Roman Women’s Dress

The book concerns female dress in Roman life and literature. The main focus is on female Roman dress as it may have been worn in daily life in Rome and in a social environment influenced by Roman culture in the time from the beginnings of the Republic until the end of the 2nd century AD

Exploring Views on Data Centre Power Consumption and Server Virtualization

The primary purpose of this Thesis is to explore views on Green IT/Computing and how it relates to Server Virtualization, in particular for Data Centre IT environments. Our secondary purpose is to explore other important aspects of Server Virtualization, in the same context. The primary research question was to determine if Data Centre (DC) power consumption reduction is related to, or perceived as, a success factor for implementing and deploying server virtualization for consolidation purposes, and if not, what other decision areas affect Server Virtualization and power consumption reduction, respectively. The conclusions from our research are that there is a difference of opinion regarding how to factor power consumption reduction from server equipment, both from promoters and deployers. However, it was a common view that power consumption reduction was usually achieved, but not necessarily considered, and thus not evaluated, as a success factor, nor that actual power consumption was measured or monitored after server virtualization deployment. We found that other factors seemed more important, such as lower cost through higher physical machine utilization, simplified high availability and disaster recovery capabilities

Functional modulation of the transient outward current Ito by KCNE beta-subunits and regional distribution in human non-failing and failing hearts

Objectives: The function of Kv4.3 (KCND3) channels, which underlie the transient outward current I,, in human heart, can be modulated by several accessory subunits such as KChIP2 and KCNE1-KCNE5. Here we aimed to determine the regional expression of Kv4.3, KChIP2, and KCNE mRNAs in non-failing and failing human hearts and to investigate the functional consequences of subunit coexpression in heterologous expression systems. Methods: We quantified mRNA levels for two Kv4.3 isoforms, Kv4.3-S and Kv4.3-L, and for KChIP2 as well as KCNE1-KCNE5 with real-time RT-PCR. We also studied the effects of KCNEs on Kv4.3 + KChIP2 current characteristics in CHO cells with the whole-cell voltage-clamp method. Results: In non-failing hearts, low expression was found for KCNE1, KCNE3, and KCNE5, three times higher expression for KCNE2, and 60 times higher for KCNE4. Transmural gradients were detected only for KChIP2 in left and right ventricles. Compared to non-failing tissue, failing hearts showed higher expression of Kv4.3-L and KCNE1 and lower of Kv4.3-S, KChIP2, KCNE4, and KCNE5. In CHO cells, Kv4.3 + KChIP2 currents were differentially modified by co-expressed KCNEs: time constants of inactivation were shorter with KCNE1 and KCNE3-5 while time-to-peak was decreased, and V-0.5 of steady-state inactivation was shifted to more negative potentials by all KCNE subunits. Importantly, KCNE2 induced a unique and prominent 'overshoot' of peak current during recovery from inactivation similar to that described for human I-to while other KCNE subunits induced little (KCNE4,5) or no overshoot. Conclusions: All KCNEs are expressed in the human heart at the transcript level. Compared to It. in native human myocytes, none of the combination of KChIP2 and KCNE produced an ideal congruency in current characteristics, suggesting that additional factors contribute to the regulation of the native I-to channel

Ist die präoperative Antiaggregation bei der Behandlung einer Karotisstenose effektiv und sinnvoll?

Frage: Es soll geklärt werden, ob Patienten von einer Karotisendarteriektomie unter ASS profitieren, und welche Komplikationen durch ASS reduziert werden können. Außerdem wird die Korrelation von bestimmten Risikofaktoren mit dem Auftreten von Komplikationen untersucht. Methoden: Daten von 540 Patienten, die ohne ASS (n = 267) beziehungsweise unter ASS (n = 273) operiert worden sind, wurden im Hinblick auf vorhandene Risikofaktoren und aufgetretene Komplikationen ausgewertet. Ergebnisse: In der ASS-Gruppe erlitten 5,2% der Patienten eine Komplikation, während in der Non-ASS-Gruppe 17,6 % betroffen waren (p < 0,0001). Durch ASS können je nach vorliegenden Risikofaktoren kardiale und neurologische Komplikationen signifikant reduziert werden, während Blutungskomplikationen nicht signifikant häufiger auftreten. Fazit: Offene Karotisoperationen sollten unter ASS durchgeführt werden, um das Risiko postopertiver Komplikationen signifikant zu reduzieren

