43 research outputs found
Đ Đ°Đ·ŃĐ°Đ±ĐŸŃĐșĐ° ŃĐ”Ń ĐœĐžŃĐ”ŃĐșĐžŃ ŃŃДЎŃŃĐČ ĐżĐŸĐČŃŃĐ”ĐœĐžŃ ŃŃŃĐ”ĐșŃĐžĐČĐœĐŸŃŃĐž ŃĐŸĐ»ĐœĐ”ŃĐœŃŃ ŃŃŃĐ°ĐœĐŸĐČĐŸĐș
In this paper a method and means of increasing the power generated by solar installations during the day are considered. It is recommended to use acrylic concentrator and solar tracker with active type of tracking based on the control board without microcontrollers. This feature allows using DC commutator motor as an electric drive component, which simplifies the construction of the whole system significantly
The tight junction protein CAR regulates cardiac conduction and cellâcell communication
The Coxsackievirus-adenovirus receptor (CAR) is known for its role in virus uptake and as a protein of the tight junction. It is predominantly expressed in the developing brain and heart and reinduced upon cardiac remodeling in heart disease. So far, the physiological functions of CAR in the adult heart are largely unknown. We have generated a heart-specific inducible CAR knockout (KO) and found impaired electrical conduction between atrium and ventricle that increased with progressive loss of CAR. The underlying mechanism relates to the cross talk of tight and gap junctions with altered expression and localization of connexins that affect communication between CAR KO cardiomyocytes. Our results indicate that CAR is not only relevant for virus uptake and cardiac remodeling but also has a previously unknown function in the propagation of excitation from the atrium to the ventricle that could explain the association of arrhythmia and Coxsackievirus infection of the heart
AstroGrid-D: Grid Technology for Astronomical Science
We present status and results of AstroGrid-D, a joint effort of
astrophysicists and computer scientists to employ grid technology for
scientific applications. AstroGrid-D provides access to a network of
distributed machines with a set of commands as well as software interfaces. It
allows simple use of computer and storage facilities and to schedule or monitor
compute tasks and data management. It is based on the Globus Toolkit middleware
(GT4). Chapter 1 describes the context which led to the demand for advanced
software solutions in Astrophysics, and we state the goals of the project. We
then present characteristic astrophysical applications that have been
implemented on AstroGrid-D in chapter 2. We describe simulations of different
complexity, compute-intensive calculations running on multiple sites, and
advanced applications for specific scientific purposes, such as a connection to
robotic telescopes. We can show from these examples how grid execution improves
e.g. the scientific workflow. Chapter 3 explains the software tools and
services that we adapted or newly developed. Section 3.1 is focused on the
administrative aspects of the infrastructure, to manage users and monitor
activity. Section 3.2 characterises the central components of our architecture:
The AstroGrid-D information service to collect and store metadata, a file
management system, the data management system, and a job manager for automatic
submission of compute tasks. We summarise the successfully established
infrastructure in chapter 4, concluding with our future plans to establish
AstroGrid-D as a platform of modern e-Astronomy.Comment: 14 pages, 12 figures Subjects: data analysis, image processing,
robotic telescopes, simulations, grid. Accepted for publication in New
Astronom
Functional Implications of LH/hCG Receptors in Pregnancy-Induced Cushing Syndrome
Context: Elevated human choriogonadotropin (hCG) may stimulate aberrantly
expressed luteinizing hormone (LH)/hCG receptor (LHCGR) in adrenal glands,
resulting in pregnancy-induced bilateral macronodular adrenal hyperplasia and
transient Cushing syndrome (CS). Objective: To determine the role of LHCGR in
transient, pregnancy-induced CS. Design, Setting, Patient, and Intervention:
We investigated the functional implications of LHCGRs in a patient presenting,
at a tertiary referral center, with repeated pregnancy-induced CS with
bilateral adrenal hyperplasia, resolving after parturition. Main Outcome
Measures and Results: Acute testing for aberrant hormone receptors was
negative except for arginine vasopressin (AVP)âincreased cortisol secretion.
