The comparative study of fibrin degradation products in normal pregnancy and pregnancy induced hypertension

Background: Pregnancy induced hypertension is a multisystem disorder and is characterized by changes in haemostatic system. The assessment of the coagulation parameters of the patients of pre-eclampsia and eclampsia is important because it helps to diagnose the severity of the disease, and to predict the outcome. There is no universal agreement as to the need for further investigations if the platelet count comes normal. Hence in such cases it is always prudent to get the coagulation profile. D dimer of such patients is done to diagnose the cases of coagulation failure early and to manage it efficiently. The objectives of the study to compare the Fibrin Degradation Products in term normal pregnancy, pre eclamptic and eclamptic patients, to assess the severity of pregnancy induced hypertension and to detect coagulation failure early and manage before it worsens.Methods: This study was conducted in the Department of Obstetrics and Gynaecology at Karnataka Institute of Medical Sciences, Hubli during the period of March 2014 to February 2015 on 100 patients between 37-42 weeks of gestation. 50 controls were well matched with the study population which included a total of 50 patients with pre-eclampsia and eclampsia. Pregnant women with known bleeding disorders, on anticoagulant therapy, with abruptio placentae, with IUD, in labour and with established DIC were excluded.The blood coagulation parameters which were compared between the control and the study population were Bleeding time (BT), Platelet Count, Clotting time (CT), Prothrombin time (PT), Activated partial thromboplastin time (aPTT) and D-dimer.Results: The BT, CT, PT, aPTT values were nearly identical in all the groups. The platelet count showed a decreasing trend from normal control to eclampsia group. The D dimer showed an increasing trend from the normal control to eclampsia group. D dimer level was raised in all patients who were in sub clinical and clinical coagulation failure.Conclusions: This study shows that even with the normal routine coagulation parameters, D dimer was significantly elevated in both subclinical and clinical DIC. So, D dimer can be used as a specific tool in early diagnosis and deciding appropriate management of PIH

Food spectrum and dietary preferences of the Indian anchovy Stolephorus indicus (van Hasselt, 1823) from Thiruvananthapuram coast, Kerala

The food preferences of the Indian anchovy Stolephorus indicus (van Hasselt, 1823) along the Thiruvananthapuram coast of Kerala was studied for a period of one year from June 2013 to May 2014, dividing the entire period into three seasons as pre-monsoon, monsoon and post-monsoon. A total of 141 samples were collected and the gut contents were analysed. The principal food item was the crustaceans which included copepods, lucifers, mysids, Acetes and amphipods. The other preferred prey items were molluscs (bivalves and gastropods), small fishes, tintinnids and dinoflagellates. The gastrosomatic and stomach fullness indices revealed almost uniform feeding preferences with copepods being the preferred food item throughout the three seasons. Analysis of variance showed significant (p0.05) seasonal variation was observed in the gut contents of S. indicus. Analyses of the different prey indices [prey diversity index (H), niche width indices (B) and prey evenness indices (e)] of S. indicus for the three seasons indicated an almost uniform distribution of prey species throughout the study period which directly indicate the abundance of the prey items and indirectly indicate a stable potential fishery and ecosystem

