19,238 research outputs found
Mirror Dark Matter
There appear to be three challenges that any theory of dark matter must face:
(i) why is of the same order as ? (ii) what
are the near solar mass objects () observed by the MACHO
microlensing project ? and (iii) understanding the shallow core density profile
of the halos of dwarf as well as low surface brightness galaxies. The popular
cold dark matter candidates, the SUSY LSP and the axion fail to meet these
challenges. We argue that in the mirror model suggested recently to explain the
neutrino anomalies, the mirror baryons being 15-20 times heavier than familiar
baryons, can play the role of the cold dark matter and provide reasonable
explanation of all three above properties without extra assumptions.Comment: Latex, 10 pages; Invited talk presented in PASCOS99 workshop, held in
Lake Tahoe, Dec. 1999 and DM2000 workshop held in Los Angeles, February, 200
Application of the DRA method to the calculation of the four-loop QED-type tadpoles
We apply the DRA method to the calculation of the four-loop `QED-type'
tadpoles. For arbitrary space-time dimensionality D the results have the form
of multiple convergent sums. We use these results to obtain the
epsilon-expansion of the integrals around D=3 and D=4.Comment: References added, some typos corrected. Results unchange
Phenomenological Consequences of sub-leading Terms in See-Saw Formulas
Several aspects of next-to-leading (NLO) order corrections to see-saw
formulas are discussed and phenomenologically relevant situations are
identified. We generalize the formalism to calculate the NLO terms developed
for the type I see-saw to variants like the inverse, double or linear see-saw,
i.e., to cases in which more than two mass scales are present. In the standard
type I case with very heavy fermion singlets the sub-leading terms are
negligible. However, effects in the percent regime are possible when
sub-matrices of the complete neutral fermion mass matrix obey a moderate
hierarchy, e.g. weak scale and TeV scale. Examples are cancellations of large
terms leading to small neutrino masses, or inverse see-saw scenarios. We
furthermore identify situations in which no NLO corrections to certain
observables arise, namely for mu-tau symmetry and cases with a vanishing
neutrino mass. Finally, we emphasize that the unavoidable unitarity violation
in see-saw scenarios with extra fermions can be calculated with the formalism
in a straightforward manner.Comment: 22 pages, matches published versio
Challenges in Bridging Social Semantics and Formal Semantics on the Web
This paper describes several results of Wimmics, a research lab which names
stands for: web-instrumented man-machine interactions, communities, and
semantics. The approaches introduced here rely on graph-oriented knowledge
representation, reasoning and operationalization to model and support actors,
actions and interactions in web-based epistemic communities. The re-search
results are applied to support and foster interactions in online communities
and manage their resources
Increased gravitational force reveals the mechanical, resonant nature of physiological tremor
Human physiological hand tremor has a resonant component. Proof of this is that its frequency can be modified by adding mass. However, adding mass also increases the load which must be supported. The necessary force requires muscular contraction which will change motor output and is likely to increase limb stiffness. The increased stiffness will partly offset the effect of the increased mass and this can lead to the erroneous conclusion that factors other than resonance are involved in determining tremor frequency. Using a human centrifuge to increase head-to-foot gravitational field strength, we were able to control for the increased effort by increasing force without changing mass. This revealed that the peak frequency of human hand tremor is 99% predictable on the basis of a resonant mechanism. We ask what, if anything, the peak frequency of physiological tremor can reveal about the operation of the nervous system.This work was funded by a BBSRC Industry Interchange Award
to J.P.R.S. and R.F.R. C.J.O. was funded by BBSRC grant
BB/I00579X/1. C.A.V. was funded by A∗Midex (Aix-Marseille
Initiative of Excellence
Tubulin and Tubulin Posttranslational Modifications in Alzheimer’s Disease and Vascular Dementia
Copyright \ua9 2021 Santiago-Mujika, Luthi-Carter, Giorgini, Kalaria and Mukaetova-Ladinska. Alzheimer’s disease (AD) and vascular dementia (VaD) are the two most common forms of dementia in older people. Although these two dementia types differ in their etiology, they share many pathophysiological and morphological features, including neuronal loss, which is associated with the microtubule (MT) destabilization. Stabilization of MTs is achieved in different ways: through interactions with MT binding proteins (MTBP) or by posttranslational modifications (PTMs) of tubulin. Polyglutamylation and tyrosination are two foremost PTMs that regulate the interaction between MTs and MTBPs, and play, therefore, a role in neurodegeneration. In this review, we summarize key information on tubulin PTMs in relation to AD and VaD and address the importance of studying further the tubulin code to reveal sites of potential intervention in development of novel and effective dementia therapy
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