Atlanti linguistici e archivi vocali di lingue locali e minoritarie in Italia

In quest’articolo sono riassunte alcune considerazioni sull’utilità della trascrizione/ annotazione dei dati linguistici con particolare attenzione alla funzione di conservazione delle parlate dialettali o delle lingue minacciate di estinzione. Alla descrizione sommaria delle prime operazioni dialettologiche dei grandi progetti atlantistici, si associa un riferimento al crescente diffondersi di progetti di allestimento di archivi vocali e alla necessità di adottare protocolli condivisi in un’ottica di coordinamento internazionale (sul modello di quelli offerti da consorzi come ELRA o CLARIN).Cet article prend en compte quelques considérations sur l’utilité de la transcription/ annotation de données linguistiques en accordant une attention particulière à la fonction de conservation des dialectes ou des langues dialectales menacées d’extinction. À la brève description des premières opérations dialectologiques des grands projets d’atlas, nous associons une référence à la diffusion croissante des projets de constitution d’archives vocales et à la nécessité d’adopter des protocoles partagés en vue d’une coordination internationale (sur le modèle de consortiums tels que ELRA ou CLARIN).This article summarizes some considerations on the usefulness of the transcription/ annotation of linguistic data with particular attention to the conservation function of dialectal dialects or languages threatened with extinction. To the brief description of the first dialectological operations of the major atlases projects, we associate a reference to the growing spread of projects to set up vocal archives and the need to adopt shared protocols with a view to international coordination (on the model of those offered by consortia such as ELRA or CLARIN)

STIMOLAZIONE COGNITIVA DI PERSONE CON DECLINO COGNITIVO LIEVE (MCI): REPORT DI UN’ESPERIENZA.

Awareness of the decline in one's cognitive abilities, present in the initial stages, can produce anxiety and depression, especially in the case of rapid worsening. A path towards the unknown, not chosen but suffered.We have been dealing with these states of mind for the past thirteen years at Socialmente cognitive gym (Sociamente), operating since 2009 in Chieri (Turin).The purpose of this contribution is to describe the cognitive stimulation practiced Socially with people, generally elderly, who are at the beginning of a path of cognitive decline, before possible resignation and, in any case, before the severity of the decline take pitying steps to remove the most painful memories.La consapevolezza del declino delle proprie capacità cognitive, presente nelle fasi iniziali, può produrre ansia e depressione, soprattutto nel caso di rapidopeggioramento. Un cammino verso l’ignoto, non scelto ma subìto. Con questi stati d’animo ci confrontiamo da ormai tredici anni a Socialmente palestra cognitiva (Socialmente), operante dal 2009 a Chieri (Torino).Scopo del presente contributo è di descrivere la stimolazione cognitiva praticata a Socialmente nei confronti di persone, generalmente anziane, che si trovano all’inizio di un percorso di declino cognitivo, prima della possibile rassegnazione e, in ogni caso, prima che la severità del declino provveda, pietosamente, a rimuovere i ricordi più dolorosi

ADPKD: Prototype of Cardiorenal Syndrome Type 4

The cardiorenal syndrome type 4 (Chronic Renocardiac Syndrome) is characterized by a condition of primary chronic kidney disease (CKD) that leads to an impairment of the cardiac function, ventricular hypertrophy, diastolic dysfunction, and/or increased risk of adverse cardiovascular events. Clinically, it is very difficult to distinguish between CRS type 2 (Chronic Cardiorenal Syndrome) and CRS type 4 (Chronic Renocardiac Syndrome) because often it is not clear whether the primary cause of the syndrome depends on the heart or the kidney. Autosomal dominant polycystic kidney disease (ADPKD), a genetic disease that causes CKD, could be viewed as an ideal prototype of CRS type 4 because it is certain that the primary cause of cardiorenal syndrome is the kidney disease. In this paper, we will briefly review the epidemiology of ADPKD, conventional and novel biomarkers which may be useful in following the disease process, and prevention and treatment strategies

single nucleotide polymorphism profiles of patients with acute renal rejection to personalize immunosuppressive therapy preliminary results from an on going italian study

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Effectiveness of polymyxin B-immobilized fiber column in sepsis: a systematic review

INTRODUCTION: Severe sepsis and septic shock are common problems in the intensive care unit and carry a high mortality. Endotoxin, one of the principal components on the outer membrane of gram-negative bacteria, is considered important to their pathogenesis. Polymyxin B bound and immobilized to polystyrene fibers (PMX-F) is a medical device that aims to remove circulating endotoxin by adsorption, theoretically preventing the progression of the biological cascade of sepsis. We performed a systematic review to describe the effect in septic patients of direct hemoperfusion with PMX-F on outcomes of blood pressure, use of vasoactive drugs, oxygenation, and mortality reported in published studies. METHODS: We searched PubMed, the Cochrane Collaboration Database, and bibliographies of retrieved articles and consulted with experts to identify relevant studies. Prospective and retrospective observational studies, pre- and post-intervention design, and randomized controlled trials were included. Three authors reviewed all citations. We identified a total of 28 publications - 9 randomized controlled trials, 7 non-randomized parallel studies, and 12 pre-post design studies - that reported at least one of the specified outcome measures (pooled sample size, 1,425 patients: 978 PMX-F and 447 conventional medical therapy). RESULTS: Overall, mean arterial pressure (MAP) increased by 19 mm Hg (95% confidence interval [CI], 15 to 22 mm Hg; p < 0.001), representing a 26% mean increase in MAP (range, 14% to 42%), whereas dopamine/dobutamine dose decreased by 1.8 microg/kg per minute (95% CI, 0.4 to 3.3 microg/kg per minute; p = 0.01) after PMX-F. There was significant intertrial heterogeneity for these outcomes (p < 0.001), which became non-significant when analysis was stratified for baseline MAP. The mean arterial partial pressure of oxygen/fraction of inspired oxygen (PaO2/FiO2) ratio increased by 32 units (95% CI, 23 to 41 units; p < 0.001). PMX-F therapy was associated with significantly lower mortality risk (risk ratio, 0.53; 95% CI, 0.43 to 0.65). The trials assessed had suboptimal method quality. CONCLUSION: Based on this critical review of the published literature, direct hemoperfusion with PMX-F appears to have favorable effects on MAP, dopamine use, PaO2/FiO2 ratio, and mortality. However, publication bias and lack of blinding need to be considered. These findings support the need for further rigorous study of this therapy

