analysis of dynamic instabilities in bridges under wind action through a simple friction based mechanical model

Abstract In the field of stability of structures under nonconservative loads, the concept of follower force has long been debated by scientists due to the lack of actual experimental evidence. Bigoni and Noselli's work [2] aimed to investigate flutter and divergence instability phenomena through a purely mechanical model with Coulomb friction represents a praiseworthy attempt to shed light on this issue. A two-degree-of-freedom (DOF) system, conceived as a variant of the Ziegler column, was set up experimentally. The follower load was induced by a frictional force acting on a wheel mounted at the column end, so that the rolling friction vanishes and the sliding frictional force keeps always coaxial to the column, thus representing a tangential follower force. Along this research line, in this contribution a model is elaborated that stems from the analysis of an elastically supported rigid plate that represents the behaviour of a bridge deck suspended on springs and subjected to a wind-induced force. The wind force has been simulated by a Coulomb friction force acting on a wheel mounted on the plate aerodynamic centre, so that the sliding friction force keeps perpendicular to the plate axis throughout the system motion, thus representing a follower force. To properly reproduce the wind force, the friction force is applied to the wheel by a lever mechanism wherein one of the two lever arms involves the plate rotation via a particular circular guide. The corresponding equations of motion of the bridge deck are derived in a completely dimensionless form. Depending on the mechanical characteristics of the plate and the magnitude of the friction force, stability, flutter or divergence phenomena may occur. The occurrence of these phenomena is numerically investigated by integration of the equations of motion. The development of an experimental framework of the model to corroborate these intuitions is the object of an ongoing research

Mass spectrometric evidence for collisionally induced removal of H2 from monoanions of 10B nido-carborane derivatives investigated by electrospray ionization quadrupole linear ion trap and Fourier transform ion cyclotron resonance mass spectrometry

Some newly synthesized 10B nido-carborane derivatives, i.e., 7,8-dicarba-nido-undecaborane monoanions ([7-Me-8-R-C2B9H10]-K+, R = H, butyl, hexyl, octyl and decyl), have been fully characterised and examined by electrospray ionization and Fourier transform ion cyclotron resonance mass spectrometry with liquid chromatographic separation (LC/ESI-FTICR-MS). These boron-containing compounds exhibit abundant molecular ions ([M]−) at m/z 140.22631 [CB9H14]−, m/z 196.28883 [CB9H22]−, m/z 224.32032 [CB9H26]−, m/z 252.35133 [CB9H30]− and m/z 280.38354 [CB9H34]− at the normal tube lens voltage setting of −90 V, which was an instrumental parameter value selected in the tuning operation. Additional [M–nH2]− (n = 1−4) ions were observed in the mass spectra when higher tube lens voltages were applied, i.e., −140 V. High-resolution FTICR-MS data revealed the accurate masses of fragment ions, bearing either an even or an odd number of electrons. Collision-induced dissociation of the [M–nH2]− ions (n = 0–4) in the quadrupole linear ion trap (LTQ) analyzer confirmed the loss of hydrogen molecules from the molecular ions. It is suggested that the loss of H2 molecules from the alkyl chain is a consequence of the stabilization effect of the nido-carborane charged polyhedral skeleton

Health technology assessment through Six Sigma Methodology to assess cemented and uncemented protheses in total hip arthroplasty

The purpose of this study is to use Health Technology Assessment (HTA) through the Six Sigma (SS) and DMAIC (Define, Measure, Analyse, Improve, Control) problem-solving strategies for comparing cemented and uncemented prostheses in terms of the costs incurred for Total hip arthroplasty (THA) and the length of hospital stay (LOS). Multinomial logistic regression analysis for modelling the data was also performed. Quantitative parameters extracted from gait analysis, electromyography and computed tomography images were used to compare the approaches, but the analysis did not show statistical significance. The variables regarding costs were studied with the Mann-Whitney and Kruskal-Wallis tests. No statistically significant difference between cemented and uncemented prosthesis for the total cost of LOS was found, but the cost of the surgeon had an influence on the overall expenses, affecting the cemented prosthetic approach. The material costs of surgery for the uncemented prosthesis and the cost of theatre of surgery for the cemented prosthesis were the most influential. Multinomial logistic regression identified the Vastus Lateralis variable as statistically significant. The overall accuracy of the model is 93.0%. The use of SS and DMAIC cycle as tools of HTA proved that the cemented and uncemented approaches for THA have similar costs and LO