FORMULATION AND IN VITRO EVALUATION OF DAPAGLIFLOZIN AND SAXAGLIPTIN BILAYERED TABLETS

Dapagliflozin (DG) is a sodium glucose cotransporter-2 (SGLT-2) inhibitor and Saxagliptin (SG) is a dipeptidyl peptidase-4 (DPP-4) inhibitor. The aim of the present work is to formulate a bilayered tablet (BT) of DG as immediate release (IR) layer and SG as sustained release (SR) layer by direct compression method for the effective treatment of type 2 diabetes mellitus. Type and concentration of superdisintegrant among [sodium starch glycolate (SSG)/Lycoat RS720/ Ludiflash] was optimized to enhance the dissolution rate (DR) of DG from the IR layer of BT. Type and concentration of SR polymer among (Carbapol 940/ Karaya gum/ HPMC K15M) was optimized to extend the release of SG up to 12 h with zero order release profile from the SR layer of BT. It was concluded that the optimization of the ratio of SG: SR polymer (HPMC K15M), had significant effect on extending the release profiles of SG. The ratio of SG: HPMC K15M at 1:18 respectively forms a better matrix for the extending the release of SG up to 12 h from the SR layer of BT. The optimized formulation; BT9 [IR9 (6% w/w Ludiflash as superdisintegrant and SR9 (with 60% HPMC K15M as SR polymer)] releases 100% of DG from the IR layer with in 45 min and extends the release of SG up to 12 h with a better zero order release profile (r2=0.994). It passes the accelerated stability studies as per ICH guidelines. A combination of these two classes [SGLT-2 inhibitors (DG) and DPP-4 inhibitors (SG)] of glucose-lowering agents and formulating them as a BT is more effective in the treatment and maintenance of type 2 diabetes mellitus

TO STUDY THE EFFICACY OF AGNIKARMA IN VATAKANTAKA W.S.R.TO PLANTER FASCIITIS

Heel pain symptom is commonly found in 80% of population in the society. Vatakantaka is the painful condition in which the person can’t walk properly, that hampers his daily activity. Almost all signs and symptoms of Vatakantaka resembles with the condition of chronic plantar fasciitis described by the modern texts.Chronic plantar fasciitis is mostly required analgesic and anti-inflammatory and surgical correction to stabilize the patient as well as to cure the condition, but in developing countries such type of treatment modalities were avoided because of Complications of NSAID, pain, fear and other psychological factors, longer hospitalization and also economical expenses. So there is scope for non surgical treatment modalities with less economical expenditure as well as minimum hospitalization. Agnikarma has Shulahara, Shothahara and Vatahara properties, less painful with minimum expenditure. Hence it can be proved as a most affordable and convenient parasurgical treatment modalities in the developing countries which can provide relevant treatment modalities in medical sciences. In the present study in dependable variables are Agnikarma and Inj. Therapy while dependable variables are Vedana, Stambha, Sparashasahatva, Kriyahani and demographic variables are age, sex, religion, habitat, Prakruti, diet etc.The present study designed as a prospective randomized control single blind clinical trial with hypothesis that, Agnikarna acts as Shulahara, Shothahara and Parasurgical properties in management of Vatakantak. In the present study, 60 patients of Vatakantak will be selected & randomly categorized in to 2 groups, each of comprising 30 Patients. and following hypothesis should be considered. Agnikarma acts as a Shulahara, Shothahara and Parasurgical properties in management of Vatakantak. Result of present study shows significant result in Vatakantak to cure as well as prevent recurrences of the condition

A Study of Reproductive Morbidities among Women Reporting to Primary and Tertiary Care Centres in and around Delhi

Purpose: To assess reproductive morbidities among women reporting to a tertiary and a primary health centres in and around Delhi, India. Methods: 581 women (388 were from Safdarjung Hospital and 193 from the Primary Health Centre in Najafgarh) of all age groups who attended the gynecological out-patient departments at both centres were interviewed using a structured questionnaire comprising of questions relating to general socio-demographic information and the reasons for coming to the centre and examined. These were categorized into gynecological, obstetrical or contraceptive after obtaining a detailed history. Results: The frequency of reproductive morbidities in the present study was observed to be quite high with gynecological conditions being the most common (88.64%), followed by obstetric (65.93%) and contraceptive (11.53%) morbidities. Conclusion: Gynaecological conditions were the major reasons while the women visited the healthcare facilities. Early identification of RTIs and other types of morbidities needs to be encouraged through regular check-ups. The antenatal clinics also need to be strengthened in order to ensure better obstetric health care.Keywords: Contraceptive, Gynecology, Morbidity, Obstetrics, RTI

