Sex- and Diet-Specific Changes of Imprinted Gene Expression and DNA Methylation in Mouse Placenta under a High-Fat Diet

Changes in imprinted gene dosage in the placenta may compromise the prenatal control of nutritional resources. Indeed monoallelic behaviour and sensitivity to changes in regional epigenetic state render imprinted genes both vulnerable and adaptable

Write, draw, show, and tell: a child-centred dual methodology to explore perceptions of out-of-school physical activity

Background Research to increase children’s physical activity and inform intervention design has, to date, largely underrepresented children’s voices. Further, research has been limited to singular qualitative methods that overlook children’s varied linguistic ability and interaction preference. The aim of this study was to use a novel combination of qualitative techniques to explore children’s current views, experiences and perceptions of out-of-school physical activity as well as offering formative opinion about future intervention design. Methods Write, draw, show and tell (WDST) groups were conducted with 35 children aged 10–11 years from 7 primary schools. Data were analysed through a deductive and inductive process, firstly using the Youth Physical Activity Promotion Model as a thematic framework, and then inductively to enable emergent themes to be further explored. Pen profiles were constructed representing key emergent themes. Results The WDST combination of qualitative techniques generated complimentary interconnected data which both confirmed and uncovered new insights into factors relevant to children’s out-of-school physical activity. Physical activity was most frequently associated with organised sports. Fun, enjoyment, competence, and physical activity provision were all important predictors of children’s out-of-school physical activity. Paradoxically, parents served as both significant enablers (i.e. encouragement) and barriers (i.e. restricting participation) to physical activity participation. Some of these key findings would have otherwise remained hidden when compared to more traditional singular methods based approaches. Conclusions Parents are in a unique position to promote health promoting behaviours serving as role models, physical activity gatekeepers and choice architects. Given the strong socialising effect parents have on children’s physical activity, family-based physical activity intervention may offer a promising alternative compared to traditional school-based approaches. Parents' qualitative input is important to supplement children’s voices and inform future family-based intervention design. The WDST method developed here is an inclusive, interactive and child-centred methodology which facilitates the exploration of a wide range of topics and enhances data credibility

Phytoplankton responses to marine climate change – an introduction

Phytoplankton are one of the key players in the ocean and contribute approximately 50% to global primary production. They serve as the basis for marine food webs, drive chemical composition of the global atmosphere and thereby climate. Seasonal environmental changes and nutrient availability naturally influence phytoplankton species composition. Since the industrial era, anthropogenic climatic influences have increased noticeably – also within the ocean. Our changing climate, however, affects the composition of phytoplankton species composition on a long-term basis and requires the organisms to adapt to this changing environment, influencing micronutrient bioavailability and other biogeochemical parameters. At the same time, phytoplankton themselves can influence the climate with their responses to environmental changes. Due to its key role, phytoplankton has been of interest in marine sciences for quite some time and there are several methodical approaches implemented in oceanographic sciences. There are ongoing attempts to improve predictions and to close gaps in the understanding of this sensitive ecological system and its responses

Aplib: Tactical Agents for Testing Computer Games

Modern interactive software, such as computer games, employ complex user interfaces. Although these user interfaces make the games attractive and powerful, unfortunately they also make them extremely difficult to test. Not only do we have to deal with their functional complexity, but also the fine grained interactivity of their user interface blows up their interaction space, so that traditional automated testing techniques have trouble handling it. An agent-based testing approach offers an alternative solution: agents’ goal driven planning, adaptivity, and reasoning ability can provide an extra edge towards effective navigation in complex interaction space. This paper presents aplib, a Java library for programming intelligent test agents, featuring novel tactical programming as an abstract way to exert control over agents’ underlying reasoning-based behavior. This type of control is suitable for programming testing tasks. Aplib is implemented in such a way to provide the fluency of a Domain Specific Language (DSL). Its embedded DSL approach also means that aplib programmers will get all the advantages that Java programmers get: rich language features and a whole array of development tools

Aplib: Tactical Agents for Testing Computer Games

Modern interactive software, such as computer games, employ complex user interfaces. Although these user interfaces make the games attractive and powerful, unfortunately they also make them extremely difficult to test. Not only do we have to deal with their functional complexity, but also the fine grained interactivity of their user interface blows up their interaction space, so that traditional automated testing techniques have trouble handling it. An agent-based testing approach offers an alternative solution: agents’ goal driven planning, adaptivity, and reasoning ability can provide an extra edge towards effective navigation in complex interaction space. This paper presents aplib, a Java library for programming intelligent test agents, featuring novel tactical programming as an abstract way to exert control over agents’ underlying reasoning-based behavior. This type of control is suitable for programming testing tasks. Aplib is implemented in such a way to provide the fluency of a Domain Specific Language (DSL). Its embedded DSL approach also means that aplib programmers will get al.l the advantages that Java programmers get: rich language features and a whole array of development tools