Success Stories in National Innovations on Climate Resilient Agriculture

Not AvailableIn recent years, climate change pertains to significant rise in the frequency of extreme weather events affecting the productivity of crops. Another climate change feature significantly influencing agro eco systems in the change in seasonal rainfall patterns. Enhancing resilience of agriculture to climate risk is of immense importance for protecting livelihoods of farmers. Rainfed agriculture in India accounts for about 60 per cent of the net cultivated area which supports 40 per cent human and 60 per cent livestock population. The contribution from agricultural sector towards GDP is very crucial as 65 – 70 per cent of the population is mainly dependent on agriculture for their livelihood. The Agricultural growth in dryland areas is determined by the bio-physical and socioeconomic factors and their interactions. Rainfed agriculture is diverse and risk prone mainly depending on rainfall. Location specific technologies are essential to attain sustainability in agriculture in these areas. The All India Co-ordinated Research Project for Dryland Agriculture (AICRPDA) main centre, Ananthapuramu was started in 1971 and has carried out commendable research work on dryland agriculture for the past four and half decades. This project has been carrying out location specific adaptive research on rain water management, soil and water conservation, crops and cropping system, farming system crop improvement, energy management, integrated nutrient management and alternate land use systems. This publication contains the essence of important technologies developed for profitable rainfed farming including improved crop varieties, soil test based fertilizer application through integrated nutrient management, insitu and exsitu water conservation methods like rain water harvesting, farm ponds, crops and cropping system, seed to seed mechanization in groundnut, contingency plans for climate exigencies and farming systems approach for enhancing health and income. I compliment Dr. B. Sahadeva Reddy, Chief Scientist, all other scientists and staff involved in bringing out this publication entitled “Success Stories in National Innovations on Climate Resilient Agriculture”. I am sure that this publication would form a valuable source of scientific information for scientists, extension workers, stake holders/farmers and all others engaged in the development of dryland agriculture to improve productivity in rainfed agriculture and enhance the livelihood security of farming.Not Availabl

Ranking of Search Engines in View of Information Explosion

Deals with collection of number of records published on Web, on 23 Main Classes of Colon Classification from 1st January to 31st March 2014 on daily basis, using 5 Search Engines – Google, Lycos, Microsoft, Rediff and Yahoo. Ranking of 5 Search Engines, 23 Main Classes, and the months of January, February and March 2014 has been carried-out, based on number of records they retrieved during the period of study. DOI: 10.17762/ijritcc2321-8169.150518

Extraction and characterization of novel lignocellulosic fibers from Thespesia lampas plant

In this work, the lignocellulosic fibers from the plant Thespesia lampas were extracted and investigated in detail. The prime objective of this work was to study the effect of alkali treatment on the chemical composition, tensile properties, morphological and structural changes, and thermal degradation of Thespesia lampas fibers. Chemical analysis, FT-IR, and 13C CP-MAS NMR spectroscopic studies indicated lowering of amorphous hemicellulose content on alkali treatment. Wide-angle X-ray diffraction studies indicated increase in crystallinity of the fibers on alkali treatment. The tensile strength and modulus of the fibers and thermal stability increased on alkali treatment. Scanning electron micrographs revealed roughening of the surface of the fibers due to the removal of the hemicellulose layer on alkali treatment. Tensile properties of Thespesia fibers were compared to those of other important natural fibers, and it was indicated as an alternative suitable source for composite construction

Evaluation of analgesic and anti-inflammatory activity of a combination of tramadol-pregabalin in animal models of pain and inflammation

Background: A major goal of pain management is to provide pain relief that is clinically meaningful, sustained, and associated with minimum and reversible adverse effects. Since single analgesic drug is not effective in all patients, there is a need either to develop new and more effective drugs or to identify favourable combinations of drugs that are already available. The aim of the present was to evaluate the analgesic and anti-inflammatory activity of tramadol and pregabalin when used alone or in combination in animal models of pain and inflammation.Methods: The animals (rats and mice) were divided into eight groups with six animals in each group. Analgesia was assessed by acetic acid induced writhing and tail flick methods in mice and hot plate method in rats. Paw oedema model in rats after induction with 0.1 ml of 1% carrageenan was used to assess the anti‑inflammatory activity. The percentage inhibition of writhes and prolongation of reaction time were used for assessing analgesic activity and reduction in paw volume was used for assessing anti-inflammatory activity. The results obtained were analysed by ANOVA and Tukey HSD Post-hoc Test.Results: Treatment with tramadol pregabalin alone or in combination reduced writhing episodes significantly in acetic acid induced writhing in mice as compared to control indicating its analgesic effect and the highest percentage inhibition of pain was seen with high dose tramadol plus pregabalin. Treatment in Hot plate and Tail flick methods significantly prolonged the reaction time at all time points.Conclusions: Tramadol when combined with pregabalin may enhance its anti-nociceptive effects. If confirmed in additional models of acute and/or chronic pain this combination might be useful in the clinical management of pain not associated with inflammation