Alternative management in a case of placenta accreta with previous caesarean

The rate of caesarean is increasing day by day, and with it the chance of repeat caesarean. This has led to a rise in the chance of occurrence of placenta accreta. Control of bleeding is the main goal in such cases, which usually necessitates hysterectomy. But alternative methods are useful when retaining fertility is important. We present this case of a 30 yr old female who was admitted as a case of central placenta previa with previous caesarean. Per operatively, placenta was attached along the incision and baby was delivered by separating the placenta attached above the upper margin of incision. On attempting to remove the placenta attached to lower part of incision, it was found to be adherent along the previous scar. So placenta was removed piece meal, some part was left behind. Box sutures were taken over that part and uterine packing was done to control the bleeding. Post operatively the patient was fine and given injection Methotrexate on 8th day following the regime of 1, 3, 5, 7 days. She failed to expulse the placenta by 6wks, so D&E was done and retained products were removed. Leaving the placenta in situ followed by Methotrexate and interval removal of placenta can thus be helpful in conserving the uterus and hence, the fertility

Immediate and long-term results of bronchial artery embolisation for life-threatening hemoptysis in bronchiectasis

Background: Bronchial artery embolization (BAE) has been established as an effective technique in the emergency treatment of life-threatening hemoptysis, but few data concerning long-term results of the procedure are available The aim of this study was to analyze the immediate and long-term results of bronchial artery embolization (BAE) for hemoptysis due to bronchiectasis.Methods: Twenty five patients (aged 28–76 years) who underwent bronchial artery embolization with polyvinyl alcohol particles, gelatin sponge and coil for massive or continuing moderate hemoptysis caused by bronchiectasis were included in the study. These patients were followed up for 3 years. Initially patients were followed up monthly for 6months by clinical examination. Then yearly follow up by clinical and radiological examination. Results analyzed using SPSS 16 version.Results: In our study16 patients (64%) were males. 11 patients (44%) had bilateral bronchiectasis.14 patients (56%) had no rebleeding in the three year follow-up period. Only 8% developed rebleeding within 24hrs.Only one patient (4%) developed massive hemoptysis within one month and died. Other rebleed were very minimal. In our study there was no significant relation with side of bronchiectasis and rebleed.Conclusions: Bronchial artery embolisation can yield immediate and long-term benefit in patients with hemoptysis due to bronchiectasis.

A Web-based interactive Student Advising system using Java frameworks

The use of open source frameworks and tools has become popular in Java development. These frameworks and tools have core strengths and weaknesses and are selected accordingly for development. Consequently, one of the key issues that developers face is to integrate and configure these tools together. This paper demonstrates the use of popular Java frameworks and tools to develop a Web-based interactive Student Registration and Advising system

Prevalence of diabetes mellitus in tuberculosis patients: a hospital based study

Background: Screening of high risk individuals with weak immunity as in diabetics for active tuberculosis is of great public health importance. The prevalence of diabetes in tuberculosis is high and the data regarding the same is necessary for strengthening TB control activities.Methods: This study was conducted to know the prevalence of diabetes mellitus in tuberculosis patients diagnosed from the hospital. This was a hospital based descriptive study conducted in Department of Respiratory medicine, Academy of Medical Sciences, Northern Kerala in association with DOTS center during a one year period from August 2014 to July 2015. All patients diagnosed as a case of tuberculosis from our institution were included for the study. All patients were screened for diabetes mellitus using Fasting Plasma Glucose value. Additional information regarding age, body mass index (BMI), sputum smear positivity and treatment category of tuberculosis were collected.Results: There was a higher prevalence of diabetes in tuberculosis patients than in general population and the rate was found to be 19.6%. There was a statistically significant association of diabetes with older age, higher BMI and sputum positivity.Conclusions: Routine screening for diabetes needs to be intensified in the community and more importantly in Tuberculosis patients.