Partially Annealed Disorder and Collapse of Like-Charged Macroions

Charged systems with partially annealed charge disorder are investigated using field-theoretic and replica methods. Charge disorder is assumed to be confined to macroion surfaces surrounded by a cloud of mobile neutralizing counterions in an aqueous solvent. A general formalism is developed by assuming that the disorder is partially annealed (with purely annealed and purely quenched disorder included as special cases), i.e., we assume in general that the disorder undergoes a slow dynamics relative to fast-relaxing counterions making it possible thus to study the stationary-state properties of the system using methods similar to those available in equilibrium statistical mechanics. By focusing on the specific case of two planar surfaces of equal mean surface charge and disorder variance, it is shown that partial annealing of the quenched disorder leads to renormalization of the mean surface charge density and thus a reduction of the inter-plate repulsion on the mean-field or weak-coupling level. In the strong-coupling limit, charge disorder induces a long-range attraction resulting in a continuous disorder-driven collapse transition for the two surfaces as the disorder variance exceeds a threshold value. Disorder annealing further enhances the attraction and, in the limit of low screening, leads to a global attractive instability in the system.Comment: 21 pages, 2 figure

Appraising empirical applications of Structuration Theory in management and organization studies

There is an increasing interest in the application of Structuration Theory in the fields of management and organization studies. Based upon a thorough literature review, we have come up with a data-set to assess how Structuration Theory has been used in empirical research. We use three key concepts of this theory (duality of structure, knowledgeability, and time-space) as sensitizing concepts for our analysis. We conclude that the greatest potential of Structuration Theory for management and organization studies is to view it as a process theory that offers a distinct building block for explaining intra and interorganizational change, as exemplified through concepts such as routine, script, genre, practice, and discourse

Global perspectives on observing ocean boundary current systems

Ocean boundary current systems are key components of the climate system, are home to highly productive ecosystems, and have numerous societal impacts. Establishment of a global network of boundary current observing systems is a critical part of ongoing development of the Global Ocean Observing System. The characteristics of boundary current systems are reviewed, focusing on scientific and societal motivations for sustained observing. Techniques currently used to observe boundary current systems are reviewed, followed by a census of the current state of boundary current observing systems globally. Next steps in the development of boundary current observing systems are considered, leading to several specific recommendations

A meta-analysis of dry matter intake in Nellore and Zebu-crosses cattle

The study was carried out to develop and to evaluate new equations to predict dry matter intake (DMI) of Nellore and Zebu-crosses cattle using meta-analysis procedure. The data used to estimate the parameters were collected from independent performance experiments using growing and fattening Nellore and Zebu-crosses cattle, and they were compiled from 561 experimental units. Before proposing an equation to predict DMI, it was observed that the genetic group was a source of statisticaly significant variation. Therefore, equations to predict dry matter intake in the Zebu-Crosses and Nellore cattle were independently developed. The regression equations for Zebu-crosses cattle were: DMI = -2.6098 + 0.08844BW0.75 + 4.4672ADG - 1.3579ADG2 and DMI = -1.0094 + 0.01608BW + 4.4363ADG -1.2548ADG2. The regression equations for Nellore cattle were: DMI = -2.7878 + 0.08789BW0.75 + 5.0487ADG - 1.6835ADG2 and DMI = -1.3559 + 0.0159BW + 5.6397ADG - 1.8494ADG2. In order to evaluate fitted equations, it was utilized data from independent experiments published from 2005 to 2008 in the Revista Brasileira de Zootecnia. The equations (DMI) for Nellore overpredicted dry matter intake for estimates lower than 7 and higher than 10 kg·d-1. For Zebu-crosses cattle, dispersions of 3 kg d-1 were observed when extreme intakes were evaluated, however, when the equation included BW 0.75, the intercept did not differ from zero and the slope did not differ from 1. It is not possible to fit only one equation for preditcting DMI for beef cattle in tropical conditions, because there are differences between Zebu and Zebu-crosses. Fitted equations that include ADG and BW 0.75 should be used as an alternative method to predict dry matter intake of Zebu-crosses and Nellore beef cattle in tropical conditions.Objetivou-se desenvolver e avaliar novas equações para predição do consumo de matéria seca (CMS) em bovinos Nelore e mestiço, utilizando-se meta-análise. Os dados utilizados para estimar os parâmetros foram coletados em experimentos de desempenho independentes com bovinos Nelore e mestiço nas fases de recria e engorda, compilados a partir de 561 unidades experimentais. Antes de propor uma equação para predizer o CMS, observou-se que o grupo genético foi uma fonte de variação estatisticamente significativa. Neste sentido, equações para predizer o CMS em bovinos Nelores e mestiços foram desenvolvidas de forma independente. As equações de regressão para bovinos mestiços foram: CMS = -2,6098 + 0,08844PV0,75 + 4,4672GMD - 1,3579GMD2 e CMS = -1,0094 + 0,01608PV + 4,4363GMD -1.2548GMD2. As equações de regressão para bovinos Nelore foram: CMS = -2,7878 + 0,08789PV0,75 + 5,0487GMD - 1,6835GMD2 e CMS = -1,3559 +,0159PV + 5,6397GMD - 1,8494GMD2. Para avaliar as equações ajustadas, utilizaram-se dados de experimentos independentes publicados entre 2005 e 2008 na Revista Brasileira de Zootecnia. As equações (CMS) para Nelore superestimaram o CMS para estimativas menores que 7 e maiores que 10 kg d-1. Para bovinos mestiços, as dispersões de 3 kg·d-1 foram observadas quando pontos extremos foram avaliados, no entanto, quando a equação incluiu PV0,75, o intercepto não diferiu de zero e a inclinação não diferiu de 1. Não é possível ajustar uma única equação para predizer o CMS para bovinos de corte em condições tropicais, porque há diferenças entre Nelores e mestiços. Equações ajustadas que incluem GMD e PV0,75 devem ser usadas como um método alternativo para predizer o CMS em bovinos Nelores e mestiços em condições tropicais

Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries

Background Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres. Methods This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries. Results In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia. Conclusion This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries

Whole-genome sequencing reveals host factors underlying critical COVID-19

Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care1 or hospitalization2,3,4 after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically ill individuals compared with 48,400 controls to discover and replicate 23 independent variants that significantly predispose to critical COVID-19. We identify 16 new independent associations, including variants within genes that are involved in interferon signalling (IL10RB and PLSCR1), leucocyte differentiation (BCL11A) and blood-type antigen secretor status (FUT2). Using transcriptome-wide association and colocalization to infer the effect of gene expression on disease severity, we find evidence that implicates multiple genes—including reduced expression of a membrane flippase (ATP11A), and increased expression of a mucin (MUC1)—in critical disease. Mendelian randomization provides evidence in support of causal roles for myeloid cell adhesion molecules (SELE, ICAM5 and CD209) and the coagulation factor F8, all of which are potentially druggable targets. Our results are broadly consistent with a multi-component model of COVID-19 pathophysiology, in which at least two distinct mechanisms can predispose to life-threatening disease: failure to control viral replication; or an enhanced tendency towards pulmonary inflammation and intravascular coagulation. We show that comparison between cases of critical illness and population controls is highly efficient for the detection of therapeutically relevant mechanisms of disease