8,360 research outputs found
Anomalous structure in the single particle spectrum of the fractional quantum Hall effect
The two-dimensional electron system (2DES) is a unique laboratory for the
physics of interacting particles. Application of a large magnetic field
produces massively degenerate quantum levels known as Landau levels. Within a
Landau level the kinetic energy of the electrons is suppressed, and
electron-electron interactions set the only energy scale. Coulomb interactions
break the degeneracy of the Landau levels and can cause the electrons to order
into complex ground states. In the high energy single particle spectrum of this
system, we observe salient and unexpected structure that extends across a wide
range of Landau level filling fractions. The structure appears only when the
2DES is cooled to very low temperature, indicating that it arises from delicate
ground state correlations. We characterize this structure by its evolution with
changing electron density and applied magnetic field. We present two possible
models for understanding these observations. Some of the energies of the
features agree qualitatively with what might be expected for composite
Fermions, which have proven effective for interpreting other experiments in
this regime. At the same time, a simple model with electrons localized on
ordered lattice sites also generates structure similar to those observed in the
experiment. Neither of these models alone is sufficient to explain the
observations across the entire range of densities measured. The discovery of
this unexpected prominent structure in the single particle spectrum of an
otherwise thoroughly studied system suggests that there exist core features of
the 2DES that have yet to be understood.Comment: 15 pages, 10 figure
Fast synthesis of platinum nanopetals and nanospheres for highly-sensitive non-enzymatic detection of glucose and selective sensing of ions
Novel methods to obtain Pt nanostructured electrodes have raised particular interest due to their high performance in electrochemistry. Several nanostructuration methods proposed in the literature use costly and bulky equipment or are time-consuming due to the numerous steps they involve. Here, Pt nanostructures were produced for the first time by one-step template-free electrodeposition on Pt bare electrodes. The change in size and shape of the nanostructures is proven to be dependent on the deposition parameters and on the ratio between sulphuric acid and chloride-complexes (i.e., hexachloroplatinate or tetrachloroplatinate). To further improve the electrochemical properties of electrodes, depositions of Pt nanostructures on previously synthesised Pt nanostructures are also performed. The electroactive surface areas exhibit a two order of magnitude improvement when Pt nanostructures with the smallest size are used. All the biosensors based on Pt nanostructures and immobilised glucose oxidase display higher sensitivity as compared to bare Pt electrodes. Pt nanostructures retained an excellent electrocatalytic activity towards the direct oxidation of glucose. Finally, the nanodeposits were proven to be an excellent solid contact for ion measurements, significantly improving the time-stability of the potential. The use of these new nanostructured coatings in electrochemical sensors opens new perspectives for multipanel monitoring of human metabolism
Partonic description of a supersymmetric p-brane
We consider supersymmetric extensions of a recently proposed partonic
description of a bosonic p-brane which reformulates the Nambu-Goto action as an
interacting multi-particle action with Filippov-Lie algebra gauge symmetry. We
construct a worldline supersymmetric action by postulating, among others, a
p-form fermion. Demanding a local worldline supersymmetry rather than the full
worldvolume supersymmetry, we circumvent a known no-go theorem against the
construction of a Ramond-Neveu-Schwarz supersymmetric action for a p-brane of
p>1. We also derive a spacetime supersymmetric Green-Schwarz extension from the
preexisting kappa-symmetric action.Comment: 1+16 pages, no figure; References added and Concluding section
expanded. Final version to appear in JHE
AdS/BCFT Correspondence for Higher Curvature Gravity: An Example
We consider the effects of higher curvature terms on a holographic dual
description of boundary conformal field theory. Specifically, we consider
three-dimensional gravity with a specific combination of Ricci tensor square
and curvature scalar square, so called, new massive gravity. We show that a
boundary entropy and an entanglement entropy are given by similar expression
with those of the Einstein gravity case when we introduce an {\it effective}
Newton's constant and an {\it effective} cosmological constant. We also show
that the holographic g-theorem still holds in this extension, and we give some
comments about the central charge dependence of boundary entropy in the
holographic construction. In the same way, we consider new type black holes and
comment on the boundary profile. Moreover, we reproduce these results through
auxiliary field formalism in this specific higher curvature gravity.Comment: 27pages, minor corrections, accepted in JHE
Towards the âultimate earthquake-proofâ building: Development of an integrated low-damage system
The 2010â2011 Canterbury earthquake sequence has highlighted the
severe mismatch between societal expectations over the reality of seismic performance
of modern buildings. A paradigm shift in performance-based design criteria
and objectives towards damage-control or low-damage design philosophy and
technologies is urgently required. The increased awareness by the general public,
tenants, building owners, territorial authorities as well as (re)insurers, of the severe
socio-economic impacts of moderate-strong earthquakes in terms of damage/dollars/
downtime, has indeed stimulated and facilitated the wider acceptance and
implementation of cost-efficient damage-control (or low-damage) technologies.
