicate that deletion of this Hand1 enhancer and by consequence a family of murine-specific lncRNAs does not impact embryonic development in observable ways