Long-term hCG stimulation induced hypercortisolism, which was unsuppressed by
dexamethasone. Postadrenalectomy histopathology demonstrated steroidogenically
active adrenocortical hyperplasia and ectopic cortical cell clusters in the
medulla. Quantitative polymerase chain reaction showed upregulated expression
of LHCGR, transcription factors GATA4, ZFPM2, and proopiomelanocortin (POMC),
AVP receptors (AVPRs) AVPR1A and AVPR2, and downregulated melanocortin 2
receptor (MC2R) vs control adrenals. LHCGR was localized in subcapsular, zona
glomerulosa, and hyperplastic cells. Single adrenocorticotropic
hormoneâpositive medullary cells were demonstrated in the zona reticularis.
The role of adrenal adrenocorticotropic hormone was considered negligible due
to downregulated MC2R. Coexpression of CYP11B1/CYP11B2 and AVPR1A/AVPR2 was
observed in ectopic cortical cells in the medulla. hCG stimulation of the
patientâs adrenal cell cultures significantly increased cyclic adenosine
monophosphate, corticosterone, 11-deoxycortisol, cortisol, and androstenedione
production. CTNNB1, PRKAR1A, ARMC5, and PRKACA gene mutational analyses were
negative. Conclusion: Nongenetic, transient, somatic mutation-independent,
pregnancy-induced CS was due to hCG-stimulated transformation of LHCGR-
positive undifferentiated subcapsular cells (presumably adrenocortical
progenitors) into LHCGR-positive hyperplastic cortical cells. These cells
respond to hCG stimulation with cortisol secretion. Without the ligand, they
persist with aberrant LHCGR expression and the ability to respond to the same
stimulus
ĐŃŃĐ»Đ”ĐŽĐŸĐČĐ°ĐœĐžĐ” ĐŒĐ”ŃĐŸĐŽĐŸĐČ ĐžĐ·ĐŒĐ”ŃĐ”ĐœĐžŃ ŃĐŸĐ»ŃĐžĐœŃ ŃŃĐ”ĐœĐșĐž лДгĐșĐŸŃплаĐČĐœŃŃ Đ±ŃŃОлŃĐœŃŃ ŃŃŃб
ĐąĐŸĐ»ŃĐžĐœĐ° ŃŃĐ”ĐœĐșĐž бŃŃОлŃĐœĐŸĐč ŃŃŃĐ±Ń ĐžĐ· Đ°Đ»ŃĐŒĐžĐœĐžĐ”ĐČĐŸĐłĐŸ ŃплаĐČĐ° ĐžĐ·ĐŒĐ”ŃŃĐ”ŃŃŃ ĐČĐžŃ
ŃĐ”ŃĐŸĐșĐŸĐČŃĐŒ ĐŒĐ”ŃĐŸĐŽĐŸĐŒ, Đ°ĐșŃŃŃĐžŃĐ”ŃĐșĐžĐŒ ĐŒĐ”ŃĐŸĐŽĐŸĐŒ, ĐŒĐ°ĐłĐœĐžŃĐœŃĐŒ ĐŒĐ”ŃĐŸĐŽĐŸĐŒ, Đ Đ°ĐŽĐžaŃĐžĐŸĐœĐœŃĐŒ ĐŒĐ”ŃĐŸĐŽĐŸĐŒ Đž ĐČОзŃĐ°Đ»ŃĐœĐŸ-ĐŸĐżŃĐžŃĐ”ŃĐșĐžĐŒ ĐŒĐ”ŃĐŸĐŽĐŸĐŒ. ĐŃĐžĐœŃОп ŃĐŸĐŸŃĐČĐ”ŃŃŃĐČŃŃŃĐ”ĐłĐŸ ĐžĐœŃŃŃŃĐŒĐ”ĐœŃĐ° ŃĐ°ĐșжД ĐŸĐżĐžŃŃĐČĐ°Đ”ŃŃŃ Ń ĐżĐŸĐŒĐŸŃŃŃ ĐżŃĐžĐœŃОпа ĐČŃŃĐ”ŃĐżĐŸĐŒŃĐœŃŃĐŸĐłĐŸ ĐŒĐ”ŃĐŸĐŽĐ°.Through the eddy current method, acoustic method, electromagnetic method, radiation method, visual optical method, to measure the thickness of the aluminum alloy drill pipe wall. The corresponding instrument principles are also described through the principles of the above methods
Testing gravitational-wave searches with numerical relativity waveforms: Results from the first Numerical INJection Analysis (NINJA) project
The Numerical INJection Analysis (NINJA) project is a collaborative effort
between members of the numerical relativity and gravitational-wave data
analysis communities. The purpose of NINJA is to study the sensitivity of
existing gravitational-wave search algorithms using numerically generated
waveforms and to foster closer collaboration between the numerical relativity
