100 research outputs found
Generalized Geometry and M theory
We reformulate the Hamiltonian form of bosonic eleven dimensional
supergravity in terms of an object that unifies the three-form and the metric.
For the case of four spatial dimensions, the duality group is manifest and the
metric and C-field are on an equal footing even though no dimensional reduction
is required for our results to hold. One may also describe our results using
the generalized geometry that emerges from membrane duality. The relationship
between the twisted Courant algebra and the gauge symmetries of eleven
dimensional supergravity are described in detail.Comment: 29 pages of Latex, v2 References added, typos fixed, v3 corrected
kinetic term and references adde
Counting supersymmetric branes
Maximal supergravity solutions are revisited and classified, with particular
emphasis on objects of co-dimension at most two. This class of solutions
includes branes whose tension scales with g_s^{-\sigma} for \sigma>2. We
present a group theory derivation of the counting of these objects based on the
corresponding tensor hierarchies derived from E11 and discrete T- and U-duality
transformations. This provides a rationale for the wrapping rules that were
recently discussed for \sigma<4 in the literature and extends them. Explicit
supergravity solutions that give rise to co-dimension two branes are
constructed and analysed.Comment: 1+33 pages. To the memory of Laurent Houart. v2: Published version
with added reference
Eisenstein series for infinite-dimensional U-duality groups
We consider Eisenstein series appearing as coefficients of curvature
corrections in the low-energy expansion of type II string theory four-graviton
scattering amplitudes. We define these Eisenstein series over all groups in the
E_n series of string duality groups, and in particular for the
infinite-dimensional Kac-Moody groups E9, E10 and E11. We show that,
remarkably, the so-called constant term of Kac-Moody-Eisenstein series contains
only a finite number of terms for particular choices of a parameter appearing
in the definition of the series. This resonates with the idea that the constant
term of the Eisenstein series encodes perturbative string corrections in
BPS-protected sectors allowing only a finite number of corrections. We underpin
our findings with an extensive discussion of physical degeneration limits in
D<3 space-time dimensions.Comment: 69 pages. v2: Added references and small additions, to be published
in JHE
Stochastic Gravity: Theory and Applications
Whereas semiclassical gravity is based on the semiclassical Einstein equation
with sources given by the expectation value of the stress-energy tensor of
quantum fields, stochastic semiclassical gravity is based on the
Einstein-Langevin equation, which has in addition sources due to the noise
kernel. In the first part, we describe the fundamentals of this new theory via
two approaches: the axiomatic and the functional. In the second part, we
describe three applications of stochastic gravity theory. First, we consider
metric perturbations in a Minkowski spacetime, compute the two-point
correlation functions of these perturbations and prove that Minkowski spacetime
is a stable solution of semiclassical gravity. Second, we discuss structure
formation from the stochastic gravity viewpoint. Third, we discuss the
backreaction of Hawking radiation in the gravitational background of a black
hole and describe the metric fluctuations near the event horizon of an
evaporating black holeComment: 100 pages, no figures; an update of the 2003 review in Living Reviews
in Relativity gr-qc/0307032 ; it includes new sections on the Validity of
Semiclassical Gravity, the Stability of Minkowski Spacetime, and the Metric
Fluctuations of an Evaporating Black Hol
The αGal Epitope of the Histo-Blood Group Antigen Family Is a Ligand for Bovine Norovirus Newbury2 Expected to Prevent Cross-Species Transmission
Among Caliciviridae, the norovirus genus encompasses enteric viruses that infect humans as well as several animal species, causing gastroenteritis. Porcine strains are classified together with human strains within genogroup II, whilst bovine norovirus strains represent genogroup III. Various GI and GII human strains bind to carbohydrates of the histo-blood group family which may be shared among mammalian species. Genetic relatedness of human and animal strains as well as the presence of potentially shared ligands raises the possibility of norovirus cross-species transmission. In the present study, we identified a carbohydrate ligand for the prototype bovine norovirus strain Bo/Newbury2/76/UK (NB2). Attachment of virus-like particles (VLPs) of the NB2 strain to bovine gut tissue sections showed a complete match with the staining by reagents recognizing the Galα1,3 motif. Alpha-galactosidase treatment confirmed involvement of a terminal alpha-linked galactose. Specific binding of VLPs to the αGal epitope (Galα3Galβ4GlcNAcβ-R) was observed. The binding of Galα3GalαOMe to rNB2 VLPs was characterized at atomic resolution employing saturation transfer difference (STD) NMR experiments. Transfection of human cells with an α1,3galactosyltransferase cDNA allowed binding of NB2 VLPs, whilst inversely, attachment to porcine vascular endothelial cells was lost when the cells originated from an α1,3galactosyltransferase KO animal. The αGal epitope is expressed in all mammalian species with the exception of the Hominidaea family due to the inactivation of the α1,3galactosyltransferase gene (GGTA1). Accordingly, the NB2 carbohydrate ligand is absent from human tissues. Although expressed on porcine vascular endothelial cells, we observed that unlike in cows, it is not present on gut epithelial cells, suggesting that neither man nor pig could be infected by the NB2 bovine strain
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