Results of the First Coincident Observations by Two Laser-Interferometric Gravitational Wave Detectors

We report an upper bound on the strain amplitude of gravitational wave bursts in a waveband from around 800Hz to 1.25kHz. In an effective coincident observing period of 62 hours, the prototype laser interferometric gravitational wave detectors of the University of Glasgow and Max Planck Institute for Quantum Optics, have set a limit of 4.9E-16, averaging over wave polarizations and incident directions. This is roughly a factor of 2 worse than the theoretical best limit that the detectors could have set, the excess being due to unmodelled non-Gaussian noise. The experiment has demonstrated the viability of the kind of observations planned for the large-scale interferometers that should be on-line in a few years time.Comment: 11 pages, 2 postscript figure

Nonperturbative Renormalization and the QCD Vacuum

We present a self consistent approach to Coulomb gauge Hamiltonian QCD which allows one to relate single gluon spectral properties to the long range behavior of the confining interaction. Nonperturbative renormalization is discussed. The numerical results are in good agreement with phenomenological and lattice forms of the static potential.Comment: 23 pages in RevTex, 4 postscript figure

A Derivation of Three-Dimensional Inertial Transformations

The derivation of the transformations between inertial frames made by Mansouri and Sexl is generalised to three dimensions for an arbitrary direction of the velocity. Assuming lenght contraction and time dilation to have their relativistic values, a set of transformations kinematically equivalent to special relativity is obtained. The ``clock hypothesis'' allows the derivation to be extended to accelerated systems. A theory of inertial transformations maintaining an absolute simultaneity is shown to be the only one logically consistent with accelerated movements. Algebraic properties of these transformations are discussed. Keywords: special relativity, synchronization, one-way velocity of light, ether, clock hypothesis.Comment: 16 pages (A5), Latex, one figure, to be published in Found. Phys. Lett. (1997

Spatial migration of temporal earthquake clusters driven by the transfer of differential stress between neighbouring fault/shear-zone structures

Uncertainty concerning the processes responsible for slip-rate fluctuations associated with temporal clustering of surface faulting earthquakes is a fundamental, unresolved issue in tectonics, because strain-rates accommodated by fault/shear-zone structures are the key to understanding the viscosity structure of the crust and seismic hazard. We constrain the timing and amplitude of slip-rate fluctuations that occurred on three active normal faults in central Italy over a time period of 20–30 kyrs, using in situ 36Cl cosmogenic dating of fault planes. We identify five periods of rapid slip on individual faults lasting a few millennia, separated time periods of up to 10 millennia with low or zero slip-rate. The rapid slip pulses migrated across the strike between the faults in two waves from SW to NE. We replicate this migration with a model where rapid slip induces changes in differential stress that drive changes in strain-rate on viscous shear zones that drive slip-rate variability on overlying brittle faults. Earthquakes increase the differential stress and strain-rate on underlying shear zones, which in turn accumulate strain, re-loading stress onto the overlying brittle fault. This positive feedback produces high strain-rate episodes containing several large magnitude surface faulting earthquakes (earthquake clusters), but also reduce the differential stress on the viscous portions of neighbouring fault/shear-zones slowing the occurrence of large-magnitude surface faulting earthquakes (earthquake anticlusters). Shear-zones on faults experiencing anticlusters continue to accumulate viscous strain at a lowered rate, and eventually this loads the overlying brittle fault to failure, initiating a period of rapid slip through the positive feedback process described above, and inducing lowered strain-rates onto neighbouring fault/shear-zones. We show that these patterns of differential stress change can replicate the measured earthquake clustering implied by the 36Cl data. The stress changes are related to the fault geometry in terms of distance and azimuth from the slipping structure, implying that (a) strain-rate and viscosity fluctuations for studies of continental rheology, and (b) slip-rates for seismic hazard purposes are to an extent predictable given knowledge of the fault system geometry

Distributed normal faulting in the tip zone of the South Alkyonides Fault System, Gulf of Corinth, constrained using 36Cl exposure dating of late-Quaternary wave-cut platforms

