The effectiveness of the question and answer relationship (QAR) strategy in enhancing reading comprehension among ESL students. (1st. 24 pages)

The purpose of this study was to analyse whether the Question and Answer Relationship (QAR) strategy is effective in enhancing the reading comprehension performance of upper secondary, English as a Second Language (ESL) students of low English proficiency (LEP). A quasi-experimental pre-test post-test non-equivalent control group research design was employed in this quantitative study. Two intact Form Four classes in a rural secondary school were used as the experimental (35 students) and control groups (32 students). Explicit strategy instruction of QAR was conducted over six weeks for the experimental group while the control group was taught using the traditional method. Results of the pre and post-tests were statistically analysed using One-way ANOVA, Repeated measures ANOVA and 95% confidence intervals. Significant improvements in marks were found in the experimental group for three variables namely, the subjective reading comprehension questions and summary as a whole, ‘In my Head’ questions and the summary question. For the subjective reading comprehension questions, the result was inconclusive while for ‘In the Book’ questions, there was no significant improvement in both the experimental and control groups. Based on the results, it was concluded that explicit cognitive strategy instruction was effective in enhancing reading comprehension performance to a large extent. However, limited vocabulary seems to have hindered LEP students from locating the appropriate answers in the text for ‘In the Book’ questions. Therefore, this study found that in order to be fully effective, the QAR strategy should ideally be taught together with strategies that increase the vocabulary of LEP students. (Author's abstract

The outsider figure in Lewis Nkosi's Mating birds and Underground People.

Thesis (M.A)-University of Durban Westville, 2005.This thesis will examine the trope of the outsider figure in Lewis Nkosi's two novels, Mating Birds (1986) and Underground People (2002). Since both novels are set in South Africa and are informed by the political context of this country at particular junctures, the thesis will focus on the. effects of apartheid on the two black protagonists - central characters yet 'outsider figures' - in these novels. This thesis will argue that Lewis Nkosi's own position as an 'outsider figure' in South African letters plays an important function in his writing. In support of this point, I will therefore also refer to his non fictional books, Home and Exile and Other Selections (1965) and Tasks and Masks: themes and styles of African Literature (1981). These books are particularly important because they document Nkosi's comments on South African literature and his position as the 'outsider' acerbic critic. Nkosi can be seen as an outsider figure being a young, black South African living in an apartheid South Africa, and also, later, as a writer in exile. I have chosen Mating Birds and Underground People to illustrate my argument because they are not simply 'protest' novels, (in the sense Nkosi argued in Home and Exile and Tasks and Masks that so much black South African literature of a certain era was), but rather they examine the complex effects of exclusion, with regard to race and politics, on the individual. As the 'outsider' figure found full expression in French existentialist writing, I will also look at constructions of the outsider figure from an existentialist perspective. In his preface to the 2002 edition of Mating Birds, Nkosi reveals that the novel was to a large extent influenced by Albert Camus' The Outsider (1942). In writing The Outsider, Camus explores questions raised by the philosophy of existentialism. Similarly, Nkosi looks at black existence in a hostile apartheid environment, the absurdity of Sibiya's predicament and how he came to be there. He also explores the harshness of the physical environment which is a literal representation of Sibiya's anguish. Postcolonial analysis of 'othering', a logical extension of existentialism's 'outsider' figure will be used to support my argument. Mating Birds (1986), among other accolades, won the prestigious Macmillan International Pen Prize. Set between the 1950's and 1960's, it explores the divisions and prejudices that were experienced between white and black in a country steeped in racism and division. It deals primarily with the obsession an educated, young, black man, Ndi Sibiya, has for a white woman, Veronica Slater. Their illicit sexual relationship results in Sibiya being tried and convicted, by a white court, for rape. Underground People (2002), Nkosi's second novel, set in the late 1980's and early 1990's, takes the reader into the world of politics and underground resistance during the apartheid regime in South Africa. It narrates the adventures of Cornelius Molapo, an awkward member of the "National Liberation Movement", the fictional name of the African National Congress. Chapter One of this mini-dissertation will focus on a definition and exploration of the outsider figure in selected literary and theoretical works. Chapter Two will focus on the life and works of Lewis Nkosi in an effort to link the trope of the outsider figure to Nkosi's own life experience. His books, Tasks and Masks and Home and Exile, both collections of essays, help the reader to develop a picture of Nkosi, not only as a writer but also as a literary critic whose writing developed while in exile. Chapter Three and Four will provide a literary analysis of Mating Birds and Underground People, respectively. The analysis will deal with the outsider figure as a prominent feature of both these novels. Post-colonial analyses such as forwarded by Edward Said, Gayatri Spivak and Homi Bhabha will be used to advance the thesis. The conclusion (Chapter Five) will refer briefly to Nkosi's current writing projects and situate them in the post-apartheid South African context. An assessment of the on-going potential for the 'outsider' figure in Nkosi's contemporary work will be made

