Good work, little soldier: Text and pretext

This article reads the relation between Denis's Beau Travail and Jean-Luc Godard's 1960 film Le Petit Soldat as a film-on-film variant of film-on-book adaptation. The model informing this reading is not so much intertextual as pretextual. The principal points of contact between the two films discussed are 'actor' (Michel Subor), 'character' (Bruno Forestier) and 'narrator' (Forestier/Galoup). The use in Beau Travail of Le Petit Soldat is compared with and differentiated from the use of Melville's 'Billy Budd, Sailor'. The conclusion arrived at is that the film-on-film relation can be read as a development of the mirror motif borrowed from Godard by Denis, in order to replace abyssal models of intertextual infinity with the finitudes of abyssal reflexivity. This is to offer a model of pretextuality that is not dependent on privileging the pretext: implicit is the suggestion that Beau Travail and Le Petit Soldat may be read as a single, if hybrid, text

Guinea pigs sublethally infected with aerosolized Legionella pneumophila develop humoral and cell-mediated immune responses and are protected against lethal aerosol challenge. A model for studying host defense against lung infections caused by intracellular pathogens.

We have employed the guinea pig model of L. pneumophila infection, which mimics Legionnaires' disease in humans both clinically and pathologically, to study humoral and cell-mediated immune responses to L. pneumophila and to examine protective immunity after aerosol exposure, the natural route of infection. Guinea pigs exposed to sublethal concentrations of L. pneumophila by aerosol developed strong humoral immune responses. By the indirect fluorescent antibody assay, exposed guinea pigs had a median serum antibody titer (expressed as the reciprocal of the highest positive dilution) of 32, whereas control guinea pigs had a median titer of less than 1. Sublethally infected (immunized) guinea pigs also developed strong cell-mediated immune responses. In response to L. pneumophila antigens, splenic lymphocytes from immunized but not control animals proliferated strongly in vitro, as measured by their capacity to incorporate [3H]thymidine. Moreover, immunized but not control guinea pigs developed strong cutaneous delayed-type hypersensitivity to intradermally injected L. pneumophila antigens. Sublethally infected (immunized) guinea pigs exhibited strong protective immunity to L. pneumophila. In two independent experiments, all 22 immunized guinea pigs survived aerosol challenge with one or three times the lethal dose of L. pneumophila whereas none of 16 sham-immunized control guinea pigs survived (p less than 0.0001 in each experiment). Immunized guinea pigs were not protected significantly from challenge with 10 times the lethal dose. Immunized but not control animals cleared the bacteria from their lungs. This study demonstrates that guinea pigs sublethally infected with L. pneumophila by the aerosol route develop strong humoral immune responses to this pathogen, develop strong cell-mediated immune responses and cutaneous delayed-type hypersensitivity to L. pneumophila antigens, are protected against subsequent lethal aerosol challenge, and are able to clear the bacteria from their lungs. The guinea pig model of L. pneumophila pulmonary infection is as an excellent one for studying general principles of host defense against pulmonary infections caused by intracellular pathogens

Spatial attention shifting and phonological processing in adults with dyslexia

According to Hari and Renvall’s (2001) sluggish attentional shifting (SAS) hypothesis people with dyslexia have a central deficit in attention shifting. Here we assessed whether a group of adults with dyslexia showed impaired performance on shifting visual spatial attention. Twelve adults with dyslexia and 12 control adult participants took part in a Posner style focused attention orientation task and a shift attention orientation task. The participants also completed standardized measures of single word reading, spelling, IQ, phonological processing, speed of processing and non-word reading. Overall, the dyslexic participants showed the same pattern of performance as the control participants on the attention-orienting task, but completed the tasks at a consistently slower pace. Specifically, participants in both groups found short target presentation intervals more difficult than longer target presentation intervals, and participants in both groups were more impaired when cue-to-target information was invalid 20% of the time (shift task) than when it was valid all of the time (focused task). However, the group with dyslexia was significantly more impaired across the board

The Role of Costimulatory Receptors of the Tumour Necrosis Factor Receptor Family in Atherosclerosis

Atherosclerosis is a chronic inflammatory disease that is mediated by both the innate and adaptive immune responses. T lymphocytes, that together with B cells are the cellular effectors of the adaptive immune system, are currently endowed with crucial roles in the development and progression of atherosclerosis. Costimulatory receptors are a class of molecules expressed by T lymphocytes that regulate the activation of T cells and the generation of effector T-cell responses. In this review we present the roles of costimulatory receptors of the tumour necrosis factor receptor (TNFR) superfamily in atherosclerosis and discuss the implications for future therapies that could be used to specifically modulate the immune response of pathogenic T cells in this disease

On a batch arrival queuing system equipped with a stand-by server during vacation periods or the repairs times of the main server

This Article is provided by the Brunel Open Access Publishing Fund - Copyright @ 2011 Hindawi PublishingWe study a queuing system which is equipped with a stand-by server in addition to the main server. The stand-by server provides service to customers only during the period of absence of the main server when either the main server is on a vacation or it is in the state of repairs due to a sudden failure from time to time. The service times, vacation times, and repair times are assumed to follow general arbitrary distributions while the stand-by service times follow exponential distribution. Supplementary variables technique has been used to obtain steady state results in explicit and closed form in terms of the probability generating functions for the number of customers in the queue, the average number of customers, and the average waiting time in the queue while the MathCad software has been used to illustrate the numerical results in this work

Monitoring and Modelling the Vibrational Effects of Small (<50 kW) Wind Turbines on the Eskdalemuir IMS Station

It is known (Styles et al., 2005) that windfarms generate low frequency vibrations which propagate through the ground and have the potential to adversely affect sensitive installations, most notably seismometer arrays set up to monitor for nuclear tests. Significant work on the effects of large wind turbines has been carried out by Keele University as well as by Schofield (2002) and Fiori et al (2009). For the Eskdalemuir International Monitoring System station in Scotland, a vibration threshold was set, for wind farms within 50 km of Eskdalemuir, at frequencies around the 4 to 5 Hz region. However, with increased development, the threshold is being approached and small wind turbines (less than 50kW), even of the order of 15kW have also been restricted despite the differences in scale and modes of vibration. In order to protect Eskdalemuir a threshold limit was set for any turbine as a holding measure and a programme to try to establish whether they were really problematic has been carried out. Models for two wind turbine types from the manufacturers Proven and Gaia-Wind have been calculated and measurement programmes carried out. It has been possible to demonstrate that in most cases these small turbines do not generate significant energy in the band of concern and that the levels are low enough to be negligible. Small turbines once evaluated and monitored by Keele University and given approval by the UK Ministry of Defence, will receive clearance for deployment around the Eskdalemuir site at distances greater than 10km

Endogenous mammalian lectin localized extracellularly in lung elastic fibers.

An affinity-purified antibody preparation raised against a beta-galactoside-binding lectin from bovine lung was used to localize a similar lectin in rat lung by immunofluorescence and by electron microscopy after on-grid staining visualized with colloidal gold conjugated second antibody. The endogenous mammalian lectin was found in smooth muscle cells and squamous alveolar epithelial (type I) cells and was concentrated extracellularly in elastic fibers of pulmonary parenchyma and blood vessels. The extracellular localization of this lectin suggests that it, like others, functions by interaction with extracellular glycoconjugates