1,613 research outputs found
Predictions for Impurity-Induced Tc Suppression in the High-Temperature Superconductors
We address the question of whether anisotropic superconductivity is
compatible with the evidently weak sensitivity of the critical temperature Tc
to sample quality in the high-Tc copper oxides. We examine this issue
quantitatively by solving the strong-coupling Eliashberg equations numerically
as well as analytically for s-wave impurity scattering within the second Born
approximation. For pairing interactions with a characteristically low energy
scale, we find an approximately universal dependence of the d-wave
superconducting transition temperature on the planar residual resistivity which
is independent of the details of the microscopic pairing. These results, in
conjunction with future systematic experiments, should help elucidate the
symmetry of the order parameter in the cuprates.Comment: 13 pages, 4 figures upon request, revtex version
Identification of epidermal Pdx1 expression discloses different roles of Notch1 and Notch2 in murine KrasG12D-induced skin carcinogenesis in vivo
Background
The Ras and Notch signaling pathways are frequently activated during development to control many diverse cellular processes and are often dysregulated during tumorigenesis. To study the role of Notch and oncogenic Kras signaling in a progenitor cell population, Pdx1-Cre mice were utilized to generate conditional oncogenic KrasG12D mice with ablation of Notch1 and/or Notch2.
Methodology/Principal Findings
Surprisingly, mice with activated KrasG12D and Notch1 but not Notch2 ablation developed skin papillomas progressing to squamous cell carcinoma providing evidence for Pdx1 expression in the skin. Immunostaining and lineage tracing experiments indicate that PDX1 is present predominantly in the suprabasal layers of the epidermis and rarely in the basal layer. Further analysis of keratinocytes in vitro revealed differentiation-dependent expression of PDX1 in terminally differentiated keratinocytes. PDX1 expression was also increased during wound healing. Further analysis revealed that loss of Notch1 but not Notch2 is critical for skin tumor development. Reasons for this include distinct Notch expression with Notch1 in all layers and Notch2 in the suprabasal layer as well as distinctive p21 and β-catenin signaling inhibition capabilities.
Conclusions/Significance
Our results provide strong evidence for epidermal expression of Pdx1 as of yet not identified function. In addition, this finding may be relevant for research using Pdx1-Cre transgenic strains. Additionally, our study confirms distinctive expression and functions of Notch1 and Notch2 in the skin supporting the importance of careful dissection of the contribution of individual Notch receptors
Exchange Instabilities in Semiconductor Double Quantum Well Systems
We consider various exchange-driven electronic instabilities in semiconductor
double-layer systems in the absence of any external magnetic field. We
establish that there is no exchange-driven bilayer to monolayer charge transfer
instability in the double-layer systems. We show that, within the unrestricted
Hartree-Fock approximation, the low density stable phase (even in the absence
of any interlayer tunneling) is a quantum ``pseudospin rotated'' spontaneous
interlayer phase coherent spin-polarized symmetric state rather than the
classical Ising-like charge-transfer phase. The U(1) symmetry of the double
quantum well system is broken spontaneously at this low density quantum phase
transition, and the layer density develops quantum fluctuations even in the
absence of any interlayer tunneling. The phase diagram for the double quantum
well system is calculated in the carrier density--layer separation space, and
the possibility of experimentally observing various quantum phases is
discussed. The situation in the presence of an external electric field is
investigated in some detail using the
spin-polarized-local-density-approximation-based self-consistent technique and
good agreement with existing experimental results is obtained.Comment: 24 pages, figures included. Also available at
http://www-cmg.physics.umd.edu/~lzheng/preprint/ct.uu/ . Revised final
version to appear in PR
Intentional and unintentional medication nonadherence in psoriasis: the role of patients’ medication beliefs and habit strength [abstract only]