Wettability Gradients on Soft Surfaces

Properties, behaviors, and applications of soft materials depend decisively on the characteristics of their surfaces. Physical features and chemical functionality of the soft surfaces control their interactions with the surroundings thereby deciding their responses to various physical and chemical phenomena. A gradient of such surface features i.e, a gradual change in a chemical or physical characteristic across a surface will result in a gradual change in the response of the surface to its surroundings in the same direction. Chemical as well as physical (morphological) gradients on soft surface enable useful properties pertinent to a variety of fields such as microfluidics, surface coatings, sensing, optics, and biology. Numerous methods have been used for the preparation of chemical as well as morphological gradients. Practical applications of soft surface gradients require stable large-scale surfaces with precisely controlled directionality and resolution of the gradients. Wettability gradients are one of the prominent classes of gradients created on soft surfaces. These gradients are constituted by gradual increase or decrease of hydrophobicity/hydrophilicity across a surface. One-dimensional (1D) as well as two-dimensional (2D) wettability gradients are fabricated with different patterns. This short review will summarize the advancements in the preparation, properties, and applications of wettability gradients on soft surfaces. Qualitative description of the fabrication processes, properties, and practical applications of the gradients are included along with our comments about the future prospects of these systems.&nbsp

Hepatic lipid peroxidation and cytochrome P-450 2E1 in pediatric nonalcoholic fatty liver disease and its subtypes

GOAL: To compare hepatic lipid peroxidation and cytochrome P-450 2E1 (CYP2E1) protein content in liver biopsies from children with nonalcoholic fatty liver disease (NAFLD) and 2 control groups. BACKGROUND: Elevated hepatic lipid peroxidation resulting from increased hepatic CYP2E1 enzyme activity is involved in the pathogenesis of NAFLD and nonalcoholic steatohepatitis (NASH) in adults, but studies in children are lacking. STUDY: Liver biopsies from 59 children with NAFLD (49 with NASH), 10 children with normal liver histology, and 9 children with mild chronic hepatitis C (HCV) infection were examined. Hepatic malondialdehyde (a measure of lipid peroxidation) levels and CYP2E1 protein content were quantitated, as a percentage of the total area, by immunohistochemical staining of liver biopsy material followed by digital image quantitation. RESULTS: Lipid peroxidation was significantly greater in NAFLD liver biopsies (46.7 ± 20.8%) compared with biopsies from children with normal liver histology (7.6 ± 9.4%; P<0.001) or HCV infection (7.7 ± 7.6%; P<0.001). However, hepatic CYP2E1 expression was not different across the NAFLD, normal liver histology, and HCV groups (60.7 ± 8.7%, 53.5 ± 10.7%, and 60.0 ± 11.9%, respectively; P=0.116). Among children with NAFLD, lipid peroxidation and CYP2E1 protein content did not differ between biopsies with and without NASH. Body mass index was independently associated with hepatic lipid peroxidation levels (r=0.549; P<0.001). CONCLUSIONS: Hepatic lipid peroxidation is increased in children with NAFLD but this is not related to hepatic CYP2E1 expression. No difference in lipid peroxidation in pediatric NAFLD versus NASH argues against a role in disease progression

A Novel Dimer-Tetramer Transition Captured by the Crystal Structure of the HIV-1 Nef

HIV-1 Nef modulates disease progression through interactions with over 30 host proteins. Individual chains fold into membrane-interacting N-terminal and C-terminal core (Nefcore) domains respectively. Nef exists as small oligomers near membranes and associates into higher oligomers such as tetramers or hexadecamers in the cytoplasm. Earlier structures of the Nefcore in apo and complexed forms with the Fyn-kinase SH3 domain revealed dimeric association details and the role of the conserved PXXP recognition motif (residues 72–78) of Nef in SH3-domain interactions. The crystal structure of the tetrameric Nef reported here corresponds to the elusive cytoplasmic stage. Comparative analyses show that subunits of Nefcore dimers (open conformation) swing out with a relative displacement of ∼22 Å and rotation of ∼174° to form the ‘closed’ tetrameric structure. The changes to the association are around Asp125, a conserved residue important for viral replication and the important XR motif (residues 107–108). The tetramer associates through C4 symmetry instead of the 222 symmetry expected when two dimers associate together. This novel dimer-tetramer transition agrees with earlier solution studies including small angle X-ray scattering, analytical ultracentrifugation, dynamic laser light scattering and our glutaraldehyde cross-linking experiments. Comparisons with the Nefcore—Fyn-SH3 domain complexes reveal that the PXXP motif that interacts with the SH3-domain in the dimeric form is sterically occluded in the tetramer. However the 151–180 loop that is distal to the PXXP motif and contains several protein interaction motifs remains accessible. The results suggest how changes to the oligomeric state of Nef can help it distinguish between protein partners

