Fluoride-assisted trifluoromethylation of aromatic thiones with (trifluoromethyl)trimethylsilane

International audienc

Trifluoromethylated Vinylic and Aromatic Compounds from α-(Trifluoro­methyl)allyl Alcohols

International audienc

Regioselective N-alkylation of imidazo[4,5-b]pyridine-4-oxide derivatives: an experimental and DFT study

International audienc

Synthesis of [6,n] cis-fused ring compounds via Cr-mediated dearomatisation-ring-closing metathesis

cis-Fused [6,8], [6,7], [6,6] and [6,5] ring systems containing a cyclohexadiene ring unit, a cycloenone ring and a quaternary carbon at the ring junction were obtained in only two steps from [Cr(CO)3(eta6-p-methoxyphenyl oxazoline)]. The sequence proceeds via diastereoselective addition of three C-substituents across an arene double bond, followed by allylation and ring closing metathesis (RCM). RAMP-hydrazone and (R)-isopropyloxazoline were used as chiral auxiliaries to provide, after removal of the auxiliaries, the enantiomerically highly enriched [6,7] cis-fused system

Efficient Access to Fused Ring Compounds via Dearomatization/Ring-Closing Metathesis

The complex (p-methoxyphenyl oxazoline)Cr(CO)3 is converted in two steps into a cis-fused [6,8] ring system containing a cycohexadiene ring unit, a cyclooctenone ring and a quaternary carbon at the ring junction. The key steps involve a diastereoselective addition of three C-substituents across an arene double bond, followed by an allylation and ring closing metathesis step. cis-Fused [6,7], [6,6], and [6,5] ring systems are also accessible via this methodology

Unsymmetrical α,ω-end-functionalized oligo(cyclohexylidenes): efficient synthesis and conformational analysis

International audienc

Design, synthesis and evaluation of progesterone–adenine hybrids as bivalent inhibitors of P-glycoprotein-mediated multidrug efflux

International audienc

Synthesis and modulation properties of imidazo[4,5-b]pyridin-7-one and indazole-4,7-dione derivatives towards the Cryptosporidium parvum CpABC3 transporter

International audienc

Solvent- and metal-free hydroboration of alkynes under microwave irradiation

International audienc

Enhancement of iodinin solubility by encapsulation into cyclodextrin nanoparticles

International audienc