The accurate diagnosis of psoriasis has remained a challenge, as no disease-specific biomarkers have yet been identified. Currently, the diagnosis of chronic inflammatory diseases relies mainly on the assessment of visible symptoms or the histological features of the biopsy. This approach is heavily reliant on the experience of the clinician and, therefore, may lead to misdiagnosis as there are numerous different chronic inflammatory skin diseases that may present similar clinical features. Hence, the need for diagnostic biomarkers is clear. Although different investigations have reported the discovery of potential psoriasis biomarkers, still no accurate and reliable biomarker is available. Rather than searching for a single valid biomarker, we propose that applying a multicomponent bio-marker-based approach would result in a higher degree of success and translation into clinical practice. An extensive review of published studies to identify the most relevant psoriasis-specific biomarker candidates was conducted. This led us to conclude that the expression levels of specific genes in the skin hold the most promise as discriminatory biomarkers, resulting in the selection of five genes, the expression levels of which have been demonstrated to be exclusive for psoriasis vulgaris. We first conducted a preliminary validation study applying support vector machine-based classification and principle component analysis on the skin-derived expression data of 12 patients with psoriasis vulgaris and 12 healthy controls, previously produced in our departments. We then confirmed that the expression levels of the five genes in psoriatic lesions indeed present a unique pattern. Encouraged by these results, we continued to develop a quantitative polymerase chain reaction panel to allow the accurate measurement of expression levels for the five genes to be used in the studies to follow. Although we have yet to confirm these results in the context of other chronic inflammatory skin diseases, the results of previously published studies regarding these five genes are promising. Therefore, we are in the process of collecting additional skin samples from patients with chronic inflammatory disease (including different papulosquamous disorders and atopic dermatitis) to validate the discriminatory power of our panel. These results may further be translated to viable clinical diagnostic tests in the near future. This work was supported by the ERA Chair for Translational Genomics and Personalized Medicine at the University of Tartu
Critical role of endothelial Notch1 signaling in postnatal angiogenesis
Notch receptors are important mediators of cell fate during embryogenesis, but their role in adult physiology, particularly in postnatal angiogenesis, remains unknown. Of the Notch receptors, only Notch1 and Notch4 are expressed in vascular endothelial cells. Here we show that blood flow recovery and postnatal neovascularization in response to hindlimb ischemia in haploinsufficient global or endothelial-specific Notch1(+/-) mice, but not Notch4(-/-) mice, were impaired compared with wild-type mice. The expression of vascular endothelial growth factor (VEGF) in response to ischemia was comparable between wild-type and Notch mutant mice, suggesting that Notch1 is downstream of VEGF signaling. Treatment of endothelial cells with VEGF increases presenilin proteolytic processing, gamma-secretase activity, Notch1 cleavage, and Hes-1 (hairy enhancer of split homolog-1) expression, all of which were blocked by treating endothelial cells with inhibitors of phosphatidylinositol 3-kinase/protein kinase Akt or infecting endothelial cells with a dominant-negative Akt mutant. Indeed, inhibition of gamma-secretase activity leads to decreased angiogenesis and inhibits VEGF-induced endothelial cell proliferation, migration, and survival. Overexpression of the active Notch1 intercellular domain rescued the inhibitory effects of gamma-secretase inhibitors on VEGF-induced angiogenesis. These findings indicate that the phosphatidylinositol 3-kinase/Akt pathway mediates gamma-secretase and Notch1 activation by VEGF and that Notch1 is critical for VEGF-induced postnatal angiogenesis. These results suggest that Notch1 may be a novel therapeutic target for improving angiogenic response and blood flow recovery in ischemic limbs
Sensitivity of european temperature to albedo parameterization in the regional climate model COSMO-CLM linked to extreme land use changes
