1,319 research outputs found
Improving Surgical Care in Low- and Middle-Income Countries: A Pivotal Role for the World Health Organization
In response to increasing evidence that surgical conditions are an important global public health problem, and data suggesting that essential surgical services can be delivered in a cost-effective manner in low- and middle-income countries, the World Health Organization (WHO) has expanded its interest in surgical care. In 2004, WHO established a Clinical Procedures Unit within the Department of Essential Health Technologies. This unit has developed the Emergency and Essential Surgical Project (EESC), which includes a basic surgical training program based on the âIntegrated Management of Emergency and Essential Surgical Careâ Toolkit and the textbook âSurgery at the District Hospital.â To promote the importance of emergency and essential surgical care, a Global Initiative for Emergency and Essential Care was launched in 2005. In what maybe the most important development, surgical care is included in WHOâs new comprehensive primary health care plan. Given these rapid developments, surgical care at WHO may be approaching a critical âtipping point.â Lobbying for a World Health Assembly resolution on emergency and essential surgical care, and developing âstructured collaborationsâ between WHO and various stakeholders are potential ways to ensure that the global surgery agenda continues to move forward
Improving the Quantitative Basis of the Surgical Burden in Low-Income Countries
Theo Vos discusses how surgery is beginning to be considered an essential component of primary health care in low-income countries, and how we need to improve our understanding of the burden of surgical conditions in these settings
Trust Perceptions of Online Travel Information by Different Content Creators: Some Social and Legal Implications
Consumers are increasingly turning to the online
environment to provide information to assist them in
making purchase decisions related to travel products. They
often rely on travel recommendations from different
sources, such as sellers, independent experts and, increasingly,
other consumers. A new type of online content, usergenerated
content (UGC), provides a number of legal and
social challenges to providers and users of that content,
especially in relation to areas such as defamation, misrepresentation
and social embarrassment. This paper reports
research that examined the level of trustworthiness of
online travel information from these different sources. The
study used a survey of Australian travel consumers (n=
12,000) and results support the notion that there are
differences in the level of trust for online travel information
from different sources. Respondents âtended to agreeâ that
they trusted information provided by travel agents, information
from commercial operators and comments made by
travellers on third party websites. However, the highest
level of trust was afforded to information provided on State
government tourism websites. These results suggest that
greater trust is placed in online travel comments when they
are on a specific travel website than when they are on a
more generic social networking website. However, respondents
were ânot sureâ that they trusted comments made by
travellers on weblogs and on social networking sites. Some
88% of respondents that had not visited UGC websites (or
were unsure if they had) indicated that they thought that
UGC would be useful in the future â suggesting that they
feel that any concerns they may have in relation to legal and
social problems resulting from its use will be resolved
A phase III, multi-centre, double-masked randomised controlled trial of adjunctive intraocular and peri-ocular steroid (triamcinolone acetonide) versus standard treatment in eyes undergoing vitreoretinal surgery for open globe trauma (ASCOT): statistical analysis plan
Histone deacetylases as new therapy targets for platinum-resistant epithelial ovarian cancer
Introduction: In developed countries, ovarian cancer is the fourth most common cancer in women. Due to the nonspecific symptomatology associated with the disease many patients with ovarian cancer are diagnosed late, which leads to significantly poorer prognosis. Apart from surgery and radiotherapy, a substantial number of ovarian cancer patients will undergo chemotherapy and platinum based agents are the mainstream first-line therapy for this disease. Despite the initial efficacy of these therapies, many women relapse; therefore, strategies for second-line therapies are required. Regulation of DNA transcription is crucial for tumour progression, metastasis and chemoresistance which offers potential for novel drug targets. Methods: We have reviewed the existing literature on the role of histone deacetylases, nuclear enzymes regulating gene transcription. Results and conclusion: Analysis of available data suggests that a signifant proportion of drug resistance stems from abberant gene expression, therefore HDAC inhibitors are amongst the most promising therapeutic targets for cancer treatment. Together with genetic testing, they may have a potential to serve as base for patient-adapted therapies
Methods for specifying the target difference in a randomised controlled trial : the Difference ELicitation in TriAls (DELTA) systematic review
Peer reviewedPublisher PD
Dynamic Causal Modeling in PTSD and Its Dissociative Subtype: Bottom-Up Versus Top-Down Processing Within Fear and Emotion Regulation Circuitry