DESIGN AND PERFORMANCE ANALYSIS OF FULL ADDER USING 6-T XOR–XNOR CELL

In this paper, the design and simulation of a high-speed, low power 6-T XOR-XNOR circuit is carried out. Also, the design and simulation of 1-bit hybrid full adder (consisting of 16 transistors) using XOR-XNOR circuit, sum, and carry, is performed to improve the area and speed performance. Its performance is being compared with full adder designs with 20 and 18 transistors, respectively. The performance of the proposed circuits is measured by simulating them in Microwind tool using 180 and 90nm CMOS technology. The performance of the proposed circuit is measured in terms of power, delay, and PDP (Power Delay Product)

A review of antibiotic synergy in carbapenemase-producing bacteria

The problem of antibiotic resistance has garnered too much attention over the last few decades for posing a global hazard to the clinical handling and the inhibition of several deadly infections caused by bacteria. It burdens the world not only clinically but also economically... Antibiotic agents known as carbapenems are a very effective and  typically designated for the treatment of multidrug-resistant (MDR) bacterial infections. To identify a suitable antibiotic combination to be used in vivo, one must be able to determine the synergism between the antibiotics in vitro. Several methods, such as the checkerboard method, multiple-combination bactericidal test, time-kill and E-test, have been used for this purpose. However, the lack of proper standardization procedures, types of bacterial agents, bacterial load, stage of infection and other factors make it very difficult to reproduce or correlate the results with other methods.Carbapenem-destroying lactases, which have recently emerged as mechanisms of resistance, are increasing in number and decreasing the treatment alternatives available. These infections are treated with colistin and tigecycline, but monotherapy may result in clinical breakdown because of a variety of factors. To control these infections, clinicians often choose combinations of drugs over monotherapy. There is an extreme lack of information on synergistic antibiotic combinations accounting for the diverse mechanisms of GNB resistance commonly encountered. The incidence of carbapenem-resistant GNB in Indian articles is also unknown. Therefore, we anticipate that this study may provide methodology for the selection of an appropriate antibiotic combination

Alterations in the leaf lipidome of \u3ci\u3eBrassica carinata\u3c/i\u3e under high-temperature stress

Background: Brassica carinata (A) Braun has recently gained increased attention across the world as a sustainable biofuel crop. B. carinata is grown as a summer crop in many regions where high temperature is a significant stress during the growing season. However, little research has been conducted to understand the mechanisms through which this crop responds to high temperatures. Understanding traits that improve the high-temperature adaption of this crop is essential for developing heat-tolerant varieties. This study investigated lipid remodeling in B. carinata in response to high-temperature stress. A commercial cultivar, Avanza 641, was grown under sunlit-controlled environmental conditions in Soil-Plant-Atmosphere-Research (SPAR) chambers under optimal temperature (OT; 23/ 15°C) conditions. At eight days after sowing, plants were exposed to one of the three temperature treatments [OT, high-temperature treatment-1 (HT-1; 33/25°C), and high-temperature treatment-2 (HT-2; 38/30°C)]. The temperature treatment period lasted until the final harvest at 84 days after sowing. Leaf samples were collected at 74 days after sowing to profile lipids using electrospray-ionization triple quadrupole mass spectrometry. Results: Temperature treatment significantly affected the growth and development of Avanza 641. Both hightemperature treatments caused alterations in the leaf lipidome. The alterations were primarily manifested in terms of decreases in unsaturation levels of membrane lipids, which was a cumulative effect of lipid remodeling. The decline in unsaturation index was driven by (a) decreases in lipids that contain the highly unsaturated linolenic (18: 3) acid and (b) increases in lipids containing less unsaturated fatty acids such as oleic (18:1) and linoleic (18:2) acids and/or saturated fatty acids such as palmitic (16:0) acid. A third mechanism that likely contributed to lowering unsaturation levels, particularly for chloroplast membrane lipids, is a shift toward lipids made by the eukaryotic pathway and the channeling of eukaryotic pathway-derived glycerolipids that are composed of less unsaturated fatty acids into chloroplasts. Conclusions: The lipid alterations appear to be acclimation mechanisms to maintain optimal membrane fluidity under high-temperature conditions. The lipid-related mechanisms contributing to heat stress response as identified in this study could be utilized to develop biomarkers for heat tolerance and ultimately heat-tolerant varieties