Previous studies based on observations and models are uncertain about the biophysical impact of af- and deforestation in the northern hemisphere mid-latitude summers, and show either a cooling or warming. The spatial distribution, magnitude and direction are still uncertain. In this study, the effect of three different albedo parameterizations in the regional climate model COSMO-CLM (v5.09) is examined performing idealized experiments at 0.44° horizontal resolution across the EURO-CORDEX domain during 1986–2015. De- and af-forestation simulations are compared to a simulation with no land cover change. Emphasis is put on the impact of changes in radiation and turbulent fluxes. A clear latitudinal pattern is found, which results partly due to the strong land cover conversion from forest- to grassland in the high latitudes and open land to forest conversion in mid-latitudes. Afforestation warms the climate in winter, and strongest in mid-latitudes. Results are indifferent in summer owing to opposing albedo and evapotranspiration effects of comparable size but different sign. Thus, the net effect is small for summer. Depending on the albedo parameterization in the model, the temperature effect can turn from cooling to warming in mid-latitude summers. The summer warming due to deforestation to grassland is up to 3°C higher than due to afforestation. The cooling by grass or warming by forest is in magnitude comparable and small in winter. The strength of the described near-surface temperature changes depends on the magnitude of the individual biophysical changes in the specific background climate conditions of the region. Thus, the albedo parameterization need to account for different vegetation types. Furthermore, we found that, depending on the region, the land cover change effect is more important than the model uncertainty due to albedo parameterization. This is important information for model development
Edge states and determination of pairing symmetry in superconducting Sr2RuO4
We calculate the energy dispersion of the surface Andreev states and their
contribution to tunneling conductance for the order parameters with horizontal
and vertical lines of nodes proposed for superconducting Sr2RuO4. For vertical
lines, we find double peaks in tunneling spectra reflecting the van Hove
singularities in the density of surface states originating from the turning
points in their energy dispersion. For horizontal lines, we find a single
cusp-like peak at zero bias, which agrees very well with the experimental data
on tunneling in Sr2RuO4.Comment: 6 pages, 6 figures. V.2: comparison with experiment added and
discussion of horizontal nodes expanded. v.3: significant expansion: 1 figure
and 2 pages added. v.4: acknowledgements added. Additional viewgraphs with
experimental and theoretical curves superimposed are available at
http://www2.physics.umd.edu/~yakovenk/talks/Sr2RuO4
Superconducting Order Parameter Symmetry in Multi-layer Cuprates
We discuss the allowed order parameter symmetries in multi-layer cuprates and
their physical consequences using highly non-specific forms of the inter- and
intra-plane interactions. Within this framework, the bi-layer case is discussed
in detail with particular attention paid to the role of small orthorhombic
distortions as would derive from the chains in YBCO or superlattice effects in
BSCCO. In the orthorhombic bi-layer case the (s,-s) state is of special
interest, since for a wide range of parameters this state exhibits pi phase
shifts in corner Josephson junction experiments. In addition, its transition
temperature is found to be insensitive to non-magnetic inter-plane disorder, as
would be present at the rare earth site in YBCO, for example. Of particular
interest, also, are the role of van Hove singularities which are seen to
stabilize states with d_{x^2 - y^2}-like symmetry, (as well as nodeless
s-states) and to elongate the gap functions along the four van Hove points,
thereby leading to a substantial region of gaplessness. We find that d_{x^2 -
y^2}-like states are general solutions for repulsive interactions; they possess
the fewest number of nodes and therefore the highest transition temperatures.
In this way, they should not be specifically associated with a spin fluctuation
driven pairing mechanism.Comment: REVTeX documentstyle, 34 pages, 10 figures include
On asymptotic continuity of functions of quantum states
A useful kind of continuity of quantum states functions in asymptotic regime
is so-called asymptotic continuity. In this paper we provide general tools for
checking if a function possesses this property. First we prove equivalence of
asymptotic continuity with so-called it robustness under admixture. This allows
us to show that relative entropy distance from a convex set including maximally
mixed state is asymptotically continuous. Subsequently, we consider it arrowing
- a way of building a new function out of a given one. The procedure originates
from constructions of intrinsic information and entanglement of formation. We
show that arrowing preserves asymptotic continuity for a class of functions
(so-called subextensive ones). The result is illustrated by means of several
examples.Comment: Minor corrections, version submitted for publicatio
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