and data analysis communities. We describe the results of the first NINJA
analysis which focused on gravitational waveforms from binary black hole
coalescence. Ten numerical relativity groups contributed numerical data which
were used to generate a set of gravitational-wave signals. These signals were
injected into a simulated data set, designed to mimic the response of the
Initial LIGO and Virgo gravitational-wave detectors. Nine groups analysed this
data using search and parameter-estimation pipelines. Matched filter
algorithms, un-modelled-burst searches and Bayesian parameter-estimation and
model-selection algorithms were applied to the data. We report the efficiency
of these search methods in detecting the numerical waveforms and measuring
their parameters. We describe preliminary comparisons between the different
search methods and suggest improvements for future NINJA analyses.Comment: 56 pages, 25 figures; various clarifications; accepted to CQ
ĐĐŸĐœĐșŃŃĐ”ĐœŃĐŸŃĐżĐŸŃĐŸĐ±ĐœĐŸŃŃŃ ŃĐžŃĐŒ ĐČ ŃŃĐ»ĐŸĐČĐžŃŃ ŃŃĐœĐŸŃĐœĐŸĐč ŃĐșĐŸĐœĐŸĐŒĐžĐșĐž
ĐĐœĐ°Đ»ĐžĐ· ŃŃŃĐ”ĐșŃĐžĐČĐœĐŸŃŃĐž ĐŸŃĐłĐ°ĐœĐžĐ·Đ°ŃОО ĐșĐŸĐŒĐŒĐ”ŃŃĐ”ŃĐșĐŸĐč ĐŽĐ”ŃŃДлŃĐœĐŸŃŃĐž ĐżŃДЎпŃĐžŃŃĐžŃ Đž ĐŸŃĐ”ĐœĐșĐ° ĐșĐŸĐœĐșŃŃĐ”ĐœŃĐŸŃĐżĐŸŃĐŸĐ±ĐœĐŸŃŃĐž ŃĐžŃĐŒŃ. ĐŃŃĐ»Đ”ĐŽĐŸĐČĐ°ĐœĐžĐ” Đž ŃĐ°Đ·ŃĐ°Đ±ĐŸŃĐșĐ° ŃĐžŃŃĐ”ĐŒŃ ĐżĐŸĐČŃŃĐ”ĐœĐžŃ ĐșĐŸĐœĐșŃŃĐ”ĐœŃĐŸŃĐżĐŸŃĐŸĐ±ĐœĐŸŃŃĐž ĐżŃДЎпŃĐžŃŃĐžŃ ŃŃĐœĐșĐ° ŃĐ”ĐșĐ»Đ°ĐŒĐœŃŃ
ŃŃĐ»ŃĐł.Analysis of the effectiveness of the organization of commercial activities of the enterprise and evaluation of the firm's competitiveness. Research and development of a system for increasing the competitiveness of a service enterprise
Conformation-regulated mechanosensory control via titin domains in cardiac muscle
The giant filamentous protein titin is ideally positioned in the muscle sarcomere to sense mechanical stimuli and transform them into biochemical signals, such as those triggering cardiac hypertrophy. In this review, we ponder the evidence for signaling hotspots along the titin filament involved in mechanosensory control mechanisms. On the way, we distinguish between stress and strain as triggers of mechanical signaling events at the cardiac sarcomere. Whereas the Z-disk and M-band regions of titin may be prominently involved in sensing mechanical stress, signaling hotspots within the elastic I-band titin segment may respond primarily to mechanical strain. Common to both stress and strain sensor elements is their regulation by conformational changes in protein domains
CX3CR1 knockout aggravates Coxsackievirus B3-induced myocarditis
Studies on inflammatory disorders elucidated the pivotal role of the
CX3CL1/CX3CR1 axis with respect to the pathophysiology and diseases
progression. Coxsackievirus B3 (CVB3)-induced myocarditis is associated with
severe cardiac inflammation, which may progress to heart failure. We therefore
investigated the influence of CX3CR1 ablation in the model of acute