Acromion Clavicular Joint Reconstruction with LARS Ligament in Acute Dislocation

Background: The acromion clavicular joint dislocations are common injuries of the shoulder. The severity is dependent upon the degree of ligamentous injury. Surgical treatment is typically performed in higher grade acromioclavicular separation with several static and dynamic operative procedures with or without primary ligament replacement. Methods: 47 patients with acute Rockwood type III, IV, and V injuries were treated surgically with LARS reconstruction. The success of technique was evaluated by radiographic outcomes for each patient at every follow-up visit (one,three, 12 months), while to assess pain reduction and clinical evaluation Visual Analogue scale score (VAS) and Constant-Murley score (CMA) was performed, respectively. An One Way Analysis of Variance (Kruskal-Wallis test), a multiple comparison Turket test, or a t-test (Mann-Whitney Rank Sum Test) were used when required. Results: Follow-up radiographs revealed maintenance of anatomical reduction in 41 patients, and no bone erosions has been identified. In short-term joint functional recovery has been observed. Indeed, after 12 months pain on the VAS-scale in all groups decreased significantly (P < 0.05), and the CMS revealed a significant overall improvement (P < 0.05). Conclusion: These data demonstrate that the use of the LARS allows to provide stability to the joint and especially to ensure its natural elasticity, relieving pain and improving joint function already one month post-surgery. Level of evidence: II

A comparative study of different integrate-and-fire neurons: spontaneous activity, dynamical response, and stimulus-induced correlation

Stochastic integrate-and-fire (IF) neuron models have found widespread applications in computational neuroscience. Here we present results on the white-noise-driven perfect, leaky, and quadratic IF models, focusing on the spectral statistics (power spectra, cross spectra, and coherence functions) in different dynamical regimes (noise-induced and tonic firing regimes with low or moderate noise). We make the models comparable by tuning parameters such that the mean value and the coefficient of variation of the interspike interval match for all of them. We find that, under these conditions, the power spectrum under white-noise stimulation is often very similar while the response characteristics, described by the cross spectrum between a fraction of the input noise and the output spike train, can differ drastically. We also investigate how the spike trains of two neurons of the same kind (e.g. two leaky IF neurons) correlate if they share a common noise input. We show that, depending on the dynamical regime, either two quadratic IF models or two leaky IFs are more strongly correlated. Our results suggest that, when choosing among simple IF models for network simulations, the details of the model have a strong effect on correlation and regularity of the output.Comment: 12 page

Carmustine Wafers Implantation in Patients With Newly Diagnosed High Grade Glioma: Is It Still an Option?

Background: The implantation protocol for Carmustine Wafers (CWs) in high grade glioma (HGG) was developed to offer a bridge between surgical resection and adjuvant treatments, such as radio- and chemotherapy. In the last years, however, a widespread use of CWs has been limited due to uncertainties regarding efficacy, in addition to increased risk of infection and elevated costs of treatment. Objective: The aims of our study were to investigate the epidemiology of patients that underwent surgery for HGG with CW implantation, in addition to the assessment of related complications, long-term overall survival (OS), and associated prognostic factors. Methods: Three different medical databases were screened for conducting a systematic review of the literature, according to the PRISMA statement guidelines, evaluating the role of BCNU wafer implantation in patients with newly diagnosed HGG. The search query was based on a combination of medical subject headings (MeSH): “high grade glioma” [MeSH] AND “Carmustine” [MeSH] and free text terms: “surgery” OR “BCNU wafer” OR “Gliadel” OR “systemic treatment options” OR “overall survival.” Results: The analysis of the meta-data demonstrated that there was a significant advantage in using CWs in newly diagnosed GBM in terms of OS, and a very low heterogeneity among the included studies [mean difference 2.64 (95% CI 0.85, 4.44); p = 0.004; I2149 = 0%]. Conversely, no significant difference between the two treatment groups in terms of PFS wad detected (p = 0.55). The analysis of complications showed a relatively higher rate in Carmustine implanted patients, although this difference was not significant (p = 0.53). Conclusions: This meta-analysis seems to suggest that CWs implantation plays a significant role in improving the OS, when used in patients with newly diagnosed HGG. To minimize the risk of side effects, however, a carful patient selection based mainly on patient age and tumor volume should be desirable