Occult HCV Infection: An Unexpected Finding in a Population Unselected for Hepatic Disease

BACKGROUND:Occult Hepatitis C virus (HCV) infection is a new pathological entity characterized by presence of liver disease and absence or very low levels of detectable HCV-RNA in serum. Abnormal values of liver enzymes and presence of replicative HCV-RNA in peripheral blood mononuclear cells are also observed. Aim of the study was to evaluate occult HCV occurrence in a population unselected for hepatic disease. METHODOLOGY/PRINCIPAL FINDINGS:We chose from previous epidemiological studies three series of subjects (n = 276, age range 40-65 years) unselected for hepatic disease. These subjects were tested for the presence of HCV antibodies and HCV-RNA in plasma and in the peripheral blood mononuclear cells (PBMCs) by using commercial systems. All subjects tested negative for HCV antibodies and plasma HCV-RNA and showed normal levels of liver enzymes; 9/276 patients (3.3%) were positive for HCV-RNA in PBMCs, identifying a subset of subjects with potential occult HCV infection. We could determine the HCV type for 8 of the 9 patients finding type 1a (3 patients), type 1b (2 patients), and type 2a (3 patients). CONCLUSIONS:The results of this study show evidence that occult HCV infection may occur in a population unselected for hepatic disease. A potential risk of HCV infection spread by subjects harbouring occult HCV infection should be considered. Design of prospective studies focusing on the frequency of infection in the general population and on the clinical evolution of occult HCV infection will be needed to verify this unexpected finding

A new classification of cardio-oncology syndromes

Abstract Increasing evidence suggests a multifaceted relationship exists between cancer and cardiovascular disease (CVD). Here, we introduce a 5-tier classification system to categorize cardio-oncology syndromes (COS) that represent the aspects of the relationship between cancer and CVD. COS Type I is characterized by mechanisms whereby the abrupt onset or progression of cancer can lead to cardiovascular dysfunction. COS Type II includes the mechanisms by which cancer therapies can result in acute or chronic CVD. COS Type III is characterized by the pro-oncogenic environment created by the release of cardiokines and high oxidative stress in patients with cardiovascular dysfunction. COS Type IV is comprised of CVD therapies and diagnostic procedures which have been associated with promoting or unmasking cancer. COS Type V is characterized by factors causing systemic and genetic predisposition to both CVD and cancer. The development of this framework may allow for an increased facilitation of cancer care while optimizing cardiovascular health through focused treatment targeting the COS type

B-Type Natriuretic Peptide in the Critically Ill with Acute Kidney Injury

Introduction. Acute kidney injury (AKI) is common in the intensive care unit (ICU) and associated with poor outcome. Plasma B-type natriuretic peptide (BNP) is a biomarker related to myocardial overload, and is elevated in some ICU patients. There is a high prevalence of both cardiac and renal dysfunction in ICU patients. Aims. To investigate whether plasma BNP levels in the first 48 hours were associated with AKI in ICU patients. Methods. We studied a cohort of 34 consecutive ICU patients. Primary outcome was presence of AKI on presentation, or during ICU stay. Results. For patients with AKI on presentation, BNP was statistically higher at 24 and 48 hours than No-AKI patients (865 versus 148 pg/mL; 1380 versus 131 pg/mL). For patients developing AKI during 48 hours, BNP was statistically higher at 0, 24 and 48 hours than No-AKI patients (510 versus 197 pg/mL; 552 versus 124 pg/mL; 949 versus 104 pg/mL). Conclusion. Critically ill patients with AKI on presentation or during ICU stay have higher levels of the cardiac biomarker BNP relative to No-AKI patients. Elevated levels of plasma BNP may help identify patients with elevated risk of AKI in the ICU setting. The mechanism for this cardiorenal connection requires further investigation

Cooperation beyond development. Rethinking international aid for the self- determination of recipient communities.

Questo articolo propone un dibattito critico e costruttivo sui temi della cooperazione negli ambienti stessi della cooperazione, soprattutto sugli obiettivi reali e apparenti, sugli effetti sortiti inconsapevolmente, e sui vincitori e vinti dell’aiuto internazionale, il tutto visto da una prospettiva socio-economica mondiale. Sono qui presentati i primi esiti di un Seminario Partecipativo tenuto proprio su tali tematiche, articolato in quattro tavoli di lavoro: autodeterminazione e reciprocità, emergenza e sviluppo, formazione, co-progettazione / progettazione partecipata.A critical and constructive debate is proposed on and inside cooperation, specifically on the real and the apparent goals, on the unaware effects, and on the winners and losers of international aid, framed in a global socio-economic perspective. The first outcomes of a recent participatory workshop on such themes are hereby illustrated, divided in four working tables: self-determination and reciprocity, emergency and development, training, and co-design / participatory design