myocarditis, which was induced by inoculation with 5x105 plaque forming units
of CVB3 (Nancy strain) in either CX3CR1-/- or C57BL6/j (WT) mice. Seven days
after infection, myocardial inflammation, remodeling, and titin expression and
phosphorylation were examined by immunohistochemistry, real-time PCR and Pro-Q
diamond stain. Cardiac function was assessed by tip catheter. Compared to WT
CVB3 mice, CX3CR1-/- CVB3 mice exhibited enhanced left ventricular expression
of inflammatory cytokines and chemokines, which was associated with an
increase of immune cell infiltration/presence. This shift towards a pro-
inflammatory immune response further resulted in increased cardiac fibrosis
and cardiomyocyte apoptosis, which was reflected by an impaired cardiac
function in CX3CR1-/- CVB3 compared to WT CVB3 mice. These findings
demonstrate a cardioprotective role of CX3CR1 in CVB3-infected mice and
indicate the relevance of the CX3CL1/CX3CR1 system in CVB3-induced
myocarditis
Pleiotropy among common genetic loci identified for cardiometabolic disorders and C-reactive protein.
Pleiotropic genetic variants have independent effects on different phenotypes. C-reactive protein (CRP) is associated with several cardiometabolic phenotypes. Shared genetic backgrounds may partially underlie these associations. We conducted a genome-wide analysis to identify the shared genetic background of inflammation and cardiometabolic phenotypes using published genome-wide association studies (GWAS). We also evaluated whether the pleiotropic effects of such loci were biological or mediated in nature. First, we examined whether 283 common variants identified for 10 cardiometabolic phenotypes in GWAS are associated with CRP level. Second, we tested whether 18 variants identified for serum CRP are associated with 10 cardiometabolic phenotypes. We used a Bonferroni corrected p-value of 1.1Ă10-04 (0.05/463) as a threshold of significance. We evaluated the independent pleiotropic effect on both phenotypes using individual level data from the Women Genome Health Study. Evaluating the genetic overlap between inflammation and cardiometabolic phenotypes, we found 13 pleiotropic regions. Additional analyses showed that 6 regions (APOC1, HNF1A, IL6R, PPP1R3B, HNF4A and IL1F10) appeared to have a pleiotropic effect on CRP independent of the effects on the cardiometabolic phenotypes. These included loci where individuals carrying the risk allele for CRP encounter higher lipid levels and risk of type 2 diabetes. In addition, 5 regions (GCKR, PABPC4, BCL7B, FTO and TMEM18) had an effect on CRP largely mediated through the cardiometabolic phenotypes. In conclusion, our results show genetic pleiotropy among inflammation and cardiometabolic phenotypes. In addition to reverse causation, our data suggests that pleiotropic genetic variants partially underlie the association between CRP and cardiometabolic phenotypes