6,922 research outputs found

    Controls on macrotidal rip current circulation and hazard

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    EPSRC funded. NERC - RNLI partnership grant NE/H004262/1, Dynamics of Rip Currents and Implications for Beach Safety. The full text is under embargo until 01.06.15. NOTICE: this is the author’s version of a work that was accepted for publication in <Geomorphology. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Geomorphology, [VOl 214, (01.06.14)] DOI 10.1016/j.geomorph.2014.02.00

    Causal Reasoning for Algorithmic Fairness

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    In this work, we argue for the importance of causal reasoning in creating fair algorithms for decision making. We give a review of existing approaches to fairness, describe work in causality necessary for the understanding of causal approaches, argue why causality is necessary for any approach that wishes to be fair, and give a detailed analysis of the many recent approaches to causality-based fairness

    Continuous disclosure

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    University of Technology, Sydney. Faculty of Business.This thesis evaluates the operation of Continuous Disclosure Regulation (CDR) in Australia and considers whether it is effective in reducing uncertainty about the value of the firm. A feature of the CDR is that it adopts a principles-based approach to prescribing disclosure, and in general terms it requires that listed companies disclose price sensitive information to the market on a timely basis. A consequence of adopting this approach is that firms must exercise considerable discretion in applying the regulation. Those judgments relating to whether information is price sensitive are addressed in chapter 2, while those relating to when the information should be disclosed are addressed in chapter 3. Evidence is provided in Chapter 2 that disclosures made under the regulation are generally associated with a reduction in information asymmetry. Although, there is some evidence that when firms disclose bad news this may actually increase information asymmetry. In chapter 3 there is evidence that disclosures under CDR result in timelier price discovery, with this result strongest for loss firms and firms reporting high returns. Accordingly, this is supportive of the CDR meeting at least some of its objectives. However, there is evidence of cross sectional variation in the application of the regulation which suggests that firm disclosure practices are still influenced by firm characteristics such as size, the nature of the news, and managerial incentives

    Cellular localization and associations of the major lipolytic proteins in human skeletal muscle at rest and during exercise

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    Lipolysis involves the sequential breakdown of fatty acids from triacylglycerol and is increased during energy stress such as exercise. Adipose triglyceride lipase (ATGL) is a key regulator of skeletal muscle lipolysis and perilipin (PLIN) 5 is postulated to be an important regulator of ATGL action of muscle lipolysis. Hence, we hypothesized that non-genomic regulation such as cellular localization and the interaction of these key proteins modulate muscle lipolysis during exercise. PLIN5, ATGL and CGI-58 were highly (&gt;60%) colocated with Oil Red O (ORO) stained lipid droplets. PLIN5 was significantly colocated with ATGL, mitochondria and CGI-58, indicating a close association between the key lipolytic effectors in resting skeletal muscle. The colocation of the lipolytic proteins, their independent association with ORO and the PLIN5/ORO colocation were not altered after 60 min of moderate intensity exercise. Further experiments in cultured human myocytes showed that PLIN5 colocation with ORO or mitochondria is unaffected by pharmacological activation of lipolytic pathways. Together, these data suggest that the major lipolytic proteins are highly expressed at the lipid droplet and colocate in resting skeletal muscle, that their localization and interactions appear to remain unchanged during prolonged exercise, and, accordingly, that other post-translational mechanisms are likely regulators of skeletal muscle lipolysis

    Magnetism, FeS colloids, and Origins of Life

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    A number of features of living systems: reversible interactions and weak bonds underlying motor-dynamics; gel-sol transitions; cellular connected fractal organization; asymmetry in interactions and organization; quantum coherent phenomena; to name some, can have a natural accounting via physicalphysical interactions, which we therefore seek to incorporate by expanding the horizons of `chemistry-only' approaches to the origins of life. It is suggested that the magnetic 'face' of the minerals from the inorganic world, recognized to have played a pivotal role in initiating Life, may throw light on some of these issues. A magnetic environment in the form of rocks in the Hadean Ocean could have enabled the accretion and therefore an ordered confinement of super-paramagnetic colloids within a structured phase. A moderate H-field can help magnetic nano-particles to not only overcome thermal fluctuations but also harness them. Such controlled dynamics brings in the possibility of accessing quantum effects, which together with frustrations in magnetic ordering and hysteresis (a natural mechanism for a primitive memory) could throw light on the birth of biological information which, as Abel argues, requires a combination of order and complexity. This scenario gains strength from observations of scale-free framboidal forms of the greigite mineral, with a magnetic basis of assembly. And greigite's metabolic potential plays a key role in the mound scenario of Russell and coworkers-an expansion of which is suggested for including magnetism.Comment: 42 pages, 5 figures, to be published in A.R. Memorial volume, Ed Krishnaswami Alladi, Springer 201
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