The âbarâ has been raised significantly with the request to fast-track the development
of what the wider general public would hope, and somehow expect, to live
in, i.e. an âearthquake-proofâ building system, capable of sustaining the shaking of
a severe earthquake basically unscathed.
The paper provides an overview of recent advances through extensive research,
carried out at the University of Canterbury in the past decade towards the development
of a low-damage building system as a whole, within an integrated
performance-based framework, including the skeleton of the superstructure, the
non-structural components and the interaction with the soil/foundation system.
Examples of real on site-applications of such technology in New Zealand, using
concrete, timber (engineered wood), steel or a combination of these materials, and
featuring some of the latest innovative technical solutions developed in the laboratory
are presented as examples of successful transfer of performance-based seismic
design approach and advanced technology from theory to practice
The phylogenetically-related pattern recognition receptors EFR and XA21 recruit similar immune signaling components in monocots and dicots
During plant immunity, surface-localized pattern recognition receptors (PRRs) recognize pathogen-associated molecular patterns (PAMPs). The transfer of PRRs between plant species is a promising strategy for engineering broad-spectrum disease resistance. Thus, there is a great interest in understanding the mechanisms of PRR-mediated resistance across different plant species. Two well-characterized plant PRRs are the leucine-rich repeat receptor kinases (LRR-RKs) EFR and XA21 from Arabidopsis thaliana (Arabidopsis) and rice, respectively. Interestingly, despite being evolutionary distant, EFR and XA21 are phylogenetically closely related and are both members of the sub-family XII of LRR-RKs that contains numerous potential PRRs. Here, we compared the ability of these related PRRs to engage immune signaling across the monocots-dicots taxonomic divide. Using chimera between Arabidopsis EFR and rice XA21, we show that the kinase domain of the rice XA21 is functional in triggering elf18-induced signaling and quantitative immunity to the bacteria Pseudomonas syringae pv. tomato (Pto) DC3000 and Agrobacterium tumefaciens in Arabidopsis. Furthermore, the EFR:XA21 chimera associates dynamically in a ligand-dependent manner with known components of the EFR complex. Conversely, EFR associates with Arabidopsis orthologues of rice XA21-interacting proteins, which appear to be involved in EFR-mediated signaling and immunity in Arabidopsis. Our work indicates the overall functional conservation of immune components acting downstream of distinct LRR-RK-type PRRs between monocots and dicots
Fluctuations of a holographic quantum Hall fluid
We analyze the neutral spectrum of the holographic quantum Hall fluid
described by the D2-D8' model. As expected for a quantum Hall state, we find
the system to be stable and gapped and that, at least over much of the
parameter space, the lowest excitation mode is a magneto-roton. In addition, we
find magneto-rotons in higher modes as well. We show that these magneto-rotons
are direct consequences of level crossings between vector and scalar modes.Comment: 20 pages, 8 figures; v.2 figures improved, 2 figures added, and text
clarified particularly in Sec. 5, to appear in JHE
In an in vitro model of human tuberculosis, monocyte-microglial networks regulate matrix metalloproteinase-1 and -3 gene expression and secretion via a p38 mitogen activated protein kinase-dependent pathway.
BACKGROUND: Tuberculosis (TB) of the central nervous system (CNS) is characterized by extensive tissue inflammation, driven by molecules that cleave extracellular matrix such as matrix metalloproteinase (MMP)-1 and MMP-3. However, relatively little is known about the regulation of these MMPs in the CNS. METHODS: Using a cellular model of CNS TB, we stimulated a human microglial cell line (CHME3) with conditioned medium from Mycobacterium tuberculosis-infected primary human monocytes (CoMTb). MMP-1 and MMP-3 secretion was detected using ELISAs confirmed with casein zymography or western blotting. Key results of a phospho-array profile that detects a wide range of kinase activity were confirmed with phospho-Western blotting. Chemical inhibition (SB203580) of microglial cells allowed investigation of expression and secretion of MMP-1 and MMP-3. Finally we used promoter reporter assays employing full length and MMP-3 promoter deletion constructs. Student's t-test was used for comparison of continuous variables and multiple intervention experiments were compared by one-way ANOVA with Tukey's correction for multiple pairwise comparisons. RESULTS: CoMTb up-regulated microglial MMP-1 and MMP-3 secretion in a dose- and time-dependent manner. The phospho-array profiling showed that the major increase in kinase activity due to CoMTb stimulation was in p38 mitogen activated protein kinase (MAPK), principally the α and γ subunits. p38 phosphorylation was detected at 15 minutes, with a second peak of activity at 120 minutes. High basal extracellular signal-regulated kinase activity was further increased by CoMTb. Secretion and expression of MMP-1 and MMP-3 were both p38 dependent. CoMTb stimulation of full length and MMP-3 promoter deletion constructs demonstrated up-regulation of activity in the wild type but a suppression site between -2183 and -1612 bp. CONCLUSIONS: Monocyte-microglial network-dependent MMP-1 and MMP-3 gene expression and secretion are dependent upon p38 MAPK in tuberculosis. p38 is therefore a potential target for adjuvant therapy in CNS TB
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