Interrupted versus uninterrupted NOAC peri-implantation of cardiac device: A single-centre randomised prospective pilot trial

BACKGROUND: Many patients requiring cardiac implantable electronic device (CIED) implantation are on long-term oral anticoagulant therapy. While continuation of warfarin has been shown to be safe and reduce bleeding complications compared to interruption of warfarin therapy and heparin bridging, it is not known which novel oral anticoagulants (NOAC) regimen (interrupted vs. uninterrupted) is better in this setting. METHODS: One-hundred and one patients were randomized to receive CIED implantation with either interrupted or uninterrupted/continuous NOAC therapy before surgery. No heparin was used in either treatment arm. The primary end-point was the presence of a clinically significant pocket haematoma after CIED implantation. The secondary end-point was a composite of other major bleeding events, device-related infection, thrombotic events and device-related admission length post device implantation. RESULTS: Both treatment groups were equally balanced for baseline variables and concomitant medications. One clinically significant pocket haematoma occurred in the uninterrupted NOAC group and none in the interrupted group (p = 0.320). There was no difference in other bleeding complications. No thrombotic events were observed in either of the two groups. CONCLUSIONS: Despite the paucity of bleeding events, data from this pilot study suggest that uninterrupted NOAC therapy for CIED implantation appears to be as safe as NOAC interruption and does not increase bleeding complications

Analytical Solution for the Deformation of a Cylinder under Tidal Gravitational Forces

Quite a few future high precision space missions for testing Special and General Relativity will use optical resonators which are used for laser frequency stabilization. These devices are used for carrying out tests of the isotropy of light (Michelson-Morley experiment) and of the universality of the gravitational redshift. As the resonator frequency not only depends on the speed of light but also on the resonator length, the quality of these measurements is very sensitive to elastic deformations of the optical resonator itself. As a consequence, a detailed knowledge about the deformations of the cavity is necessary. Therefore in this article we investigate the modeling of optical resonators in a space environment. Usually for simulation issues the Finite Element Method (FEM) is applied in order to investigate the influence of disturbances on the resonator measurements. However, for a careful control of the numerical quality of FEM simulations a comparison with an analytical solution of a simplified resonator model is beneficial. In this article we present an analytical solution for the problem of an elastic, isotropic, homogeneous free-flying cylinder in space under the influence of a tidal gravitational force. The solution is gained by solving the linear equations of elasticity for special boundary conditions. The applicability of using FEM codes for these simulations shall be verified through the comparison of the analytical solution with the results gained within the FEM code.Comment: 23 pages, 3 figure

Symmetry energy of fragments produced in multifragmentation

Isospin properties of fragments measured in multifragmentation of 136Xe and 124Xe projectiles in mid-peripheral collisions with a lead target at 1 A GeV were studied within the statistical approach describing the liquid-gas nuclear phase transition. By analyzing the isoscaling phenomenon and the mean N-over-Z ratio of the fragments with Z=10-13 we have concluded that the symmetry energy of hot fragments produced in multifragment environment at subnuclear densities at high temperatures decreases in comparison with cold nuclei.Comment: 10 pages, 4 figures, background information on http://www-w2k.gsi.de/charms