289 research outputs found
CCL5 regulation of mucosal chlamydial immunity and infection
<p>Abstract</p> <p>Background</p> <p>Following genital chlamydial infection, an early T helper type 1 (Th1)-associated immune response precedes the activation and recruitment of specific Th1 cells bearing distinct chemokine receptors, subsequently leading to the clearance of <it>Chlamydia</it>. We have shown that CCR5, a receptor for CCL5, is crucial for protective chlamydial immunity. Our laboratory and others have also demonstrated that CCL5 deficiencies found in man and animals can increase the susceptibility and progression of infectious diseases by modulating mucosal immunity. These findings suggest the CCR5-CCL5 axis is necessary for optimal chlamydial immunity. We hypothesized CCL5 is required for protective humoral and cellular immunity against <it>Chlamydia</it>.</p> <p>Results</p> <p>The present study revealed that CCR5 and CCL5 mRNAs are elevated in the spleen, iliac lymph nodes (ILNs), and genital mucosa following <it>Chlamydia muriduram </it>challenge. Antibody (Ab)-mediated inhibition of CCL5 during genital chlamydial infection suppressed humoral and Th1 > Th2 cellular responses by splenic-, ILN-, and genital mucosa-derived lymphocytes. Antigen (Ag)-specific proliferative responses of CD4<sup>+ </sup>T cells from spleen, ILNs, and genital organs also declined after CCL5 inhibition.</p> <p>Conclusion</p> <p>The suppression of these responses correlated with delayed clearance of <it>C. muriduram</it>, which indicate chlamydial immunity is mediated by Th1 immune responses driven in part by CCL5. Taken together with other studies, the data show that CCL5 mediates the temporal recruitment and activation of leukocytes to mitigate chlamydial infection through enhancing adaptive mucosal humoral and cellular immunity.</p
The Princeton Protein Orthology Database (P-POD): A Comparative Genomics Analysis Tool for Biologists
Many biological databases that provide comparative genomics information and tools are now available on the internet. While certainly quite useful, to our knowledge none of the existing databases combine results from multiple comparative genomics methods with manually curated information from the literature. Here we describe the Princeton Protein Orthology Database (P-POD, http://ortholog.princeton.edu), a user-friendly database system that allows users to find and visualize the phylogenetic relationships among predicted orthologs (based on the OrthoMCL method) to a query gene from any of eight eukaryotic organisms, and to see the orthologs in a wider evolutionary context (based on the Jaccard clustering method). In addition to the phylogenetic information, the database contains experimental results manually collected from the literature that can be compared to the computational analyses, as well as links to relevant human disease and gene information via the OMIM, model organism, and sequence databases. Our aim is for the P-POD resource to be extremely useful to typical experimental biologists wanting to learn more about the evolutionary context of their favorite genes. P-POD is based on the commonly used Generic Model Organism Database (GMOD) schema and can be downloaded in its entirety for installation on one's own system. Thus, bioinformaticians and software developers may also find P-POD useful because they can use the P-POD database infrastructure when developing their own comparative genomics resources and database tools
Measurement of the branching fraction for
We present a measurement of the branching fraction for the decay B- --> D0 K*- using a sample of approximately 86 million BBbar pairs collected by the BaBar detector from e+e- collisions near the Y(4S) resonance. The D0 is detected through its decays to K- pi+, K- pi+ pi0 and K- pi+ pi- pi+, and the K*- through its decay to K0S pi-. We measure the branching fraction to be B.F.(B- --> D0 K*-)= (6.3 +/- 0.7(stat.) +/- 0.5(syst.)) x 10^{-4}
Observation of a significant excess of events in B meson decays
We present an observation of the decay based on a sample of 124 million pairs recorded by the BABAR detector at the PEP-II asymmetric-energy Factory at SLAC. We observe events, where the first error is statistical and the second is systematic, corresponding to a significance of 4.2 standard deviations including systematic uncertainties. We measure the branching fraction \BR(B^{0} \to \pi^{0} \pi^{0}) = (2.1 \pm 0.6 \pm 0.3) \times 10^{-6}, averaged over and decays
Observation of the Decay B=> J/psi eta K and Search for X(3872)=> J/psi eta
We report the observation of the meson decay
and evidence for the decay , using {90} million
events collected at the \ensuremath{\Upsilon{(4S)}}\xspace resonance
with the detector at the PEP-II asymmetric-energy storage
ring. We obtain branching fractions of )= and
)=. We search for the new narrow mass state, the
X(3872), recently reported by the Belle Collaboration, in the decay B^\pm\to
X(3872)K^\pm, X(3872)\to \jpsi \eta and determine an upper limit of
(B^\pm \to X(3872) K^\pm \to \jpsi \eta K^\pm)
at 90% C.L.Comment: 7 pages and two figures, submitted to Phys. Rev. Lett
Measurement of the Ratio of b Quark Production Cross Sections in Antiproton-Proton Collisions at 630 GeV and 1800 GeV
We report a measurement of the ratio of the bottom quark production cross
section in antiproton-proton collisions at 630 GeV to 1800 GeV using bottom
quarks with transverse momenta greater than 10.75 GeV identified through their
semileptonic decays and long lifetimes. The measured ratio
sigma(630)/sigma(1800) = 0.171 +/- .024 +/- .012 is in good agreement with
next-to-leading order (NLO) quantum chromodynamics (QCD)
Measurement of the branching fraction for B±→χc0K±
We present preliminary results for the measurement of the branching fraction of the decay B+- -> chi_c0 K+- from a sample of 75 million BB pairs collected by the BABAR detector at the PEP-II asymmetric-energy B Factory at SLAC. The chi_c0 meson is reconstructed through its two-body decays to pi+ pi- and K+ K-. We measure BR(B+- -> chi_c0 K+-) * BR(chi_c0 -> pi+ pi-) = (1.08 +- 0.35 (stat) +- 0.10 (syst))*10^-6 and BR(B+- -> chi_c0 K+-) * BR(chi_c0 -> K+ K-) = (1.48 +- 0.44 (stat) +- 0.17 (syst)) * 10^-6. Using the known values for the chi_c0 decays branching fractions, we combined these results to obtain BR(B+- -> chi_c0 K+-) = (2.4 +- 0.7) * 10^-4
Search for the rare leptonic decay B+->mu(+)nu(mu) (vol 92, art no 221803, 2004)
Corrections to the article published in the same review - same title (vol 92, art no 221803, 2004
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Measurement of the branching fraction for B-->(DK)-K-0*(-)
We present a measurement of the branching fraction for the decay B--->(DK*-)-K-0 using a sample of approximately 86x10(6) B (B) over bar pairs collected by the BABAR detector from e(+)e(-) collisions near the Y(4S) resonance. The D-0 is detected through its decays to K(-)pi(+), K(-)pi(+)pi(0), and K(-)pi(+)pi(-)pi(+), and the K*- through its decay to K(S)(0)pi(-). We measure the branching fraction to be B(B--->(DK*-)-K-0)=[6.3+/-0.7(stat)+/-0.5(syst)]x10(-4).The Particle Physics and Astronomy Research Council (United Kingdom); A. P. Sloan Foundation; the Research Corporation; and the Alexander von Humboldt Foundation
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