Posttraumatic stress disorder (PTSD) is associated with decreased topâdown emotion modulation from medial prefrontal cortex (mPFC) regions, a pathophysiology accompanied by hyperarousal and hyperactivation of the amygdala. By contrast, PTSD patients with the dissociative subtype (PTSDâ+âDS) often exhibit increased mPFC topâdown modulation and decreased amygdala activation associated with emotional detachment and hypoarousal. Crucially, PTSD and PTSDâ+âDS display distinct functional connectivity within the PFC, amygdala complexes, and the periaqueductal gray (PAG), a region related to defensive responses/emotional coping. However, differences in directed connectivity between these regions have not been established in PTSD, PTSDâ+âDS, or controls. Methods: To examine directed (effective) connectivity among these nodes, as well as group differences, we conducted resting-state stochastic dynamic causal modeling (sDCM) pairwise analyses of coupling between the ventromedial (vm)PFC, the bilateral basolateral and centromedial (CMA) amygdala complexes, and the PAG, in 155 participants (PTSD [nâ=â62]; PTSDâ+âDS [nâ=â41]; age-matched healthy trauma-unexposed controls [nâ=â52]). Results: PTSD was characterized by a pattern of predominant bottomâup connectivity from the amygdala to the vmPFC and from the PAG to the vmPFC and amygdala. Conversely, PTSDâ+âDS exhibited predominant topâdown connectivity between all node pairs (from the vmPFC to the amygdala and PAG, and from the amygdala to the PAG). Interestingly, the PTSDâ+âDS group displayed the strongest intrinsic inhibitory connections within the vmPFC. Conclusions: These results suggest the contrasting symptom profiles of PTSD and its dissociative subtype (hyper- vs. hypo-emotionality, respectively) may be driven by complementary changes in directed connectivity corresponding to bottomâup defensive fear processing versus enhanced topâdown regulation
The quest for the solar g modes
Solar gravity modes (or g modes) -- oscillations of the solar interior for
which buoyancy acts as the restoring force -- have the potential to provide
unprecedented inference on the structure and dynamics of the solar core,
inference that is not possible with the well observed acoustic modes (or p
modes). The high amplitude of the g-mode eigenfunctions in the core and the
evanesence of the modes in the convection zone make the modes particularly
sensitive to the physical and dynamical conditions in the core. Owing to the
existence of the convection zone, the g modes have very low amplitudes at
photospheric levels, which makes the modes extremely hard to detect. In this
paper, we review the current state of play regarding attempts to detect g
modes. We review the theory of g modes, including theoretical estimation of the
g-mode frequencies, amplitudes and damping rates. Then we go on to discuss the
techniques that have been used to try to detect g modes. We review results in
the literature, and finish by looking to the future, and the potential advances
that can be made -- from both data and data-analysis perspectives -- to give
unambiguous detections of individual g modes. The review ends by concluding
that, at the time of writing, there is indeed a consensus amongst the authors
that there is currently no undisputed detection of solar g modes.Comment: 71 pages, 18 figures, accepted by Astronomy and Astrophysics Revie
Angular-momentum coupling through the tachocline
Astronomical observation of stellar rotation suggests that at least the
surface layers of the Sun have lost a substantial amount of the angular
momentum that they possessed at the beginning of the main-sequence phase of
evolution; and solar-wind observations indicate that magnetic coupling is still
draining angular momentum from the Sun today. In addition, helioseismological
analysis has shown that the specific angular momentum at the top of the almost
uniformly rotating radiative interior is approximately (although not exactly)
the same as the spherically averaged value at the base of the (differentially
rotating) convection zone, suggesting that angular momentum is being
transported through the tachocline. The mechanism by which that transport is
taking place is not understood. Nor is there a consensus of opinion. I review
some of the suggestions that have been put forward, biassing my discussion, no
doubt, according to my own opinions.Comment: 19 pages, 7 figures, conference on `Magnetic coupling between the
interior and the atmosphere of the Sun' ed. S. S. Hasan and R. J. Rutten,
Bangalore, December 200
Interaction Between Convection and Pulsation
This article reviews our current understanding of modelling convection
dynamics in stars. Several semi-analytical time-dependent convection models
have been proposed for pulsating one-dimensional stellar structures with
different formulations for how the convective turbulent velocity field couples
with the global stellar oscillations. In this review we put emphasis on two,
widely used, time-dependent convection formulations for estimating pulsation
properties in one-dimensional stellar models. Applications to pulsating stars
are presented with results for oscillation properties, such as the effects of
convection dynamics on the oscillation frequencies, or the stability of
pulsation modes, in classical pulsators and in stars supporting solar-type
oscillations.Comment: Invited review article for Living Reviews in Solar Physics. 88 pages,
14 figure
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