Roman Women’s Dress

The book concerns female dress in Roman life and literature. The main focus is on female Roman dress as it may have been worn in daily life in Rome and in a social environment influenced by Roman culture in the time from the beginnings of the Republic until the end of the 2nd century AD

Improved Detection of Foreign Bodies on Radiographs Using X-ray Dark-Field and Phase-Contrast Imaging

Purpose: The aim of this study was to investigate whether the detection of foreign bodies can be improved using dark-field and phase-contrast radiography compared with conventional (transmission) radiographs. Materials and Methods: Experiments were performed using ex vivo pig paws, which were prepared with differently sized foreign bodies of metal, wood, and glass (n = 10 each). Paws without foreign bodies served as controls (n = 30). All images were acquired using an experimental grating-based large object radiography system. Five blinded readers (second- to fourth-year radiology residents) were asked to assess the presence or absence of any foreign body. Sensitivity and specificity for the detection of metal, wood, glass, and any foreign body were calculated and compared using McNemar test and generalized linear mixed models. Results: Sensitivity for the detection of metal foreign bodies was 100% for all readers and image combinations. The sensitivity for the detection of wooden foreign bodies increased from 2% for transmission images to 78% when dark-field images were added (P < 0.0001). For glass foreign bodies, sensitivity increased from 84% for transmission images to 96% when adding phase-contrast images (P = 0.041). Sensitivity for the detection of any foreign body was 91% when transmission, dark-field, and phase-contrast images were viewed simultaneously, compared with 62% for transmission images alone (P < 0.0001). Specificity was 99% to 100% across all readers and radiography modalities. Conclusions: Adding dark-field images substantially improves the detection of wooden foreign bodies compared with the analysis of conventional (transmission) radiographs alone. Detection of glass foreign bodies was moderately improved when adding phase-contrast images

KCNQ1 subdomains involved in KCNE modulation revealed by an invertebrate KCNQ1 orthologue

KCNQ1 channels are voltage-gated potassium channels that are widely expressed in various non-neuronal tissues, such as the heart, pancreas, and intestine. KCNE proteins are known as the auxiliary subunits for KCNQ1 channels. The effects and functions of the different KCNE proteins on KCNQ1 modulation are various; the KCNQ1–KCNE1 ion channel complex produces a slowly activating potassium channel that is crucial for heartbeat regulation, while the KCNE3 protein makes KCNQ1 channels constitutively active, which is important for K+ and Cl− transport in the intestine. The mechanisms by which KCNE proteins modulate KCNQ1 channels have long been studied and discussed; however, it is not well understood how different KCNE proteins exert considerably different effects on KCNQ1 channels. Here, we approached this point by taking advantage of the recently isolated Ci-KCNQ1, a KCNQ1 homologue from marine invertebrate Ciona intestinalis. We found that Ci-KCNQ1 alone could be expressed in Xenopus laevis oocytes and produced a voltage-dependent potassium current, but that Ci-KCNQ1 was not properly modulated by KCNE1 and totally unaffected by coexpression of KCNE3. By making chimeras of Ci-KCNQ1 and human KCNQ1, we determined several amino acid residues located in the pore region of human KCNQ1 involved in KCNE1 modulation. Interestingly, though, these amino acid residues of the pore region are not important for KCNE3 modulation, and we subsequently found that the S1 segment plays an important role in making KCNQ1 channels constitutively active by KCNE3. Our findings indicate that different KCNE proteins use different domains of KCNQ1 channels, and that may explain why different KCNE proteins give quite different outcomes by forming a complex with KCNQ1 channels