BrisSynBio:a BBSRC/EPSRC-funded Synthetic Biology Research Centre

BrisSynBio is the Bristol-based Biotechnology and Biological Sciences Research Council (BBSRC)/Engineering and Physical Sciences Research Council (EPSRC)-funded Synthetic Biology Research Centre. It is one of six such Centres in the U.K. BrisSynBio's emphasis is on rational and predictive bimolecular modelling, design and engineering in the context of synthetic biology. It trains the next generation of synthetic biologists in these approaches, to facilitate translation of fundamental synthetic biology research to industry and the clinic, and to do this within an innovative and responsible research framework

Social inclusion and valued roles : a supportive framework

The aim of this paper is to examine the concepts of social exclusion, social inclusion and their relevance to health, well-being and valued social roles. The article presents a framework, based on Social Role Valorization (SRV), which was developed initially to support and sustain socially valued roles for those who are, or are at risk of, being devalued within our society. The framework incorporates these principles and can be used by health professionals across a range of practice, as a legitimate starting point from which to support the acquisition of socially valued roles which are integral to inclusio

Communicating REDD+ Issues at Local Level: Creating Latent and Manifest Conflict

”Carbon offsetting”in forestry-related projects is widely regarded as the ideal solution to the three challenges of the 21st Century: climate change, biodiversity conservation andsocio-economic development. At the same time, there is scepticism about the Reducing Emissions from Deforestation and Forest Degradation (REDD) proposal particularly because of the weak governance and institutional capacities in many developing countries, which could jeopardize the delivery of benefits at the local level. One major problem is that most people have little knowledge on the causes and consequences of the climate change. This is partly because the information is largely scattered among scientific journals, and obscured by jargon and sophisticated mathematical models. Consequently, REDD+ is beyond thereach of manyof the people affected by REDD+. This paper examines the efforts and the capacity of the local governments and other development agents in explaining the REDD + issues and its impacts on the local people, especially customary communities. The research shows that lack of policy communication and promotion, as well as consultations with the affected groups arethe main contributing factors to latent and manifest conflicts. In turn, this conflicth as proven that NGOs, district governments and scientists have not been successful intermediaries. Thus, in the future policy communication on REDD+ should beaimed at improved network formation (i.e. between farmer groups with business partners and NGOs and other related actors), learning, negotiation and relationship building (i.e. between members of farmer groups, not only withtheir leaders within the farmer groups but also with governmental and business sectors). Policy communication should also create a new configuration of support and services in form of advocacy, empowerment and management skills and technical skills for conserving their natural resources, for adaptation to climate change and building more equitable governance and transparency at local level

Expression, purification and preliminary characterisation of the choline transporter LicB from opportunistic bacterial pathogens

\ua9 2021. Many opportunistic bacteria that infect the upper respiratory tract decorate their cell surface with phosphorylcholine to support colonisation and outgrowth. These surface modifications require the active import of choline from the host environment, a process thought to be mediated by a family of dedicated integral membrane proteins that act as choline permeases. Here, we present the expression and purification of the archetype of these choline transporters, LicB from Haemophilus influenzae. We show that LicB can be recombinantly produced in Escherichia coli and purified to homogeneity in a stable, folded state using the detergent n-dodecyl-β-D-maltopyranoside. Equilibrium binding studies with the fluorescent ligand dansylcholine suggest that LicB is selective towards choline, with reduced affinity for acetylcholine and no apparent activity towards other small molecules including glycine, carnitine and betaine. We also identify a conserved sequence motif within the LicB family and show that mutations within this motif compromise protein structure and function. Our results are consistent with previous observations that LicB is a specific high-affinity choline transporter, and provide an experimental platform for further studies of this permease family

Family support and cardiac rehabilitation: A comparative study of the experiences of South Asian and White-European patients and their carer's living in the United Kingdom

Background: Effective lifestyle modification facilitated by cardiac rehabilitation is known to reduce the occurrence of adverse coronary events and mortality. South Asians have poorer outcomes after a myocardial infarction than the general UK population, but little is known about their experiences of family support, cardiac rehabilitation and lifestyle change. Aims: To explore the nature of family support available to a sample of South Asian and White-European cardiac patients and to highlight similarities and differences between these groups with regard to cardiac rehabilitation and lifestyle modification. Methods: Using a qualitative approach, semi-structured interviews (in 1 of 6 languages) were conducted by researchers with; 45 South Asian patients and 37 carers and 20 White-European patients and 17 carers. Interviews were conducted in a home setting, up to eighteen months after discharge from hospital following myocardial infarction, coronary artery bypass surgery or unstable angina. Results: The main themes that emerged related to the provision of advice and information, family support and burden, dietary change and exercise regimes. Conclusions: Several cultural and ethnic differences were identified between patients and their families alongside similarities, irrespective of ethnicity. These may represent generic characteristics of recovery after a cardiac event. Health professionals should develop a cultural repertoire to engage with diversity and difference. Not every difficulty a person encounters as they try to access appropriate service delivery can be attributed to ethnic background. By improving services generally, support for South Asian populations can be improved. The challenge is to know when ethnicity makes a difference and mediates a person's relationship with service support and when it does not. (C) 2007 European Society of Cardiology. Published by Elsevier B.V. All rights reserved

Towards machine learning approaches for predicting the self-healing efficiency of materials

Acknowledgement This research is supported by the Engineering and Physical Sciences Research Council (EPSRC) funded Project on New Industrial Systems: Manufacturing Immortality (EP/R020957/1). The authors are also grateful to the Manufacturing Immortality consortium.Peer reviewedPublisher PD