DYNAMICS OF COMPOSITE MATERIALS CUTTING

S u m m a r y The paper presents stability analysis of milling process of epoxide polymer composite material with carbon fibres. In order to determine zones of stable milling , times series of cutting forces are applied. Next, recurrence quantification analysis is conducted which can define three stability indexes: recurrence rate, ratio of recurrence rate to determinism, and recurrence time. Finally, stability lobs diagram for the composite material is proposed. Keywords: milling stability, recurrence quantification analysis Dynamika skrawania materiałów kompozytowych S t r e s z c z e n i e W pracy zaprezentowano wyniki badania stabilności procesu frezowania kompozytu epoksydowo--polimerowego wzmacnianego włóknem węglowym. Określono obszary skrawania stabilnego. Prowadzono analizę przebiegów czasowych sił skrawania opartą na kwantyfikatorach wykresów rekurencyjnych. Stosowano trzy z nich: recurrence rate, proporcję recurrence rate i determinizmu oraz czas rekurencji. Opracowano wykres stabilności frezowania materiału kompozytowego. Słowa kluczowe: stabilność frezowania, wykresy rekurencyjn

Chatter identification in milling of Inconel 625 based on recurrence plot technique and Hilbert vibration decomposition

In the paper a cutting stability in the milling process of nickel based alloy Inconel 625 is analysed. This problem is often considered theoretically, but the theoretical finding do not always agree with experimental results. For this reason, the paper presents different methods for instability identification during real machining process. A stability lobe diagram is created based on data obtained in impact test of an end mill. Next, the cutting tests were conducted in which the axial cutting depth of cut was gradually increased in order to find a stability limit. Finally, based on the cutting force measurements the stability estimation problem is investigated using the recurrence plot technique and Hilbert vibration decomposition method

Perspectives for 3D-Bioprinting in Modeling of Tumor Immune Evasion

In a living organism, cancer cells function in a specific microenvironment, where they exchange numerous physical and biochemical cues with other cells and the surrounding extracellular matrix (ECM). Immune evasion is a clinically relevant phenomenon, in which cancer cells are able to direct this interchange of signals against the immune effector cells and to generate an immunosuppressive environment favoring their own survival. A proper understanding of this phenomenon is substantial for generating more successful anticancer therapies. However, classical cell culture systems are unable to sufficiently recapture the dynamic nature and complexity of the tumor microenvironment (TME) to be of satisfactory use for comprehensive studies on mechanisms of tumor immune evasion. In turn, 3D-bioprinting is a rapidly evolving manufacture technique, in which it is possible to generate finely detailed structures comprised of multiple cell types and biomaterials serving as ECM-analogues. In this review, we focus on currently used 3D-bioprinting techniques, their applications in the TME research, and potential uses of 3D-bioprinting in modeling of tumor immune evasion and response to immunotherapies

Rekomendacje Polskich Towarzystw Naukowych „Diagnostyka i leczenie raka tarczycy”. Aktualizacja na rok 2018

Significant advances have been made in thyroid can­cer research in recent years, therefore relevant clinical guidelines need to be updated. The current Polish guidelines “Diagnostics and Treatment of Thyroid Carcinoma” have been formulated at the “Thyroid Cancer and Other Malignancies of Endocrine Glands” conference held in Wisła in November 2015 [1].Gwałtowny postęp, dokonujący się w ostatnich latach w badaniach nad rakiem tarczycy spowodował, że konieczne jest aktualizowanie bieżących rekomendacji klinicznych. Obowiązujące dotychczas Rekomendacje „Diagnostyka i leczenie raka tarczycy” zostały ustalone na Konferencji „Rak Tarczycy” w Wiśle w listopadzie 2015 roku [1]