Venous air embolisms and sitting position in Helsinki pineal region surgery

Peer reviewe

The key complications of hemophilia and recent advancements in their management: an update

Hemophilia A is an X-linked recessive disorder which is due to factor VIII deficiency. It is a life-threatening coagulation disorder leading to complications including hemophilic-arthropathy, development of inhibitors, transfusion-related infections and profound psychosocial impact on the life of the patients. The aim of this study is to analyze the challenges in complications and the latest advancements in managing those complications. A thorough and systemic literature review was done to fulfill the objective of this study. The emergence of hemophilic arthropathy due to repeated symptoms of hemarthrosis is the most frequent complication found in haemophiliacs. Another critical complication, mainly seen in resource-poor settings is the development of lethal and severe bleeding episodes including episodes of intracranial hemorrhage. The development of inhibitors is another major challenge which often adds profoundly to the financial burden faced by hemophilia patients. Another major challenge is acquiring various transfusion-transmitted infections which was particularly more common few decades back. Studies also have revealed that there are myriads of significant psychosocial effects affecting the quality of life of hemophiliacs. Emerging treatments such as gene therapy, non-clotting factor concentrate products and extended half-life therapy can usher a new era in the management and the quality of life in hemophilia patients

Paradoxical lucidity: A potential paradigm shift for the neurobiology and treatment of severe dementias

Unexpected cognitive lucidity and communication in patients with severe dementias, especially around the time of death, have been observed and reported anecdotally. Here, we review what is known about this phenomenon, related phenomena that provide insight into potential mechanisms, ethical implications, and methodologic considerations for systematic investigation. We conclude that paradoxical lucidity, if systematically confirmed, challenges current assumptions and highlights the possibility of networkâ level return of cognitive function in cases of severe dementias, which can provide insight into both underlying neurobiology and future therapeutic possibilities.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/153062/1/alzjjalz201904002.pd

Vulnerability-Based Spatial Sampling Stratification for the National Children\u27s Study, Worcester County, Massachusetts: Capturing Health-Relevant Environmental and Sociodemographic Variability

Background: The National Children\u27s Study is the most ambitious study ever attempted in the United States to assess how environmental factors impact child health and development. It aims to follow 100,000 children from gestation until 21 years of age. Success requires breaking new interdisciplinary ground, starting with how to select the sample of \u3e 1,000 children in each of 105 study sites; no standardized protocol exists for stratification of the target population by factoring in the diverse environments it inhabits. Worcester County, Massachusetts, like other sites, stratifies according to local conditions and local knowledge, subject to probability sampling rules.Objectives: We answer the following questions: How do we divide Worcester County into viable strata that represent its health-relevant environmental and sociodemographic heterogeneity, subject to sampling rules? What potential does our approach have to inform stratification at other sites?Results: We developed a multivariable, vulnerability-based method for spatial sampling consisting of two descriptive indices: a hazards/stressors exposure index (comprising three proxy variables), and an adaptive capacity/sociodemographic character index (five variables). Multivariable, health-relevant stratification at the start of the study may improve detection power for environment-child health associations down the line. Eighteen strata capture countywide heterogeneity in the indices and have optimal relative homogeneity within each. They achieve comparable expected birth counts and conform to local concepts of space. Conclusion: The approach offers moderate to high potential to inform other sites, limited by intersite differences in data availability, geodemographics, and technical capacity. Energetic community engagement from the start promotes local stratification coherence, plus vital researcher-community trust and co-ownership for sustainability

Praying Sitting Position for Pineal Region Surgery : An Efficient Variant of a Classic Position in Neurosurgery

BACKGROUND: The sitting position has lost favor among neurosurgeons partly owing to assumptions of increased complications, such as venous air embolisms and hemodynamic disturbances. Moreover, the surgeon must assume a tiring posture. We describe our protocol for the "praying position" for pineal region surgery; this variant may reduce some of the risks of the sitting position, while providing a more ergonomic surgical position. METHODS: A retrospective review of 56 pineal lesions operated on using the praying position between January 2008 and October 2015 was performed. The praying position is a steeper sitting position with the upper torso and the head bent forward and downward. The patient's head is tilted about 30 degrees making the tentorium almost horizontal, thus providing a good viewing angle. G-suit trousers or elastic bandages around the lower extremities are always used. RESULTS: Complete lesion removal was achieved in 52 cases; subtotal removal was achieved in 4. Venous air embolism associated with persistent hemodynamic changes was nonexistent in this series. When venous air embolism was suspected, an immediate reaction based on good teamwork was imperative. No cervical spine cord injury or peripheral nerve damage was reported. The microsurgical time was CONCLUSIONS: A protocolized praying position that includes proper teamwork management may provide a simple, fast, and safe approach for proper placement of the patient for pineal region surgery.Peer reviewe