Sweetpotato cultivars responses to interactive effects of warming, drought, and elevated carbon dioxide

Plants are sensitive to changes projected in climates, such as elevated carbon dioxide (eCO2), high temperature (T), and drought stress (DS), which affect crop growth, development, and yield. These stresses, either alone or in combination, affect all aspects of sweetpotato plant growth and development, including storage root development and yield. We tested three sweetpotato cultivars (Beauregard, Hatteras, and LA1188) responses to eight treatments (Control, DS, T, eCO2, DS + T, T + eCO2, DS + eCO2, DS + T + eCO2). All treatments were imposed 36 days after transplanting (DAP) and continued for 47 days. Treatments substantially affected gas exchange, photosynthetic pigments, growth, and storage root components. Cultivars differed considerably for many of the measured parameters. The most significant negative impact of DS was recorded for the shoot and root weights. The combination of DS + T had a significant negative effect on storage root parameters. eCO2 alleviated some of the damaging effects of DS and high T in sweetpotato. For instance, eCO2 alone or combined with DS increased the storage root weights by 22% or 42% across all three cultivars, respectively. Based on the stress response index, cultivar “Hatteras” was most tolerant to individual and interactive stresses, and “LA 1188” was sensitive. Our findings suggest that eCO2 negates the negative impact of T or DS on the growth and yield of sweetpotato. We identified a set of individual and interactive stress-tolerant traits that can help select stress cultivars or breed new lines for future environments

Limonene and BEZ 235 induce apoptosis in COLO-320 and HCT-116 colon cancer cells

Deregulated apoptosis is the hall mark of many cancers, therefore every defect in apoptosis pathway could be a potential target for cancer treatment.The anticancer mechanism of limonene could be multifactorial. However, induction of apoptosis in cancer cells is proposed as the predominant mechanism in several of preclinical studies. Therefore, we determined to investigate the role of apoptosis in the anticancer activity of limonene and BEZ235 combination in COLO-320 and HCT-116 colon cancer cells. Cells after treatments were assessed for apoptosis by DAPI staining for fluorescent microscopic examination of apoptotic cells, estimation of caspases activities, Bcl-2 family proteins in addition to cell cycle analysis by flowcytometry. Results show that both drugs induced apoptosis as demonstrated by increased caspases activity, significant alterations in pro and anti-apoptotic proteins of Bcl-2 family in promoting apoptosis and cell cycle arrest at G1 phase. Over all, it is indicated that limonene and BEZ exerted anticancer activity is mediated through induction of apoptosis involving mitochondria mediated intrinsic death pathway in the selected CRC cells

Limonene and BEZ 235 inhibits growth of COLO-320 and HCT-116 colon cancer cells

D-Limonene is a dietary monoterpene with significant anticancer activity against many cancer types in preclinical and clinical studies. The study is designed to investigate synergistic anticancer effects of limonene and BEZ235 combination in COLO-320 and HCT-116 colon cancer cells. Cells were treated with both the drugs alone and in combination and the effects on cell viability; cell migration and clonogenic potential were examined. Results show that both drugs exhibited dose and time dependant cytotoxicity on the cell lines tested. CompuSyn analysis of the drug combination effects revealed the strong synergistic interaction of the combination. Our results also indicate that COLO-320 cells were more sensitive for anticancer effects of the drugs than HCT-116 cells. The presence of Ras and PI3K mutations in HCT-116 cells could possibly be one of the main reasons for the observed outcome as compared to the wild type expressions of them in COLO-320 cells