Cook, MJ

Edwards, DR

Moreno, M

Russell, DA

Stuchinskaya, T

English

Tanya Stuchinskaya

Miguel Moreno

Michael J. Cook

Dylan R. Edwards

David A. Russell

Crossref

Photochemical & Photobiological Sciences

Targeted photodynamic therapy of breast cancer cells using antibody-phthalocyanine-gold nanoparticle conjugates

A 4-component antibody-phthalocyanine-polyethylene glycol-gold nanoparticle conjugate is described for use as a potential drug for targeted photodynamic cancer therapy. Gold nanoparticles (4 nm) were stabilised with a self-assembled layer of a zinc-phthalocyanine derivative (photosensitiser) and a heterobifunctional polyethylene glycol. Anti-HER2 monoclonal antibodies were covalently bound to the nanoparticles via a terminal carboxy moiety on the polyethylene glycol. The nanoparticle conjugates were stable towards aggregation, and under irradiation with visible red light efficiently produced cytotoxic singlet oxygen. Cellular experiments demonstrated that the nanoparticle conjugates selectively target breast cancer cells that overexpress the HER2 epidermal growth factor cell surface receptor, and that they are effective photodynamic therapy agents

Stuchinskaya, Tanya

Moreno, Miguel

Cook, Michael J.

Edwards, Dylan R.

Russell, David A.

University of East Anglia digital repository

Targeted photodynamic therapy of breast cancer cells using antibody–phthalocyanine–gold nanoparticle conjugates

https://ueaeprints.uea.ac.uk/35148/1/Stuchinskaya_et_al_2011.pdf

Targeted photodynamic therapy of breast cancer cells using antibody–phthalocyanine–gold nanoparticle conjugates

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Crossref

University of East Anglia digital repository