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Testing the new economic geography's wage equation: a case study of Japan using a spatial panel model
This paper estimates the parameters of the wage equation of the new economic geography (NEG) using a newly developed spatial panel model. The results show that wage rate variation across different prefectures in Japan can be explained by market potential, which is a key variable in NEG theory, whilst controlling for variation in labour efficiency. Spatial heterogeneity is particularly important in the context of Japan in part because of its complex physical geography and the spatial distribution of its principal urban centres. The paper considers the challenges associated with representing the spatial relationships between prefectures describing and implementing different approaches to measuring transport costs
LPS-binding protein and its interactions with P. gingivalis LPS modulate pro-inflammatory response and Toll-like receptor signaling in human oral keratinocytes
published_or_final_versio
Heterogeneous <i>Porphyromonas gingivalis</i> LPS modulates immuno-inflammatory response, antioxidant defense and cytoskeletal dynamics in human gingival fibroblasts
published_or_final_versio
Novel cyclic di-GMP effectors of the YajQ protein family control bacterial virulence
Bis-(3 ',5 ') cyclic di-guanylate (cyclic di-GMP) is a key bacterial second messenger that is implicated in the regulation of many critical processes that include motility, biofilm formation and virulence. Cyclic di-GMP influences diverse functions through interaction with a range of effectors. Our knowledge of these effectors and their different regulatory actions is far from complete, however. Here we have used an affinity pull-down assay using cyclic di-GMP-coupled magnetic beads to identify cyclic di-GMP binding proteins in the plant pathogen Xanthomonas campestris pv. campestris (Xcc). This analysis identified XC_3703, a protein of the YajQ family, as a potential cyclic di-GMP receptor. Isothermal titration calorimetry showed that the purified XC_3703 protein bound cyclic di-GMP with a high affinity (K-d similar to 2 mu M). Mutation of XC_3703 led to reduced virulence of Xcc to plants and alteration in biofilm formation. Yeast two-hybrid and far-western analyses showed that XC_3703 was able to interact with XC_2801, a transcription factor of the LysR family. Mutation of XC_2801 and XC_3703 had partially overlapping effects on the transcriptome of Xcc, and both affected virulence. Electromobility shift assays showed that XC_3703 positively affected the binding of XC_2801 to the promoters of target virulence genes, an effect that was reversed by cyclic di-GMP. Genetic and functional analysis of YajQ family members from the human pathogens Pseudomonas aeruginosa and Stenotrophomonas maltophilia showed that they also specifically bound cyclic di-GMP and contributed to virulence in model systems. The findings thus identify a new class of cyclic di-GMP effector that regulates bacterial virulence
Probing microwave fields and enabling in-situ experiments in a transmission electron microscope.
A technique is presented whereby the performance of a microwave device is evaluated by mapping local field distributions using Lorentz transmission electron microscopy (L-TEM). We demonstrate the method by measuring the polarisation state of the electromagnetic fields produced by a microstrip waveguide as a function of its gigahertz operating frequency. The forward and backward propagating electromagnetic fields produced by the waveguide, in a specimen-free experiment, exert Lorentz forces on the propagating electron beam. Importantly, in addition to the mapping of dynamic fields, this novel method allows detection of effects of microwave fields on specimens, such as observing ferromagnetic materials at resonance
Incoherent non-Fermi liquid scattering in a Kondo lattice
One of the most notorious non-Fermi liquid properties of both archetypal
heavy-fermion systems [1-4] and the high-Tc copper oxide superconductors [5] is
an electrical resistivity that evolves linearly with temperature, T. In the
heavy-fermion superconductor CeCoIn5 [5], this linear behaviour was one of the
first indications of the presence of a zero-temperature instability, or quantum
critical point. Here, we report the observation of a unique control parameter
of T-linear scattering in CeCoIn5, found through systematic chemical
substitutions of both magnetic and non-magnetic rare-earth, R, ions into the Ce
sub-lattice. We find that the evolution of inelastic scattering in Ce1-xRxCoIn5
is strongly dependent on the f-electron configuration of the R ion, whereas two
other key properties -- Cooper-pair breaking and Kondo-lattice coherence -- are
not. Thus, T-linear resistivity in CeCoIn5 is intimately related to the nature
of incoherent scattering centers in the Kondo lattice, which provides insight
into the anomalous scattering rate synonymous with quantum criticality [7].Comment: 4 pages, 3 figures (published version
Gopakumar-Vafa invariants via vanishing cycles
In this paper, we propose an ansatz for defining Gopakumar-Vafa invariants of
Calabi-Yau threefolds, using perverse sheaves of vanishing cycles. Our proposal
is a modification of a recent approach of Kiem-Li, which is itself based on
earlier ideas of Hosono-Saito-Takahashi. We conjecture that these invariants
are equivalent to other curve-counting theories such as Gromov-Witten theory
and Pandharipande-Thomas theory. Our main theorem is that, for local surfaces,
our invariants agree with PT invariants for irreducible one-cycles. We also
give a counter-example to the Kiem-Li conjectures, where our invariants match
the predicted answer. Finally, we give examples where our invariant matches the
expected answer in cases where the cycle is non-reduced, non-planar, or
non-primitive.Comment: 63 pages, many improvements of the exposition following referee
comments, final version to appear in Inventione
Globular Cluster Distance Determinations
The present status of the distance scale to Galactic globular clusters is
reviewed. Six distance determination techniques which are deemed to be most
reliable are discussed in depth. These different techniques are used to
calibrate the absolute magnitude of the RR Lyrae stars. The various
calibrations fall into three groups. Main sequence fitting using Hipparcos
parallaxes, theoretical HB models and the RR Lyrae in the LMC all favor a
bright calibration, implying a `long' globular cluster distance scale. White
dwarf fitting and the astrometric distances yield a somewhat fainter RR Lyrae
calibration, while the statistical parallax solution yields faint RR Lyrae
stars implying a `short' distance scale to globular clusters. Various secondary
distance indicators discussed all favor the long distance scale. The `long' and
`short' distance scales differ by (0.31+/-0.16) mag. Averaging together all of
the different distance determinations yields Mv(RR) = (0.23+/-0.04)([Fe/H] +
1.6) + (0.56+/-0.12) mag.Comment: Invited review article to appear in: `Post-Hipparcos Cosmic Candles',
A. Heck & F. Caputo (Eds), Kluwer Academic Publ., Dordrecht, in pres
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