The geometry, rates and kinematics of active faulting in the region close to the tip of a major crustal-scale normal fault in the Gulf of Corinth, Greece, are investigated using detailed fault mapping and new absolute dating. Fault offsets have been dated using a combination of 234U/230Th coral dates and in situ 36Cl cosmogenic exposure ages for sediments and wave-cut platforms deformed by the faults. Our results show that deformation in the tip zone is distributed across as many as eight faults arranged within ~700 m across strike, each of which deforms deposits and landforms associated with the 125 ka marine terrace of Marine Isotope Stage 5e. Summed throw-rates across strike achieve values as high as 0.3–1.6 mm/yr, values that are comparable to those at the centre of the crustal-scale fault (2–3 mm/yr from Holocene palaeoseismology and 3–4 mm/yr from GPS geodesy). The relatively high deformation rate and distributed deformation in the tip zone are discussed in terms of stress enhancement from rupture of neighbouring crustal-scale faults and in terms of how this should be considered during fault-based seismic hazard assessment

Boost-Invariant Running Couplings in Effective Hamiltonians

We apply a boost-invariant similarity renormalization group procedure to a light-front Hamiltonian of a scalar field phi of bare mass mu and interaction term g phi^3 in 6 dimensions using 3rd order perturbative expansion in powers of the coupling constant g. The initial Hamiltonian is regulated using momentum dependent factors that approach 1 when a cutoff parameter Delta tends to infinity. The similarity flow of corresponding effective Hamiltonians is integrated analytically and two counterterms depending on Delta are obtained in the initial Hamiltonian: a change in mu and a change of g. In addition, the interaction vertex requires a Delta-independent counterterm that contains a boost invariant function of momenta of particles participating in the interaction. The resulting effective Hamiltonians contain a running coupling constant that exhibits asymptotic freedom. The evolution of the coupling with changing width of effective Hamiltonians agrees with results obtained using Feynman diagrams and dimensional regularization when one identifies the renormalization scale with the width. The effective light-front Schroedinger equation is equally valid in a whole class of moving frames of reference including the infinite momentum frame. Therefore, the calculation described here provides an interesting pattern one can attempt to follow in the case of Hamiltonians applicable in particle physics.Comment: 24 pages, LaTeX, included discussion of finite x-dependent counterterm

Reversible Band Gap Engineering in Carbon Nanotubes by Radial Deformation

We present a systematic analysis of the effect of radial deformation on the atomic and electronic structure of zigzag and armchair single wall carbon nanotubes using the first principle plane wave method. The nanotubes were deformed by applying a radial strain, which distorts the circular cross section to an elliptical one. The atomic structure of the nanotubes under this strain are fully optimized, and the electronic structure is calculated self-consistently to determine the response of individual bands to the radial deformation. The band gap of the insulating tube is closed and eventually an insulator-metal transition sets in by the radial strain which is in the elastic range. Using this property a multiple quantum well structure with tunable and reversible electronic structure is formed on an individual nanotube and its band-lineup is determined from first-principles. The elastic energy due to the radial deformation and elastic constants are calculated and compared with classical theories.Comment: To be appear in Phys. Rev. B, Apr 15, 200

Characterizing the Diverse Mutational Pathways Associated with R5-Tropic Maraviroc Resistance: HIV-1 That Uses the Drug-Bound CCR5 Coreceptor

