CL-MAE: Curriculum-Learned Masked Autoencoders

Masked image modeling has been demonstrated as a powerful pretext task for generating robust representations that can be effectively generalized across multiple downstream tasks. Typically, this approach involves randomly masking patches (tokens) in input images, with the masking strategy remaining unchanged during training. In this paper, we propose a curriculum learning approach that updates the masking strategy to continually increase the complexity of the self-supervised reconstruction task. We conjecture that, by gradually increasing the task complexity, the model can learn more sophisticated and transferable representations. To facilitate this, we introduce a novel learnable masking module that possesses the capability to generate masks of different complexities, and integrate the proposed module into masked autoencoders (MAE). Our module is jointly trained with the MAE, while adjusting its behavior during training, transitioning from a partner to the MAE (optimizing the same reconstruction loss) to an adversary (optimizing the opposite loss), while passing through a neutral state. The transition between these behaviors is smooth, being regulated by a factor that is multiplied with the reconstruction loss of the masking module. The resulting training procedure generates an easy-to-hard curriculum. We train our Curriculum-Learned Masked Autoencoder (CL-MAE) on ImageNet and show that it exhibits superior representation learning capabilities compared to MAE. The empirical results on five downstream tasks confirm our conjecture, demonstrating that curriculum learning can be successfully used to self-supervise masked autoencoders

Self-Supervised Predictive Convolutional Attentive Block for Anomaly Detection

Anomaly detection is commonly pursued as a one-class classification problem, where models can only learn from normal training samples, while being evaluated on both normal and abnormal test samples. Among the successful approaches for anomaly detection, a distinguished category of methods relies on predicting masked information (e.g. patches, future frames, etc.) and leveraging the reconstruction error with respect to the masked information as an abnormality score. Different from related methods, we propose to integrate the reconstruction-based functionality into a novel self-supervised predictive architectural building block. The proposed self-supervised block is generic and can easily be incorporated into various state-of-the-art anomaly detection methods. Our block starts with a convolutional layer with dilated filters, where the center area of the receptive field is masked. The resulting activation maps are passed through a channel attention module. Our block is equipped with a loss that minimizes the reconstruction error with respect to the masked area in the receptive field. We demonstrate the generality of our block by integrating it into several state-of-the-art frameworks for anomaly detection on image and video, providing empirical evidence that shows considerable performance improvements on MVTec AD, Avenue, and ShanghaiTech. We release our code as open source at https://github.com/ristea/sspcab.Comment: Accepted at CVPR 2022. Paper + supplementary (14 pages, 9 figures

Development of HDAC Inhibitors Exhibiting Therapeutic Potential in T-Cell Prolymphocytic Leukemia

Epigenetic targeting has emerged as an efficacious therapy for hematological cancers. The rare and incurable T-cell prolymphocytic leukemia (T-PLL) is known for its aggressive clinical course. Current epigenetic agents such as histone deacetylase (HDAC) inhibitors are increasingly used for targeted therapy. Through a structure-activity relationship (SAR) study, we developed an HDAC6 inhibitor KT-531, which exhibited higher potency in T-PLL compared to other hematological cancers. KT-531 displayed strong HDAC6 inhibitory potency and selectivity, on-target biological activity, and a safe therapeutic window in nontransformed cell lines. In primary T-PLL patient cells, where HDAC6 was found to be overexpressed, KT-531 exhibited strong biological responses, and safety in healthy donor samples. Notably, combination studies in T-PLL patient samples demonstrated KT-531 synergizes with approved cancer drugs, bendamustine, idasanutlin, and venetoclax. Our work suggests HDAC inhibition in T-PLL could afford sufficient therapeutic windows to achieve durable remission either as standalone or in combination with targeted drugs.Peer reviewe

Fifth European Dirofilaria and Angiostrongylus Days (FiEDAD) 2016

Peer reviewe

A922 Sequential measurement of 1 hour creatinine clearance (1-CRCL) in critically ill patients at risk of acute kidney injury (AKI)

Meeting abstrac

Nurses' perceptions of aids and obstacles to the provision of optimal end of life care in ICU

Contains fulltext : 172380.pdf (publisher's version ) (Open Access

CL-MAE: Curriculum-Learned Masked Autoencoders

Masked image modeling has been demonstrated as a powerful pretext task for generating robust representations that can be effectively generalized across multiple downstream tasks. Typically, this approach involves randomly masking patches (tokens) in input images, with the masking strategy remaining unchanged during training. In this paper, we propose a curriculum learning approach that updates the masking strategy to continually increase the complexity of the self-supervised reconstruction task. We conjecture that, by gradually increasing the task complexity, the model can learn more sophisticated and transferable representations. To facilitate this, we introduce a novel learnable masking module that possesses the capability to generate masks of different complexities, and integrate the proposed module into masked autoencoders (MAE). Our module is jointly trained with the MAE, while adjusting its behavior during training, transitioning from a partner to the MAE (optimizing the same reconstruction loss) to an adversary (optimizing the opposite loss), while passing through a neutral state. The transition between these behaviors is smooth, being regulated by a factor that is multiplied with the reconstruction loss of the masking module. The resulting training procedure generates an easy-to-hard curriculum. We train our Curriculum-Learned Masked Autoencoder (CL-MAE) on ImageNet and show that it exhibits superior representation learning capabilities compared to MAE. The empirical results on five downstream tasks confirm our conjecture, demonstrating that curriculum learning can be successfully used to self-supervise masked autoencoders. We release our code at https://github.com/ristea/cl-mae

Self-supervised masked convolutional transformer block for anomaly detection

Anomaly detection has recently gained increasing attention in the field of computer vision, likely due to its broad set of applications ranging from product fault detection on industrial production lines and impending event detection in video surveillance to finding lesions in medical scans. Regardless of the domain, anomaly detection is typically framed as a one-class classification task, where the learning is conducted on normal examples only. An entire family of successful anomaly detection methods is based on learning to reconstruct masked normal inputs (e.g. patches, future frames, etc.) and exerting the magnitude of the reconstruction error as an indicator for the abnormality level. Unlike other reconstruction-based methods, we present a novel self-supervised masked convolutional transformer block (SSMCTB) that comprises the reconstruction-based functionality at a core architectural level. The proposed self-supervised block is extremely flexible, enabling information masking at any layer of a neural network and being compatible with a wide range of neural architectures. In this work, we extend our previous self-supervised predictive convolutional attentive block (SSPCAB) with a 3D masked convolutional layer, a transformer for channel-wise attention, as well as a novel self-supervised objective based on Huber loss. Furthermore, we show that our block is applicable to a wider variety of tasks, adding anomaly detection in medical images and thermal videos to the previously considered tasks based on RGB images and surveillance videos. We exhibit the generality and flexibility of SSMCTB by integrating it into multiple state-of-the-art neural models for anomaly detection, bringing forth empirical results that confirm considerable performance improvements on five benchmarks