Toward a More realistic Evaluation of the United Nations

ITALIACopia digital. Madrid : Ministerio de Educación, Cultura y Deporte, 201

High speed flight vehicle control Patent

Supersonic or hypersonic vehicle control system comprising elevons with hinge line sweep and free of adverse aerodynamic cross couplin

Financial Risk, Innovation and Alternative Pathways to Decarbonising the Energy System in 2050

There is a lot of forward looking work attempting to envisage the decarbonised energy system of the future as reflected with current interest in 'smart grids'. A central tenet behind most visions of the 'smart grids' of the future are the price signals that financial and commodity markets will deliver to facilitate effective and efficient resource allocation. Most of these visions take stylised and static views of financial and commodity markets despite the fact that these markets are experiencing dramatic change due to innovation and regulation. Accordingly, the paper maps the risks associated in the fusion of financial innovation with innovation in the energy system through a theoretical framework that draws on evolutionary models of paradigm shift. Risks to both the financial and energy systems are characterised as either emanating from primary or secondary markets and these are explored in terms of alternative visions of the energy system in the long run

The Changing Structure of Arkansas\u27 Economy: A Shift-Share Analysis

The state of Arkansas enjoys the advantages of its unique central location in the nation, excellent natural surroundings, low cost of living, and one of the best business climates in the southern United States. It is home to several of the largest corporations in the world. Over the period 1980-2000, there was tremendous growth in the state’s economy. However, the growth was confined to specific regions that led to several socio-economic issues adversely affecting the state. To better understand the components and variations in economic growth, a county-wise shift-share analysis was conducted. Employment, a good indicator of economic growth, was used to analyze the changes in the local economic structure of the 75 counties in the state. Findings suggest that while services and retail trade continue to grow, manufacturing and the state/local government continue to be important employers for the state. Farm employment continues to decline, although farm-related manufacturing and services are becoming more important. This report provides a sectoral analysis of employment changes within the counties and is a potential point of reference for both government and industry engaged in community-level policy making and investment

Metabolism of formycin B by Leishmania amastigotes in vitro. Comparative metabolism in infected and uninfected human macrophages.

Formycin B is metabolized by cutaneous Leishmania amastigotes within cultured human macrophages to give formycin B 5'-monophosphate and formycin A 5'-mono-, di-, and triphosphates. Formycin A is also incorporated into RNA. The activity of formycin B against amastigotes was correlated with the levels of formycin A metabolites formed in the parasites. Uninfected macrophages also convert formycin B into the same products, but the levels are markedly lower than those seen in infected macrophages. The results suggest that a sufficient therapeutic index exists to warrant consideration of formycin B as an anti-leishmanial drug in humans

Causes and biophysical consequences of cellulose production by Pseudomonas fluorescens SBW25 at the air-liquid interface

Cellulose over-producing wrinkly spreader mutants of Pseudomonas fluorescens SBW25 have been the focus of much investigation, but conditions promoting the production of cellulose in ancestral SBW25, its effects and consequences have escaped in-depth investigation through lack of in vitro phenotype. Here, using a custom built device, we reveal that in static broth microcosms ancestral SBW25 encounters environmental signals at the air-liquid interface that activate, via three diguanylate cyclase-encoding pathways (Wsp, Aws and Mws), production of cellulose. Secretion of the polymer at the meniscus leads to modification of the environment and growth of numerous micro-colonies that extend from the surface. Accumulation of cellulose and associated microbial growth leads to Rayleigh-Taylor instability resulting in bioconvection and rapid transport of water-soluble products over tens of millimetres. Drawing upon data we build a mathematical model that recapitulates experimental results and captures the interactions between biological, chemical and physical processes.IMPORTANCE This work reveals a hitherto unrecognized behaviour that manifests at the air-liquid interface, which depends on production of cellulose, and hints to undiscovered dimensions to bacterial life at surfaces. Additionally, the study links activation of known diguanylate cyclase-encoding pathways to cellulose expression and to signals encountered at the meniscus. Further significance stems from recognition of the consequences of fluid instabilities arising from surface production of cellulose for transport of water-soluble products over large distances

Neutron moderation in supercritical water-theory and experimental design

Imperial Users onl