YesABSTRACT Entry inhibitors represent a potent class of antiretroviral drugs that target a host cell protein, CCR5, an HIV-1 entry coreceptor, and not viral protein. Lack of sensitivity can occur due to preexisting virus that uses the CXCR4 coreceptor, while true resistance occurs through viral adaptation to use a drug-bound CCR5 coreceptor. To understand this R5 resistance pathway, we analyzed >500 envelope protein sequences and phenotypes from viruses of 20 patients from the clinical trials MOTIVATE 1 and 2, in which treatment-experienced patients received maraviroc plus optimized background therapy. The resistant viral population was phylogenetically distinct and associated with a genetic bottleneck in each patient, consistent with de novo emergence of resistance. Recombination analysis showed that the C2-V3-C3 region tends to genotypically correspond to the recombinant’s phenotype, indicating its primary importance in conferring resistance. Between patients, there was a notable lack of commonality in the specific sites conferring resistance, confirming the unusual nature of R5-tropic resistance. We used coevolutionary and positive-selection analyses to characterize the genotypic determinants of resistance and found that (i) there are complicated covariation networks, indicating frequent coevolutionary/compensatory changes in the context of protein structure; (ii) covarying sites under positive selection are enriched in resistant viruses; (iii) CD4 binding sites form part of a unique covariation network independent of the V3 loop; and (iv) the covariation network formed between the V3 loop and other regions of gp120 and gp41 intersects sites involved in glycosylation and protein secretion. These results demonstrate that while envelope sequence mutations are the key to conferring maraviroc resistance, the specific changes involved are context dependent and thus inherently unpredictable. IMPORTANCE The entry inhibitor drug maraviroc makes the cell coreceptor CCR5 unavailable for use by HIV-1 and is now used in combination antiretroviral therapy. Treatment failure with drug-resistant virus is particularly interesting because it tends to be rare, with lack of sensitivity usually associated with the presence of CXCR4-using virus (CXCR4 is the main alternative coreceptor HIV-1 uses, in addition to CD4). We analyzed envelope sequences from HIV-1, obtained from 20 patients who enrolled in maraviroc clinical trials and experienced treatment failure, without detection of CXCR4-using virus. Evolutionary analysis was employed to identify molecular changes that confer maraviroc resistance. We found that in these individuals, resistant viruses form a distinct population that evolved once and was successful as a result of drug pressure. Further evolutionary analysis placed the complex network of interdependent mutational changes into functional groups that help explain the impediments to the emergence of maraviroc-associated R5 drug resistance.X.J. was supported by Medical Research Council (G1001806/1) and Wellcome Trust (097820/Z/11/A) funding and F.F. by a Biotechnology and Biological Sciences Research Council studentship to D.L.R

Towards Solving QCD - The Transverse Zero Modes in Light-Cone Quantization

We formulate QCD in (d+1) dimensions using Dirac's front form with periodic boundary conditions, that is, within Discretized Light-Cone Quantization. The formalism is worked out in detail for SU(2) pure glue theory in (2+1) dimensions which is approximated by restriction to the lowest {\it transverse} momentum gluons. The dimensionally-reduced theory turns out to be SU(2) gauge theory coupled to adjoint scalar matter in (1+1) dimensions. The scalar field is the remnant of the transverse gluon. This field has modes of both non-zero and zero {\it longitudinal} momentum. We categorize the types of zero modes that occur into three classes, dynamical, topological, and constrained, each well known in separate contexts. The equation for the constrained mode is explicitly worked out. The Gauss law is rather simply resolved to extract physical, namely color singlet states. The topological gauge mode is treated according to two alternative scenarios related to the In the one, a spectrum is found consistent with pure SU(2) gluons in (1+1) dimensions. In the other, the gauge mode excitations are estimated and their role in the spectrum with genuine Fock excitations is explored. A color singlet state is given which satisfies Gauss' law. Its invariant mass is estimated and discussed in the physical limit.Comment: LaTex document, 26 pages, one figure (obtainable by contacting authors). To appear in Physical. Review

Out of phase Quaternary uplift-rate changes reveal normal fault interaction, implied by deformed marine palaeoshorelines

We have mapped and constrained the timing of tectonically deformed uplifted Late Quaternary palaeoshorelines in the Messina Strait, southern Italy, an area above a subduction zone containing active normal faults. The palaeoshorelines are preserved from up to thirteen Late Quaternary sea-level highstands, providing a record of the deformation over this timescale (~500 ka) for the Messina-Taormina Fault, the Reggio Calabria Fault and the Armo Fault. The palaeoshorelines reveal spatial patterns of uplift through time along the strike of these normal faults, and, given the across strike arrangement of the faults, also reveal how the contribution of each fault to the regional strain-rate progressed through time. The results reveal that the uplift rates mapped within the fault hangingwalls and footwalls were not constant through time, with a marked change in the location of strain accumulation at ~50 ka. The uplift rates, once converted into throw-rates, imply that the three faults comprised similar throw-rates prior to ~50 ka (in the range 0.77–0.96 mm/yr), with the Armo and Reggio Calabria faults then switching to lower rates (0.32 mm/yr and 0.33 mm/yr respectively), whilst the Messina-Taormina Fault accelerated to 2.34 mm/yr. The regional extension rate, gained by summing the implied heave rates across the three faults, was maintained through time despite this re-organisation of local strain accumulation at ~50 ka. We explain these out-of-phase fault throw-rate changes during the constant-rate regional extension conditions as due to interactions between these upper plate normal faults. We finally discuss how fault throw-rates changing through time may affect a long-term seismic hazard assessment within active normal fault systems